个人简介

教育背景：
2003-2008：清华大学，生物科学与技术系， 博士
1998-2001：中国农业科学院研究生院，硕士
1994-1998：中国农业大学，动物科技学院，学士




研究方向
细胞分子生物学

研究方向描述：
我们主要利用生物化学，细胞生物学，分子生物学，遗传与表观遗传学，生物信息学等多学科生物实验手段，重点以去泛素化酶和去乙酰化酶为靶标，寻找其靶基因和调控因子，主攻癌症、兼顾其它如糖尿病、衰老性疾病、老年痴呆症等其它重大疾病的病理发生机理及其关键基因的调控网络，为开发具有潜在治疗价值的药物提供新靶标。

科研经历：
2014.12-现在： 重庆大学生命科学学院‘****’****、研究员、博士生导师
2012.07-2014.11：美国西北大学，Feinberg School of Medicine，研究助理教授
2009.12-2012.06：美国西北大学，Feinberg School of Medicine, 研究助理
2009.1-2009.11： 美国芝加哥大学，Ben May癌症生物学系，博士后
2008.09-2009.01：美国匹兹堡大学，医学院，博士后

主讲课程
细胞分子生物学， 动物生理学，生命科学前沿讲座等

学术兼职
1.Frontiers in Cell and Developmental Biology （影响因子5.3）的特邀客座编辑（guest editor），主持特刊（Special Issue）
2.Protein & Cell，Cancer Letters, Cell Death and Disease, Cellular and Molecular Life Sciences, Journal of Translational Medicine, Genome Instability & Disease, PLOS ONE，Life Science，Journal of Molecular Biology等杂志的审稿人
3.中国肿瘤代谢专委会委员
4.中国细胞生物学会会员
5.重庆市营养协会会员
6.美国微生物协会会员
7.重庆市自科基金一般和重点项目特邀评审专家
8.国家自科基金青年项目评审专家

主要成果
在 Molecular Cell、Cell Reports、Oncogene、Cancer Letters、 iScience、Molecular and Cellular Biology、International Journal of Molecular Sciences、Journal of Biological Chemistry、Journal of Experimental Medicine、EMBO Journal、 Genes Development. 、Journal of Immunology等国际期刊上发表学术论文30篇 。

发表论文
1)Cheng Zeng, Tingting Zou,Junyan Qu,Xu Chen,Suping Zhang*, Zhenghong Lin*. Cyclovirobuxine D Induced-Mitophagy through the p65/BNIP3/LC3 Axis Potentiates Its Apoptosis-Inducing Effects in Lung Cancer Cells. International journal of Molecular Science. 2021 May 29;22(11):5820. *通讯作者, 中科院SCI 2区, 影响因子5.9.

2)Tingting Zou, Zhenghong Lin*. The Involvement of Ubiquitination Machinery in Cell Cycle Regulation and Cancer Progression. International journal of Molecular Science.2021 May 27;22(11):5754. *通讯作者, 中科院SCI 2区, 影响因子5.9.

3)Junyan Qu,Cheng Zeng,Tingting Zou,Xu Chen,Xiaolong Yang*,Zhenghong Lin*. Autophagy Induction by Trichodermic Acid Attenuates Endoplasmic Reticulum Stress-Mediated Apoptosis in Colon Cancer Cells. International journal of Molecular Science.2021 May 25;22(11):5566. *通讯作者, 中科院SCI 2区, 影响因子5.9.

4) Junyan Qu#,Tingting Zou#,Zhenghong Lin*. The Roles of the Ubiquitin-Proteasome System in the Endoplasmic Reticulum Stress Pathway. International Journal of Molecular Sciences.2021 Feb 3;22(4):1526. 通讯作者，JCR 1区, 影响因子5.9.

5) Youbo Zhao,Menghuan Li,Xuemei Yao,Yang Fei,Zhenghong Lin,Zhengguo Li,Kaiyong Cai,Yanli Zhao,Zhong Luo. HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications. Cell Reports.2020 Dec 8;33(10):108487. 中科院SCI 1区, 影响因子8.1

6)Le Yu, Ling Dong, Hui Li, Zhaojian Liu, Zhong Luo, GuangjieDuan, Xiaotian Dai*, and Zhenghong Lin*. Ubiquitination-mediated Degradation of SIRT1 by SMURF2 Suppresses CRC Cell Proliferation and Tumorigenesis. Oncogene，2020 May;39(22):4450-4464. 通讯作者，中科院SCI 1区, 影响因子8.0

7)Ling Dong#, Le Yu#, Hui Li, Lei Shi, Zhong Luo, Huakan Zhao, Zhaojian Liu, Guobing Yin, Xiaohua Yan*, and Zhenghong Lin*. An NAD+-dependent deacetylase SIRT7 promotes HCC development through deacetylation of USP39. iScience. 2020 Aug 21;23(8):101351.通讯作者, JCR 1区，影响因子4.4

