张昱2,3,
李久义1,,,
田秀君1
1. 北京交通大学市政与环境工程系, 北京 100044;
2. 中国科学院生态环境研究中心, 环境水质学国家重点实验室, 北京 100085;
3. 中国科学院大学, 北京 100049
作者简介: 杨肖肖(1985-),女,博士研究生,讲师,研究方向为水环境中抗生素抗性基因的行为特征,E-mail:yangxiao2328@sina.com.
通讯作者: 李久义,lijy@bjtu.edu.cn ;
基金项目: 北京市科学技术研究院市级财政项目（PXM2021-178203-000001-00437109-FCG）；国家自然科学基金面上项目（51578042）；中央高校基本科研业务费专项资金资助项目（2017YJS123）中图分类号: X171.5
Distribution of Antibiotics, Antibiotic Resistant Bacteria, Antibiotic Resistance Genes in Environmental System with Reclaimed Water Irrigation: A Review
Yang Xiaoxiao1,2,Zhang Yu2,3,
Li Jiuyi1,,,
Tian Xiujun1
1. Department of Municipal and Environmental Engineering, Beijing Jiaotong University, Beijing 100044, China;
2. State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China;
3. University of Chinese Academy of Sciences, Beijing 100049, China
Corresponding author: Li Jiuyi,lijy@bjtu.edu.cn ;
CLC number: X171.5
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摘要:在城市污水处理厂设计中很少考虑抗生素的去除，因而，抗生素在污水处理厂出水和再生水中频繁检出。在各种水环境中均发现抗生素抗药菌和抗性基因，特别是在再生水及其受纳环境中，这已构成了对生态安全和人类健康的潜在威胁。本文综述了再生水回用的环境系统中抗生素分布与污染特征、抗药菌和抗性基因迁移转化规律与传播风险、再生水深度处理工艺对抗生素及抗性基因的去除。综合目前的研究进展可知，再生水回用环境系统中，抗药性分布与残留抗生素的浓度、灌溉频率及补给水量有关；Ⅰ型整合子和质粒一定程度上可反映抗性基因在环境中的迁移转化；污水深度处理对抗性基因的去除效果受消毒剂量、接触时间等工艺参数的影响。本综述有助于进一步了解受纳环境中抗药菌和抗性基因污染分布和迁移，为揭示抗生素耐药性扩散提供新视角。
关键词: 抗生素/
抗药菌/
抗性基因/
多重耐药/
再生水
Abstract:Antibiotics are frequently detected in the effluents from wastewater treatment plants and the reclaimed water, since few processes for antibiotic removal are included in the design of wastewater treatment plants. Antibiotic-resistant bacteria and resistance genes have been detected in various aquatic environments, especially in reclaimed water and its receiving environment, which has attracted wide attention from the perspectives of ecological security and human health. The paper reviews the temporal and spatial distribution of antibiotic pollution, the transport, transformation and transmission risks of antibiotic-resistant bacteria and resistance genes from reclaimed water to the environments. This work also summarizes the removal technologies for antibiotics and resistance genes in advanced treatment processes. The main conclusions are as follows:the distribution of antibiotic resistance is associated with the concentration of residual antibiotics, irrigation frequency and water quantity from reclaimed water in environmental system. ClassⅠ integrase and plasmids may, to some extent, reflect the migration and transformation of antibiotic resistance genes in the environment. The removal of antibiotic resistance genes in the advanced treatment process were influenced by the process parameters, such as the dosage of the reactive agent, and contact time. The insights in this review will help to advance the understanding on the distribution and migration of antibiotic-resistant bacteria and resistance genes in receiving environments, and provide a modern perspective to reveal the effect of contaminants on the proliferation of antibiotic resistance.
Key words:antibiotic/
antibiotic-resistant bacteria/
antibiotic resistance genes/
multiple drug resistance/
reclaimed water.
