1980至1984年在甘肃农业大学兽医学专业学习，获学士学位
1984至1987年在中国兽药监察所微生物学与免疫学专业学习，获硕士学位
1987至1991年在中国农业大学兽医学院任助教和讲师
1993至1997年在美国得克萨斯大学医学中心（University of Texas Health Science Center - Houston) 微生物学与分子遗传学专业学习，获博士学位
1998至2000年在美国圣祖德儿童医学研究所（St. Jude Children‘s Research Hospital) 传染病学系从事博士后研究
2000至2004年任美国阿尔巴尼医学院 (Albany Medical College) 助理教授
2004至2010年任美国阿尔巴尼医学院 (Albany Medical College) 副教授
2007年 获国家自然科学基金海外青年合作基金（基金B类）
2007年 被中国科学院微生物研究所聘为客座教授
2010年-至今 任清华大学医学院教授
研究领域与方向 我们实验室主要研究急性肺炎发病的分子机制。急性肺炎是当今世界范围内导致儿童和老人死亡的最重要原因之一，其主要病原体包括肺炎链球菌 (Streptococcus pneumoniae)、肺炎克雷伯菌（Klebsiella pneumoniae)、肺炎支原体（Mycoplasma pneumoniae）等。 尽管人体肺脏的天然免疫系统（如补体 、吞噬性白细胞、抗菌肽等）能够成功发现和清除非致病菌，但是无法彻底清除引起肺炎的病原体。因此，病原体在肺脏成功逃逸宿主天然免疫监控以及由此导致的细菌繁殖是导致急性肺炎的主要根源，但是目前在国际范围内对急性肺炎发病的分子机制缺乏理解。值得一提的是，日益增强的细菌耐药已经使过去用于治疗急性肺炎的许多抗生素不再有效。我们实验室目前的主要科学问题包括：1） 病原体依赖那些自身的基因及其相关功能来达到逃逸宿主天然免疫监控的目的；2） 人体的那些免疫细胞和免疫分子能够成功清除非致病菌，却容忍致病菌的生存与繁殖；3）肺炎病原体通过那些途径逃逸宿主天然免系统监控。解决这些重大科学问题将为急性肺炎的精准诊断、治疗和预防提供分子靶标与思路。
学术荣誉与奖励2007年 获国家自然科学基金海外青年合作基金（基金B类）
关键词bacterial pathogenesis, discovery of antimicrobials
代表性论文1. Liu, Yanni, Yuna Zeng, Yijia Huang, Gu L, Shaolin Wang, Chunhao Li, Donald A. Morrison, Haiteng Deng*, Jing-RenZhang*. 2019. HtrA‐mediated selective degradation of DNA uptake apparatus accelerates termination of pneumococcal transformation. Molecular Microbiology. DOI:10.1111/mmi.14364.
2. Li, Jing-Wen, Jing Li, Juanjuan Wang, Chunhao Li, and Jing-Ren Zhang*. 2019. Molecular mechanisms of hsdS inversionsin the cod locus of streptococcus pneumoniae. Journal of Bacteriology. 201(6):e00581-18. DOI:10.1128/JB.00581-18.
3. Li, Jing and Jing-Ren Zhang*. 2019. Phase variation of Streptococcus pneumoniae. Microbiology Spectrum. 7(1). DOI:10.1128/microbiolspec.GPP3-0005-2018.
4. Zong, Yu,Fang Fang, Kirsten J.Meyer, Liguo Wang, Zhihao Ni, Hongying Gao. Kim Lewis, Jing-Ren Zhang, and Yu Rao. 2019. Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics. Nature communications. 10:3268. DOI:10.1038/s41467-019-11211-y.
5. Zhang, Kai, Zhuan Qin, Yunjie Chang, Jun Liu, Michael G. Malkowski, Saimtun Shipa, Li Li, Weigang Qiu, Jing-Ren Zhang, and Chunhao Li*. 2019. Analysis of a flagellar filament cap mutant reveals that HtrA serine protease degrades unfolded flagellin protein in the periplasm of Borrelia burgdorferi. Molecular Microbiology. 111:1652-1670. DOI:10.1111/mmi.14243.
6. Wang, Xu, Yuna Zeng, Li Sheng, Peter Larson, Xue Liu, Xiaowen Zou, Shufang Wang, Kaijing Guo, Chen Ma, Gang Zhang, Huaqing Cui, David Ferguson, Yan Li, Jing-Ren Zhang*, and Courtney Aldrich*. 2019. A cinchona alkaloid antibiotic that appears to target ATP synthase in Streptococcus pneumoniae. Journal of Medicinal Chemistry. 62:2305-2332. DOI:10.1021/acs.jmedchem.8b01353.
