) 收稿日期:2019-04-01出版日期:2020-03-15发布日期:2020-01-18通讯作者:贺荟中E-mail:2008hzhe@163.com基金资助:* 上海市教育委员会科研创新计划人文科学重大项目(2019-01-07-00-05-E00007);上海市哲学社会科学规划课题(2018BYY017)Early identification of autism spectrum disorder in prospective longitudinal studies of high-risk infants
BI Xiaobin1,2, FAN Xiaozhuang1,2, MI Wenli3, HE Huizhong1,2() Received:2019-04-01Online:2020-03-15Published:2020-01-18Contact:HE Huizhong E-mail:2008hzhe@163.com摘要/Abstract
摘要： 孤独症谱系障碍(Autism Spectrum Disorder, ASD)早期识别有助于早期诊断和早期干预的实施, 对于改善ASD儿童发育结果至关重要。高风险前瞻性纵向研究以高风险婴儿(ASD儿童的年幼同胞, 入组年龄小于12个月)作为主要研究对象, 通过对ASD高风险婴儿(24至36个月之间诊断为ASD的高风险婴儿)的早期发育轨迹的描绘和核心症状早期表现的识别, 为ASD早期识别提供了重要依据。未来可以增加被试数量、延长观察时间并密集观察时间点、关注伴发障碍、综合考虑遗传、环境和文化因素影响, 并结合早期干预研究进行深入探索。未来在中国开展相关研究具有重要的科学价值和临床意义。
图/表 1
图1高风险婴儿前瞻性纵向研究范式 注：(1)高风险婴儿(high-risk infants, HR infants)：ASD儿童的年幼同胞; (2)低风险婴儿(low-risk infants, LR infants)：正常发育儿童的年幼同胞; (3) ASD高风险婴儿(ASD high-risk infants, HR-ASD)：诊断为ASD的高风险婴儿; (4)非ASD高风险婴儿(non-ASD high-risk infants, HR-non-ASD)：未诊断为ASD的高风险婴儿; (5)正常发育高风险婴儿(high-risk infants with typical development, HR-Typical)：正常发育的高风险婴儿; (6)非正常发育高风险婴儿(high-risk infants with atypical development, HR-Atypical)：非正常发育但不符合ASD诊断标准的高风险婴儿。
图1高风险婴儿前瞻性纵向研究范式 注：(1)高风险婴儿(high-risk infants, HR infants)：ASD儿童的年幼同胞; (2)低风险婴儿(low-risk infants, LR infants)：正常发育儿童的年幼同胞; (3) ASD高风险婴儿(ASD high-risk infants, HR-ASD)：诊断为ASD的高风险婴儿; (4)非ASD高风险婴儿(non-ASD high-risk infants, HR-non-ASD)：未诊断为ASD的高风险婴儿; (5)正常发育高风险婴儿(high-risk infants with typical development, HR-Typical)：正常发育的高风险婴儿; (6)非正常发育高风险婴儿(high-risk infants with atypical development, HR-Atypical)：非正常发育但不符合ASD诊断标准的高风险婴儿。参考文献 105
| [1] | 戴琼, 徐海青, 汪鸿, 赵职卫, 张玄, 周爱琴 . (2017). 2000-2016年中国儿童孤独症谱系障碍患病率Meta分析. 中国儿童保健杂志, 25(12), 1243-1246. |
| [2] | 中华医学会儿科学分会发育行为学组, 中国医师协会儿科分会儿童保健专业委员会, 儿童孤独症诊断与防治技术和标准研究项目专家组. (2017). 孤独症谱系障碍儿童早期识别筛查和早期干预专家共识. 中华儿科杂志, 55(12), 890-897. |
| [3] | American Psychiatric Association .(2013). Diagnostic and statistical manual of mental disorders (DSM-5®) (5th ed.). Washington, DC: American Psychiatric Publishing. |
| [4] | Bahrick L. E., Lickliter R., & Flom R . (2004). Intersensory redundancy guides the development of selective attention, perception, and cognition in infancy. Current Directions in Psychological Science, 13(3), 99-102. |
| [5] | Baio J., Wiggins L., Christensen D. L., Maenner M. J., Daniels J., Warren Z., ... Dowling N. F . (2018). Prevalence of autism spectrum disorder among children aged 8 years - autism and developmental disabilities monitoring network, 11 sites, United States, 2014. Mmwr Surveill Summ, 67(6), 1-23. |
| [6] | Bartholomeusz H. H., Courchesne E., & Karns C. M . (2002). Relationship between head circumference and brain volume in healthy normal toddlers, children, and adults. Neuropediatrics, 33(5), 239-241. |
| [7] | Belmonte M. K., Allen G., Beckel-Mitchener A., Boulanger L. M., Carper R. A., & Webb S. J . (2004). Autism and abnormal development of brain connectivity. The Journal of Neuroscience, 24(42), 9228-9231. |
| [8] | Bergelson E., & Swingley D . (2012). At 6-9 months, human infants know the meanings of many common nouns. Proceedings of the National Academy of Sciences of the United States of America, 109(9), 3253-3258. |
