个人简介

2002年-2006年，重庆邮电大学，自动化学院，测控技术与仪器，学士；
2006年-2009年，重庆大学，生物工程学院，生物医学工程，硕士 ；
2009年-2011年，重庆大学，生物工程学院，生物医学工程，博士 ；
2012年-2015年，新加坡南洋理工大学, 化学与生物化学系, Research Fellowship
2015年10月-现在，重庆大学生命科学学院，教授/博士生导师。




研究方向
纳米肿瘤生物学
研究描述：
针对恶性肿瘤等重大疾病的检测、诊断、治疗所面临的问题，结合医学、细胞/分子生物学和材料学，设计、发展并建立基于纳米材料的生物诊疗系统，以期实现恶性肿瘤疾病的准确性诊断、定位和高效生物治疗。主要研究方向：1. 生物功能性纳米材料的设计与抗肿瘤效应评价；2. 肿瘤生物治疗与免疫联合治疗的基础研究与临床应用；3. 恶性肿瘤发生发展的分子作用机制与干预策略。
1. Chencheng Xue#, Menghuan Li#, Changhuang Liu#, Yanan Li, Yang Fei, Yan Hu, Kaiyong Cai, Yanli Zhao, Zhong Luo*. NIR-actuated remote activation of ferroptosis in target tumor cells through a photothermally responsive iron-chelated biopolymer nanoplatform. Angewandte Chemie International Edition, 2021, 60, 8938-8947.
2. Chencheng Xue#, Menghuan Li#, Linawati Sutrisno, Beibei Yan, Yang Zhao, Yan Hu, Kaiyong Cai, Yanli Zhao, Shu-Hong Yu*, Zhong Luo*. Bioresorbable scaffolds with biocatalytic chemotherapy and in situ microenvironment modulation for postoperative tissue repair. Advanced Functional Materials, 2021, 31:**.
3. Xuan Wang#, Youbo Zhao#, Lei Shi, Yan Hu, Guanbin Song, Kaiyong Cai, Menghuan Li*, Zhong Luo*. Tumor-targeted disruption of lactate transport with reactivity-reversible nanocatalysts to amplify oxidative damage. Small, 2021, 17:**.
4. Ke Li, Chuanchuan Lin, Ye He, Lu Lu, Bailong Tao, Zengzilu Xia, Rui Zeng, Yulan Mao, Zhong Luo*, Kaiyong Cai*. Functionalized tumor-targeting nanosheets exhibiting Fe(II) overloading and GSH consumption for ferroptosis activation in liver tumor. Small, 2021, **.
5. Chencheng Xue#, Linawati Sutrisno#, Menghuan Li#, Wei Zhu, Yang Fei, Changhuang Liu, Xuan Wang, Kaiyong Cai, Yan Hu*, Zhong Luo*. Implantable multifunctional black phosphorus nanoformulation-deposited biodegradable scaffold for combinational photothermal/ chemotherapy and wound healing. Biomaterials, 2021, 269, 120623.
6. Maowen Chen, Yan Hu*, Yanhu Hou Menghuan Li, Lu Tan, Maohua Chen, Wenbo Geng, Bailong Tao, Hong Jiang, Zhong Luo*, Kaiyong Cai*. Magnesium/gallium-layered nanosheets on titanium implants mediate osteogenic differentiation of MSCs and osseointegration under osteoporotic condition. Chemical Engineering Journal, 2021, 427: 130982.
7. Zhiwen Deng, Menghuan Li, Yan Hu*, Ye He, Bailong Tao, Zhang Yuan, Rong Wang, Maowen Chen, Zhong Luo*, Kaiyong Cai*. Injectable biomimetic hydrogels encapsulating Gold/metal–organic frameworks nanocomposites for enhanced antibacterial and wound healing activity under visible light actuation. Chemical Engineering Journal, 2021, 420:129668.
