Xiuqin Zhang, M.D. Ph.D.

Principal Investigator, Pathology Core
Co-Principal Investigator, Nonhuman Primate Research Center
Room 236, Integrated Science Research Center, Yiheyuan Road 5, Haidian District,
Peking University
Beijing, China 100871
E-mail: zhangxq@pku.edu.cn
Phone: 86-10-6275-3420
2002, Ph.D., Medical Science, Kumamoto University Medical School, Japan; 1995, M.S., Clinical Pathology, China Medical University, Shenyang; 1995-1996, resident, Department of Pathology, China Academy of Medical Science, Fuwai Hospital, Beijing; 1996-1997, Research fellow, Department of Tumor Biology, Kumamoto University Medical School, Japan;. 1997-1998, stuff scientist, Department of Cell Differentiation, Kumamoto University Medical School, Japan; 2002-2006 Research Associate, Department of Molecular Biology and Pharmacology, Washington University School of Medicine, USA; 2006,3-2013.8, Associate Investigator; 2013.9-present, Principle Investigator, Institute of Molecular Medicine, Peking University.
Research Interests: mechanistic study of cardiovascular disease and metabolic syndrome; Pre-clinical study of novel drugs using nonhuman primate models; Intestine in metabolic diseases pathogenesis.
Publication:
1.Ting Zhang, Yan Zhang, Mingyao Cui, Li Jin, Yimei Wang, Fengxiang Lv, Xiuqin Zhang, Xinli Hu, Chun-Mei Cao, Rui-Ping Xiao. CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis. Nat Med. 2016 Jan 4. doi: 10.1038/nm.4017. [Epub ahead of print]
2.Ding Y, Fang H, Shang W, Xiao Y, Sun T, Hou N, Pan L, Sun X, Ma Q, Zhou J, Wang X, Zhang X, Cheng H. Mitoflash altered by metabolic stress in insulin-resistant skeletal muscle. J Mol Med (Berl). 2015 Oct;93(10):1119-30. (Corresponding author)
3.Chen JY, Peng Z, Zhang R, Yang XZ, Tan BC, Fang H, Liu CJ, Shi M, YeQ, Zhang YE, Deng M, Zhang X, Li CY. RNA editome in rhesus macaque shaped by purifying selection. PLoS Genet. 2014 Apr 10;10(4):e**. (Co-corresponding author)
4.Sun HT, Zhang J, Hou N, Zhang X, Wang J, Bai Y. Spontaneous periodontitis is associated with metabolic syndrome in rhesus monkeys. Arch Oral Biol. 2014 Apr;59(4):386-92.
5.Mao J, Hu X, Xiao Y, Yang C, Ding Y, Hou N, Wang J, Cheng H, Zhang X. Overnutrition stimulates intestinal epithelium proliferation through β-catenin signaling in obese mice. Diabetes. 2013 Nov;62(11):3736-46.
6.Song R, Peng W, Zhang Y, Lv F, Wu HK, Guo J, Cao Y, Pi Y, Zhang X, Jin L, Zhang M, Jiang P, Liu F, Meng S, Zhang X, Jiang P, Cao CM, Xiao RP. Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders. Nature. 2013 Feb 21;494(7437):375-9.
7.Zhang SJ, Liu CJ, Shi M, Kong L, Chen JY, Zhou WZ, Zhu X, Yu P, Wang J, Yang X, Hou N, Ye Z, Zhang R, Xiao R, Zhang X, Li CY. RhesusBase: a knowledgebase for the monkey research community. Nucleic Acids Res. 2013 Jan;41(Database issue):D892-905. (Co-corresponding author)
8.Zhang X, Zhang R, Raab S, Zheng W, Wang J, Liu N, Zhu T, Xue L, Song Z, Mao J, Li K, Zhang H, Zhang Y, Han C, Ding Y, Wang H, Hou N, Liu Y, Shang S, Li C, Sebokova E, Cheng H, Huang PL. Rhesus macaques develop metabolic syndrome with reversible vascular dysfunction responsive to pioglitazone. Circulation. 2011 Jul 5;124(1):77-86.