| [9] | Beuker K. T., Rommelse N. N. J., Donders R., & Buitelaar J. K . (2013). Development of early communication skills in the first two years of life. Infant Behavior & Development, 36(1), 71-83. |
| [10] | Blasi A., Lloyd-Fox S., Sethna V., Brammer M. J., Mercure E., Murray L., ... Johnson M. H . (2015). Atypical processing of voice sounds in infants at risk for autism spectrum disorder. Cortex, 71, 122-133. |
| [11] | Bradshaw J., Klaiman C., Gillespie S., Brane N., Lewis M., & Saulnier C . (2018). Walking ability is associated with social communication skills in infants at high risk for autism spectrum disorder. Infancy, 23(5), 674-691. |
| [12] | Brandwein A. B., Foxe J. J., Butler J. S., Russo N. N., Altschuler T. S., Gomes H., & Molholm S . (2013). The development of multisensory integration in high-functioning autism: High-density electrical mapping and psychophysical measures reveal impairments in the processing of audiovisual inputs. Cerebral cortex, 23(6), 1329-1341. |
| [13] | Bushnell I. W. R . (2001). Mother's face recognition in newborn infants: Learning and memory. Infant and Child Development, 10(1-2), 67-74. |
| [14] | Campbell D. J., Chang J., & Chawarska K . (2014). Early generalized overgrowth in autism spectrum disorder: Prevalence rates, gender effects, and clinical outcomes. Journal of the American Academy of Child & Adolescent Psychiatry, 53(10), 1063-1073. |
| [15] | Chevallier C., Kohls G., Troiani V., Brodkin E. S., & Schultz R. T . (2012). The social motivation theory of autism. Trends in Cognitive Sciences, 16(4), 231-239. |
| [16] | Courchesne E., Carper R., & Akshoomoff N . (2003). Evidence of brain overgrowth in the first year of life in autism. JAMA, 290(3), 337-344. |
| [17] | Courchesne E., Pierce K., Schumann C. M., Redcay E., Buckwalter J. A., Kennedy D. P., & Morgan J . (2007). Mapping early brain development in autism. Neuron, 56(2), 399-413. |
| [18] | Daluwatte C., Miles J. H., Sun J., & Yao G . (2015). Association between pupillary light reflex and sensory behaviors in children with autism spectrum disorders. Research in Developmental Disabilities, 37, 209-215. |
| [19] | Dawson G., Munson J., Webb S. J., Nalty T., Abbott R., & Toth K . (2007). Rate of head growth decelerates and symptoms worsen in the second year of life in autism. Biological Psychiatry, 61(4), 458-464. |
| [20] | Dawson G., Osterling J., Meltzoff A. N., & Kuhl P . (2000). Case study of the development of an infant with autism from birth to two years of age. Journal of Applied Developmental Psychology, 21(3), 299-313. |
| [21] | de Giacomo A., & Fombonne E . (1998). Parental recognition of developmental abnormalities in autism. European Child & Adolescent Psychiatry, 7(3), 131-136. |
| [22] | del Rosario M., Gillespie-Lynch K., Johnson S., Sigman M., & Hutman T . (2014). Parent-reported temperament trajectories among infant siblings of children with autism. Journal of Autism and Developmental Disorders, 44(2), 381-393. |
| [23] | Dinstein I., Haar S., Atsmon S., & Schtaerman H . (2017). No evidence of early head circumference enlargements in children later diagnosed with autism in Israel. Molecular Autism, 8, 15. |
