研究领域与方向 针对重大疾病（肿瘤、出生缺陷和感染性疾病）的早期诊断和伴随诊断需求，研究新型的分子诊断技术并转化。
学术荣誉与奖励北京市科技新星
关键词Molecular Diagnosis, Microfluidics, Droplets, Translational Medicine
代表性论文1.Zhu X, Liu B, Su S, Wang B, Bai Y, Huang H, Liu X, Cheng X, Wang X, Zhu L, Yang W, Gao N, Jing G, Guo Y. A “quasi” confocal droplet reader based on laser-induced fluorescence (LIF) cytometry for highly-sensitive and contamination-free detection. Talanta, 2020, 206: 120200.
2.Su S, Jing G, Zhang M, Liu B, Zhu X, Wang B, Fu M, Zhu L, Cheng J, Guo Y. One-step bonding and hydrophobic surface modification method for rapid fabrication of polycarbonate-based droplet microfluidic chips. Sensors and Actuators B: Chemical, 2019, 282:60-68.
3.Tan C, Chen X, Wang F, Wang D, Cao Z, Zhu X, Lu C, Yang W, Gao N, Gao H, Guo Y, Zhu L. A multiplex droplet digital PCR assay for non-invasive prenatal testing of fetal aneuploidies. Analyst, 2019, 144(7): 2239-2247.
4.Wang F, Zhu L, Liu B, Zhu X, Wang N, Deng T, Kang D, Pan J, Yang W, Gao H, Guo Y. Noninvasive and accurate detection of hereditary hearing loss mutations with buccal swab based on droplet digital PCR. Analytical Chemistry, 2018, 90(15): 8919-8926.
5.Tan X, Qin W, Zhang L, Hang J, Chen Z, Li B, Zhang C, Wan J, Zhou F, Shao K, Sun Y, Wu J, Zhang X, Qiu B, Li N, Shi S, Feng X, Zhao S, Wang Z, Zhao X, Yu Z, Mitchelson K, Cheng J, Guo Y, He J. A 5-microRNA signature for lung squamous cell carcinoma diagnosis and hsa-miR-31 for prognosis. Clinical Cancer Research, 2011, 17(21):6802-6811.
6.Guo H, Liu H, Mitchelson K, Luo M, Sun Y, Xie L, Zhang L, Lu Y, Zhou Y, Guo Y, Cheng J. MicroRNAs-372/373 promote the expression of hepatitis B virus through the targeting of nuclear factor I/B. Hepatology, 2011, 54(3):808-819.
7.Zhu L, Jiang G, Wang S, Wang C, Li Q, Yu H, Zhou Y, Zhao B, Huang H, Xing W, Mitchelson K, Cheng J, Zhao Y, Guo Y. Biochip system for rapid and accurate identification of mycobacterial species from isolates and sputum. Journal of Clinical Microbiology, 2010, 48(10):3654-3660.
8.Guo Y, Zhou Y, Wang C, Zhu L, Wang S, Li Q, Jiang G, Zhao B, Huang H, Yu H, Xing W, Mitchelson K, Cheng J, Zhao Y. Rapid, accurate determination of multidrug resistance in M. tuberculosis isolates and sputum using a biochip system. International Journal of Tuberculosis and Lung Disease, 2009, 13(7): 914-920.
9.Guo Y, Chen Z, Zhang L, Zhou F, Shi S, Feng X, Li B, Meng X, Ma X, Luo M, Shao K, Li N, Qiu B, Mitchelson K, Cheng J, He J. Distinctive microRNA profiles relating to patient survival in esophageal squamous cell carcinoma. Cancer Research, 2008, 68(1): 26-33
10.Guo Y, Guo H, Zhang L, Xie H, Zhao X, Wang F, Li Z, Wang Y, Ma S, Tao J, Wang W, Zhou X, Yang W, Cheng J. Genomic analysis of anti-HBV activity by siRNA and lamivudine in stable HBV-producing cell. Journal of Virology, 2005, 79(22):14392-14403
联系方式Email: yongguo at tsinghua.edu.cn
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