Heping (Peace) Cheng,Ph.D.
Professor
PrincipalInvestigator
Laboratory of Calcium Signaling and Mitochondrial Biomedicine
Room 338, Ying-Jie Conference Center,
Peking University, Beijing, China100871
E-mail: chengp@pku.edu.cn
Phone: 86-10-6276-5957
Professor Heping (Peace) Cheng received degrees in applied mathematics and mechanics, physiology, and biomedical engineering from Peking University, China, where he served as a faculty member in the Department of Electrical Engineering before earning his Ph.D. degree in Physiology in 1995 from the University of Maryland at Baltimore. He then joined the NIH Intramural Research Program as a senior staff fellow in 1995 and was selected as a tenure-track investigator in 1998. In November, 2004, he became a senior investigator and the head of the Ca2+ Signaling Section in the Laboratory of Cardiovascular Science, National Institute on Aging, NIH. He is now a full-time senior investigator of IMM, PKU. His current research focus is on the mechanism, regulation, and biology of mitochondrial “superoxide flashes”.
Selected Publications:
1. Cheng, H., Lederer, W.J., Cannell., M.B., 1993, Calcium sparks: The elementary events underlying excitation-contraction coupling in heart muscle. Science 262, 740-744
2. Cheng, H., Fill, M., Valdivia, H.H., Lederer, W.J., 1995, Models of calcium release channel adaptation, Science 267, 2009-2010
3. Cannell, M.B., Cheng, H., Lederer, W.J., 1995, The control of calcium release in heart muscle. Science 268, 1045-1050
4. Nelson, M.T., Cheng, H., Rubart, M., Santana, L.F., Bonev, A., Knot, H., Lederer, W.J., 1995, Relaxation of arterial smooth muscle by calcium sparks. Science 270, 633-637
5. Klein, M.G., Cheng, H.*, Santana, L.F., Lederer, W.J., Schneider, M.F., 1996, Discrete sarcomeric calcium release events activated by dual mechanisms in skeletal muscle. Nature 379, 455-458 (* the corresponding author)
6. Gomez, A.M., Valdivia, H.H., Cheng, H., Santana, L.F., Lederer, W.J., 1997, Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure. Science 276, 800-806
7. Wang, S.Q., Song, L.-S., Lakatta, E.G., Cheng, H., 2001, Ca2+ signalling between single L-type Ca2+ channels and ryanodine receptors in heart cells. Nature 410, 592-596
8. Pan, Z., Yang, D., Nagaraj, R.Y., Nosek, T.A., Nishi, M. Takeshima, H., Cheng, H., Ma, J., 2002, Dysfunction of store-operated Ca2+ channel in muscle cells lacking mg29 gene. Nature Cell Biol. 4, 379-383
9. Wang, S.Q., Stern, M.D., Ríos, E., Cheng, H., 2004,The quantal nature of ca2+ sparks and in situ operation of the ryanodine receptor array in cardiac cells. Proc. Natl. Acad. Sci. USA 101, 3979-3984
10. Wang, S.Q., Wei, C.L., Gao, G. L., Brochet, D., Shen, J.X., Song, L.S., Wang, W., Yang, D.M., Cheng, H., 2004, Imaging microdomain Ca2+ in muscle cells. Circ. Res. 94, 1011-1022 (invited review)
11. Wang, W., Zhu, W., Wang, S. Q., Yang, D. M., Crow, M. T., Xiao, R. P., Cheng, H., 2004, Sustained b1-adrenergic stimulation modulates cardiac contractility by Ca2+/calmodulin kinase signaling pathway. Circ. Res. 95,798-806.