| [24] | Elison J. T., Wolff J. J., Reznick J. S., Botteron K. N., Estes A. M., Gu H. B., ... Piven J . (2014). Repetitive behavior in 12-month-olds later classified with autism spectrum disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 53(11), 1216-1224. |
| [25] | Esposito G., del Carmen Rostagno M., Venuti P., Haltigan J. D., & Messinger D. S . (2014). Brief Report: Atypical expression of distress during the separation phase of the strange situation procedure in infant siblings at high risk for ASD. Journal of Autism and Developmental Disorders, 44(4), 975-980. |
| [26] | Falck-Ytter T., Nyström P., Gredebäck G., Gliga T., & Bölte S . (2018). Reduced orienting to audiovisual synchrony in infancy predicts autism diagnosis at 3 years of age. Journal of Child Psychology and Psychiatry, 59(8), 872-880. |
| [27] | Filipe M. G., Watson L., Vicente S. G., & Frota S . (2018). Atypical preference for infant-directed speech as an early marker of autism spectrum disorders? A literature review and directions for further research. Clinical Linguistics & Phonetics, 32(3), 213-231. |
| [28] | Filliter J. H., Longard J., Lawrence M. A., Zwaigenbaum L., Brian J., Garon N., ... Bryson S. E . (2015). Positive affect in infant siblings of children diagnosed with autism spectrum disorder. Journal of Abnormal Child Psychology, 43(3), 567-575. |
| [29] | Garon N., Zwaigenbaum L., Bryson S., Smith I. M., Brian J., Roncadin C., ... Roberts W . (2016). Temperament and its association with autism symptoms in a high-risk population. Journal of Abnormal Child Psychology, 44(4), 757-769. |
| [30] | Gliga T., Bedford R., Charman T., Johnson M. H., Baron- Cohen S., Bolton P., ... Tucker L . (2015). Enhanced visual search in infancy predicts emerging autism symptoms. Current Biology, 25(13), 1727-1730. |
| [31] | Haar S., Berman S., Behrmann M., & Dinstein I . (2016). Anatomical abnormalities in autism? Cerebral Cortex, 26(4), 1440-1452. |
| [32] | Hadders-Algra M . (2011). Challenges and limitations in early intervention. Developmental Medicine & Child Neurology, 53(Suppl. 4), 52-55. |
| [33] | Hazlett H. C., Gu H., Munsell B. C., Kim S. H., Styner M., Wolff J. J., ... Piven J . (2017). Early brain development in infants at high risk for autism spectrum disorder. Nature, 542(7641), 348-351. |
| [34] | Hertzig M. E . (2012). Temperament: Then and now. Journal of Nervous and Mental Disease, 200(8), 659-663. |
| [35] | Ibañez L. V., Grantz C. J., & Messinger D. S . (2013). The development of referential communication and autism symptomatology in high-risk infants. Infancy, 18(5), 687-707. |
| [36] | Imafuku M., Hakuno Y., Uchida-Ota M., Yamamoto J.-I., & Minagawa Y . (2014). "Mom called me!" Behavioral and prefrontal responses of infants to self-names spoken by their mothers. Neuroimage, 103, 476-484. |
| [37] | Itier R. J., & Batty M . (2009). Neural bases of eye and gaze processing: The core of social cognition. Neuroscience and Biobehavioral Reviews, 33(6), 843-863. |
| [38] | Iverson J. M., Shic F., Wall C. A., Chawarska K., Curtin S., Estes A., ... Young G. S . (2019). Early motor abilities in infants at heightened versus low risk for ASD: A Baby Siblings Research Consortium (BSRC) study. Journal of Abnormal Psychology, 128(1), 69-80. |