| Cheng H, Hong P Y. Removal of antibiotic-resistant bacteria and antibiotic resistance genes affected by varying degrees of fouling on anaerobic microfiltration membranes[J]. Environmental Science & Technology, 2017, 51(21):12200-12209 |
| Baquero F, Martínez J L, Cantón R. Antibiotics and antibiotic resistance in water environments[J]. Current Opinion in Biotechnology, 2008, 19(3):260-265 |
| Fang T T, Wang H, Cui Q J, et al. Diversity of potential antibiotic-resistant bacterial pathogens and the effect of suspended particles on the spread of antibiotic resistance in urban recreational water[J]. Water Research, 2018, 145:541-551 |
| Liu M M, Zhang Y, Yang M, et al. Abundance and distribution of tetracycline resistance genes and mobile elements in an oxytetracycline production wastewater treatment system[J]. Environmental Science & Technology, 2012, 46(14):7551-7557 |
| Levy S B, Marshall B. Antibacterial resistance worldwide:Causes, challenges and responses[J]. Nature Medicine, 2004, 10(12 Suppl):S122-S129 |
| Bouki C, Venieri D, Diamadopoulos E. Detection and fate of antibiotic resistant bacteria in wastewater treatment plants:A review[J]. Ecotoxicology and Environmental Safety, 2013, 91:1-9 |
| Gao P, Munir M, Xagoraraki I. Correlation of tetracycline and sulfonamide antibiotics with corresponding resistance genes and resistant bacteria in a conventional municipal wastewater treatment plant[J]. Science of the Total Environment, 2012, 421-422:173-183 |
| Chen H, Zhang M M. Effects of advanced treatment systems on the removal of antibiotic resistance genes in wastewater treatment plants from Hangzhou, China[J]. Environmental Science & Technology, 2013, 47(15):8157-8163 |
| Pruden A. Balancing water sustainability and public health goals in the face of growing concerns about antibiotic resistance[J]. Environmental Science & Technology, 2014, 48(1):5-14 |
| 苏志国, 张衍, 代天娇, 等. 环境中抗生素抗性基因与Ⅰ型整合子的研究进展[J]. 微生物学通报, 2018, 45(10):2217-2233Su Z G, Zhang Y, Dai T J, et al. Antibiotic resistance genes and class 1 integron in the environment:Research progress[J]. Microbiology China, 2018, 45(10):2217-2233(in Chinese) |
| Negreanu Y, Pasternak Z, Jurkevitch E, et al. Impact of treated wastewater irrigation on antibiotic resistance in agricultural soils[J]. Environmental Science & Technology, 2012, 46(9):4800-4808 |
| 王丽梅, 罗义, 毛大庆, 等. 抗生素抗性基因在环境中的传播扩散及抗性研究方法[J]. 应用生态学报, 2010, 21(4):1063-1069Wang L M, Luo Y, Mao D Q, et al. Transport of antibiotic resistance genes in environment and detection methods of antibiotic resistance[J]. Chinese Journal of Applied Ecology, 2010, 21(4):1063-1069(in Chinese) |
| Gogarten J P, Townsend J P. Horizontal gene transfer, genome innovation and evolution[J]. Nature Reviews Microbiology, 2005, 3(9):679-687 |
| Bergeron S, Boopathy R, Nathaniel R, et al. Presence of antibiotic resistant bacteria and antibiotic resistance genes in raw source water and treated drinking water[J]. International Biodeterioration & Biodegradation, 2015, 102:370-374 |
| Wei Z Y, Feng K, Li S Z, et al. Exploring abundance, diversity and variation of a widespread antibiotic resistance gene in wastewater treatment plants[J]. Environment International, 2018, 117:186-195 |
| Czekalski N, Gascón Díez E, Bürgmann H. Wastewater as a point source of antibiotic-resistance genes in the sediment of a freshwater lake[J]. The ISME Journal, 2014, 8(7):1381-1390 |
| Wang F H, Qiao M, Su J Q, et al. High throughput profiling of antibiotic resistance genes in urban park soils with reclaimed water irrigation[J]. Environmental Science & Technology, 2014, 48(16):9079-9085 |
| Storteboom H, Arabi M, Davis J G, et al. Tracking antibiotic resistance genes in the South Platte River basin using molecular signatures of urban, agricultural, and pristine sources[J]. Environmental Science & Technology, 2010, 44(19):7397-7404 |
| Chen C Q, Li J, Chen P P, et al. Occurrence of antibiotics and antibiotic resistances in soils from wastewater irrigation areas in Beijing and Tianjin, China[J]. Environmental Pollution, 2014, 193:94-101 |
| Martinez J L. Environmental pollution by antibiotics and by antibiotic resistance determinants[J]. Environmental Pollution, 2009, 157(11):2893-2902 |
| Pruden A, Arabi M, Storteboom H N. Correlation between upstream human activities and riverine antibiotic resistance genes[J]. Environmental Science & Technology, 2012, 46(21):11541-11549 |
| Zhu D, Xiang Q, Yang X R, et al. Trophic transfer of antibiotic resistance genes in a soil detritus food chain[J]. Environmental Science & Technology, 2019, 53(13):7770-7781 |