9.Fang H, Chen M, Ding Y, Shang W, Xu J, Zhang X, Zhang W, Li K, Xiao Y, Gao F, Shang S, Li JC, Tian XL, Wang SQ, Zhou J, Weisleder N, Ma J, Ouyang K, Chen J, Wang X, Zheng M, Wang W, Zhang X, Cheng H. Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals. Cell Res. 2011 Sep;21(9):1295-304. (Co-corresponding author)
10.Huang Y, Hong J, Zheng S, Ding Y, Guo S, Zhang H, Zhang X, Du Q, Liang Z. Elimination pathways of systemically delivered siRNA. Mol Ther. 2011 Feb;19(2):381-5.
11.Geske MJ, Zhang X, Patel KK, Ornitz DM, Stappenbeck TS. Fgf9 signaling regulates small intestinal elongation and mesenchymal development. Development. 2008 Sep;135(17):2959-68.
12.Zhao G, Zhao Y, Pan B, Liu J, Huang X, Zhang X, Cao C, Hou N, Wu C, Zhao KS, Cheng H. Hypersensitivity of BKCa to Ca2+ sparks underlies hyporeactivity of arterial smooth muscle in shock. Circ Res. 2007 Aug 31;101(5):493-502.
13.Smith SM, West LA, Govindraj P, Zhang X, Ornitz DM, Hassell JR. Heparan and chondroitin sulfate on growth plate perlecan mediate binding and delivery of FGF-2 to FGF receptors. Matrix Biol. 2007 Apr;26(3):175-84.
14.Zhang X, Ibrahimi OA, Olsen SK, Umemori H, Mohammadi M, Ornitz DM. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. J Biol Chem. 2006 Jun 9;281(23):15694-700.
15.Zhang X, Stappenbeck TS, White AC, Lavine KJ, Gordon JI, Ornitz DM. Reciprocal epithelial-mesenchymal FGF signaling is required for cecal development. Development. 2006 Jan;133(1):173-80. E
16.Lavine KJ, Yu K, White AC, Zhang X, Smith C, Partanen J, Ornitz DM. Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo. Dev Cell. 2005 Jan;8(1):85-95.
17.Pirvola U, Zhang X, Mantela J, Ornitz DM, Ylikoski J. Fgf9 signaling regulates inner ear morphogenesis through epithelial-mesenchymal interactions. Dev Biol. 2004 Sep 15;273(2):350-60.
18.Sakamoto H, Zhang XQ, Suenobu S, Ohbo K, Ogawa M, Suda T. Cell adhesion to ephrinb2 is induced by EphB4 independently of its kinase activity. Biochem Biophys Res Commun. 2004 Aug 27;321(3):681-7.
19.Oike Y, Ito Y, Hamada K, Zhang XQ, Miyata K, Arai F, Inada T, Araki K, Nakagata N, Takeya M, Kisanuki YY, Yanagisawa M, Gale NW, Suda T. Regulation of vasculogenesis and angiogenesis by EphB/ephrin-B2 signaling between endothelial cells and surrounding mesenchymal cells. Blood. 2002 Aug 15;100(4):1326-33.
20.Arai F, Ohneda O, Miyamoto T, Zhang XQ, Suda T. Mesenchymal stem cells in perichondrium express activated leukocyte cell adhesion molecule and participate in bone marrow formation. J Exp Med. 2002 Jun 17;195(12):1549-63.
21.Suenobu S, Takakura N, Inada T, Yamada Y, Yuasa H, Zhang XQ, Sakano S, Oike Y, Suda T. A role of EphB4 receptor and its ligand, ephrin-B2, in erythropoiesis. Biochem Biophys Res Commun. 2002 May 10;293(3):1124-31.
22.Tang H, Zhang XQ, Naruse T, Ohbo K, Suda T. Expression and function of NJ-1 surface antigen in megakaryopoiesis. Biochem Biophys Res Commun. 2002 Apr 5;292(3):667-74.
23.Zhang XQ, Takakura N, Oike Y, Inada T, Gale NW, Yancopoulos GD, Suda T. Stromal cells expressing ephrin-B2 promote the growth and sprouting of ephrin-B2(+) endothelial cells. Blood. 2001 Aug 15;98(4):1028-37.