7. Wang, Yang, Zhensong Wen, Xiaolei Pan, David E. Briles, Yongqun He, and Jing-Ren Zhang*. 2018. Novel immunoprotective proteins of Streptococcus pneumoniae identified by opsonophagocytosis killing screen. Infection and Immunity. 86(9):e00423-18. DOI:10.1128/IAI.00423-18.
8. He, Lihong, Dongyang Luo, Fan Yang, Chunhao Li, Xuegong Zhang, Haiteng Deng, and Jing-Ren Zhang*. 2018. Multiple domains of bacterial and human Lon proteases define substrate selectivity. Emerging Microbes and Infections. (2018):149. DOI:10.1038/s41426-018-0148-4.
9. Kurniyati, Kurni, Jun Liu, Jing-Ren Zhang, Yunjiang Min, and Chunhao Li*. 2018. A pleiotropic role of FlaG homolog in regulating the cell morphogenesis and flagellar homeostasis at the cell poles of Treponema denticola. Cellular Microbiology. 21:e12886. DOI:10.1111/cmi.12886.
10. Pan, Yushan *, Haoran An, Tong Fu, Shiyu Zhao, Chengwang Zhang, Genhui Xiao, Jing-Ren Zhang, Xinfang Zhao, Gongzheng Hu*. 2018. Characterization of Streptococcus pluranimalium from a cattle with mastitis by whole genome sequencing and functional validation. BMC Microbiology. 18:182. DOI:10.1186/s12866-018-1327-0
11. Xu, Miao, Huiping Lu, Young-Hee Lee, Y. Wu, Kewei Liu, Yuling Shi, Haoran An, Jing-Ren Zhang, Xiaohu Wang, Yuping Lai, and Chen Dong*. 2018. An Interleukin-25-mediated autoregulatory circuit in keratinocytes plays a pivotal role in psoriatic skin inflammation. Immunity 48:787-798 e4. DOI:10.1016/j.immuni.2018.03.019.
12. Liu, Xue, Jing-Wen Li, Zhixin Feng, Yongfu Luo, Jan-Willem Veening, and Jing-Ren Zhang*. 2017. Transcriptional repressor PvtR regulates phenotypic tolerance to vancomycin in Streptococcus pneumoniae. Journal of Bacteriology 199(14). pii:e00054-17. DOI:10.1128/JB.00054-17.
13. Li, Jing, Juanjuan Wang, Fangfang Jiao and Jing-Ren Zhang*. 2017. Observation of pneumococcal phase variation in colony morphology. Bio-protocol 7:Iss15. DOI:10.21769/BioProtoc.2434.
14. Yu, Yuanyuan, Jing-Wen Li, Long Jiang, Jing-Ren Zhang*, and Liansuo Zu*. 2017. Catalytic enantioselective aza-pinacol rearrangement. Angewandte Chemie International Edition English 56:9217-9221. DOI:10.1002/anie..
15. Chen, Fei, Guolin Cui, Shuxia Wang, Manoj K. Mohan Nair, Lihong He, Xinyi Qi, Xiangmin Han, Hanqi Zhang, Jing-Ren Zhang*, and Jingliang Su*. 2017. Outer membrane vesicle-associated lipase FtlA enhances cellular invasion and virulence in Francisella tularensis LVS. Emerging Microbes and Infections 6:e66. DOI:10.1038/emi.2017.53.
16. Liu, Bo, Xue Liu, Jing-Ren Zhang*, and Gang Liu*. 2017. A natural lipotrisaccharide and its derivatives selectively lyse Streptococcus pneumoniae via interaction with cell membrane. ACS Infectious Diseases 3:438-453. DOI:10.1021/acsinfecdis.7b00008.
17. Liu, Xue, Clement Gallay, Morten Kjos, Amau Domenech, Jelle Slager, Sebastiaan P. van Kessel, Kevin Knoops, Robin A. Sorg, Jing-Ren Zhang, and Jan-Willem Veening*. 2017. High-throughput CRISPRi phenotyping in Streptococcus pneumoniae identifies new essential genes involved in cell wall synthesis and competence development. Molecular Systems Biology 13:931. DOI:10.15252/msb.**.