| Wang F H, Qiao M, Su J Q, et al. High throughput profiling of antibiotic resistance genes in urban park soils with reclaimed water irrigation[J]. Environmental Science & Technology, 2014, 48(16):9079-9085 |
| Leung H W, Minh T B, Murphy M B, et al. Distribution, fate and risk assessment of antibiotics in sewage treatment plants in Hong Kong, South China[J]. Environment International, 2012, 42:1-9 |
| Wang F H, Qiao M, Lv Z E, et al. Impact of reclaimed water irrigation on antibiotic resistance in public Parks, Beijing, China[J]. Environmental Pollution, 2014, 184:247-253 |
| Munir M, Wong K, Xagoraraki I. Release of antibiotic resistant bacteria and genes in the effluent and biosolids of five wastewater utilities in Michigan[J]. Water Research, 2011, 45(2):681-693 |
| Dungan R S, McKinney C W, Leytem A B. Tracking antibiotic resistance genes in soil irrigated with dairy wastewater[J]. Science of the Total Environment, 2018, 635:1477-1483 |
| Wang F H, Qiao M, Su J Q, et al. High throughput profiling of antibiotic resistance genes in urban park soils with reclaimed water irrigation[J]. Environmental Science & Technology, 2014, 48(16):9079-9085 |
| Dong P Y, Cui Q J, Fang T T, et al. Occurrence of antibiotic resistance genes and bacterial pathogens in water and sediment in urban recreational water[J]. Journal of Environmental Sciences, 2019, 77:65-74 |
| Ham Y S, Kobori H, Kang J H, et al. Distribution of antibiotic resistance in urban watershed in Japan[J]. Environmental Pollution, 2012, 162:98-103 |
| Su H C, Ying G G, Tao R, et al. Class 1 and 2 integrons, sul resistance genes and antibiotic resistance in Escherichia coli isolated from Dongjiang River, South China[J]. Environmental Pollution, 2012, 169:42-49 |
| Ayandiran T A, Ayandele A A, Dahunsi S O, et al. Microbial assessment and prevalence of antibiotic resistance in polluted Oluwa River, Nigeria[J]. The Egyptian Journal of Aquatic Research, 2014, 40(3):291-299 |
| Titilawo Y, Obi L, Okoh A. Antimicrobial resistance determinants of Escherichia coli isolates recovered from some rivers in Osun State, South-Western Nigeria:Implications for public health[J]. Science of the Total Environment, 2015, 523:82-94 |
| Li X D, Watanabe N, Xiao C L, et al. Antibiotic-resistant E. coli in surface water and groundwater in dairy operations in Northern California[J]. Environmental Monitoring and Assessment, 2014, 186(2):1253-1260 |
| Liang X M, Chen B W, Nie X P, et al. The distribution and partitioning of common antibiotics in water and sediment of the Pearl River Estuary, South China[J]. Chemosphere, 2013, 92(11):1410-1416 |
| Al-Badaii F, Shuhaimi-Othman M. Water pollution and its impact on the prevalence of antibiotic-resistant E. coli and total coliform bacteria:A study of the Semenyih River, Peninsular Malaysia[J]. Water Quality, Exposure and Health, 2015, 7(3):319-330 |
| Sidrach-Cardona R, Hijosa-Valsero M, Marti E, et al. Prevalence of antibiotic-resistant fecal bacteria in a river impacted by both an antibiotic production plant and urban treated discharges[J]. Science of the Total Environment, 2014, 488-489:220-227 |
| Tao R, Ying G G, Su H C, et al. Detection of antibiotic resistance and tetracycline resistance genes in enterobacteriaceae isolated from the Pearl Rivers in South China[J]. Environmental Pollution, 2010, 158(6):2101-2109 |
| Xu Y, Guo C S, Luo Y, et al. Occurrence and distribution of antibiotics, antibiotic resistance genes in the urban rivers in Beijing, China[J]. Environmental Pollution, 2016, 213:833-840 |
| Harnisz M, Korzeniewska E, Gołas' I. The impact of a freshwater fish farm on the community of tetracycline-resistant bacteria and the structure of tetracycline resistance genes in river water[J]. Chemosphere, 2015, 128:134-141 |
| Ouyang W Y, Huang F Y, Zhao Y, et al. Increased levels of antibiotic resistance in urban stream of Jiulongjiang River, China[J]. Applied Microbiology and Biotechnology, 2015, 99(13):5697-5707 |
| Machado A, Bordalo A A. Prevalence of antibiotic resistance in bacteria isolated from drinking well water available in Guinea-Bissau (West Africa)[J]. Ecotoxicology and Environmental Safety, 2014, 106:188-194 |
| Mohanta T, Goel S. Prevalence of antibiotic-resistant bacteria in three different aquatic environments over three seasons[J]. Environmental Monitoring and Assessment, 2014, 186(8):5089-5100 |
| Jechalke S, Schreiter S, Wolters B, et al. Widespread dissemination of class 1 integron components in soils and related ecosystems as revealed by cultivation-independent analysis[J]. Frontiers in Microbiology, 2013, 4:420 |