| [39] | Ji N. Y., & Findling R. L . (2015). An update on pharmacotherapy for autism spectrum disorder in children and adolescents. Current Opinion in Psychiatry, 28(2), 91-101. |
| [40] | Jin Y., Wee C.-Y., Shi F., Thung K.-H., Yap P.-T., & Shen D . (2015). Identification of infants at risk for autism using multi-parameter hierarchical white matter connectomes. Machine Learning in Medical Imaging, 9352, 170-177. |
| [41] | Jones E. J. H., Gliga T., Bedford R., Charman T., & Johnson M. H . (2014). Developmental pathways to autism: A review of prospective studies of infants at risk. Neuroscience & Biobehavioral Reviews, 39, 1-33. |
| [42] | Jones E. J. H., Venema K., Earl R., Lowy R., Barnes K., Estes A., ... Webb S. J . (2016). Reduced engagement with social stimuli in 6-month-old infants with later autism spectrum disorder: A longitudinal prospective study of infants at high familial risk. Journal of Neurodevelopmental Disorders, 8, 7. |
| [43] | Jones W., & Klin A . (2013). Attention to eyes is present but in decline in 2-6-month-old infants later diagnosed with autism. Nature, 504(7480), 427-431. |
| [44] | Kim S. H., Macari S., Koller J., & Chawarska K . (2016). Examining the phenotypic heterogeneity of early autism spectrum disorder: Subtypes and short‐term outcomes. Journal of Child Psychology and Psychiatry, 57(1), 93-102. |
| [45] | Klein J. T., Shepherd S. V., & Platt M. L . (2009). Social attention and the brain. Current Biology, 19(20), R958-R962. |
| [46] | Kretch K. S., Franchak J. M., & Adolph K. E . (2014). Crawling and walking infants see the world differently. Child Development, 85(4), 1503-1518. |
| [47] | Kwon M.-K., Moore A., Barnes C. C., Cha D., & Pierce K . (2019). Typical levels of eye-region fixation in toddlers with ASD across multiple contexts. Journal of the American Academy of Child and Adolescent Psychiatry, 58(10), 1004-1015. |
| [48] | Landa R. J . (2018). Efficacy of early interventions for infants and young children with, and at risk for, autism spectrum disorders. International Review of Psychiatry, 30(1), 25-39. |
| [49] | Levin A. R., Varcin K. J., O'Leary H. M., Tager-Flusberg H., & Nelson C. A . (2017). EEG power at 3 months in infants at high familial risk for autism. Journal of Neurodevelopmental Disorders, 9(1), 34. |
| [50] | Lewis J. D., Evans A. C., Pruett J. R., Botteron K. N., McKinstry R. C., Zwaigenbaum L., ... Piven J . (2017). The emergence of network inefficiencies in infants with autism spectrum disorder. Biological Psychiatry, 82(3), 176-185. |
| [51] | Lewis J. D., Evans A. C., Pruett J. R., Botteron K., Zwaigenbaum L., Estes A., ... Piven J . (2014). Network inefficiencies in autism spectrum disorder at 24 months. Translational Psychiatry, 4(5), e388. |
| [52] | Liang S., Wang X.-L., Zou M.Y., Wang H., Zhou X., Sun C.-H., ... Tomoda A . (2014). Family-based association study of ZNF533, DOCK4 and IMMP2L gene polymorphisms linked to autism in a northeastern Chinese Han population. Journal of Zhejiang University (Science B), 15(3), 264-271. |
| [53] | Libertus K., & Violi D. A . (2016). Sit to talk: Relation between motor skills and language development in infancy. Frontiers in Psychology, 7, 475. |