12. Xu, X., Yang, D., Ding, J., Wang, W., Chu, P. H., Dalton, N. D., Wang, H. Y., Bermingham, J. R., Jr., Ye, Z., Liu, F., Rosenfeld, F. G., Manley, J. L., Ross J., Jr., Chen, J., Xiao, R.-P., Cheng, H., Fu, X. D., 2005, ASF/SF2-regulated postnatal reprogramming of CaMKIId alternative splicing modulates excitation-contraction coupling in cardiac muscle. Cell, 120, 59-72
13. Brochet, D. X. P., Yang, D., Di Maio, A., Lederer, W. J., Franzini-Armstrong, C., Cheng, H., 2005, Calcium blinks: Rapid nanoscopic store calcium signaling. Proc. Natl. Acad. Sci. USA, 102, 3099-3104
14. Ouyan, K., Wu, C. H., Cheng, H., 2005, Ca2+-induced Ca2+ release in sensory neurons: Low-gain amplification confers intrinsic stability. J. Biol. Chem. 280, 15898-15902
15. Ouyang, K., Zheng, H., Qin, X., Zhang, C., Yang, D., Wang, X., Wu, C., Zhou, Z., and Cheng, H., 2005, Ca2+ sparks and secretion in dorsal root ganglion neurons. Proc. Natl. Acad. Sci. USA. 102:12259-12264
16. Song, L-S, Sobie, EA, McCulle, S, Lederer, WJ, Balke, CW, Cheng, H., 2006, Orphaned ryanodine receptors in the failing heart. Proc. Natl. Acad. Sci. USA. 103: 4305-4310
17. Wang W, Fang H, Groom L, Cheng A, Zhang W, Liu J, Wang X, Li K, Han P, Zheng M, Yin J, Wang W, Mattson MP, Kao JP.Y, Lakatta EG, Sheu S-S, Ouyang K, Chen J, Dirksen RT, Cheng H., 2008, Superoxide Flashes in Single Mitochondria. Cell, 2008; 134:279-290.
18. Cheng, H., Lederere, W.J., 2008, Calcium sparks, Physiol. Reviews. 88,1491-1545
19. Wei, C.L., Wang, X.H, Chen, M., Ouyang, K.F., Song, L.S., Cheng, H., 2009, Calcium flickers steer cell migration. Nature 457, 901-905.
20. Zhou, P., Zhao, Y.T., Guo, Y.B., Xu, S.M., Bai, S.H., Lakatta, E.G., Cheng, H., Hao, X.M., Wang, S.Q., 2009, β-adrenergic signaling accelerates and synchronizes cardiac ryanodine receptor response to a single L-type Ca2+ channel. Proc. Natl. Acad. Sci. U S A, 106, 18028-33
21. Wang, G., Zhu, X., Xie, W., Han, P., Li,K., Sun, Z., Wang, Y., Chen, C., Song, R., Cao, C., Zhang, J., Wu, C., Liu, J., Cheng, H., 2010, Rad as a novel regulator of excitation- contraction coupling and β-adrenergic signaling in heart. Circ Res. 106， 317-327
22. Wei, C.L., Wang, X.H., Chen, M., Ouyang, K.F., Zheng, M., Cheng, H., 2010, Flickering calcium signals turning of migrating cells. Can J Physiol Pharm. 88,105-110
23. Peng, W., Zhang, Y., Zheng, M., Cheng, H., Zhu, W., Cao, C.M., Xiao, R.P. 2010, Cardioprotection by CaMKII-deltaB is mediated by phosphorylation of heat shock factor 1 and subsequent expression of inducible heat shock protein 70. Circ Res. 106, 102-110
24. Wang, X,, Xie, W., Zhang, Y., Lin, P., Han, L., Han, P., Wang, Y., Chen, Z., Ji, G., Zheng, M., Weisleder, N., Xiao, R.P., Takeshima, H, Ma, J, Cheng, H., 2010, Cardioprotection of ischemia/reperfusion injury by cholesterol-dependent MG53-mediated membrane repair. Circ Res. 107,76-83.
25. Wei, S., Guo, A., Chen, B., Kutschke, W., Xie, Y.P., Zimmerman, K., Weiss, R.M., Anderson, M.E., Cheng, H., Song, L.S. 2010, T-tubule remodeling during transition from hypertrophy to heart failure. Circ Res. 107，520-531
26. Xie, W., Brochet, D.X., Wei, S., Wang, X., Cheng, H 2010, Deciphering ryanodine receptor array operation in cardiac myocytes. J Gen Physiol. 136, 129-133
27. Wei, C., Wang, X., Zheng, M, Cheng, H. 2011, Calcium gradients underlying cell migration. Curr Opin Cell Biol. 2011 Dec 21. [Epub ahead of print]
28. Brochet, DX., Xie, W., Yang, D., Cheng, H., Lederer W.J., 2011, Quarky calcium release in the heart, Circ Res , 108, 210-218.