18. Li, Jing Jing-Wen Li, Zhixin Feng, Juanjuan Wang, Haoran An, Yanni Liu, Yang Wang, Kailing Wang, Xuegong Zhang, Zhun Miao, Wenbo Liang, Robert Sebra, Guiling Wang, Wen-Ching Wang, and Jing-Ren Zhang*. 2016. Epigenetic switch driven by DNA inversions dictates phase variation in Streptococcus pneumoniae. PLOS Pathogens 12: e**. DOI:10.1371/journal.ppat.**. Highlighted in Nature Reviews Microbiology DOI:10.1038/nrmicro.2016.122.
19. Wen, Zhensong, Yanni Liu, Fen Qu, and Jing-Ren Zhang*. 2016. Allelic variation of the capsule promoter diversifies encapsulation and virulence in Streptococcus pneumoniae. Scientific Reports 6:30176. DOI: 10.1038/srep30176.
20. Li, Guilin, Zhuowen. Liang, Xiatai Wang, Yonghong Yang, Zhujun Shao, Ma Li, Yueyun Ma, Fen Qu, Donald A. Morrison, and Jing-Ren Zhang*. 2016. Addiction of hyper-transformable pneumococcal isolates to natural transformation for in vivo fitness and virulence. Infection and Immunity 84:1887-1901. DOI:10.1128/IAI.00097-16.
21. He, Lihong, Manoj K. Mohan Nair, Yuling Chen, Xue Liu, Mengyun Zhang, Karsten R. O. Hazlett, Haiteng Deng*, and Jing-Ren Zhang*. 2016. The protease locus of Francisella tularensis LVS is required for stress tolerance and infection of mammalian host. Infection and Immunity 84:1387-402. DOI:10.1128/IAI.00076-16.
22. Bai, Xiao-Hui, Qiong Li, Yong-Liang Jiang, Jing-Ren Zhang*, Yuxin Chen*, and Cong-Zhao Zhou*. 2016. Structural comparison and simulation of pneumococcal peptidoglycan hydrolase LytB. Methods in Molecular Biology. 1440:271-83. DOI:10.1007/978-1-4939-3676-2_19.
23. Yang, Hongzhi, Xue Liu, Qingong Li, Longbo Li, Jing-Ren Zhang*, and Yefeng Tang*. 2016. Total synthesis and preliminary SAR study of (+/-)-merochlorins A and B. Organic & Biomolecular Chemistry. 14:198-205. DOI: 10.1039/c5ob01946j.
24. Yang, Tao, Gong Chen, Zitai Sang, Yuanyuan Liu, Xiaoyan Yang, Ying Chang, Haiyue Long, Wei Ang, Jianying Tang, Zhenling Wang*, Guobo Li, Shengyong Yang, Jing-Ren Zhang, Yuquan Wei, and Youfu Luo*. 2015. Discovery of a teraryl oxazolidinone compound (S)-N-((3-(3-fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)phenyl)-2-oxooxazolidin-5 -yl)methyl)acetamide phosphate as a novel antimicrobial agent with enhanced safety profile and efficacies. Journal of Medical Chemistry 58:6389-409. DOI: 10.1021/acs.jmedchem.5b00152.
25. Wang, Lei, Yong-Liang Jiang, Jing-Ren Zhang, Cong-Zhao Zhou, and Yuxin Chen*. 2015. Structural and enzymatic characterization of the choline kinase LicA from Streptococcus pneumoniae. PLoS One 10:e**. DOI:10.1371/journal.pone.**.
26. Wen, Zhensong, Odeniel Sertil, Yongxin Chen, Shanshan Zhang, Xue Liu, Wen-Ching Wang, and Jing-Ren Zhang*. 2015. The sequence elements upstream of the core promoter are necessary for the full transcription of the capsule gene operon in Streptococcus pneumoniae strain D39. Infection and Immunity 83:1957-1972. DOI:10.1128/IAI.02944-14.
27. Achila, David, Aizhou Liu, Rahui Banerjee, Yue Li, Erik Martinez-Hackert, Jing-Ren Zhang*, and Honggao Yan*. 2015. Structural Determinants of Host Specificity of Complement Factor H Recruitment by Streptococcus pneumoniae. Biochemical Journal 465:325-335. DOI:10.1042/BJ**.
28. Feng, Zhixin., Jing Li, Jing-Ren Zhang*, and Xuegong Zhang*. 2014. qDNAmod: a statistical model based tool to reveal intercellular heterogeneity of DNA modification from SMRT sequencing data. Nucleic Acids Research 42:13488-13499. DOI:10.1093/nar/gku1097.
29. Zhu, Deyu, Lijun Wang, Guijun Shang, Xue Liu, Jing Zhu, Defen Lu, Lei Wang, Biao Kan, Jing-Ren Zhang, and Ye Xiang. 2014. Structural biochemistry of a Vibrio cholerae dinucleotide cyclase reveals cyclase activity regulation by folates. Molecular Cell 55:931-937. DOI:10.1016/j.molcel.2014.08.001.
