个人简介

夏玉先，教授，1964年生，教授(二级)、博士生导师、生物学一级学科博士点学术带头人、教育部“新世纪优秀人才”、重庆市百名杰出科技领军人才、重庆市微生物学科带头人、农业农村部专家指导委员会委员、国家标准委员会生物农药分委会副秘书长。现任重庆大学基因工程研究中心主任、重庆市“杀虫真菌农药工程技术研究中心”主任、重庆市功能基因与调控技术重点实验室主任。主要从事杀虫真菌农药研制相关的基础研究和应用技术研究。先后主持国家级和省部级科研、中试和产业化项目20多项；主持完成的研究成果获2009年度重庆市技术发明一等奖和2010年获中国侨界贡献奖（创新成果），获得国家发明专利30余项。以第一或通讯作者在PLoS Pathogens、Environmental Microbiology、Journal of Pest Science、Pest Management Science等国际著名学术刊物发表SCI收录论文100余篇。带领的研究团队先后获得2019年度重庆市高校创新研究群体——“杀虫真菌重要性状的机制研究与菌株改良”、重庆市2019年研究生导师团队——“杀虫真菌农药研发团队”、2020年重庆市英才计划创新创业团队——“杀虫真菌资源挖掘及其应用研究创新团队”。

学习经历：
1997-2000 英国Bath大学 获博士学位（英国海外研究学生奖学金）
1988-1991 西南农业大学 获硕士学位
1981-1985 四川农业大学 获学士学位
工作经历
1996-1997 英国Bath大学访问****（中英友好奖学金）
1991-1997 西南大学 历任助教、讲师、副教授
2000-至今 重庆大学 教授




研究方向
分子微生物学、昆虫病理学、微生物分子育种

研究描述
围绕杀虫真菌农药创制，以绿僵菌和东亚飞蝗为模式，开展昆虫病原真菌重要性状（产孢、致病、抗逆）形成的分子机制，发掘功能基因及调控方法（分子微生物学方向）；阐明昆虫防卫病原真菌侵染的分子机制，发现新的杀虫靶标及害虫防控新途径（昆虫病理学方向）；开展杀虫真菌菌株选育新技术研究，选育高产、抗逆和高杀虫活性的菌株（微生物分子育种方向）。
本实验室研究团队有教授5人、副教授1人，中级职称1人，研究条件完善、设备设施和技术平台先进，除开展与杀虫真菌剂相关基础研究外，与国内外生物农药研究机构、生产企业、高端农产品生产企业有广泛联系，欢迎国内外对微生物农药基础研究和应用研究有兴趣的本科生、硕士生、博士生、博士后和****加入。