| [54] | Lord C., Elsabbagh M., Baird G., & Veenstra-Vanderweele J . (2018). Autism spectrum disorder. Lancet, 392(10146), 508-520. |
| [55] | Lucker J. R., & Doman A . (2015). Neural mechanisms involved in hypersensitive hearing: Helping children with ASD who are overly sensitive to sounds. Autism Research and Treatment, 369035-369038. |
| [56] | Mars A. E., Mauk J. E., & Dowrick P. W . (1998). Symptoms of pervasive developmental disorders as observed in prediagnostic home videos of infants and toddlers. The Journal of Pediatrics, 132(3), 500-504. |
| [57] | Merrick J., Kandel I., & Morad M . (2004). Trends in autism. International Journal of Adolescent Medicine and Health, 16(1), 75-78. |
| [58] | Micali N., Chakrabarti S., & Fombonne E . (2004). The broad autism phenotype: Findings from an epidemiological survey. Autism, 8(1), 21-37. |
| [59] | Miller M., Iosif A.-M., Hill M., Young G. S., Schwichtenberg A. J., & Ozonoff S . (2017). Response to name in infants developing autism spectrum disorder: A prospective study. The Journal of Pediatrics, 183, 141-146. |
| [60] | Miller M., Musser E. D., Young G. S., Olson B., Steiner R. D., & Nigg J. T . (2019). Sibling recurrence risk and cross-aggregation of attention-deficit/hyperactivity disorder and autism spectrum disorder. JAMA Pediatrics, 173(2), 147-152. |
| [61] | Moore A., Wozniak M., Yousef A., Barnes C. C., Cha D., Courchesne E., & Pierce K . (2018). The geometric preference subtype in ASD: Identifying a consistent, early- emerging phenomenon through eye tracking. Molecular Autism, 9(1), 13-19. |
| [62] | Mosconi M. W., & Sweeney J. A . (2015). Sensorimotor dysfunctions as primary features of autism spectrum disorders. Science China-Life Sciences, 58(10), 1016-1023. |
| [63] | Nichols C. M., Ibañez L. V., Foss-Feig J. H., & Stone W. L . (2014). Social smiling and its components in high-risk infant siblings without later ASD symptomatology. Journal of Autism and Developmental Disorders, 44(4), 894-902. |
| [64] | Norbury C. F., & Sparks A . (2013). Difference or disorder? Cultural issues in understanding neurodevelopmental disorders. Developmental Psychology, 49(1), 45-58. |
| [65] | Nyström P., Gliga T., Nilsson Jobs E., Gredebäck G., Charman T., Johnson M. H., ... Falck-Ytter T . (2018). Enhanced pupillary light reflex in infancy is associated with autism diagnosis in toddlerhood. Nature Communications, 9(1), 1678. |
| [66] | Nyström P., Gredebäck G., Bölte S., & Falck-Ytter T . (2015). Hypersensitive pupillary light reflex in infants at risk for autism. Molecular Autism, 6, 10. |
| [67] | Ozonoff S., Young G. S., Belding A., Hill M., Hill A., Hutman T., ... Iosif A. M . (2014). The broader autism phenotype in infancy: When does it emerge? Journal of the American Academy of Child & Adolescent Psychiatry, 53(4), 398-407. |
| [68] | Ozonoff S., Young G. S., Carter A., Messinger D., Yirmiya N., Zwaigenbaum L., ... Stone W. L . (2011). Recurrence risk for autism spectrum disorders: A baby siblings research consortium study. Pediatrics, 128(3), e488-e495. |
| [69] | Ozonoff S., Young G. S., Landa R. J., Brian J., Bryson S., Charman T., ... Iosif A. M . (2015). Diagnostic stability in young children at risk for autism spectrum disorder: A baby siblings research consortium study. Journal of Child Psychology and Psychiatry, 56(9), 988-998. |