30. Zeng Xian-Fei, Yueyun Ma, Liu Yang, Lei Zhou, Yijun Xin, Liang Chang, Jing-Ren Zhang, and Xiaoke Hao*. 2014. A C-terminal truncated mutation of licC attenuates the virulence of Streptococcus pneumoniae. Research in Microbiololgy 165: 630-638. DOI:10.1016/j.resmic.2014.09.002.
31. Song, Yongxiang, Qinglian Li, Xue Liu, Yuchan Chen, Yun Zhang, Aijun Sun, Weimin Zhang, Jing-Ren Zhang, and Jianhua Ju*. 2014. Cyclic hexapeptides from the deep South China Sea-derived Streptomyces scopuliridis SCSIO ZJ46 active against pathogenic Gram-positive bacteria. Journal of Natural Products 77:1937-1941. DOI:10.1021/np500399v.
32. Bai, Xiao-Hui, Hui-Jie Chen, Yong-Liang Jiang, Zhensong Wen, Yubin Huang, Wang Cheng, Qiong Li, Lei Qi, Jing-Ren Zhang*, Yuxin Chen*, and Cong-Zhao Zhou*. 2014. Structure of pneumococcal peptidoglycan hydrolase LytB reveals insights into the bacterial cell wall remodeling and pathogenesis. Journal of Biological Chemistry 289:23403–23416. DOI:10.1074/jbc.M114.579714.
33. Yang, Yi-Hu, Yong-Liang Jiang, Juan Zhang, Lei Wang, Xiao-Hui Bai, Shi-Jie Zhang, Yan-Min Ren, Na Li, Yonghui Zhang, Zhiyong Zhang, Qingguo Gong, Yide Mei, Ting Xue, Jing-Ren Zhang, Yuxin Chen*, and Cong-Zhao Zhou*. 2014. Structural insights into SraP-mediated Staphylococcus aureus adhesion to host cells. PLOS Pathogens 10:e**. DOI:10.1371/journal.ppat.**.
34. Pan, Xiaolei, Yang Yang, and Jing-Ren Zhang*. 2014. Molecular basis of host specificity in human pathogenic bacteria. Emerging Microbes and Infections 3:e23. DOI:10.1038/emi.2014.23.
35. Gupta, R., Jun Yang, Y. Dong, E. Swiatlo, Jing-Ren Zhang, Dennis W. Metzger, and Guangchun Bai*. 2013. Deletion of arcD in Streptococcus pneumoniae D39 impairs its capsule and attenuates virulence. Infection and Immunity 81:3903-3911.
36. Qaidi, Samir E., Jun Yang, Jing-Ren Zhang, Dennis W. Metzger, and Guangchun Bai*. 2013. The vitamin B6 biosynthesis pathway in Streptococcus pneumoniae is controlled by pyridoxal 5’-phosphate and the transcription factor PdxR, and impacts on ear infection. Journal of Bacteriology 195:2187-2196.
37. Li, Guilin, Fen Z. Hu, Xianwei Yang, Yujun Cui, Jun Yang, Fen Qu, George F. Gao, and Jing-Ren Zhang*. 2012. The complete genome sequence of Streptococcus pneumoniae strain ST556, a multi-drug resistant isolate from an otitis media patient. Journal of Bacteriology 194:3294-3295.
38. Han, Huiming, Cuihua Liu, Quanhui Wang, Chunling Xuan, Beiwen Zheng, Jiaqi Tang, Jinghua Yan, Jing-Ren Zhang, Ming Li, Hao Cheng, Guangwen Lu, George F. Gao*. 2012. The two-component system Ihk/Irr contributes to the virulence of Streptococcus suis serotype 2 strain 05ZYH33 through alteration of the bacterial cell metabolism. Microbiology 158:1852-1866.
39. Su, J., J. Asare, J. Yang, M. Kumar, J. Mazurkiewicz, Y. Abu-Kwaik, and Jing-Ren Zhang*. 2011. The capBCA locus is required for intracellular growth of Francisella tularensis. Frontiers in Cellular and Infection Microbiology 2:83.
40. Zhang, Q., F. Gao, H. Peng, H. Cheng, Y. Liu, J. Tang, J. Thompson, G. Wei, Jing-Ren Zhang, Y. Du, J. Yan, and G.F. Gao*. 2009. Crystal structures of Streptococcus suis mannonate dehydratase (ManD) and its complex with substrate: genetic and biochemical evidence for a catalytic mechanism. Journal of Bacteriology 191:5832–5837.
