个人简介

西南农业大学（现西南大学）农学学士学位（1983）、硕士学位（1986）和博士学位（1996）。
1998.10-2000.9日本九州大学生物系遗传学研究室博士后
2002.02-2004.1日本东京大学农学部生物统计学与生物信息学实验室JST研究员
2004.02-2006.1英国伯明翰大学生物科学学院研究职员。
2006年全职回国服务，2008年国务院特殊津贴获得者。
1986年7月-2006年1月西南农业大学农学系讲师、副教授、教授
2006年2月-2007年12月西南大学蚕学与系统生物学研究所二级教授、博导；
2008.1至今重庆大学生命科学学院副院长，二级教授，博士生导师。




研究方向
进化与功能基因组学

研究描述
实验室主要以家蚕为模式研究驯化遗传学和进化及功能基因组学问题。研究方向：（1）动物驯化性状差异的分子解析；（2）家蚕脱皮激素代谢途径调控机制研究；（3）家蚕转座子的鉴定、功能和比较基因组学研究。目前承担国家自然科学基金等多项课题。主要成果发表在Science, Mol. Biol. Evol., Genetics, BMC Genomics，BMC Evol. Biol.等国际著名杂志。欢迎对生命科学基础研究有浓厚兴趣的同学报考本实验室的研究生。

主讲课程
本科生：《生物统计学》，研究生：《分子进化》、《遗传学研究前沿》

主要成果
发表论文
1. Wang QH, Gong Q, Zhang Z, Yu QY* (2020). Identification of genes involved in sex pheromone biosynthesis and metabolic pathway in the Chinese oak silkworm, Antheraea pernyi. Int J Biol Macromol: 1487-1497

2. Zhou QZ, Fu P, Li SS, Zhang CJ, Yu QY, Qiu CZ, Zhang HB, Zhang Z* (2020). A Comparison of Co-expression Networks in Silk Gland Reveals the Causes of Silk Yield Increase During Silkworm Domestication. Frontiers in Genetics 11: 225

3. Duan HT, Yang X, Bu ZY, Li XY, Sun W*, Zhang Z (2020). Identification and Characterization of Genes Involved in Ecdysteroid Esterification Pathway Contributing to the High 20-Hydroxyecdysone Resistance ofHelicoverpa armigera. Frontiers in Physiology 11: 508

4. Fang SM, Zhou QZ, Yu QY*, Zhang Z (2020). Genetic and genomic analysis for cocoon yield traits in silkworm. Scientific Reports 10: 5682

5. Zhu ZL*, Wang YW, Zhou X, Yang L, Meng G*, Zhang Z (2020). SWAV: a web-based visualization browser for sliding window analysis. Scientific Reports 10: 149

6. Zhu ZL*, Guan ZF, Liu GX, Wang YW, Zhang, Z* (2019). SGID: a comprehensive and interactive database of the silkworm. Database (Oxford) 2019: baz134

7. Yu SH, Zhang YL, Wu YY, Yang HY, Chen Y, Yang YB & Zhang Z* (2019). Subcellular localization of mutated -catenins with different incidences of cis-peptide bonds at the Xaa246-P247 site in HepG2 cells. FASEB J 33(5): 6574-6583

8. Wang CF, Sun W, Zhang Z* (2019). Functional characterization of the horizontally transferred 4,5-DOPA extradiol dioxygenase gene in the domestic silkworm, Bombyx mori. Insect Mol Biol 28(3): 409-419

9. Dai ZJ, Sun W, Zhang Z* (2019). Comparative analysis of iTRAQ-based proteomes for cocoons between the domestic silkworm (Bombyx mori) and wild silkworm (Bombyx mandarina). Journal of Proteomics 192: 366-373

10. Qiu CZ, Zhou QZ, Liu TT, Fang SM, Fang X, Yu QY*, Chen CH, Zhang Z (2018). Evidence of peripheral olfactory impairment in the domestic silkworms: insight from the comparative transcriptome and population genetics. BMC genomics 19: 788

11. Zhang HH*, Zhou QZ, Wang PL, Xiong XM, Andrea L, Didier R, Han MJ & Zhang Z* (2018). Unexpected invasion of miniature inverted-repeat transposable elements in viral genomes. Mob DNA 9(1): 19

12. Zhou QZ, Fang SM, Zhang Q, Yu QY, Zhang Z* (2018). Identification and comparison of long non-coding RNAs in the silk gland between domestic and wild silkworms. Insect Sci 25(4): 604-616

13. Wang CF, Zhang Z*, Sun W* (2018). Ecdysone oxidase and 3-dehydroecdysone-3β-reductase contribute to the synthesis of ecdysone during early embryonic development of the silkworm. Int J Biol Sci 14(11):1472-1482