| [70] | Pérez-Edgar K., & Fox N. A . (2005). Temperament and anxiety disorders. Child and Adolescent Psychiatric Clinics of North America, 14(4), 681-706. |
| [71] | Perra O., & Gattis M . (2010). The control of social attention from 1 to 4 months. British Journal of Developmental Psychology, 28(4), 891-908. |
| [72] | Pierce K., Conant D., Hazin R., Stoner R., & Desmond J . (2011). Preference for geometric patterns early in life as a risk factor for autism. Archives of General Psychiatry, 68(1), 101-109. |
| [73] | Pierce K., Marinero S., Hazin R., McKenna B., Barnes C. C., & Malige A . (2015). Eye tracking reveals abnormal visual preference for geometric images as an early biomarker of an autism spectrum disorder subtype associated with increased symptom severity. Biological Psychiatry, 79(8), 657-666. |
| [74] | Pijl M. K. J., Bussu G., Charman T., Johnson M. H., Jones E. J. H., Pasco G., ... The B. T . (2019). Temperament as an early risk marker for autism spectrum disorders? A longitudinal study of high-risk and low-risk infants. Journal of Autism and Developmental Disorders, 49(5), 1825-1836. |
| [75] | Richler J., Bishop S. L., Kleinke J. R., & Lord C . (2007). Restricted and repetitive behaviors in young children with autism spectrum disorders. Journal of Autism and Developmental Disorders, 37(1), 73-85. |
| [76] | Riva V., Cantiani C., Mornati G., Gallo M., Villa L., Mani E., ... Molteni M . (2018). Distinct ERP profiles for auditory processing in infants at-risk for autism and language impairment. Scientific Reports, 8(1), 711-715. |
| [77] | Sacrey L.-A. R., Bryson S., Zwaigenbaum L., Brian J., Smith I. M., Roberts W., ... Garon N . (2018). The autism parent screen for infants: Predicting risk of autism spectrum disorder based on parent-reported behavior observed at 6-24 months of age. Autism, 22(3), 322-334. |
| [78] | Schreibman L., Dawson G., Stahmer A. C., Landa R., Rogers S. J., McGee G. G., ... Halladay A . (2015). Naturalistic developmental behavioral interventions: Empirically validated treatments for autism spectrum disorder. Journal of Autism and Developmental Disorders, 45(8), 2411-2428. |
| [79] | Shattuck P. T., & Grosse S. D . (2007). Issues related to the diagnosis and treatment of autism spectrum disorders. Mental Retardation and Developmental Disabilities Research Reviews, 13(2), 129-135. |
| [80] | Sheinkopf S. J., Iverson J. M., Rinaldi M. L., & Lester B. M . (2012). Atypical cry acoustics in 6-month-old infants at risk for autism spectrum disorder. Autism Research, 5(5), 331-339. |
| [81] | Shen M. D., Kim S. H., McKinstry R. C., Gu H., Hazlett H. C., Nordahl C. W., ... Gu H . (2017). Increased extra- axial cerebrospinal fluid in high-risk infants who later develop autism. Biological Psychiatry, 82(3), 186-193. |
| [82] | Shen M. D., Nordahl C. W., Young G. S., Wootton-Gorges S. L., Lee A., Liston S. E., ... Amaral D. G . (2013). Early brain enlargement and elevated extra-axial fluid in infants who develop autism spectrum disorder. Brain, 136(Pt 9), 2825-2835. |
