研究领域与方向
1. 研究学习记忆的分子机制，开发新的药物靶点和药物，用于改善和增强正常人和老年性痴呆病 人的学习记忆能力；
2. 研究神经细胞死亡和存活的新机制，特别是内质网应激和 RNA 代谢紊乱的神经退行性致病机制， 为缓解神经退行性疾病中的神经细胞死亡提供新的药物靶点；
3. 开发新一代基因操作技术和基因治疗手段，治疗基因突变引起的神经退行性疾病和其他人类最 大遗传性疾病 。
Neurodegenerative diseases afflict millions of people worldwide, but so far no effective cure has been developed for these devastating disorders, partially due to our poor understanding of disease mechanisms. Because mouse shares over 90% gene similarity with human, to study chemical-induced mutant mice carrying neurodegenerative phenotypes will great enhance our knowledge on the disease mechanisms and accelerate the speed in identification of therapeutic interventions. In addition, our disease-orientated research on these disease-associated genes also significantly deepens our understanding on physiological functions of these genes. Our long-term goal is to combine molecular biology and mouse genetics to better understand the neurological disease mechanisms and bridge our basic researc h with therapeutic target discoveries.
学术荣誉与奖励
关键词high through-put sequencing, molecular and cell biology, mouse forward genetics
代表性论文1.Yichang Jia, John Mu, Susan Ackerman. (2012) Mutation of a U2 snRNA Gene Causes Global Disruption of Alternative Splicing and Neurodegeneration. Cell. 148, 296-308.
2.Jian Zhou, Wanlu Du, Kechun Zhou, Yilin Tai, Hanlan Yao, Yichang Jia, Yuqiang Ding, Yizheng Wang. (2008) Critical role of TRPC6 channels in the formation of excitatory synapses. Nat Neurosci. 11, 741-3.
3.YiqunYao, Xia Ding, Yichang Jia, Chuanxin Huang, Yizheng Wang, and Yunhui Xu. (2008) Anti-tumor effect of b-elemene in glioblastoma cells 3 depends on p38 MAPK activation. Cancer Lett. 264, 127-134.
4.Zenghua Wang, Bin Shen, Haolan Yao, Yichang Jia, Jing Ren, Youji Feng and Yizheng Wang. (2007) Blockage of intermediate-conductance-Ca2+-activated K+ channels inhibits progression of human endometrial cancer. Oncogene. 26, 5107-5114.
5.Chuanxin Huang, Yichang Jia, Shenglian Yang, Biao Chen, Hongwei Sun, Feng Shen and Yizheng Wang. (2007) Characterization of ZNF23, a KRAB-containing protein that is downregulated in human cancers and inhibits cell cycle progression. Exp. Cell Res. 313, 254-263.
6.Yichang Jia*, Jian Zhou*, Yilin Tai and Yizheng Wang. (2007) TRPC channels promote cerebellar granule neuron survival. Nature Neurosci. 10, 559-567. * These authors contributed equally to this work. (also see News and Views, Nature Neurosci. 10, 537-538)
7.Yan Li*, Yichang Jia*, Kai Cui*, Ning Li, Zai-Yu Zheng, Yi-Zheng Wang and Xiao-Bing Yuan. (2005) Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor. Nature. 434, 894-898. * These authors contributed equally to this work. (also see News and Views, Nature 434, 835-838)
联系方式Email: yichangjia at mail.tsinghua.edu.cn
Phone: +86-
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