14. Qiu CZ, Zhou QZ, Liu TT, Fang SM, Wang YW, Fang X, Huang CL, Yu QY*, Chen CH, Zhang Z (2018). Evidence of peripheral olfactory impairment in the domestic silkworms: insight from the comparative transcriptome and population genetics. BMC Genomics 19(1):788

15. Fu P, Sun W, Lai J, Shen YH, Zhang Z* (2018). Identification of two isoforms of Pop in the domestic silkworm, Bombyx mori: Cloning, characterization and expression analysis. Gene 667:101-111

16. Zhou QZ, Fang SM, Zhang Q, Yu QY, Zhang Z* (2018). Identification and comparison of long non-coding RNAs in the silk gland between domestic and wild silkworms. Insect Sci. doi: 10.1111/1744-7917.12443

17. Zhang Q, Sun W, Sun BY, Xiao Y, Zhang Z* (2017). The dynamic landscape of gene regulation during Bombyx mori oogenesis. BMC Genomics 18: 714

18. Sun W*, Wang CF, Zhang Z (2017).Transcription factor E74A affects the ecdysone titer by regulating the expression of the EO gene in the silkworm, Bombyx mori. BBA-General Subjects 1861:551–558

19. Han MJ#, Zhou QZ#, Zhang HH, Tong X, Lu C, Zhang Z, Dai F* (2016). iMITEdb: the genome-wide landscape of miniature inverted-repeat transposable elements in insects. Database (Oxford) 2016: baw148

20. Yu QY*, Fang SM, Zhang Z, Jiggins CD* (2016). The transcriptome response of Heliconius melpomene larvae to a novel host plant. Mol Ecol 25(19): 4850-65

21. Zhou QZ, Zhang B, Yu QY, Zhang Z* (2016). BmncRNAdb: a comprehensive database of non-coding RNAs in the silkworm, Bombyx mori. BMC Bioinformatics 17(1): 370

22. Sun W, Shen YH, Zhou LX, Zhang Z* (2016). Ecdysone titer determined by 3DE-3β-reductase enhances the immune response in the silkworm. J Immunol 196(4): 1646-1654

23. Fu P, Sun W, Zhang Z* (2016). Molecular cloning, expression and characterization of acylpeptide hydrolase in the silkworm, Bombyx mori. Gene 580(1): 8-16

24. Sun W, Zhao XW, Zhang Z* (2015). Identification and evolution of the orphan genes in the domestic silkworm, Bombyx mori. FEBS Letters 589: 2731-2738

25. Han MJ, Xiong CL, Zhang HB, Zhang MQ, Zhang HH, Zhang Z* (2015). The diversification of PHIS transposon superfamily in eukaryotes. Mob DNA 6: 12

26. Fang SM#, Hu BL#, Zhou QZ, Yu QY*, Zhang Z (2015). Comparative analysis of the silk gland transcriptomes between the domestic and wild silkworms. BMC Genomics 16: 60

27. Tang Z, Zhang HH, Huang K, Zhang XG, Han MJ, Zhang Z* (2015). Repeated horizontal transfers of four DNA transposons in invertebrates and bats. Mob DNA 6(1): 3

28. Sun W, Shen YH, Han MJ, Cao YF, Zhang Z* (2014). An adaptive transposable element insertion in the regulatory region of the EO gene in the domesticated silkworm, Bombyx mori. Mol Biol Evol 31: 3302-3313

29. Yang SY#, Han MJ#, Kang LF, Li ZW, Shen YH*, Zhang Z (2014). Demographic history and gene flow during silkworm domestication. BMC Evol Biol 14:185

30. Han MJ, Xu HE, Zhang HH, Feschotte C & Zhang Z* (2014). Spy: A new group of eukaryotic DNA transposons without target site duplications. Genome Biol Evol 6(7):1748-57

31. Zhang HH, Feschotte C, Han MJ & Zhang Z* (2014). Recurrent horizontal transfers of Chapaev transposons in diverse invertebrate and vertebrate animals. Genome Biol Evol 6(6): 1375-1386

32. Zhao Q, Han MJ, Sun W & Zhang Z* (2014). Copy number variations among silkworms. BMC Genomics 15: 251

33. Zhang HH, Xu HE, Shen YH, Han MJ & Zhang Z* (2013). The origin and evolution of six miniature inverted-repeat transposable elements (MITEs) in Bombyx mori and Rhodnius prolixus. Genome Biol Evol 5(11): 2020-2031

34. Zhang HH, Shen YH, Xu HE, Liang HY, Han MJ & Zhang Z* (2013). A novel hAT element in Bombyx mori and Rhodnius prolixus: its relationship with miniature inverted repeat transposable elements (MITEs) and horizontal transfer. Insect Mol Biol 22(5): 584-596

35. Han MJ, Shen YH, Xu MS, Liang HY, Zhang HH & Zhang Z* (2013). Identification and evolution of the silkworm Helitrons and their contribution to transcripts. DNA Res 20: 471-484