8. Maohua Chen, Yan Hu*, Yanhu Hou, Yuting Sun, Maowen Chen, Menghuan Li, LuTan, Zhong Luo*, KaiyonCai*. Construction of a reactive oxygen species-responsive biomimetic multilayered titanium implant for in situ delivery of α-melanocyte-stimulating hormone to improve bone remolding in osteoporotic rats. Applied Materials Today, 2021, 23:101059.
9. Lei Shi#, Yingqi Liu#, Menghuan Li*, Zhong Luo*. Emerging roles of ferroptosis in the tumor immune landscape: from danger signals to anti-tumor immunity. FEBS Journal, DOI:10.1111/febs.16034.
10. Rui Zeng,? Tingting He,? Lu Lu, Ke Li, Zhong Luo*, Kaiyong Cai*. Ultra-thin metal–organic framework nanosheets for chemo-photodynamic synergistic therapy. Journal of Materials Chemistry B, 2021, 9:4143-4153.
11. Maowen Chen, Bailong Tao, Yan Hu*, Menghuan Li, Maohua Chen, Lu Tan, Zhong Luo*, Kaiyong Cai*. Enhanced biocompatibility and osteogenic differentiation of mesenchymal stem cells of titanium by Sr–Ga clavate double hydroxides. Journal of Materials Chemistry B, 2021, DOI:10.1039/D1TB00805F.
12. Li Liu, Liqi Li, Menghuan Li*, Zhong Luo*. Autophagy-dependent ferroptosis as a therapeutic target in cancer. ChemMedChem, 2021, DOI:10.1002/cmdc..
13. Chencheng Xue#, Menghuan Li#, Yang Zhao#, Jun Zhou, Yan Hu, Kaiyong Cai, Yanli Zhao, Shu-Hong Yu*, Zhong Luo*. Tumor microenvironment-activatable Fe-doxorubicin preloaded amorphous CaCO3 nanoformulation triggers ferroptosis in target tumor cells. Science Advances, 2020, 6: eaax1346.
14. Youbo Zhao#, Menghuan Li#, Xuemei Yao, Yang Fei, Zhenghong Lin, Zhengguo Li, Kaiyong Cai, Yanli Zhao, Zhong Luo*. HCAR1/MCT1 regulates tumor ferroptosis through the lactate-mediated AMPK-SCD1 activity and its therapeutic implications. Cell Reports, 2020, 33: 108487.
15. Xuan Wang#, Menghuan Li#, Yanhua Hou, Yanan Li, Xuemei Yao, Chencheng Xue, Yang Fei, Yang Xiang, Kaiyong Cai, Yanli Zhao*, Zhong Luo*. Tumor-microenvironment-activated in situ self-assembly of sequentially responsive biopolymer for targeted photodynamic therapy. Advanced Functional Materials, 2020, 30: **.
16. Ke Li, Chuanchuan Lin, Ye He, Lu Lu, Kun Xu, Bailong Tao, Zengzilu Xia, Rui Zeng, Yulan Mao, Zhong Luo*, Kaiyong Cai*. Engineering of cascade-responsive nanoplatform to inhibit lactate efflux for enhanced tumor chemo-immunotherapy. ACS Nano, 2020, 14: 14164-14180.
17. Lu Lu#, Xiaojing Zhao#, Tiwei Fu, Ke Li, Ye He, Zhong Luo*, Liangliang Dai, Rui Zeng, Kaiyong Cai*. An iRGD-conjugated prodrug micelle with blood-brain-barrier penetrability for anti-glioma therapy. Biomaterials, 2020, 230: 119666.
18. Xuemei Yao#, Menghuan Li#, Bing Li#, Chencheng Xue, Kaiyong Cai, Yanli Zhao*, Zhong Luo*. Tumor-targeted upconverting nanoplatform constructed by host-guest interaction for near-infrared-light-actuated synergistic photodynamic-/chemotherapy. Chemical Engineering Journal, 2020, 390: 124516.
19. Menghuan Li#, Hui Zhang#, Yanhua Hou, Xuan Wang, Chencheng Xue, Wei Li, Kaiyong Cai, Yanli Zhao*, Zhong Luo*. State-of-the-art iron-based nanozymes for biocatalytic tumor therapy. Nanoscale Horizons, 2020, 5: 202-217.