| [83] | Soto T., Kiss I. G., & Carter A. S . (2016). Symptom presentations and classification of autism spectrum disorder in early childhood: Application to the diagnostic classification of mental health and developmental disorders of infancy and early childhood (dc:0-5). Infant Mental Health Journal, 37(5), 486-497. |
| [84] | Surén P., Stoltenberg C., Bresnahan M., Hirtz D., Lie K. K., Lipkin W. I., ... Hornig M . (2013). Early growth patterns in children with autism. Epidemiology, 24(5), 660-670. |
| [85] | Swettenham J., Baron-Cohen S., Charman T., Cox A., Baird G., Drew A., ... Wheelwright S . (1998). The frequency and distribution of spontaneous attention shifts between social and nonsocial stimuli in autistic, typically developing, and nonautistic developmentally delayed infants. Journal of Child Psychology and Psychiatry, 39(5), 747-753. |
| [86] | Szatmari P., Chawarska K., Dawson G., Georgiades S., Landa R., Lord C., ... Halladay A . (2016). Prospective longitudinal studies of infant siblings of children with autism: Lessons learned and future directions. Journal of the American Academy of Child & Adolescent Psychiatry, 55(3), 179-187. |
| [87] | Thorup E., Nyström P., Gredebäck G., Bölte S., & Falck-Ytter T . (2018). Reduced alternating gaze during social interaction in infancy is associated with elevated symptoms of autism in toddlerhood. Journal of Abnormal Child Psychology, 46(7), 1547-1561. |
| [88] | Tick B., Bolton P., Happé F., Rutter M., & Rijsdijk F . (2016). Heritability of autism spectrum disorders: A meta-analysis of twin studies. Journal of Child Psychology and Psychiatry, 57(5), 585-595. |
| [89] | Unwin L. M., Bruz I., Maybery M. T., Reynolds V., Ciccone N., Dissanayake C., ... Whitehouse A . (2017). Acoustic properties of cries in 12-month old infants at high-risk of autism spectrum disorder. Journal of Autism and Developmental Disorders, 47(7), 2108-2119. |
| [90] | Varcin K. J., & Jeste S. S . (2017). The emergence of autism spectrum disorder: Insights gained from studies of brain and behaviour in high-risk infants. Current Opinion in Psychiatry, 30(2), 85-91. |
| [91] | Veness C., Prior M., Eadie P., Bavin E., & Reilly S . (2014). Predicting autism diagnosis by 7 years of age using parent report of infant social communication skills. Journal of Paediatrics and Child Health, 50(9), 693-700. |
| [92] | Venezia M., Messinger D. S., Thorp D., & Mundy P . (2004). The development of anticipatory smiling. Infancy, 6(3), 397-406. |
| [93] | Vissers M. E., Cohen M. X., & Geurts H. M . (2012). Brain connectivity and high functioning autism: A promising path of research that needs refined models, methodological convergence, and stronger behavioral links. Neuroscience & Biobehavioral Reviews, 36(1), 604-625. |
| [94] | Vlaskamp C., Oranje B., Madsen G. F., Møllegaard Jepsen J. R., Durston S., Cantio C., ... Bilenberg N . (2017). Auditory processing in autism spectrum disorder: Mismatch negativity deficits. Autism Research, 10(11), 1857-1865. |
| [95] | Wang T. Y., Guo H., Xiong B., Stessman H. A. F., Wu H. D., Coe B. P., ... Eichler E. E . (2016). De novo genic mutations among a Chinese autism spectrum disorder cohort. Nature Communications, 7(1), 13316. |
