2000- 至今 生物芯片北京国家工程研究中心 主任
2000- 至今 博奥生物集团有限公司 总裁
1999-2000 清华大学生物科学与技术系 教授、博士生导师
1996-2000 Pennsylvania 大学医学院 研究助理教授
美国 Nanogen 公司 资深科学家暨工程师
首席研究员
美国 AVIVA 公司 技术总监
1994-1996 美国 Pennsylvania 大学 博士后
1993-1994 美国 Aberdeen 大学 博士后
1992-1993 英国 Strathclyde 大学 博士后
1989-1992 英国 Strathclyde 大学司法生物学博士
1986-1999 西南政法大学法鉴定中心助理工程师、研究员
1983-1986 铁道部资阳内燃机车厂柴油机分厂助理工程师
1979-1983 上海铁道大学（现同济大学）电气工程系 , 工学士
研究领域与方向
主要从事 DNA 芯片、蛋白芯片、细胞芯片和芯片缩微实验室的研究开发和在健康管理、疾病诊断、 食品安全检测、药物开发中的应用研究，以及依托互联网大数据和人工智能的大健康管理相关研究。
1.The design and development of biochips: Develop novel biochips including microarrays, microfluidics chips and lab-on-a-chip devices for mutation detection, gene expression, protein analysis, cell assay, etc.
2.Translational study in using chips for personalized medicine: Emphasize application of biochips for personalized medical applications in oncology, inherited diseases, infectious diseases, reproductive medicine etc.
3.The study of new detection methods: Interested in developing new labeling and labelless detection technologies.
学术荣誉与奖励国家基金获得者
关键词Medical Biophysics
代表性论文1. Meng, X., Zhu, Y., Chen, Y., Lu, Y., Xu, Y. and Cheng, J. "Conditional siphon priming for multi-step assays on centrifugalmicrofluidic platforms"
Sensors and Actuators B: Chemical, 2017, 242: 710-717
2. Xu, Y.,Xie, X.,Duan, Y.,Wang, L.,Cheng, Z. and Cheng, J. (2016)“A reviewofimpedancemeasurementsofwholecells”
Biosensors and Bioelectronics, 2016, 77: 824-836
3. Xie, X., Liu, R., X,u Y., Wang, L., Lan, Z., Chen, W., Liu, H., Lu, Y., Cheng, J. "In vitro hyperthermia studied in a continuous manner using electric impedance sensing"
RSC Advances, 2015, 5(76):62007-62016
4. Liu,W., Chen,W., Liu, ., Ou,Y., Liu, H., Xie,L., Lu,Y., Li,C., Li,B., Cheng,J."Separation of sperm and epithelial cells based on the hydrodynamic effect for forensic analysis"
Biofluidics, 2015, 9(4):044127
5. Li, Z., Liu, W., Qiu, T., Xie, L., Chen, W., Liu, R., Lu, Y., Mitchelson, K., Wang, J., Qiao, J. Cheng, J."The construction of an interfacial valve-based microfluidic chip for thermotaxis evaluation of human sperm"
Biomicrofluidics, 2014, 8:024102
6. Qin, W., Dong, P., Ma, C., Mitchelson, K., Deng, T., Zhang, L., Sun, Y., Feng, X., Ding, Y., Lu, X., He, J., Wen, H. and Cheng, J. MicroRNA-133b is a key promoter of cervical carcinoma development through the activation of the ERK and AKT1 pathways. Onc ogene, 2012, 31: 4067–4075.
7. Cheng, J.Biochips for translational medicine. Science, Selected Presentations from the 2011 Sino-American Symposium on Clinical and Translational Medicine, S. Sanders Ed. (Science/AAAS, Washington, DC, 2011): 68.
8. Guo, H., Liu, H., Mitchelson, K., Rao, H., Luo, M., Xie, L., Sun, Y., Zhang, L., Lu, Ying., Liu, R., Ren, A., Liu, S., Zhou, S., Zhu, J., Zhou, Y., Huang, A., Wei, L., Guo, Y. and Cheng, J. MicroRNAs-372/373 promote the expression of hepatitis B virus through the targeting of nuclear factor I/B. Hepetology, 2011, 54 (3): 808–819.
9. Xie, L., Ma, R., Han, C., Su, K., Zhang, Q., Qiu, T., Wang, L., Huang, G., Qiao, J., Wang, J. and Cheng, J. Integration of sperm motility and chemotaxis screening with a microchannel-based device. Clinical Chemistry, 2010, 56(8): 1270-1278.
10. Wang, L., Zhu, J., Deng C., Xing W. and Cheng, J. An automatic and quantitative on-chip cell migration assay using self-assembled monolayers combined with real-time cellular impedance sensing. Lab on a Chip, 2008, 8(6): 872-878. (Cover)
11. Li, C., Pan, Q., Guo, Y., Li, Y., Gao, H., Zhang, D., Hu, H., Xing, W., Mitchelson, K., Xia, K., Dai, P. and Cheng, J. Construction of a multiplex all ele-specific PCR-based universal array (ASPUA) and its application to hearing loss screening. Human Mutation, 2008, 29(2): 306-314.
12. Qiao, J., Shao, W., Wei, H., Sun, Y., Zhao, Y., Xing, W., Zhang, L., Mitchelson, K. and Cheng, J. Novel high-throughput profiling of human transcription factors and its use for systematic pathway mapping. Journal of Proteome Research, 2008, 7(7): 2769-2779.
13. Shi, L., Reid, L.H., Jones, W.D., Shippy, R., Warrington, J.A., Baker, S.C., Collins, P.J., de Longueville, F., Kawasaki, E.S., Lee, K.Y., Luo, Y., Sun, Y.A., Willey, J.C., Setterquist, R.A., Fischer, G.M., Tong, W., Dragan, Y.P., Dix, D.J., Frueh, F.W., Goodsaid, F.M., Herman, D., Jensen, R.V., Johnson, C.D., Lobenhofer, E.K., Puri, R.K., Scherf, U., Thierry-M ieg, J., Wang, C., Wilson, M., Wolber, P.K., Zhang, L., Amur, S., Bao, W., Barbacioru, C.C., Lucas, A.B., Bertholet, V., Boysen, C., Bromley, B., Brown, D., Brunner, A., Canales, R., Cao, X.M., Cebula, T.A., Chen, J.J., Cheng, J., et al. The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression me asurements. Nature Biotechnology, 2006, 24(9): 1151-1161.
14. Cheng, J., Sheldon, E.L., Wu, L., Uribe, A., Gerrue, L.O., Carrino J., Heller, M.J., Carrino, J. and O￠Connell, J.P. Preparation and hybridization analysis of DNA/RNA from E. coli on microfabricated bioelectronic chips. Nature Biotechnology, 1998, 16(6): 541-546. (Cover)
15. Cheng,J. and Kricka, L.J. (eds.) Biochip Technology. Harwood Academic Publishers, Pennsylvania, U.S.A.,2001.
联系方式Email: jcheng at tsinghua.edu.cn
Phone: +86-
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