20. Caiyun Mu, Ye He, Yan Hu*, Menghuan Li, Maowen Chen, Rong Wang, Yang Xiang, Zhong Luo*, Kaiyong Cai*. Construction of chemokine substance P-embedded biomimetic multilayer onto bioactive magnesium silicate-titanium implant for bone regeneration. Applied Materials Today, 2020, 20: 100777.
21. Yang Fei#, Menghuan Li#, Yanan Li, Xuan Wang, Chencheng Xue, Zuosu Wu, Jiaying Xu, Zengzilu Xia*, Kaiyong Cai*, Zhong Luo*. Hierarchical integration of degradable mesoporous silica nanoreservoirs and supramolecular dendrimer complex as a general-purpose tumor-targeted biomimetic nanoplatform for gene/small-molecule anticancer drug co-delivery. Nanoscale, 2020, 12: 16102-16112.
22. Ke Li, Lu Lu, Chencheng Xue, Ju Liu, Ye He, Jun Zhou, Zengzilu Xia, Liangliang Dai*, Zhong Luo*, Yulan Mao, Kaiyong Cai*. Polarization of tumor-associated macrophage phenotype via porous hollow iron nanoparticles for tumor immunotherapy in vivo. Nanoscale, 2020, 12: 130-144.
23. Yanan Li#, Linawati Sutrisno#, Yanhua Hou, Yang Fei, Chengcheng Xue, Yan Hu, Menghuan Li*, Zhong Luo*. A redox-activatable biopolymer-based micelle for sequentially enhanced mitochondria-targeted photodynamic therapy and hypoxia-dependent chemotherapy. Chemical Communications, 2020, 56: 9978-9981.
24. Maowen Chen, Yan Hu*, Yanhua Hou, Menghuan Li, Maohua Chen, Lu Tan, Caiyun Mu, Bailong Tao, Zhong Luo*, Kaiyong Cai*. Osteogenesis regulation of mesenchymal stem cells via autophagy induced by silica-titanium composite surfaces with different mechanical moduli. Journal of Materials Chemistry B, 2020, 8: 9314-9324.
25. Lu Tan, Yan Hu*, Yanhua Hou, Maowen Chen, Chencheng Xue, Maohua Chen, Yuting Sun, Caiyun Mu, Zhong Luo*, Kaiyong Cai*. Osteogenic differentiation of mesenchymal stem cells by silica/calcium micro-galvanic effects on the titanium surface. Journal of Materials Chemistry B, 2020, 8: 2286-2295.
26. Lu Lu, Bing Li, Chuanchuan Lin, Ke Li, Genhua Liu, Zengzilu Xia, Zhong Luo*, Kaiyong Cai*. Redox-responsive amphiphilic camptothecin prodrug nanoparticles for targeted liver tumor therapy. Journal of Materials Chemistry B, 2020, 8: 3918-3928.
27. Youbo Zhao#, Hui Zhang#, Yanhua Hou, Menghuan Li*, Zhong Luo*. Progress toward safe tumor diagnosis and therapy via degradable inorganic nanomaterials constructed with metabolically safe elements. ACS Applied Nano Materials, 2020, 3: 1028-1042.
28. Wee Kong Ong#, Xuemei Yao#, Deblin Jana, Menghuan Li, Yanli Zhao,* Zhong Luo*. Efficient Production of Reactive Oxygen Species from Fe3O4/ZnPC Co-Loaded Nanoreactor for Cancer Therapeutics in Vivo. Small Structure, 2020,1:**.
29. Yuchen Qian, Lei Shi*, Zhong Luo*. Long Non-coding RNAs in cancer: implications for diagnosis, prognosis, and therapy. Frontiers in Medicine, 2020, 7: 612393.
30. Linawati Sutrisno, Yan Hu, Yanhua Hou, Kaiyong Cai, Menghuan Li*, Zhong Luo*. Progress of iron-based nanozymes for antitumor therapy. Frontiers in Chemistry, 2020, 8: 680.
