张秀琴 研究员
M.D. Ph.D.
非人灵长类动物研究中心Co-PI
实验病理中心PI
联系电话：010-6275-3420
E-mail：zhangxq@pku.edu.cn
通讯地址：北京大学综合科研楼236房间 100871
2002年获日本熊本大学医学博士学位；1995年获中国医科大学病理学硕士学位；1995-1996年中国医学科学院阜外医院病理科医师；1996-1997年日本熊本大学医学部肿瘤生物学研究室客座研究员；1997-1998年日本熊本大学医学部分化控制研究室日本文部省特别研究员（非常勤讲师）；2002-2006年美国华盛顿大学医学院分子生物学及药理学系助理研究员；2006-2013年，北京大学分子医学研究所副研究员；2013年8月至今，北京大学分子医学研究所研究员。
主要研究兴趣：建立非人灵长类心血管和代谢疾病模型；基于灵长类动物模型研究心血管疾病及代谢综合症发病机理；肠道系统在代谢性疾病发生发展过程中的作用及其机理研究；利用非人灵长类疾病模型进行新药的临床前药效和药物作用机理研究。 发表论文：
1.Ting Zhang, Yan Zhang, Mingyao Cui, Li Jin, Yimei Wang, Fengxiang Lv, Xiuqin Zhang, Xinli Hu, Chun-Mei Cao, Rui-Ping Xiao. CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis. Nat Med. 2016 Jan 4. doi: 10.1038/nm.4017. [Epub ahead of print]
2.Ding Y, Fang H, Shang W, Xiao Y, Sun T, Hou N, Pan L, Sun X, Ma Q, Zhou J, Wang X, Zhang X, Cheng H. Mitoflash altered by metabolic stress in insulin-resistant skeletal muscle. J Mol Med (Berl). 2015 Oct;93(10):1119-30. (通讯作者)
3.Chen JY, Peng Z, Zhang R, Yang XZ, Tan BC, Fang H, Liu CJ, Shi M, Ye ZQ, Zhang YE, Deng M, Zhang X, Li CY. RNA editome in rhesus macaque shaped by purifying selection. PLoS Genet. 2014 Apr 10;10(4):e**. (共同通讯作者)
4.Sun HT, Zhang J, Hou N, Zhang X, Wang J, Bai Y. Spontaneous periodontitis is associated with metabolic syndrome in rhesus monkeys. Arch Oral Biol. 2014 Apr;59(4):386-92.
5.Mao J, Hu X, Xiao Y, Yang C, Ding Y, Hou N, Wang J, Cheng H, Zhang X. Overnutrition stimulates intestinal epithelium proliferation through β-catenin signaling in obese mice. Diabetes. 2013 Nov;62(11):3736-46. (通讯作者)
6.Song R, Peng W, Zhang Y, Lv F, Wu HK, Guo J, Cao Y, Pi Y, Zhang X, Jin L, Zhang M, Jiang P, Liu F, Meng S, Zhang X, Jiang P, Cao CM, Xiao RP. Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders. Nature. 2013 Feb 21;494(7437):375-9.
7.Zhang SJ, Liu CJ, Shi M, Kong L, Chen JY, Zhou WZ, Zhu X, Yu P, Wang J, Yang X, Hou N, Ye Z, Zhang R, Xiao R, Zhang X, Li CY. RhesusBase: a knowledgebase for the monkey research community. Nucleic Acids Res. 2013 Jan;41(Database issue):D892-905. (共同通讯作者)
8.Zhang X, Zhang R, Raab S, Zheng W, Wang J, Liu N, Zhu T, Xue L, Song Z, Mao J, Li K, Zhang H, Zhang Y, Han C, Ding Y, Wang H, Hou N, Liu Y, Shang S, Li C, Sebokova E, Cheng H, Huang PL. Rhesus macaques develop metabolic syndrome with reversible vascular dysfunction responsive to pioglitazone. Circulation. 2011 Jul 5;124(1):77-86.