8)Liu Liu#, Le Yu#, Cheng Zeng, # Hua Long, GuangjieDuan, Guobing Yin, Xiaotian Dai*, and Zhenghong Lin*. The E3 ubiquitin ligase HRD1 promotes lung tumorigenesis by promoting sirtuin 2 ubiquitination and degradation. Molecular and Cellular Biology, 2020 Mar 16;40(7):e00257-19. 通讯作者, 中科院SCI 2区，影响因子3.5

9)Le Yu#, Ling Dong#, Yang Wang, Liu Liu, Hua Long, Hui Li, Jinping Li, Xiaolong Yang, Zhaojian Liu, GuangjieDuan, Xiaotian Dai, Zhenghong Lin*. Reversible Regulation of SATB Ubiquitination by USP47 and SMURF2 Mediates Colon Cancer Cell Proliferation and Tumor Progression. Cancer Letters, 2019 Apr 28;448:40-51. 通讯作者，中科院SCI 1区, 影响因子7.4

10) Liu Liu, Hua Long, Yan Wu, Hui Li, Ling Dong, Li Zhong, Zhaojian Liu, Xiaolong Yang, Xiaotian Dai, Lei Shi, Maozhi Ren, Zhenghong Lin*. HRD1-mediated PTEN degradation promotes cell proliferation and hepatocellular carcinoma progression. Cellular Signaling. 2018 Oct;50:90-99. (通讯作者，IF=3.5, JCR 2区）

11)Shumin Zhang,Sen Liu,Jiankui Zhang,Russel J Reiter,Ying Wang,Dan Qiu,Xiumei Luo,A Rehman Khalid,Hanyan Wang,Li Feng,Zhenghong Lin,Maozhi Ren. Synergistic anti-oomycete effect of melatonin with a biofungicide against oomycetic black shank disease. Journal of Pineal Research. 2018 Sep;65(2):e12492. (IF=10.2, 中科院1区）

12)Ting Zhao,Lu-Lin Xu,Yan Zhang,Zheng-Hong Lin,Tao Xia,Deng-Feng Yang,Ye-Miao Chen,Xiao-Long Yang. Three new α-pyrone derivatives from the plant endophytic fungus Penicillium ochrochloronthe and their antibacterial, antifungal, and cytotoxic activities. J Asian Nat Prod Res. 2018 Aug 21:1-8. (IF=1.1, JCR 4区）

13)Ling Dong; Le Yu; Chunrong Bai; Liu Liu; Hua Long; Lei Shi; Zhenghong Lin*. USP27-mediated Cyclin E Stabilization Drives Cell Cycle Progression and Hepatocellular Tumorigenesis. Oncogene. 2018 May; 37(20):2702-2713. (通讯作者，IF=6.9, 中科院1区）

14)Lei Shi*; Lihua Yu; Fagui Zou; Huimin Hu; Kun Liu; Zhenghong Lin*. Gene expression profiling and functional analysis reveals that p53 pathway-related gene expression is highly activated in cancer cells treated by cold atmosphe c plasma-activated medium. Peer J, 2017 Aug, 5: e3751. (共同通讯作者，IF=2.1, JCR 2区）

15)Yuqiong Wang; Xiyu Zhang; Wei Tang; Zhenghong Lin; Limei Xu; Ruifen Dong; Yiluo Li; Jieyin Li; Zaixin Zhang; Xiangzhi Li; Ling Zhao; Jian-jun Wei; Changshun Shao; Beihua Kong; Zhaojian Liu. miR-130a upregulates mTOR pathway by targeting TSC1 and is transactivated by NF-κB in high-grade serous ovarian carcinoma. Cell Death Differ, 2017 Dec, 24(12): 2089~2100 ; (IF=8.0, 中科院1区）

16)Yan Wu，Chunxiang Bian，Chunlin Zhen，Liu Liu，Zhenghong Lin，Muhammad Farrukh Nisar，Mei Wang，Joerg W.Bartsch，Enyi Huang，Ping Ji，Li Yang，Yanhong Yu，Junfeng Yang，Xuemei Jiang，Julia Li Zhong,*. Telomerase reverse transcriptase mediates EMT through NF-kappa B signaling in tongue squamous cell carcinoma. Oncotarget，2017.10.17，8（49）：85492~85503; 8.

17)Xuebao Zhang，Juan Cai，Ze Zheng，Lisa Polin，Zhenghong Lin，Aditya Dandekar，Li Li，Fei Sun，Russell L Finley Jr，Deyu Fang，Zeng-Quan Yang，Kezhong Zhang*. A novel ER–microtubule-binding protein, ERLIN2, stabilizes Cyclin B1 and regulates cell cycle progression. Cell Discovery，2015.9.8，1：15024 (IF=4.5, 中科院2区)

18)Sinyi Kong，Hongxin Dong，Jianxun Song，Muthusamy Thiruppathi，Bellur S.Prabhakar，Quan Qiu, Zhenghong Lin，Chini, Eduardo，Bin Zhang，Deyu Fang. Deleted in Breast Cancer 1 Suppresses B Cell Activation through RelB and Is Regulated by IKK alpha Phosphorylation. J Immunol.，2015.10.15，195（8）：3685~3693 . (IF=4.5, 中科院2区）