31. Ke Li, Menghuan Li, Zhong Luo*, Yulan Mao, Yonglin Yu, Ye He, Jun Zhou, Yang Fei, Yuxia Pei, Kaiyong Cai*. Overcoming the hypoxia-induced drug resistance in liver tumor by the concurrent use of apigenin and paclitaxel. Biochemical and Biophysical Research Communications, 2020, 526: 321-327.
32. Jun Zhou, Chencheng Xue, Yanhua Hou, Menghuan Li*, Yan Hu, Qiufang Chen, Yanan Li, Ke Li, Guanbin Song, Kaiyong Cai*, Zhong Luo*. Oxygenated theranostic nanoplatforms with intracellular agglomeration behavior for improving the treatment efficacy of hypoxic tumors. Biomaterials, 2019, 197: 129-145.
33. Soo Zeng Fiona Phua#, Chencheng Xue#, Wei Qi Lim, Guangbao Yang, Hongzhong Chen, Yuanyuan Zhang, Chintya Fransisca Wijaya, Zhong Luo*, Yanli Zhao*. Light-responsive prodrug-based supramolecular nanosystems for site-specific combination therapy of cancer. Chemistry of Materials, 2019, 31: 3349-3358.
34. Menghuan Li, Zhong Luo*, Zhihong Peng, Kaiyong Cai*. Cascade-amplification of therapeutic efficacy: An emerging opportunity in cancer treatment. WIREs Nanomedicine and Nanobiotechnology, 2019, 11: e1555.
35. Maowen Chen, Yan Hu*, Yanhua Hou, Menghuan Li, Maohua Chen, Caiyun Mu, Bailong Tao, We Zhu, Zhong Luo*, Kaiyong Cai*. Differentiation regulation of mesenchymal stem cells via autophagy induced by structurally-different silica based nanobiomaterials. Journal of Materials Chemistry B, 2019, 7: 2657-2666.
36.Lu Lu, Xinkun Shen, Bailong Tao, Chuanchuan Lin, Ke Li, Zhong Luo*, Kaiyong Cai*. The nanoparticle-facilitated autophagy inhibition of cancer stem cells for improved chemotherapeutic effects on glioblastomas. Journal of Materials Chemistry B, 2019, 7: 2054-2062.
37. Youbo Zhao#, Wei Li#, Menghuan Li*, Yan Hu, Hui Zhang, Guanbin Song, Li Yang, Kaiyong Cai, Zhong Luo*. Targeted inhibition of MCT4 disrupts intracellular pH homeostasis and confers self-regulated apoptosis on hepatocellular carcinoma. Experimental Cell Research, 2019, 384: 111591.
38. Jun Zhou, Menghuan Li, Yanhua Hou, Zhong Luo*, Qiufang Chen, Hexu Cao, Runlan Huo, Chencheng Xue, Linawati Sutrisno, Lan Hao, Yang Cao, Haitao Ran, Lu Lu, Ke Li, Kaiyong Cai*. Engineering of a nanosized biocatalyst for combined tumor starvation and low-temperature photothermal therapy. ACS Nano, 2018, 12: 2858-2872.
39. Menghuan Li, Zhong Luo*, Yanli Zhao*. Self-assembled hybrid nanostructures: versatile multifunctional nanoplatforms for cancer diagnosis and therapy. Chemistry of Materials, 2018, 30: 25-53.
40. Jun Zhou#, Menghuan Li#, Wei Qi Lim#, Zhong Luo*, Soo Zeng Fiona Phua, Runlan Huo, Liqi Li, Ke Li, Liangliang Dai, Junjie Liu, Kaiyong Cai, Yanli Zhao*. A transferrin-conjugated hollow nanoplatform for redox-controlled and targeted chemotherapy of tumor with reduced inflammatory reactions. Theranostics, 2018, 8: 518-532.
41. Menghuan Li, Zhong Luo*, Yanli Zhao*. Recent advancements in 2D nanomaterials for cancer therapy. Science China-Chemistry, 2018, 61: 1214-1226.