36. Xu HE, Zhang HH, Xia T, Han MJ, Shen YH & Zhang Z* (2013). BmTEdb: a collective database of transposable elements in the silkworm genome. Database (Oxford) 2013: bat055

37. Zhao Q, Zhu Z, Kasahara M, Morishita S & Zhang Z* (2013). Segmental duplications in the silkworm genome. BMC Genomics 14: 521

38. Hu YG, Shen YH *, Zhang Z & Shi GQ (2013). Melanin and urate act to prevent ultraviolet damage in the integument of the silkworm, Bombyx mori. Arch Insect Biochem Physiol 83(1): 41-55

39. Sun W, Shen YH, Yang WJ, Cao YF, Xiang ZH & Zhang Z* (2012). Expansion of the silkworm GMC oxidoreductase genes is associated with immunity. Insect Biochem Mol Biol 42: 935-945

40. Shi GQ, Yu QY, Shi L & Zhang Z* (2012). Molecular cloning and characterization of peroxiredoxin 4 involved in protection against oxidative stress in the silkworm Bombyx mori. Insect Mol Biol 21: 581-92

41. Zhang YE, Ma HJ, Feng DD, Lai XF, Chen ZM, Xu MY, Yu QY & Zhang Z* (2012). Induction of detoxification enzymes by quercetin in the silkworm. J Econ Entomol 105(3): 1034-42

42. Kang L, Zhu Z*, Zhao Q, Chen L* & Zhang Z (2012). Newly evolved introns in human retrogenes provide novel insights into their evolutionary roles. BMC Evol Biol 12(1): 128

43. Sun W, Yu HS, Shen YH, Banno Y, Xiang ZH & Zhang Z* (2012). Phylogeny and evolutionary history of the silkworm. Sci China Life Sci. 55(6): 483-96

44. Shi GQ, Yu QY & Zhang Z* (2012). Annotation and evolution of the antioxidant genes in the silkworm, Bombyx mori. Arch Insect Biochem Physiol 79(2): 87-103

45. Sun W, Shen YH, Qi DW, Xiang ZH & Zhang Z* (2012). Molecular cloning and characterization of ecdysone oxidase and 3-dehydroecdysone-3α-reductase involved in the ecdysone inactivation pathway of silkworm, Bombyx mori. Int J Biol Sci 8: 125-138

46. Li ZW, Shen YH, Xiang ZH & Zhang Z* (2011). Pathogen-origin horizontally transferred genes contribute to the evolution of Lepidopteran insects. BMC Evol Biol 11: 356

47. Guo Y, Shen YH, Sun W, Kishino H, Xiang ZH & Zhang Z* (2011). Nucleotide diversity and selection signature in the domesticated silkworm, Bombyx mori, and wild silkworm, Bombyx mandarina. J Insect Sci 11:155

48. Yu QY, Fang SM, Zuo WD, Dai FY, Zhang Z & Lu C* (2011). Effect of organophosphate phoxim exposure on certain oxidative stress biomarkers in the silkworm. J Econ Entomol 104(1): 101-106

49. Yu HS, Shen YH, Yuan GX, Hu YG, Xu HE, Xiang ZH & Zhang Z* (2011). Evidence of selection at melanin synthesis pathway loci during silkworm domestication. Mol Biol Evol 28: 1785-1799

50. Han MJ, Shen YH, Gao YH, Chen LY*, Xiang ZH & Zhang Z* (2010). Burst expansion, distribution and diversification of MITEs in the silkworm genome. BMC Genomics 11: 520

51. Xia Q#, Guo Y#, Zhang Z#, Li D#, Xuan Z#, Li Z#, Dai F, Li Y, Cheng D, Li R, Cheng T, Jiang T, Becquet C, Xu X, Liu C, Zha X, Fan W, Lin Y, Shen YH, Jiang L, Jensen J, Hellmann I, Tang S, Zhao P, Xu H, Yu C, Zhang G, Li J, Cao J, Liu S, He N, Zhou Y, Liu H, Zhao J, Ye C, Du Z, Pan G, Zhao A, Shao H, Zeng W, Wu P, Li C, Pan M, Li J, Yin X, Li D, Wang J, Zheng H, Wang W, Zhang X, Li S, Yang H, Lu C, Nielsen R, Zhou Z, Wang J, Xiang ZH* & Wang J* (2009). Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx). Science 326: 433-436(#: Co-first authors)

52. Li ZW, Li X, Yu QY, Xiang ZH, Kishino H & Zhang Z* (2009). The small heat shock protein (sHSP) genes in the silkworm, Bombyx mori, and comparative analysis with other insect sHSP genes. BMC Evol Biol 9: 215

联系方式
邮箱：zezhang@cqu.edu.cn
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