41. Chen, Huaiqing, Yueyun Ma, Jun Yang, Christopher J. O'Brien, Scott L. Lee, Joseph E. Mazurkiewicz, Sauli Haataja, Jinghua Yan, George F. Gao, and Jing-Ren Zhang*. 2008. Genetic requirement for pneumococcal ear infection. PLoS One 3:e2950.
42. Lu, Ling, Zhuo Ma, T. Sakari Jokiranta, Adeline R. Whitney, Frank R. DeLeo, and Jing-Ren Zhang*. 2008. Species-specific interaction of Streptococcus pneumoniae with human complement factor H. Journal of Immunology 181:7138-7146.
43. Ma, Zhuo and Jing-Ren Zhang*. 2007. RR06 activates the transcription of spr1996 and cbpA in Streptococcus pneumoniae. Journal of Bacteriology 189:2497-2509.
44. Su, Jingliang, Jun Yang, Daimin Zhao, Thomas H. Kawula, Jeffery. A. Banas, and Jing-Ren Zhang*. 2007. Genome-wide identification of Francisella tularensis virulence determinants. Infection and Immunity 75:3089-3101.
45. Lu, Ling, Yueyun Ma, and Jing-Ren Zhang*. 2006. Streptococcus pneumoniae recruits complement factor H through the amino terminus of CbpA. Journal of Biological Chemistry 278:48178-48187.
46. Lu, Ling, Michael E. Lamm, Hongmin Li, Blaise Corthesy, and Jing-Ren Zhang*. 2003. The human polymeric immunoglobulin receptor binds to Streptococcus pneumoniae via domains 3 and 4. Journal of Biological Chemistry 278:48178-48187.
47. Zhang, Jing-Ren, Keith E. Mostov, Michael E. Lamm, Masanobu Nanno, Shin-ichiro Shimida, Makoto Ohwaki, and Elaine Tuomanen*. 2000. The polymeric immunoglobulin receptor translocates pneumococci across human nasopharyngeal epithelial cells. Cell 102:827-837.
48. Zhang, Jing-Ren, Ilona Idanpaan-Heikkila, Werner Fischer, and Elaine Tuomanen*. 1999. Pneumococcal licD2 gene is involved in phosphorylcholine metabolism. Molecular Microbiology 31:1477-1488.
49. Zhang, Jing-Ren and Elaine Tuomanen*. 1999. Molecular and cellular mechanisms for microbial entry into the CNS. Journal of NeuroVirology 5:591-603.
50. Zhang, Jing-Ren and Steven J. Norris*. 1998. Kinetics and in vivo induction of genetic variation of vlsE in Borrelia burgdorferi. Infection and Immunity 66:3689-3697.
51. Zhang, Jing-Ren and Steven J. Norris*. 1998. Genetic variation of the Borrelia burgdorferi gene vlsE involves cassette-specific, segmental gene conversion. Infection and Immunity 66:3698-3704.
52. Zhang, Jing-Ren, John. M. Hardham, Alan. G. Barbour, and Steven J. Norris*. 1997. Antigenic variation in Lyme disease borrelia by promiscuous recombination of vmp-like sequence cassettes. Cell 89:275-285.
53. Dabbert, C. Brad, R.obert L. Lochmiller*, Jing-Ren Zhang, Charles W. Qualls, and Kim Burnham. 1994. High in vitro endotoxin responsiveness of macrophage from an endotoxin-resistant wild rodent species, Sigmodon hispidus. Developmental and Comparative Immunology 18:147-153.
Book chapter
1. Jing Li and Jing-Ren Zhang*. 2019. Phase variation of Streptococcus pneumoniae. In Gram-Positive Pathogens Reference (Vincent A. Fischetti ed.) (book chapter). American Society for Microbiology Press, Washington, D.C.
2. Jing-Ren Zhang*, M. G. Marinus, and Haiteng Deng. 2015. Methylation and other modifications of nucleic acids and proteins. In Reference Module in Biomedical Sciences (Michael Caplan ed.), chapter 2448 (book chapter). Page 1-11, DOI: 10.1016/B978-0-12-801238-3.02448-X, Elsevier, Amsterdam.
3.Wen, Zhensong and Jing-Ren Zhang*. 2015. Bacterial capsules, p. 33-52 (book chapter). In Molecular Medical Microbiology (Y.-W. Tang, M. Sussman, D. Liu, I. Poxton, and J. Schwartzman ed.). Academic Press, Amsterdam.
联系方式Email: zhanglab at tsinghua.edu.cn
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