Rui-Ping Xiao, M.D. Ph.D
Professor
Director of IMM/PKU
Principal Investigator, Laboratory of Signal Transduction
Room 322, Ying-Jie Conference Center, Yiheyuan Road 5, Haidian District,
Peking University, Beijing, China 100871
E-mail: imm@pku.edu.cn
Phone: 86-10-6275-7243
Dr. Rui-Ping Xiao was trained as a physician-scientist in both China and the United States. She received her M.D. and medical training at Tong-Ji Medical University, China. In 1988, she went to the United States, and spent 20 years in National Institute on Aging (NIA), NIH, from a postdoctoral fellow to a tenured Senior Investigator and the Chief of the Receptor Signaling Section. Overlapping with her training at NIH, she also completed her Ph.D. study in the Medical School of University of Maryland from 1991 to 1995. Additionally, in 2005, she was invited by Peking University to serve as the Founding Director of the Institute of Molecular of Medicine (IMM) at Peking University (initially as a volunteer), and became a full-time returnee.
Dr. Xiao has made important discoveries in beta-adrenergic receptor (AR) subtype signaling, with an emphasis on translating bench discoveries to the bedside. She was the first to show that?beta2-AR dually couples to Gs and Gi, revealing a new signaling paradigm of the G protein-coupled receptor superfamily. While chronic beta1-AR stimulation causes heart cell death and cardiomyopathy by Ca2+/calmodulin kinase II-dependent pathways, beta2-AR is cardiac protective. She co-invented the Gs-biased, chiral beta2-AR agonist R,R-feneterol and co-supervised its Phase I clinical trial (Phase II planned), spearheading a novel therapy treating heart failure with beta2-AR agonist R,R-feneterol or derivatives combined with beta1-AR blocker. Her current research has revealed that MG53 E3 ligase-mediated, ubiquitin-dependent degradation of insulin receptor and insulin receptor substrate 1 constitutes a fundamental mechanism for the development of systemic insulin resistance, leading to the sequelae of metabolic syndrome and cardiovascular complications. She has authored >140 peer-reviewed publications. She has been global leader in biomedical research and served as the founding director of the Institute of Molecular Medicine, Peking University since 2005. She has also played a leadership role in clinical translational research and currently serves as an Associate Editor of The New England Journal of Medicine.
List of Selected Publications (All publications):
1. Zhu WZ, Zheng M, Koch WJ, Lefkowitz RJ, Kobilka BK, Xiao RP. Dual modulation of cell survival and cell death by β2-adrenergic signaling in adult mouse cardiac myocytes. Proc Nat Acad Sci USA. 98: 1607-1612, 2001.
2. Zhu WZ, Wang SQ, Chakir K, Yang D, Zhang T, Brown JH, Devic E, Kolbilka BK, Cheng H, Xiao RP. Linkage of β1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/Calmodulin Kinase II. J Clin Invest. 111: 617-625, 2003.
3. Xiao RP, Zhang SJ, Chakir K, Avdonin P, Zhu W, Bond RA, Balke CW, Lakatta EG, Cheng H. Enhanced Gi signaling selectively negates β1-AR but not β1-AR-mediated positive inotropic effect in myocytes from failing rat hearts. Circulation. 108: 1633-1639, 2003.
4. Song R, Peng W, Zhang Y, Lv F, Wu HK, Guo J, Cao Y, Pi Y, Zhang X, Jin L, Zhang M, Jiang P, Liu F, Meng S, Zhang X, Jiang P, Cao CM, Xiao RP. Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders. Nature. 494: 375-379, 2013.
5. Liu F, Song R, Feng Y, Guo J, Chen Y, Zhang Y, Chen T, Wang Y, Huang Y, Li CY, Cao C, Zhang Y, Hu X, Xiao RP. Upregulation of MG53 induces diabetic cardiomyopathy through transcriptional activation of PPAR α. Circulation. 131: 795-804, 2015.
6. Zhang T, Zhang Y, Cui M, Jin L, Wang Y, Lv F, Liu Y, Zheng W, Shang H, Zhang J, Zhang M, Wu HK, Guo J, Zhang X, Hu X, Cao CM, Xiao RP. CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis. Nat Med. 22: 175-182, 2016.
