2016-2017 Research Assistant Professor, University of Chicago, Chicago, IL, USA
2013-2016 Postdoctoral Scholar, Department of Pathology, University of Chicago, Chicago, IL, USA
2007-2012 PhD in Cell Biology, Institute of Biophysics, Chinese Academy of Science, Beijing, China
2003-2007 Bachelor of Pharmacology, Capital Medical University, Beijing, China
研究领域与方向 Our goal is to unravel the complex interactions between immune cells, tumor cells and tumor microenvironment (TME) in different cancer settings, thereby developing novel anticancer immunotherapies to improve clinical benefit. We are particularly focusing on how mRNAepitranscriptomeand post-transcriptional regulation determine the fate and function of immune cells that impacts antitumor immunity.
学术荣誉与奖励
关键词Anti-tumor immune response, tumor microenvironment, immunotherapy
代表性论文1.MengMichelle Xu, Yang Pu, Dali Han,YaoyaoShi,XuezhiCao, Hua Liang, Xiang Chen, Xiao-Dong Li,LiufuDeng,ZhijianJ. Chen, Ralph R.Weichselbaum, Yang-Xin Fu*. Dendritic cells but not macrophages sense tumor mitochondrial DNA for cross-priming through signal regulatory protein α signaling.Immunity2017, 47, 363-373.
2.MengMichelle Xu, Yang Pu, Ralph R.Weichselbaum*,Yang-Xin Fu*.Integrating conventional and antibody-based targeted anticancer treatment into immunotherapy.Oncogene2017, 36, 585-592.
3. Yang Pu,MengXu, Yong Liang,KaitingYang,YajunGuo,XuanmingYang,*and Yang-
Xin Fu*. Androgen receptor antagonists compromise T cell response against prostate cancer leading to early tumor relapse.Science Translational Medicine2016, 8, 333ra47.
4.MengMichelle Xu,Yang Pu, Yuan Zhang and Yang-Xin Fu*. The role of adaptive immunity in the efficacy of targeted cancer therapies.Trends in immunology2016, 37 (2), 141-153.
5.XiaojuanLiu#, Yang Pu, KyleCron,LiufuDeng, Justin Kline, William A Frazier,HairongXu, Hua Peng, Yang-Xin Fu*,MengMichelle Xu# *.CD47 blockade triggers T cell-mediated destruction of immunogenic tumors.Nature Medicine2015, 21(10), 1209-1215.
6.MengXu#,MingyueLiu#,XuexiangDu,SiruiLi, Hang Li,XiaozhuLi, Ying Li, Yang Wang,ZhihaiQin, Yang-Xin Fu*,ShengdianWang*.Intratumoraldelivery of IL-21 overcomes anti-Her2/Neuresistance through shifting tumor-associated macrophages from M2 to M1 phenotype.The Journal of Immunology2015, 194(10), 4997-5006.
7.LiufuDeng, Hua Liang,MengMichelle Xu,XuanmingYang, Byron Burnette,AinhoaArina, Xiao-Dong Li, HelenaMauceri, Michael Beckett, ThomasDarga,XiaonaHuang, Thomas FGajewski,ZhijianJ Chen, Yang-Xin Fu*, Ralph RWeichselbauman*. STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors.Immunity2014, 41(5), 843-852.
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