9.Fang H, Chen M, Ding Y, Shang W, Xu J, Zhang X, Zhang W, Li K, Xiao Y, Gao F, Shang S, Li JC, Tian XL, Wang SQ, Zhou J, Weisleder N, Ma J, Ouyang K, Chen J, Wang X, Zheng M, Wang W, Zhang X, Cheng H. Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals. Cell Res. 2011 Sep;21(9):1295-304. (共同通讯作者)
10.Huang Y, Hong J, Zheng S, Ding Y, Guo S, Zhang H, Zhang X, Du Q, Liang Z. Elimination pathways of systemically delivered siRNA. Mol Ther. 2011 Feb;19(2):381-5.
11.Geske MJ, Zhang X, Patel KK, Ornitz DM, Stappenbeck TS. Fgf9 signaling regulates small intestinal elongation and mesenchymal development. Development. 2008 Sep;135(17):2959-68.
12.Zhao G, Zhao Y, Pan B, Liu J, Huang X, Zhang X, Cao C, Hou N, Wu C, Zhao KS, Cheng H. Hypersensitivity of BKCa to Ca2+ sparks underlies hyporeactivity of arterial smooth muscle in shock. Circ Res. 2007 Aug 31;101(5):493-502.
13.Smith SM, West LA, Govindraj P, Zhang X, Ornitz DM, Hassell JR. Heparan and chondroitin sulfate on growth plate perlecan mediate binding and delivery of FGF-2 to FGF receptors. Matrix Biol. 2007 Apr;26(3):175-84.
14.Zhang X, Ibrahimi OA, Olsen SK, Umemori H, Mohammadi M, Ornitz DM. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. J Biol Chem. 2006 Jun 9;281(23):15694-700.
15.Zhang X, Stappenbeck TS, White AC, Lavine KJ, Gordon JI, Ornitz DM. Reciprocal epithelial-mesenchymal FGF signaling is required for cecal development. Development. 2006 Jan;133(1):173-80.
16.Lavine KJ, Yu K, White AC, Zhang X, Smith C, Partanen J, Ornitz DM. Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo. Dev Cell. 2005 Jan;8(1):85-95.
17.Pirvola U, Zhang X, Mantela J, Ornitz DM, Ylikoski J. Fgf9 signaling regulates inner ear morphogenesis through epithelial-mesenchymal interactions. Dev Biol. 2004 Sep 15;273(2):350-60.
18.Sakamoto H, Zhang XQ, Suenobu S, Ohbo K, Ogawa M, Suda T. Cell adhesion to ephrinb2 is induced by EphB4 independently of its kinase activity. Biochem Biophys Res Commun. 2004 Aug 27;321(3):681-7. 19.Oike Y, Ito Y, Hamada K, Zhang XQ, Miyata K, Arai F, Inada T, Araki K, Nakagata N, Takeya M, Kisanuki YY, Yanagisawa M, Gale NW, Suda T. Regulation of vasculogenesis and angiogenesis by EphB/ephrin-B2 signaling between endothelial cells and surrounding mesenchymal cells. Blood. 2002 Aug 15;100(4):1326-33.
20.Arai F, Ohneda O, Miyamoto T, Zhang XQ, Suda T. Mesenchymal stem cells in perichondrium express activated leukocyte cell adhesion molecule and participate in bone marrow formation. J Exp Med. 2002 Jun 17;195(12):1549-63.
21.Suenobu S, Takakura N, Inada T, Yamada Y, Yuasa H, Zhang XQ, Sakano S, Oike Y, Suda T. A role of EphB4 receptor and its ligand, ephrin-B2, in erythropoiesis. Biochem Biophys Res Commun. 2002 May 10;293(3):1124-31.
22.Tang H, Zhang XQ, Naruse T, Ohbo K, Suda T. Expression and function of NJ-1 surface antigen in megakaryopoiesis. Biochem Biophys Res Commun. 2002 Apr 5;292(3):667-74.
23.Zhang XQ, Takakura N, Oike Y, Inada T, Gale NW, Yancopoulos GD, Suda T. Stromal cells expressing ephrin-B2 promote the growth and sprouting of ephrin-B2(+) endothelial cells. Blood. 2001 Aug 15;98(4):1028-37.