42. Yuxia Pei#, Menghuan Li#, Yanhua Hou, Yan Hu*, Guangyu Chu, Liangliang Dai, Ke Li, Yuxin Xing, Bailong Tao, Yonglin Yu, Chencheng Xue, Ye He, Zhong Luo*, Kaiyong Cai*. An autonomous tumor-targeted nanoprodrug for reactive oxygen species-activatable dual-cytochrome c/doxorubicin antitumor therapy. Nanoscale, 2018, 10:11418-11429.
43. Menghuan Li, Zhong Luo*, Zhining Xia, Xinkun Shen, Kaiyong Cai*. Time-sequenced drug delivery approaches towards effective chemotherapeutic treatment of glioma. Materials Horizons, 2017, 4:977-996.
44. Ling Huang#, Zhong Luo#, Yan Hu*, Xinkun Shen, Menghuan Li, Liqi Li, Yuan Zhang, Weihu Yang, Peng Liu, Kaiyong Cai*. Enhancement of local bone remodeling in osteoporotic rabbits by biomimic multilayered structures on Ti6Al4V implants. Journal of Biomedical Materials Research Part A, 2016, 104(6):1437-1451.
45. Menghuan Li, Zhong Luo*, Yanli Zhao*. Hybrid nanoparticles as drug carriers for controlled chemotherapy of cancer. Chemical Record, 2016, 16: 1833-1851.
46. Zhong Luo, Yan Hu,* Kaiyong Cai, Xingwei Ding, Quan Zhang, Menghuan Li, Xing Ma, Beilu Zhang, Yongfei Zeng, Peizhou Li, Jinghua Li, Junjie Liu, Yanli Zhao,* Intracellular redox-activated anticancer drug delivery by functionalized hollow mesoporous silica nanoreservoirs with tumor specificity. Biomaterials, 2014, 35, 7951-7962.
47. Zhong Luo, Yan Hu, Renlong Xin, Beilu Zhang, Jinghua Li, Xingwei Ding, Yanhua Hou, Li Yang, Kaiyong Cai*, Surface functionalized mesoporous silica nanoparticles with natural proteins for reduced immunotoxicity. Journal of Biomedical Materials Research Part A, 2014, 102(11):3781-94.
48. Zhong Luo, Xingwei Ding, Yan Hu, Shaojue Wu, Yang Xiang, Yongfei Zeng, Beilu Zhang, Hong Yan, Huacheng Zhang, Liangliang Zhu, Junjie Liu, Jinghua Li, Kaiyong Cai, and Yanli Zhao*. Engineering a hollow nanocontainer platform with multifunctional molecular machines for tumor-targeted therapy in vitro and in vivo. ACS Nano, 2013, 7(11):10271-84.
49. Zhong Luo, Kaiyong Cai*, Yan Hu, Beilu Zhang and Dawei Xu. Cell-specific intracellular anticancer drug delivery from mesoporous silica nanoparticles with pH sensitivity. Advanced Healthcare Materials. 2012, 1(3):321-5.
50. Zhong Luo, Kaiyong Cai*, Yan Hu, Jinghua Li, Xingwei Ding, Beilu Zhang, Dawei Xu, Weihu Yang, Peng Liu. Redox-responsive molecular nanoreservoirs for controlled intracellular anticancer drug delivery based on magnetic nanoparticles. Advanced Materials, 2012, 24(3):431-435.
51. Zhong Luo, Kaiyong Cai, Beilu Zhang, Lin Duan, Aiping Liu, Duan Gong. Application of Mesoporous Silica Nanoreservoir in Smart Drug Controlled Release Systems. Progress in Chemistry(化学进展), 2011, 23: 2326-2338.
52. Zhong Luo, Kaiyong Cai*, Yan Hu, Li Zhao, Peng Liu, Lin Duan, Weihu Yang. Mesoporous silica nanoparticles dnd-capped with collagen: redox-responsive nanoreservoirs for targeted drug delivery. Angewandte Chemie International Edition, 2011, 50(3):640643.
