1991/01-1992/12美国衣阿华大学预防医学硕士
1992/12-1998/06美国衣阿华大学免疫学博士
1988/09-1991/01上海检疫所医师
1998/06-2006/03美国马萨诸塞大学博士后及助教授
2006/03-2010/03加拿大卡尔加里大学助理教授
2010/03-2012/03加拿大卡尔加里大学副教授
2012/03-至今 清华大学教授
研究领域与方向 从事免疫学方向的研究，主要通过单细胞力谱仪和高分辨单细胞成像技术分析树突状细胞的激活过程。于2012年从加拿大回国任职，担任清华大学终身教授。早期发现尿酸是哺乳动物的免疫危险因子。
近年来的主要研究成果:
1.发现了树突状细胞表面脂质对外界的固态物质反应。这个效应是固态颗粒免疫激活或者佐剂作用的基础。申请人发现力学作用所产生的免疫调节可以延伸到细胞与细胞之间的相互作用。在调节性T细胞和树突状细胞接触中，强烈的粘合作用导致后者细胞骨架极化，形成免疫抑制。
2.肠道菌落和外界免疫系统发育之间的关系:近年来的实验室结果显示，新生小鼠的肠道中的真菌可以释放生物物质，刺激肠道的CD103阳性的树突状细胞，这些细胞向外周淋巴结转移，并带去视黄酸，诱导这些组织的发育。
学术荣誉与奖励
关键词免疫自身调节, 原子力显微镜, 树突状细胞
代表性论文1.JiahuanChen,AnutoshGanguly, Ashley D.Mucsi,JunchenMeng,JiacongYan, PascalDetampel, Fay Munro,ZongdeZhang, Mei Wu,AswinHari, Melanie D.Stenner,WenchengZheng, PaulKubes, Tie Xia, Matthias W.Amrein, Hai Qi, and Yan Shi*,Strongadhesion by regulatory T cells induces dendritic cell cytoskeletal polarization and contact-dependent lethargy, The Journal of Experimental Medicine,2017,DOI: 10.1084
2.ZongdeZhang,JianjianLi,WenchengZheng,GuangZhao, Hong Zhang,XiaofeiWang,YaqianGuo,ChuanQin, and Yan Shi*. Peripheral lymphoid volume expansion and maintenance are controlled by gut microbiota via RALDH+ dendritic cells. Immunity, 2016, 1074-7613
3. RongH and Shi Y*.Disruption of keyGTPaseregulators ofendocyticrecycling compartment does not interfere with soluble antigencrosspresentationin dendritic cells.CellMolImmunolAOP, March 16, 2015; doi:10.1038/cmi.2015.17
4. HariA, Zhang Y,TuZ,DetampelP,StennerM,GangulyA, Shi Y*. Activation of NLRP3inflammasomeby crystalline structures via cell surface contact.SciRep. 2014, 2;4:7281.
5. Shi Y*.To forge a solid immune recognition. Protein Cell,2012, (8):564-70.
6.GhaemiOskouie, F., A.Shameli, A. Yang, M. D.Desrosiers, A. D.Mucsi, M. R. Blackburn, Y. Yang, P. Santamaria, and Y. Shi*. High levels of adenosinedeaminaseon dendritic cells promoteautoreactiveT cell activation and diabetes innonobesediabetic mice. J Immunol,2011,186(12):6798-806.
7.Flach, T. L., G. Ng, A.Hari, M. D.Desrosiers, P. Zhang, S. M. Ward, M. E.Seamone, A.Vilaysane, A. D.Mucsi, Y. Fong, E.Prenner, C. C. Ling, J.Tschopp, D. A.Muruve, M. W.Amrein, and Y. Shi*. Alum interaction with dendritic cell membrane lipids is essential for itsadjuvanticity. Nat Med, 2011, 17: 479-87.
8.Flach, T. L., G. Ng, A.Hari, M. D.Desrosiers, P. Zhang, S. M. Ward, M. E.Seamone, A.Vilaysane, A. D.Mucsi, Y. Fong, E.Prenner, C. C. Ling, J.Tschopp, D. A.Muruve, M. W.Amrein, and Y. Shi. 2011. Alum interaction with dendritic cell membrane lipids is essential for itsadjuvanticity. Nat Med 17: 479-87.
9.Shi, Y., J. E. Evans, and K. L. Rock. 2003. Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 425: 516-21.
联系方式Email: yanshiemail at mail.tsinghua.edu.cn
Phone: +86-
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