| Bengtsson-Palme J, Boulund F, Fick J, et al. Shotgun metagenomics reveals a wide array of antibiotic resistance genes and mobile elements in a polluted lake in India[J]. Frontiers in Microbiology, 2014, 5:648 |
| Binh C T T, Heuer H, Kaupenjohann M, et al. Piggery manure used for soil fertilization is a reservoir for transferable antibiotic resistance plasmids[J]. FEMS Microbiology Ecology, 2008, 66(1):25-37 |
| Szczepanowski R, Linke B, Krahn I, et al. Detection of 140 clinically relevant antibiotic-resistance genes in the plasmid metagenome of wastewater treatment plant bacteria showing reduced susceptibility to selected antibiotics[J]. Microbiology, 2009, 155(Pt 7):2306-2319 |
| Gao H, Zhang L X, Lu Z H, et al. Complex migration of antibiotic resistance in natural aquatic environments[J]. Environmental Pollution, 2018, 232:1-9 |
| 崔二苹, 高峰, 陈红, 等. 再生水利用对环境中抗生素抗性基因影响的研究进展[J]. 灌溉排水学报, 2017, 36(2):32-38Cui E P, Gao F, Chen H, et al. Occurrence of antibiotic resistance genes in environment with the application of reclaimed water:A review[J]. Journal of Irrigation and Drainage, 2017, 36(2):32-38(in Chinese) |
| Guo M T, Yuan Q B, Yang J. Ultraviolet reduction of erythromycin and tetracycline resistant heterotrophic bacteria and their resistance genes in municipal wastewater[J]. Chemosphere, 2013, 93(11):2864-2868 |
| Shi P, Jia S Y, Zhang X X, et al. Metagenomic insights into chlorination effects on microbial antibiotic resistance in drinking water[J]. Water Research, 2013, 47(1):111-120 |
| Riquelme Breazeal M V, Novak J T, Vikesland P J, et al. Effect of wastewater colloids on membrane removal of antibiotic resistance genes[J]. Water Research, 2013, 47(1):130-140 |
| Oh J, Salcedo D E, Medriano C A, et al. Comparison of different disinfection processes in the effective removal of antibiotic-resistant bacteria and genes[J]. Journal of Environmental Sciences, 2014, 26(6):1238-1242 |
| Zhang Y Y, Zhuang Y, Geng J J, et al. Inactivation of antibiotic resistance genes in municipal wastewater effluent by chlorination and sequential UV/chlorination disinfection[J]. Science of the Total Environment, 2015, 512-513:125-132 |
| Sullivan B A, Vance C C, Gentry T J, et al. Effects of chlorination and ultraviolet light on environmental tetracycline-resistant bacteria and tet(W) in water[J]. Journal of Environmental Chemical Engineering, 2017, 5(1):777-784 |
| Yoon Y, Chung H J, Wen Di D Y, et al. Inactivation efficiency of plasmid-encoded antibiotic resistance genes during water treatment with chlorine, UV, and UV/H2O2[J]. Water Research, 2017, 123:783-793 |
| Zhang T Y, Hu Y R, Jiang L, et al. Removal of antibiotic resistance genes and control of horizontal transfer risk by UV, chlorination and UV/chlorination treatments of drinking water[J]. Chemical Engineering Journal, 2019, 358:589-597 |
| Guo M T, Yuan Q B, Yang J. Distinguishing effects of ultraviolet exposure and chlorination on the horizontal transfer of antibiotic resistance genes in municipal wastewater[J]. Environmental Science & Technology, 2015, 49(9):5771-5778 |
| Sharma V K, Yu X, McDonald T J, et al. Elimination of antibiotic resistance genes and control of horizontal transfer risk by UV-based treatment of drinking water:A mini review[J]. Frontiers of Environmental Science & Engineering, 2019, 13(3):37 |
| Sousa J M, Macedo G, Pedrosa M, et al. Ozonation and UV254nm radiation for the removal of microorganisms and antibiotic resistance genes from urban wastewater[J]. Journal of Hazardous Materials, 2017, 323(Pt A):434-441 |
| Michael-Kordatou I, Karaolia P, Fatta-Kassinos D. The role of operating parameters and oxidative damage mechanisms of advanced chemical oxidation processes in the combat against antibiotic-resistant bacteria and resistance genes present in urban wastewater[J]. Water Research, 2018, 129:208-230 |
| Czekalski N, Imminger S, Salhi E, et al. Inactivation of antibiotic resistant bacteria and resistance genes by ozone:From laboratory experiments to full-scale wastewater treatment[J]. Environmental Science & Technology, 2016, 50(21):11862-11871 |
| Jeon D, Kim J, Shin J, et al. Transformation of ranitidine during water chlorination and ozonation:Moiety-specific reaction kinetics and elimination efficiency of NDMA formation potential[J]. Journal of Hazardous Materials, 2016, 318:802-809 |
| Liu S S, Qu H M, Yang D, et al. Chlorine disinfection increases both intracellular and extracellular antibiotic resistance genes in a full-scale wastewater treatment plant[J]. Water Research, 2018, 136:131-136 |