删除或更新信息,请邮件至freekaoyan#163.com(#换成@)
北京大学分子医学研究所导师教师师资介绍简介-Rui-PingXiao
本站小编 Free考研考试/2020-04-13
相关话题/北京大学 师资
北京大学分子医学研究所导师教师师资介绍简介-张秀琴研究员
张秀琴研究员M.D.Ph.D.非人灵长类动物研究中心Co-PI实验病理中心PI联系电话:010-6275-3420E-mail:zhangxq@pku.edu.cn通讯地址:北京大学综合科研楼236房间1008712002年获日本熊本大学医学博士学位;1995年获中国医科大学病理学硕士学位;1995-1996年中国医学科学院阜外医院病理科医师;1996-1997年日本熊本大学医学部肿瘤生物学研究室 ...北京大学考研导师 本站小编 Free考研考试 2020-04-13北京大学分子医学研究所导师教师师资介绍简介-RongliZhang
RongliZhang,M.D.Ph.D.AssistantInvestigatorNonhumanPrimateResearchCenterRoom304,Ying-JieConferenceCenter,PekingUniversityBeijing,China100871E-mail:zrl@pku.edu.cnPhone:86-10-6275-7799ProfessionalExperie ...北京大学考研导师 本站小编 Free考研考试 2020-04-13北京大学分子医学研究所导师教师师资介绍简介-XiuqinZhang
XiuqinZhang,M.D.Ph.D.PrincipalInvestigator,PathologyCoreCo-PrincipalInvestigator,NonhumanPrimateResearchCenterRoom236,IntegratedScienceResearchCenter,YiheyuanRoad5,HaidianDistrict,PekingUniversityBeij ...北京大学考研导师 本站小编 Free考研考试 2020-04-13北京大学分子医学研究所导师教师师资介绍简介-You-TangShen
You-TangShenProfessorConsultant,NonhumanPrimateResearchCenterDirector,PhysiologyProgramsandLaboratoriesDepartmentofCellBiologyandMolecularMedicineNewJerseyMedicalSchoolUniversityofMedicineandDentistry ...北京大学考研导师 本站小编 Free考研考试 2020-04-13北京大学分子医学研究所导师教师师资介绍简介-沈幼棠教授
沈幼棠教授灵长类研究中心顾问 生理学实验室主任细胞生物学与分子医学系美国新泽西牙医科大学E-mail:sheny1@umdnj.edu代表论文(与灵长类研究相关论文):1.ShenY-T,VatnerDE,GagnonHE,VatnerSF:Speciesdifferencesinregulationofa-adrenergicreceptorfunction.AmJPhysiol257:R111 ...北京大学考研导师 本站小编 Free考研考试 2020-04-13北京大学分子医学研究所导师教师师资介绍简介-程和平教授
程和平教授Ph.D.博士生导师中国科学院院士钙信号与线粒体生物医学实验室主任联系电话:010-6276-5957E-mail:chengp@pku.edu.cn通讯地址:北京大学英杰交流中心338室1008711980-1987年就学于北京大学力学系,获学士和生物工程专业硕士学位,同时辅修生物学系生理学专业,获第二学士学位;1987-1989任教于北京大学无线电电子学系;1990-1995年留学美 ...北京大学考研导师 本站小编 Free考研考试 2020-04-13北京大学分子医学研究所导师教师师资介绍简介-钙信号与线粒体生物医学研究室
钙离子是细胞内最重要的信使物质,参与神经递质释放、肌肉收缩、能量代谢乃至细胞凋亡等重要生物学过程。程和平等1993年发现心肌细胞内钙释放的基元事件,命名为“钙火花”(CalciumSpark),后来形成一个新兴研究领域—“钙火花学”(Sparkology)。线粒体是真核细胞特有的内含自身基因组的一种细胞器。它既是细胞能量代谢的中心,也是细胞稳态调控、应激反应、生存与凋亡信号转导的枢纽。线粒体功能障 ...北京大学考研导师 本站小编 Free考研考试 2020-04-13北京大学分子医学研究所导师教师师资介绍简介-王显花副研究员
王显花副研究员Ph.D.钙信号研究室Co-PI联系电话:010-6275-4605E-mail:xianhua@pku.edu.cn通讯地址:北京大学英杰交流中心339室1008711996-2000年就读于北京大学生命科学学院生物化学与分子生物学专业,获理学学士学位;2000-2005年于北京大学生命科学学院硕博连读,获理学博士学位;2005-2007年在北京大学分子医学研究所钙信号转导实验室进 ...北京大学考研导师 本站小编 Free考研考试 2020-04-13北京大学分子医学研究所导师教师师资介绍简介-Heping(Peace)Cheng
Heping(Peace)Cheng,Ph.D.ProfessorPrincipalInvestigatorLaboratoryofCalciumSignalingandMitochondrialBiomedicineRoom338,Ying-JieConferenceCenter,PekingUniversity,Beijing,China100871E-mail:chengp@pku.edu. ...北京大学考研导师 本站小编 Free考研考试 2020-04-13北京大学分子医学研究所导师教师师资介绍简介-马淇助理研究员
马淇博士助理研究员联系电话:010-6275-7095E-mail:maq@pku.edu.cn通讯地址:北京大学英杰交流中心339E1008712002-2006就读于北京大学生命科学学院,获学士学位;2006-2011就读于中国科学院动物研究所生物膜国家重点实验室,获博士学位;2012-2013在宾夕法尼亚大学费城儿童医院DouglasWallace实验室从事博士后研究;2013年3月起就职于 ...北京大学考研导师 本站小编 Free考研考试 2020-04-13