个人简介

教育背景
1994-2000 中国科学院上海细胞生物学所， 细胞学专业， 博士
1987-1991 南开大学生物学系， 植物生理生化专业， 学士


工作经历
2021-现在 重庆大学·生命科学学院 教授
20014-2020 北京大学医学部基础医学院生物化学与分子生物学系，特聘研究员，博士生导师
2003-2013 哥伦比亚大学（Institute for Cancer Genetics, Columbia University），助理研究员（Associate Research Scientist）
2001-2003 康莱尔医学院（Department of Pathology, Weill Cornell Medical College, Cornell University）， 博士后（Postdoctoral Fellow）
2000-2001 耶鲁大学（Department of Molecular Biochemistry and Biophysics, Medical School, Yale University）， 博士后（Postdoctoral Fellow）
1991-1994 南开大学遗传学系， 实习技术员




研究方向
分子细胞生物学

研究方向描述：
我们主要利用生物化学，分子生物学，表观遗传学，细胞生物学，生物信息学等多学科生物实验手段，研究集中在（1）泛素化酶和去泛素化酶及其调控网络，主攻癌症和免疫性疾病的病理基础，为临床开发药物提供新靶标。（2）蛋白质翻译后β-羟基丁酰化修饰，寻找其催化酶、去除酶、识别蛋白，主攻心脏病、神经退行性疾病等重大疾病的病理生理功能。

主讲课程
生物化学，分子细胞生物学，分子生物学工作基础

主要成果
在Nature、Nature Communications、JBC等杂志发表多篇论文。据Research Gate，他引超过2000次；据Web of Science，他引超过1800次。