29. Fang, H., Chen, M., Ding, Y., Shang, W., Xu, J., Zhang, X., Zhang, W., Li, K., Xiao, Y., Gao, F., Shang, S., Li, J., Tian, X., Wang, S., Zhou, J., Weisleder, N., Ma,J., Ouyang, K., Chen, J., Wang, X., Zheng, M., Wang, W., Zhang, X., Cheng, H., 2011, Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals, Cell Res, 21, 1295-1304.
30. Han, P., Cai, W., Wang, Y., Lam, C., Arvanitis, D., Singh, V.P., Chen, S., Zhang, H., Zhang, R., Cheng, H., Kranias, E.G., 2011, Catecholaminergic-induced arrhythmias in failing cardiomyocytes associated with human HRCS96A variant overexpression, Am J Physiol-Heart C, 301, H1588-1595.
31. Huang, Z., Zhang, W., Fang, H., Zheng, M., Wang, X., Xu, J., Cheng, H., Gong, G., Wang, W., Dirksen, R.T., Sheu, S., 2011, Response to "A critical evaluation of cpYFP as a probe for superoxide", Free Radical Bio Med, 51, 1937-1940.
32. Lin, N., Badie, N., Yu, L., Abraham, D., Cheng, H., Bursac, N., Rockman, H.A., Wolf, M.J., 2011, A method to measure myocardial calcium handling in adult Drosophila, Circ Res, 108, 1306-1315.
33. Ma, Q., Fang, H., Shang, W., Liu, L., Xu, Z., Ye, T., Wang, X., Zheng, M., Chen, Q., Cheng, H.,2011, Superoxide flashes: early mitochondrial signals for oxidative stress-induced apoptosis, J Biol Chem, 286, 27573-27581.
34. Zhang, X., Zhang, R., Raab, S., Zheng, W., Wang, J., Liu, N., Zhu, T., Xue, L., Song, Z., Mao, J., Li, K., Zhang, H., Zhang, Y., Han, C., Ding, Y., Wang, H., Hou, N., Liu, Y., Shang, S., Li, C., Sebokova, E., Cheng, H., Huang, P., 2011, Rhesus macaques develop metabolic syndrome with reversible vascular dysfunction responsive to pioglitazone, Circulation, 124, 77-86.
35. Zhou, Q., Xiao, J., Jiang, D., Wang, R., Vembaiyan, K., Wang, A., Smith, C.D., Xie, C., Chen, W., Zhang, J., Tian, X., Jones, P., Zhong, X., Guo, A., Chen, H., Zhang, L., Zhu, W., Yang, D., Li, X., Chen, J., Gillis, A.M., Duff, H.J., Cheng, H., Feldman, A.M., Song, L., Fill, M., Back, T.G., Chen, S.R., 2011, Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release, Nat Med, 17, 1003-1009.
36. Wang, X. H.,Jian, C. S.,,Zhang, X., Huang, Z. L., Xu, J. J,. Hou, T. T., Shang, W., Ding, Y. Zhang, W. R. Ouyang, M. Wang, Y. F., Yang, Z., Zheng M., Cheng,H., 2012, Superoxide flashes: Elemental events of mitochondrial ROS signaling in the heart. J Mol Cell Cardiol 52,940-948. 37. Li,K.,
37. Zhang, W. R., Fang, H. Q., Xie, W. J., Liu, J. Zheng, M. Wang, X. H., Wang, W., Tan, W. C., Cheng, H. 2012, Superoxide Flashes Reveal Novel Properties of Mitochondrial Reactive Oxygen Species Excitability in Cardiomyocytes. Biophysical J,102, 1011-1021.