| [96] | Werner E., Dawson G., Osterling J., & Dinno N . (2000). Brief report: Recognition of autism spectrum disorder before one year of age: A retrospective study based on home videotapes. Journal of Autism and Developmental Disorders, 30(2), 157-162. |
| [97] | Wolff J. J., Botteron K. N., Dager S. R., Elison J. T., Estes A. M., Gu H., ... Piven J . (2014). Longitudinal patterns of repetitive behavior in toddlers with autism. Journal of Child Psychology and Psychiatry, 55(8), 945-953. |
| [98] | Wolff J. J., Dimian A. F., Botteron K. N., Dager S. R., Elison J. T., Estes A. M., ... The I. N . (2019). A longitudinal study of parent-reported sensory responsiveness in toddlers at-risk for autism. Journal of Child Psychology and Psychiatry, 60(3), 314-324. |
| [99] | Wolff J. J., Swanson M. R., Elison J. T., Gerig G., Pruett J. J., Styner M. A., ... Piven J . (2017). Neural circuitry at age 6 months associated with later repetitive behavior and sensory responsiveness in autism. Molecular Autism, 8, 8. |
| [100] | Yale M. E., Messinger D. S., Cobo-Lewis A. B., & Delgado C. F . (2003). The temporal coordination of early infant communication. Developmental Psychology, 39(5), 815-824. |
| [101] | Yirmiya N., & Ozonoff S . (2007). The very early autism phenotype. Journal of Autism and Developmental Disorders, 37(1), 1-11. |
| [102] | Yuen R. K. C., Thiruvahindrapuram B., Merico D., Walker S., Tammimies K., Hoang N., ... Scherer S. W . (2015). Whole-genome sequencing of quartet families with autism spectrum disorder. Nature Medicine, 21(2), 185-191. |
| [103] | Zhang D. J., Roche L., Bartl-Pokorny K. D., Krieber M., McLay L., Bölte S., ... Marschik P. B . (2018). Response to name and its value for the early detection of developmental disorders: Insights from autism spectrum disorder, Rett syndrome, and fragile X syndrome. A perspectives paper. Research in Developmental Disabilities, 82, 95-108. |
| [104] | Zwaigenbaum L., Bryson S., Rogers T., Roberts W., Brian J., & Szatmari P . (2005). Behavioral manifestations of autism in the first year of life. International Journal of Developmental Neuroscience, 23(2-3), 143-152. |
| [105] | Zwaigenbaum L., Young G. S., Stone W. L., Dobkins K., Ozonoff S., Brian J., ... Messinger D . (2014). Early head growth in infants at risk of autism: A baby siblings research consortium study. Journal of the American Academy of Child & Adolescent Psychiatry, 53(10), 1053-1062. |
相关文章 9
| [1] | 王琳, 王志丹, 王泓婧. 孤独症儿童动作发展障碍的神经机制[J]. 心理科学进展, 2021, 29(7): 1239-1250. |
| [2] | 荆伟, 王庭照. 双通路理论视角下孤独症谱系障碍者的视线加工障碍[J]. 心理科学进展, 2019, 27(3): 508-521. |
| [3] | 赵晓宁, 胡金生, 李松泽, 刘西, 刘琼阳, 吴娜. 基于眼动研究的孤独症谱系障碍早期预测[J]. 心理科学进展, 2019, 27(2): 301-311. |
| [4] | 白晓宇, TawandaS.Mutusva, 祝卓宏. PEAK关系训练系统：孤独症语言障碍康复的新方法[J]. 心理科学进展, 2019, 27(11): 1896-1905. |
| [5] | 李涛涛, 胡金生, 王琦, 李骋诗, 李松泽, 何建青, 李辰洋, 刘淑清. 孤独症谱系障碍者的视听时间整合 *[J]. 心理科学进展, 2018, 26(6): 1031-1040. |
| [6] | 巨兴达, 宋伟, 徐婧. CHRM3基因与孤独症谱系障碍[J]. 心理科学进展, 2018, 26(12): 2141-2152. |
| [7] | 王分分, 祝卓宏. 言语行为的关系框架理论视角： 孤独症谱系障碍的新探索[J]. 心理科学进展, 2017, 25(8): 1321-1326. |
| [8] | 王琦;胡金生;李骋诗;李松泽. 孤独症谱系障碍者的情绪韵律识别[J]. 心理科学进展, 2016, 24(9): 1377-1390. |
| [9] | 李松泽; 胡金生; 李骋诗; 王琦; 刘淑清; 康晓东; 崔丽 . 孤独症谱系障碍者的视觉−空间工作记忆缺陷及脑机制[J]. 心理科学进展, 2016, 24(7): 1050-1064. |
PDF全文下载地址:
http://journal.psych.ac.cn/xlkxjz/CN/article/downloadArticleFile.do?attachType=PDF&id=4985