论文：
1. Fangzhou Li, Qianqian Sun, Kun Liu, Ning Lin, Kaiqiang You, Mingwei Liu, Ning Kon, Feng Tian, Zebin Mao, Tingting Li, Tanjun Tong, Jun Qin, Wei Gu, Dawei Li, Wenhui Zhao. (2020). OTUD5 cooperates with TRIM25 in transcriptional regulation and tumor progression via the deubiquitination activity. Nature Communications. 2020 Aug 21;11(1):4184. doi: 10.1038/s41467-020-17926-7.（通讯作者）
2. Xue, Junhui; Cao, Zhengyi; Cheng, Yuning; Wang, Jiyin; Liu, Yujuan; Yang, Ruixiang; Li, Hui; Jiang, Wei; Li, Gang; Zhao, Wenhui; Zhang, Xiaowei.(2020).Acetylation of alpha-fetoprotein promotes hepatocellular carcinoma progression.Cancer Letters, 2020, 471: 12-26. doi:10.1016/j.canlet.2019.11.043
3. Fangzhou Li, Qianqian Sun, Kun Liu, Haichao Han, Ning Lin, Zhongyi Cheng, Yueming Cai, Feng Tian, Zebin Mao, Tanjun Tong, Wenhui Zhao. (2019). The deubiquitinase OTUD5 regulates Ku80 removal and non-homologous end joining. Cell Mol Life Sci. 2019 Oct;76(19):3861-3873. doi: 10.1007/s00018-019-03094-5. （通讯作者）
4. Li F, Han H, Sun Q, Liu K, Lin N, Xu C, Zhao Z, Zhao W. (2019). USP28 regulates deubiquitination of histone H2A and cell proliferation. Exp Cell Res. 2019 Jun 1;379(1):11-18. doi: 10.1016/j.yexcr.2019.03.026. （通讯作者）
5. Kun Liu, Fangzhou Li, Qianqian Sun, Ning Lin, Haichao Han, Kaiqiang You, Feng Tian, Zebin Mao, Tingting Li, Tanjun Tong, Meiyu Geng, Yingming Zhao, Wei Gu, Wenhui Zhao. (2019). p53 β-hydroxybutyrylation attenuates p53 activity. Cell Death & Disease. 2019 Mar 11;10(3):243. doi:10.1038/s41419-019-1463-y. （通讯作者）
6. Huang H, Luo Z, Qi S, Huang J, Xu P, Wang X, Gao L, Li F, Wang J, Zhao W, Gu W, Chen Z, Dai L, Dai J, Zhao Y. (2018). Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway. Cell Res. 28(1):111-125. doi: 10.1038/cr.2017.149.
7. Nan Xie, Liwei Ma, Feng Zhu, Wenhui Zhao, Feng Tian, Fuwen Yuan, Jingxuan Fu, Daoyuan Huang, Cuicui Lv & Tanjun Tong. (2016). Regulation of the MDM2-p53 pathway by the nucleolar protein CSIG in response to nucleolar stress. Scientific Reports 6:36171. doi:10.1038/srep36171
8. Liu K, Li F, Han H, Chen Y, Mao Z, Luo J, Zhao Y, Zheng B, Gu W, Zhao W. (2016). Parkin regulates the activity of pyruvate kinase M2. J Biol Chem. 291(19):10307-17. doi: 10.1074/jbc.M115.703066. （通讯作者）
9. Yu M, Liu K, Mao Z, Luo J, Gu W, Zhao W. (2016). USP11 is a negative regulator to γH2AX ubiquitylation by RNF8/RNF168. J Biol Chem. 291(2):959-67. doi: 10.1074/jbc.M114.624478. （通讯作者）
10. Li Qiang, Ning Kon, Wenhui Zhao, Ning Kon, Colette M. Knight, Carrie Welch, Utpal Pajvani, Wei Gu, and Domenico Accili. (2015). Hepatic SirT1-dependent gain of function of stearoyl-CoA desaturase-1 conveys dysmetabolic and tumor progression functions. Cell Reports 11, 1–12. doi: 10.1016/j.celrep.2015.05.025
11. Li Qiang, Liheng Wang, Ning Kon, Wenhui Zhao, Sangkyu Lee, Yiying Zhang, Michael Rosenbaum, Yingming Zhao, Wei Gu, Stephen R. Farmer, and Domenico Accili. (2012). Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of PPARg. Cell 150, 620–632. doi:10.1016/j.cell.2012.06.027
12. Yue Chen, Wenhui Zhao, Jeong Soo Yang, Zhongyi Cheng, HaoLuo, Zhike Lu, Minjia Tan, Wei Gu, and Yingming Zhao. (2012). Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Molecular & Cellular Proteomics. 11(10):1048-62. doi: 10.1074/mcp.M112.019547
13. Scortegagna M, Subtil T, Qi J, Kim H, Zhao Wenhui, Gu Wei, Kluger H, Ronai ZA. (2011). USP13 enzyme regulates Siah2 ligase stability and activity via noncatlytic ubiquitin-binding domains. J Biol Chem. 286(31):27333-41. doi: 10.1074/jbc.M111.218214
14. Jing Shan, Wenhui Zhao, and Wei Gu. (2009). Suppression of cancer cell growth by promoting cyclin D1 degradation. Mol. Cell 36, 469-476. doi:10.1016/j.molcel.2009.10.018
15. Wenhui Zhao, Jan-Philipp Kruse, Yi Tang, Sung Yun Jung, Jun Qin, Wei Gu. (2008). Negative regulation of the deacetylase SIRT1 by DBC1. Nature 451, 587-590. doi:10.1038/nature06515. （第一作者）
16. Yi Tang, Wenhui Zhao, Yue Chen, Yingming Zhao and Wei Gu. (2008). Acetylation is indispensable for p53 activation. Cell 133, 612-626. doi: 10.1016/j.cell.2008.03.025
17. Abida WM, Nikolaev A, Wenhui Zhao, Zhang W, Gu W. (2007). Fbxo11 promotes the neddylation of p53 and inhibits its transcriptional activity. J Biol Chem. 282, 1797-804. doi:10.1074/jbc.M

研究生培养
迄今总共有两位硕士，三位博士研究生都达到北京大学要求，顺利按时毕业。

联系方式
erin3163@163.com， zhaowenhui@cqu.edu.cn