19)Zhenghong Lin; Can Tan; Quan Qiu; Sinyi Kong; Heeyoung Yang; Fang Zhao; Zhaojian Liu; Jinping Li; Qingfei Kong; Beixue Gao; Terry Barrett; Guang-Yu Yang; Jianing Zhang; Deyu Fang*. Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1. Cell Discovery, 2015 Apr, 1: 15028, (IF=4.5, 中科院2区)

20)Heeyoung Yang, Quan Qiu, Beixue Gao, Sinyi Kong, Zhenghong Lin and Deyu Fang. Hrd1-mediated BLIMP-1 ubiquitination promotes dendritic cell MHCII expression for CD4 T cell priming during inflammation. J Exp Med. 2014 Nov 3 . (IF=13.9, 中科院1区)

21)Sinyi Kong, Muthusamy Thiruppathi, Quan Qiu, Zhenghong Lin, Hongxin Dong, Bellur S. Prabhakar, Eduardo Nunes Chini and Deyu Fang. DBC1 Is a Suppressor of B Cell Activation by Negatively Regulating Alternative NF-кB Transcriptional Activity. J Immunol. 2014 Oct 31. (IF=5.5, 中科2区)

22) Zhenghong Lin, Heeyoung Yang, Can Tan, Jinping Li, Zhaojian Liu, Qiu Quan, Sinyi Kong, Junsheng Ye, Beixue Gao and Deyu Fang. The Deubiquitinase USP10 Antagonizes c-Myc Transcriptional Activation through SIRT6 Stabilization to Suppress Tumor Formation. Cell Reports.2013 Dec 11. (IF=7.2, 中科院1区 )

23) Kyeorda L. Kemp, Zhenghong Lin, Fang Zhao, Beixue Gao, Jianxun Song, Kezhong Zhang and Deyu Fang. The serine-threonine kinase Inositol-requiring enzyme 1 α (IRE1α) promotes IL-4 production in T helper cells. J Biol Chem. 2013 Nov 15;288(46):33272-82. (IF=4.7, 中科院2区)

24) Quan Qiu, Ze Zheng, Lin Chang, Yuan-Si Zhao, Can Tan, Aditya Dandekar, Zheng Zhang, Zhenghong Lin, Ming Gui, Xiu Li, Tongshuai Zhang, Qingfei Kong, Hulun Li, Sha Chen, An Chen, Randal J Kaufman, Wei-Lei Yang, Hui-Kuan Lin, Donna Zhang, Harris Perlman, Edward Thorp, Kezhong Zhang, and Deyu Fang.Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis. EMBO J. 2013 Aug 13. (IF=10.8, 中科院1区)

25) Po-Han Chen, Xiaoyan Chen, Zhenghong Lin, Deyu Fang, and Xiaolin He.The structural basis of R-spondin recognition by LGR5 and RNF43. Genes & Development.2013 Jun 11. (IF=12.3, 中科院1区)

26) Zhenghong Lin and Deyu Fang. The roles of SIRT1 in cancer. Genes Cancer. 2013 Mar;4(3-4):97-104.

27) Zhenghong Lin, Heeyoung Yang, Qingfei Kong, Jinping Li, Sang-Myeong Lee, Beixue Gao, Hongxin Dong, Jianjun Wei, Jianxun Song, Donna D. Zhang, and Deyu Fang. USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppresscell apoptosis and is required for mouse embryonic development. Molecular Cell. 2012 May 25;46(4):484-94. (IF=14.2, 中科院1区)

28) Xiaohua Yan#, Zhenghong Lin#, Feng Chen, Xingang Zhao, Hua Chen, Yuanheng Ning, and Ye-Guang Chen.Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling. J Biol Chem. 2009 Oct 30;284(44):30097-104. ( #共同第一作者，IF=5.5, 中科院2区)

29) Zhenghong Lin, Chan Gao, Yuanheng Ning, Xi He, Wei Wu, and Ye-Guang Chen. The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling. J Biol Chem.2008 Nov 28;283(48):33053-8. (IF=5.3, 中科院2区)

30) YIN Chang-Cheng; WANG Shang-Zi; LIN Zheng-Hong; WANG Xiang-Bin; LIU Jing; HUANG Hua-Liang. An efficient approach to the synthesis of a high-quality random peptide repertoire. 生物化学与生物物理学报, 2003.10, 35(10): 921~924; (SCI)

获奖情况
近年主持的科研项目：
国家及重庆市自然科学基金面上项目，中央高校前沿交叉项目, 重庆大学‘****’项目等。

研究生培养
已经毕业4名博士生， 7名硕士生。欢迎有志于研究人类重大疾病发病机制及药物研发的学生和博士后等加入我们的团队。

联系方式
邮箱：zhenghonglin@cqu.edu.cn