邹海燕1,2,
高方舟1,2,
吴黛灵1,2,
张敏1,2,
何良英1,2,
应光国1,2
1. 华南师范大学环境研究院, 广东省化学品污染与环境安全重点实验室&环境理论化学教育部重点实验室, 广州 510006;
2. 华南师范大学环境学院, 广州 510006
作者简介: 陈帅(1995-),男,硕士研究生,研究方向为抗生素抗性基因,E-mail:shuai.chen@m.scnu.edu.cn.
基金项目: 国家自然科学联合基金NSFC-广东联合基金资助项目(U1701242)；国家自然科学基金-青年科学基金资助项目(41703117)中图分类号: X171.5
Co-selection Mechanism of Antibiotic, Metal and Biocide Resistance
Chen Shuai1,2,Zou Haiyan1,2,
Gao Fangzhou1,2,
Wu Dailing1,2,
Zhang Min1,2,
He Liangying1,2,
Ying Guangguo1,2
1. Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Environmental Theoretical Chemistry, South China Normal University, Guangzhou 510006, China;
2. School of Environment, South China Normal University, Guangzhou 510006, China
CLC number: X171.5
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摘要:细菌抗生素抗性已被世界卫生组织认定为对公众健康的重要威胁。细菌抗性除了受到抗生素的直接选择压力，也受到其他物质如重金属和杀生剂的共同影响。研究发现，细菌可以通过外排泵系统、细胞膜通透性改变、作用靶标点的改变、酶修饰或降解作用、应激反应改变生理特性、金属螯合和生物转化等抗性机制对这些选择压力产生抗性，或者通过协同抗性、交叉抗性和共调控抗性的机制产生多重抗性。本文综述了细菌对抗生素、重金属和杀生剂的单一抗性机制、多重抗性机制，以及重金属和杀生剂对细菌抗生素抗性的影响机制，并分析了目前研究的不足之处。
关键词: 重金属/
杀生剂/
协同抗性/
交叉抗性/
共调控抗性/
抗生素抗性机制
Abstract:Bacterial antibiotic resistance has been recognized as an important threat to public health by the World Health Organization. Besides the direct selection pressure of antibiotics, bacterial antibiotic resistance is also affected by some other substances such as heavy metals and biocides. It has been found that the mechanisms of bacterial resistance include efflux pump system, change of cell membrane permeability, change of target sites, modification or degradation of enzymes, change of physiological characteristics by stress response, metal chelation and biotransformation. And multiple resistance could be produced by synergistic, cross-resistance and co-regulation of resistance. In this paper, we summarized the single and multiple resistance mechanisms of bacteria to antibiotics, heavy metals and biocides, and the influence mechanism of heavy metals and biocides on bacterial antibiotic resistance. The short of current researches were also addressed.
Key words:heavy metal/
biocide/
co-resistance/
cross-resistance/
co-regulation resistance/
antibiotic resistance mechanism.
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