主讲课程
博士研究生：生物科学研究前沿
硕士研究生：专业英语
本科生：发酵工程学

学术兼职
《中国生物防治学报》副主编
中国留学基金委终身评委。

主要成果
近五年发表论文：
[1] Li Jun, Xie Jiaqin, Zeng Deyu, Xia Yuxian, Peng Guoxiong (2021) Effective control of Frankliniella occidentalis by Metarhizium anisopliae CQMa421 under field conditions. JOURNAL OF PEST SCIENCE, 94:111–117.
[2] Zheng Renwen, Xia Yuxian, Keyhani Nemat O (2021) Differential responses of the antennal proteome of male and female migratory locusts to infection by a fungal pathogen. JOURNAL OF PROTEOMICS,232:104050.
[3] Jiang Zeyuan, Ligoxygakis Petros, Xia Yuxian (2020) HYD3, a conidial hydrophobin of the fungal entomopathogen Metarhizium acridum induces the immunity of its specialist host locust. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 165(Pt A):1303–1311.
[4] Wen Zhiqiong, Tian Huiting, Xia Yuxian, Jin Kai (2020) MaPmt1, a protein O-mannosyltransferase, contributes to virulence through governing the appressorium turgor pressure in Metarhizium acridum. FUNGAL GENETICS AND BIOLOGY, 145: 103480.
[5] Gao Pingping, Jin Kai, Xia Yuxian (2020) The phosphatase gene MaCdc14 negatively regulates UV-B tolerance by mediating the transcription of melanin synthesis-related genes and contributes to conidiation in Metarhizium acridum. CURRENT GENETICS, 66 (1): 141–153.
[6] Guo Haoyu, Wang Hongjun, Keyhani Nemat O, Xia Yuxian, Peng Guoxiong (2020) Disruption of an adenylate-forming reductase required for conidiation, increases virulence of the insect pathogenic fungus Metarhizium acridum by enhancing cuticle invasion. PEST MANAGEMENT SCIENCE, 76 (2): 758–768.
[7] Zhang Maoge, Wei Qinglv, Xia Yuxian, Jin Kai (2020) MaPacC a pH-responsive transcription factor, negatively regulates thermotolerance and contributes to conidiation and virulence in Metarhizium acridum. CURRENT GENETICS, 66 (2): 397–408.
[8] Zhao Tingting, Wen Zhiqiong, Xia Yuxian, Jin Kai (2020) The transmembrane protein MaSho1 negatively regulates conidial yield by shifting the conidiation pattern in Metarhizium acridum. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 104 (9): 4005–4015.
[9] Peng Guoxiong, Tong Senmiao, Zeng Deyu, Xia Yuxian, Feng Mingguang (2020) Colony heating protects honey bee populations from a risk of contact with wide-spectrum Beauveria bassiana insecticides applied in the field. PEST MANAGEMENT SCIENCE, 76(8):2627–2634.
[10] Zhang Wei, Keyhani Nemat O, Zhang Hao, Cai Kaiyong, Xia Yuxian (2020) Inhibitor of apoptosis-1 gene as a potential target for pest control and its involvement in immune regulation during fungal infection. PEST MANAGEMENT SCIENCE, 76(5): 1831–1840.
[11] Zhang Wei, Zheng Xiaoli, Chen Jianhong, Keyhani Nemat O, Cai Kaiyong, Xia Yuxian (2020) Spatial and temporal transcriptomic analyses reveal locust initiation of immune responses to Metarhizium acridum at the pre-penetration stage. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 104: 103524.
[12] Zheng Renwen, Xia Yuxian, Keyhani Nemat O (2020) Sex-specific variation in the antennal proteome of the migratory locust. JOURNAL OF PROTEOMICS, 216: 103681.
[13] Zheng Xiaoli, Li Sai, Si Yang, Hu Jun, Xia Yuxian (2020) Locust can detect β-1, 3-glucan of the fungal pathogen before penetration and defend infection via the Toll signaling pathway. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 106: 103636.
[14] Li Juan, Guo Mei, Cao Yueqing, Xia Yuxian (2020) Disruption of a C69-family cysteine dipeptidase gene enhances heat shock and UV-B tolerances in Metarhizum acridum. FRONTIERS IN MICROBIOLOGY, 11:849.
[15] Song Dongxu, Shi Youhui, Ji Hengqing, Xia Yuxian, Peng Guoxiong (2019) The MaCreA gene regulates normal conidiation and microcycle conidiation in Metarhizium acridum. FRONTIERS IN MICROBIOLOGY, 10:1946.
[16] Zhang Junjie, Jiang Hui, Du Yanru, Keyhani NO, Xia Yuxian, Jin Kai (2019) Members of chitin synthase family in Metarhizium acridum differentially affect fungal growth, stress tolerances, cell wall integrity and virulence. PLOS PATHOGENS, 15(8): e**.
[17] Zhao Tingting, Tian Huiting, Xia Yuxian, Jin Kai (2019) MaPmt4, a protein O-mannosyltransferase, contributes to cell wall integrity, stress tolerance and virulence in Metarhizium acridum. CURRENT GENETICS. 65(4): 1025–1040.
[18] Hu Jun, Xia Yuxian. (2019) Increased virulence in the locust-specific fungal pathogen Metarhizium acridum expressing dsRNAs targeting the host F1F0-ATPase subunit genes. PEST MANAGEMENT SCIENCE, 75(1): 180–186.
[19] Gao Pingping, Li Muchun, Jin Kai, Xia Yuxian (2019) The homeobox gene MaH1 governs microcycle conidiation for increased conidial yield by mediating transcription of conidiation pattern shift-related genes in Metarhizium acridum. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, ?103(5):2251-2262.