53. Kaiyong Cai*, Zhong Luo, Yan Hu, Xiuyong Chen, Li Yang, Linhong Deng. Magnetically Triggered Reversible Controlled Drug Delivery from Microfabricated Polymeric Multireservoir Devices. Advanced Materials, 2009, 21: 4045-4049.

主讲课程
生物学专业英语、肿瘤生物学、肿瘤预防与治疗和新生研讨课等。

主要成果
从事恶性肿瘤发生发展的分子作用机制以及抗肿瘤纳米药物传输系统设计与活体疗效研究，目前已在Science advances、Cell Reports、Angew. Chem. Int. Ed、JACS、ACS Nano、Advanced Materials、Advanced Functional Materials、Biomaterials等期刊共发表100余篇SCI论文，第一作者/通讯作者影响因子大于10的论文20余篇，H指数45，SCI总引用4500余次，ESI高引用（>1%）论文5篇。主持国家自然科学基金重大研究计划培育项目/青年基金、国家家重点研发计划子课题、重庆市自然科学基金和重庆市青年拔尖人才支持项目等国家/省部级项目10余项，参与国家自然科学基金重点项目等研究项目。现为Advanced Materials、Advance Science、ACS Nano、Adv Funct Mater 和Biomaterials 等40余种国际期刊的特邀审稿人，应邀多次参加国际学术会议并做邀请学术报告。

部分论文列表：
1. Chencheng Xue#, Menghuan Li#, Changhuang Liu#, Yanan Li, Yang Fei, Yan Hu, Kaiyong Cai, Yanli Zhao, Zhong Luo*. NIR-actuated remote activation of ferroptosis in target tumor cells through a photothermally responsive iron-chelated biopolymer nanoplatform. Angewandte Chemie International Edition, 2021, 60, 8938-8947.
2. Chencheng Xue#, Menghuan Li#, Yang Zhao#, Jun Zhou, Yan Hu, Kaiyong Cai, Yanli Zhao, Shu-Hong Yu*, Zhong Luo*. Tumor microenvironment-activatable Fe-doxorubicin preloaded amorphous CaCO3 nanoformulation triggers ferroptosis in target tumor cells. Science Advances, 2020, 6: eaax1346.
3. Youbo Zhao#, Menghuan Li#, Xuemei Yao, Yang Fei, Zhenghong Lin, Zhengguo Li, Kaiyong Cai, Yanli Zhao, Zhong Luo*. HCAR1/MCT1 regulates tumor ferroptosis through the lactate-mediated AMPK-SCD1 activity and its therapeutic implications. Cell Reports, 2020, 33: 108487.
4. Xuan Wang#, Menghuan Li#, Yanhua Hou, Yanan Li, Xuemei Yao, Chencheng Xue, Yang Fei, Yang Xiang, Kaiyong Cai, Yanli Zhao*, Zhong Luo*. Tumor-microenvironment-activated in situ self-assembly of sequentially responsive biopolymer for targeted photodynamic therapy. Advanced Functional Materials, 2020, 30: **.
5. Jun Zhou, Menghuan Li, Yanhua Hou, Zhong Luo*, Qiufang Chen, Hexu Cao, Runlan Huo, Chencheng Xue, Linawati Sutrisno, Lan Hao, Yang Cao, Haitao Ran, Lu Lu, Ke Li, Kaiyong Cai*. Engineering of a nanosized biocatalyst for combined tumor starvation and low-temperature photothermal therapy. ACS Nano, 2018, 12: 2858-2872.

获奖情况
获得重庆市青年拔尖人才支持计划、重庆市自然科学奖一等奖和重庆市优秀博士论文等奖项。

研究生培养
培养了4名博士后，6名博士生和10余名硕士，分别在重庆大学、温州医科大学和贵州医科大学等高校任教。

联系方式
实验室主页：https://www.x-mol.com/groups/luo_zhong_cqu；邮件：luozhong918@cqu.edu.cn