程凌鹏 博士 副研究员 1993.9－2000.7 江西师范大学物理系，学士、硕士
2000.7－2001.8 珠海亚力电子有限公司，工程师
2001.9－2004.7 中山大学生命科学学院，博士
2004.7－2006.8 华南理工大学生物医学工程系，讲师
2006.8－2007.7 德克萨斯大学休斯顿医学院，博士后
2007.7－2009.6 加州大学洛杉矶分校，博士后
2009.6－2014.11 中国科学院生物物理研究所，副研究员、研究员（非PI）
2014.11至今 清华大学生命科学学院，副研究员



● 研究兴趣、领域： 生物大分子冷冻电镜三维重构方法学、双链RNA/DNA病毒结构和功能

● 代表性论文： 1.Xurong Wang, Fuxian Zhang, Rui Su, Xiaowu Li, Wenyuan Chen, Qingxiu Chen, Tao Yang, Jiawei Wang, Hongrong Liu*, Qin Fang*, Lingpeng Cheng*, Structure of RNA polymerase complex and genome within a dsRNA virus provides insights into the mechanisms of transcription and assembly, Proceedings of the National Academy of Sciences, USA, 115 (2018): 7344-7349
2.Xiong Pi, Lirong Tian, Huai-En Dai, Xiaochun Qin, Lingpeng Cheng, Tingyun Kuang, Sen-Fang Sui* and Jian-Ren Shen*, Unique organization of photosystem I–light-harvesting supercomplex revealed by cryo-EM from a red alga, Proceedings of the National Academy of Sciences, USA,115 (2018):4423-4428
3.Xiaowu Li, Niyun Zhou, Wenyuan Chen, Bin Zhu, Xurong Wang, Bin Xu, Jiawei Wang, Hongrong Liu*, Lingpeng Cheng*, Near-atomic resolution structure determination of a cypovirus capsid and polymerase complex using cryo-EM at 200 kV, Journal of Molecular Biology. 429 (2017) pp. 79-87
4.Xiaowu Li, Hongrong Liu*, Lingpeng Cheng*, Symmetry-mismatch reconstruction of genomes and associated proteins within icosahedral viruses using cryo-EM, Biophysics Reports. 2016, 2 (1): 25-32
5.Hongrong Liu* and Lingpeng Cheng*, Cryo-EM shows the polymerase structures and a nonspooled genome within a dsRNA virus, Science, Vol. 349, (2015), pp: 1347-1350
6.Bin Zhu, Chongwen Yang, Hongrong Liu*, Lingpeng Cheng*, Feng Song, Songjun Zeng, Xiaojun Huang, Gang Ji, and Ping Zhu, Identification of the active sites in the methyltransferases of a transcribing dsRNA virus, Journal of Molecular Biology, Vol. 26, (2014), pp: 2167-2174
7.Lingpeng Cheng, Xiaoxing Huang, Xiaomin Li, Wei Xiong, Wei Sun, Chongwen Yang, Kai Zhang, Ying Wang, Hongrong Liu, Xiaojun Huang, Gang Ji, Fei Sun, Congyi Zheng, and Ping Zhu, Cryo-EM structures of two bovine adenovirus type 3 intermediates, Virology. Vol. 450–451, (2014), pp: 174–181
8.Chongwen Yang, Gang Ji, Hongrong Liu, Kai Zhang, Guangqiao Liu, Fei Sun, Ping Zhu* and Lingpeng Cheng*, Cryo-EM Structure of a transcribing cypovirus, Proceedings of the National Academy of Sciences, USA. Vol. 109, (2012), pp: 6118–6123
9. Changchun Cao, Xiaoyan Dong, Xiaobing Wu, Boyun Wen, Gang Ji, Lingpeng Cheng*, and Hongrong Liu*, Conserved fiber-penton base interaction revealed by a nearly atomic resolution cryo-EM structure of adenovirus provides insight into receptor interaction, Journal of Virology. Vol. 86, (2012), pp:12322-12329
10.Lingpeng Cheng, Jingchen Sun, Kai Zhang, Zongjun Mou, Xiaoxing Huang, Gang Ji, Fei Sun, Jingqiang Zhang, and Ping Zhu, Atomic model of a cypovirus built from cryo-EM structure provides insight into the mechanism of mRNA capping. Proceedings of the National Academy of Sciences, USA. Vol. 108, (2011), pp: 1373-1378
11.Lingpeng Cheng, Jiang Zhu, Qin Fang, Wong Hoi Hui, Xiaokang Zhang, Barry Honig and Z. Hong Zhou. Backbone model of an aquareovirus by cryo-electron microscopy and bioinformatics. Journal of Molecular Biology. Vol. 397, (2010), pp: 852-863
12. Jiang Zhu, Lingpeng Cheng, Qin Fang, Z. Hong Zhou and Barry Honig. Building Atomic Models for Molecular Assemblies Using CryoEM Maps, Homology Modeling and Multi-Scale Structure Refinement. Journal of Molecular Biology. Vol. 397 (2010), pp: 835-851
13. Lingpeng Cheng, Qin Fang, Sanket Shah, Ivo C. Atanasov and Z. Hong Zhou. Subnanometer-resolution Structures of the Grass Carp Reovirus Core and Virion, Journal of Molecular Biology. Vol. 382, (2008), pp: 213-222
14.Hongrong Liu, Lingpeng Cheng, Songjun Zeng, Canying Cai, Z. Hong Zhou and Qibin Yang. Symmetry-adapted spherical harmonics method for high-resolution 3D single-particle reconstructions, Journal of Structural Biology, Vol. 161, Issue 1, (2008), pp: 64-73



● 联系方式： 电子邮箱：lingpengcheng@tsinghua.edu.cn