[20] Zhang Jie, Wang Zhenglong, Nemat O. Keyhani, Peng Guoxiong, Jin Kai, Xia Yuxian (2019) The protein phosphatase gene MaPpt1 acts as a programmer of microcycle conidiation and a negative regulator of UV-B tolerance in Metarhizium acridum. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, ?103:1351-1362.
[21] Xie Mushan, Zhou Xuan, Xia Yuxian, Cao Yueqing (2019) Mid1 affects ion transport, cell wall integrity, and host penetration of the entomopathogenic fungus Metarhizium acridum. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 103(4): 1801–1810.
[22] Xie Jiaqin, Li Shangji, Zhang Wei, Xia Yuxian. (2019) RNAi-knockdown of the Locusta migratoria nuclear export factor protein results in insect mortality and alterations in gut microbiome. PEST MANAGEMENT SCIENCE, 75(5): 1383–1390.
[23] Zhang Erhao, Cao Yueqing, Xia Yuxian (2018) Ethanol dehydrogenase i contributes to growth and sporulation under low oxygen condition via detoxification of acetaldehyde in Metarhizium acridum. FRONTIERS IN MICROBIOLOGY. 9: 1932
[24] Du YR, Jin K, and Xia YX (2018) Involvement of MaSom1, a downstream transcriptional factor of cAMP/PKA pathway, in conidial yield, stress tolerances, and virulence in Metarhizium acridum. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, ? 102:5611–5623.
[25] Xie Mushan, Xia Yuxian, Cao Yueqing (2018) The Rab GTPase activating protein Gyp2 contributes to UV stress tolerance in Metarhizium acridum. WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 34(6): 78.
[26] Li Hongbo, Xia Yuxian. (2018) Recombinant production of the insecticidal scorpion toxin Bj alpha IT in Escherichia coli. PROTEIN EXPRESSION AND PURIFICATION, 142: 62–67.
[27] Li Hongbo, Xia Yuxian. (2018) Improving the secretory expression of active recombinant AaIT in Pichia pastoris by changing the expression strain and plasmid. WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 34 (7): 104.
[28] Li Hongbo, Xia Yuxian. (2018) High cell density fed-batch production of insecticidal recombinant ribotoxin hirsutellin A from Pichia pastoris. MICROBIAL CELL FACTORIES, 17: 145.
[29] Li Hongbo, Xia Yuxian. (2018) High-level expression and purification of active scorpion long-chain neurotoxin Bj alpha IT from Pichia pastoris. PROTEIN EXPRESSION AND PURIFICATION, 152: 77–83.
[30] Li G, Fan A, Peng G, Keyhani NO, Xin J, Cao Y, Xia Y (2017) A bifunctional catalase-peroxidase, MakatG1, contributes to virulence of Metarhizium acridum by overcoming oxidative stress on the host insect cuticle. ENVIRONMENTAL MICROBIOLOGY, 19(10): 4365–4378.
[31] Chen X, Liu Y, Keyhani NO, Xia Y, Cao Y (2017) The regulatory role of the transcription factor Crz1 in stress tolerance, pathogenicity, and its target gene expression in Metarhizium acridum. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, ?101:5033-5043.
[32] Wei QL, Du YR, Jin K, and Xia YX. (2017). The Ste12-like transcription factor MaSte12 is involved in pathogenicity by regulating the appressorium formation in the entomopathogenic fungus, Metarhizium acridum. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 101:8571–8584.
[33] Zhang W, Chen J, Keyhani N.O, Jin K, Wei Q, Xia Y (2017). Central nervous system responses of the oriental migratory, Locusta migratoria manilensis, to fungal infection. SCIENTIFIC REPORTS, 7(1), 10340.
[34] Hu Jun, Xia Yuxian (2016) F-1-ATP synthase alpha-subunit: a potential target for RNAi-mediated pest management of Locusta migratoria manilensis. PEST MANAGEMENT SCIENCE, 72(7): 1433–1439.
[35] Hong M., Peng G., Keyhani N.O., Xia Y (2017) Application of the entomogenous fungus, Metarhizium anisopliae for leafroller (Cnaphalocrocis medinalis) control and its effect on rice phyllosphere microbial diversity. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, ?101: 6793–6807.
[36] Wang, Zhenglong, Jin Kai, Xia Yuxian (2016) Transcriptional analysis of the conidiation pattern shift of the entomopathogenic fungus Metarhizium acridum in response to different nutrients. BMC GENOMICS, 17: 586.
[37] Zhang Jie, Jin Kai, Xia Yuxian (2017) Contributions of beta-tubulin to cellular morphology, sporulation and virulence in the insect-fungal pathogen, Metarhizium acridum. FUNGAL GENETICS AND BIOLOGY, 103: 16–24.
[38] Yu Ying, Cao Yueqing, Xia Yuxian, Liu Feihong (2016) Wright-Giemsa staining to observe phagocytes in Locusta migratoria infected with Metarhizium acridum. JOURNAL OF INVERTEBRATE PATHOLOGY, 139: 19–24.

获奖情况
2009年主持完成的研究成果获重庆市技术发明一等奖；
2010年获中国侨界贡献奖（创新成果）。

研究生培养
招收博士后2人，毕业博士生30余名，毕业硕士生60余名。在读硕士博士共12人。

联系方式
邮箱：yuxianxia@cqu.edu.cn