Xianhua Wang, Ph.D.
Associate Investigator
Room 339, Ying-Jie Conference Building
Peking University,
Beijing, China 100871
E-mail: xianhua@pku.edu.cn
Phone: 86-10-6275-4605
Dr. Xianhua Wang received her B.Sc degree in 2000 and Ph.D. degree in 2005 from Peking University. She got her postdoc training in the Institute of Molecular Medicine, Peking University during 2005-2007. She visited National Institute on Aging of NIH during 2009-2010. From 2007 to now, she worked in the Institute of Molecular Medicine, Peking University.
Research Interests: 1) Mechanism and significance of mitochondrial ROS signals, especially the elemental “superoxide flash”; 2) Molecular identification of mitochondrial permeability transition pore (mPTP) components.
Selected Publications:
1. Wang X.H., Jian C.S., Zhang X., Huang Z.L., Xu J.J., Hou T.T., Shang W., Ding Y., Zhang W.R., Ouyang M., Wang Y.F., Yang Z., Zheng M., Cheng H.P., Superoxide flashes: elemental events of mitochondrial ROS signaling in heart. J Mol Cell Cardiol., 2012, 52:940
2. Li K.T., Zhang W.R., Fang H.Q., Xie W.J., Liu J., Zheng M., Wang X.H., Wang W., Tan W.C., Cheng H.P., Superoxide Flashes Reveal Novel Properties of Mitochondrial ROS Excitability in Cardiomyocytes. Biophys J., 2012, 102:1011
3. Weisleder N., Takizawa N., Lin P., Wang X.H., Cao C., Zhang Y., Tan T., Ferrante C., Zhu H., Chen P.J., Yan R., Sterling M., Zhao X., Hwang M., Takeshima M., Cai C., Cheng H.P., Takeshima H., Xiao R.P., Ma J.Recombinant MG53 protein modulates therapeutic cell membrane repair in treatment of muscular dystrophy. Sci Transl Med., 2012, 4:139
4. Lin P., Zhu H., Cai C., Wang X.H., Cao C., Xiao R., Pan Z., Weisleder N., Takeshima H., Ma J., Nonmuscle myosin IIA facilitates vesicle trafficking for MG53-mediated cell membrane repair. FASEB J., 2012, 26:1875
5. Wei C.L., Wang X.H.*, Zheng M., Cheng H.P., Calcium gradients underlying cell migration. Curr Opin Cell Biol., 2012, 24:254, * co-corresponding author.
6. Huang Z., Zhang W., Gong G., Fang H., Zheng M., Wang X.H., Xu J., Dirksen R.T., Sheu S.S., Cheng H.P., Wang W., Response to "A critical evaluation of cpYFP as a probe for superoxide". Free Radic Biol Med., 2011, 51:1937.
7. Chen M., Wang Y.R., Hou T.T., Zhang H.L., Qu A.J., Wang X.H., Differential mitochondrial calcium responses in different cell types detected with a mitochondrial calcium fluorescent indicator, mito-GCaMP2. Acta Biochim Biophys Sin., 2011, 43: 822.
8. Fang H.Q., Chen M., Ding Y., Shang W., Xu J.J, Zhang X., Zhang W.R., Li K.T., Xiao Y., Gao F., Shang S.J., Li J.C., Tian X.L., Wang S.Q., Zhou J.S., Weisleder N., Ma J.J., Ouyang K.F., Chen J., Wang X.H., Zheng M., Wang W., Zhang X.Q., Cheng H.P., Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals. Cell Res., 2011, 21: 1295.
9. Ma Q., Fang H.Q., Shang W., Liu L., Xu Z., Ye T., Wang X.H., Zheng M., Chen Q., Cheng H.P., Superoxide flashes: early mitochondrial signals for oxidative stress-induced apoptosis. J Biol Chem., 2011, 286: 27573.
10. Xie W.J., Brochet D.X.P., Wei S., Wang X.H., Cheng H.P., Deciphering ryanodine receptor array operation in cardiac myocytes. J Gen Physiol., 2010, 136: 129.
11. Wang X.H.*, Xie W.J., Zhang Y., Lin P.H., Han L., Han P.D., Wang Y.R., Chen Z., Ji G.J., Zheng M., Weisleder N., Xiao R.P., Takeshima H., Ma J.J., Cheng H.P., Cardioprotection of ischemia-reperfusion injury by cholesterol-dependent MG53-mediated membrane repair. Circ Res., 2010，107: 76. *, co-corresponding author.
12. Cao C.M., Zhang Y., Weisleder N., Ferrante C., Wang X.H., Lv F.X., Zhang Y., Song R.S., Hwang M.S., Jin L., Guo J.J., Peng W., Li G., Nishi M., Takeshima H., Ma J.J., Xiao R.P., MG53 constitutes a primary determinant of cardiac ischemic preconditioning. Circulation, 2010， 121: 2565.
13. Wei C.L., Wang X.H., Chen M., Ou-Yang K.F., Zheng M., Cheng H.P., Flickering calcium microdomains signal turning of migrating cells. Can J Physiol Pharmacol., 2010, 88: 105.
14. Wei C.L., Wang X.H., Ou-Yang K.F., Chen M., Song L.-S., Cheng H.P., Calcium flickers steer cell migration. Nature, 2009, 457:901.
15. Wang W., Fang H.Q., Groom L.D., Cheng A.W., Zhang W.R., Liu J., Wang X.H., Li K.T., Han P.D., Zheng M., Yin J.H., Wang W.D., Mattson M.P., Kao J.P.Y., Lakatta1 E.G., Sheu S.S., Ou-Yang K.F., Chen J., Dirksen R.T., Cheng H.P., Superoxide flashes in single mitochondria. Cell, 2008, 134: 279.
16. Xiao B.L., Tian X.X., Xie W.J., Jones P. P., Cai S.T., Wang X.H., Jiang D.W., Kong H.H., Zhang L., Chen K.Y., Walsh M.P., Cheng H.P., Wayne Chen S.R., Functional consequence of PKA-dependent phosphorylation of the cardiac ryanodine receptor: sensitization of store-overload-induced Ca2+ release. J Biol Chem., 2007, 282: 30256.
17. Yao L.J., Wang G., Ou-Yang K.F., Wei C.L., Wang X.H., Wang S.R., Yao W., Huang H.P., Luo J.H., Wu C.H., Liu J., Zhou Z., Cheng H.P., Ca2+ sparks and Ca2+ glows in superior cervical ganglion neurons. Acta Pharmacol Sin., 2006, 27(7):848