陈凡
职称：研究员

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研究方向：植物发育的分子控制与应答


陈 凡，博士，研究员，博士生导师
　　1991年毕业于武汉大学生物化学专业，获理学学士学位。1994年在中国科学院武汉植物所获植物学专业硕士学位。1997年毕业于日本爱媛大学联合研究生院植物生物化学及分子生物学专业，获哲学博士学位。2013年国家****科学基金获得者。

　　 陈 凡博士领导的创新研究组主要研究方向是植物分子控制与应答,研究植物发育过程中特定信号转导途径及相关基因的表达与调控。主要研究内容：
　　1．植物环境耐受性形成及环境影响其生长发育的遗传基础
　　植物的生长发育与形态建成是一个复杂而有序的过程，正常生长、发育与分化是外界环境通过影响有限的特定调控元件和调控因子，使基因受控而有序表达的结果。非生物逆境，诸如干旱、低温、高盐碱等，都对植物生长构成环境压力，由此导致其生理应答与耐受性的形成。围绕植物内源激素在分子水平上对植物发育进程的调控和信号转导，对特定转录因子及相关基因进行功能研究，结合转录组分析和表观遗传学分析开展功能基因组学及基因表达调控网络研究，以期认识环境因素影响植物形态建成的本质。
　 　2．水稻侧分生组织分化及形态建成的分子调控
　　植物分枝发育在植物形态建成中具有十分重要的地位，作物的分枝是影响作物结实多少并进而影响单产的重要农艺性状之一，水稻植株在营养生长时期所产生的分蘖数及在生殖生长过程中所形成的花序分枝数和小花数，是影响其产量的重要的因子。水稻的分蘖、花序分枝以及它所着生的小花都是由侧生分生组织形成的。通过分离控制水稻侧发生组织发育相关的功能基因，从基因结构和互作，基因表达和调控，以及基因表达产物的生物学功能等方面，解析水稻穗型和分蘖等复杂性状形成的分子调控网络，以期揭示水稻侧发生组织分化和形态建成的遗传调控机理，为开展水稻高产的分子设计奠定基础。
KEY PUBLICATIONS
Liu S, Hua L, Dong S, Chen H, Zhu X, Jiang J, Zhang F, Li Y, Fang X, Chen F. OsMAPK6, a mitogen-activated protein kinase, influences rice grain size and biomass production. Plant Journal. 2015; 84, 672–681.
Bai J, Zhu X, Wang Q, Zhang J, Chen H, Dong G, Zhu L, Zheng H, Xie Q, Nian J, Chen F, Fu Y, Qian Q, Zuo J. Rice TUTOU1 Encodes a Suppressor of cAMP Receptor-Like Protein That Is Important for Actin Organization and Panicle Development. Plant Physiol. 2015;169(2):1179-91.
Mao J, Chi W, Ouyang M, He B, Chen F, Zhang L. PAB is an assembly chaperone that functions downstream of chaperonin 60 in the assembly of chloroplast ATP synthase coupling factor 1. Proceedings of the National Academy of Sciences of the United States of America. 2015;112(13):4152-7.
Wu P, Zhou C, Cheng S, Wu Z, Lu W, Han J, Chen Y, Ni P, Wang Y, Xu X, Huang Y, Song C, Wang Z, Shi N, Zhang X, Fang X, Yang Q, Jiang H, Li M, Chen F, Wang J, Wu G. Integrated genome sequence and linkage map of physic nut (Jatropha curcas L.), a biodiesel plant. Plant Journal. 2015;81(5):810-21.
Liu H, Wang C, Chen F, Shen S. Proteomic analysis of oil bodies in mature Jatropha curcas seeds with different lipid content. Journal of proteomics. 2015;113: 403-14.
Yanxia Xu, Saina Zhang, Haipeng Guo, Suikang Wang, Ligen Xu, Chuanyou Li, Qian Qian, Fan Chen, Markus Geisler, Yanhua Qi, and De An Jiang. OsABCB14 functions in auxin transport and iron homeostasis in rice (Oryza sativa L.). Plant Journal. 2014;79(1):106-17.
Jinjun Zhou, Qianqian Liu, Fang Zhang, Yingying Wang, Shiyong Zhang, Huimin Cheng, Lihua Yan, Li Li, Fan Chen, Xianzhi Xie. Overexpression of OsPIL15, a phytochrome-interacting factor-like protein gene, represses etiolated seedling growth in rice. Journal of Integrative Plant Biology. 2014; 56, 373-387.
Yu-Chan Zhang, Yang Yu, Cong-Ying Wang, Ze-Yuan Li, Qing Liu, Jie Xu, Jian-You Liao, Xiao-Jing Wang, Liang-Hu Qu, Fan Chen, Peiyong Xin, Cunyu Yan, Jinfang Chu, Hong-Qing Li & Yue-Qin Chen. Overexpression of microRNA OsmiR397 improves rice yield by increasing grain size and promoting panicle branching. Nature Biotechnology, 2013;31(9):848-52.
Jun Liu, Huixia Yang, Qingtao Lu, Xiaogang Wen, Fan Chen, Liangwei Peng, Lixin Zhang, Congming Lu. PSBP-DOMAIN PROTEIN1, a Nuclear-Encoded Thylakoid Lumenal Protein, Is Essential for Photosystem I Assembly in Arabidopsis. Plant Cell. 2012;24 (12):4992-5006.
Changhui Sun, Jun Fang, Taolan Zhao, Bo Xu, Fantao Zhang, Linchuan Liu, Jiuyou Tang, Genfa Zhang, Xiaojian Deng, Fan Chen, Qian Qian, Xiaofeng Cao, and Chengcai Chu. The Histone Methyltransferase SDG724 Mediates H3K36me2/3 Deposition at MADS50 and RFT1 and Promotes Flowering in Rice. Plant Cell, 2012, 24: 3235-3247.
Cheng Zhang, Fang Zhang, Jinjun Zhou, Zhongxue Fan, Fan Chen, Huiquan Ma, Xianzhi Xie. Overexpression of a phytochrome-regulated tandem zinc finger protein gene, OsTZF1 , confers hypersensitivity to ABA and hyposensitivity to red light and far-red light in rice seedlings. Plant Cell Reports. 2012, 31(7):1333-43.
Huawu Jiang, Pingzhi Wu, Sheng Zhang, Chi Song, Yaping Chen, Meiru Li, Yongxia Jia, Xiaohua Fang, Fan Chen, Guojiang Wu. Global Analysis of Gene Expression Profiles in Developing Physic Nut (Jatropha curcas L.) Seeds. PLoS One , 2012, 7(5): e36522.
Zhipan Yang, Qingtao Lu, Xiaogang Wen, Fan Chen, Congming Lu. Functional analysis of the rice rubisco activase promoter in transgenic Arabidopsis. Biochemical and Biophysical Research Communications. 2012, 418(3): 565-70.
Jing Liu, Fang Zhang, Jinjun Zhou, Fan Chen, Baoshan Wang, Xianzhi Xie. Phytochrome B control of total leaf area and stomatal density affects drought tolerance in rice. Plant Mol Biol. 2012, 78:289–300
Hiroaki Tabuchi, Yu Zhang, Susumu Hattori, Minami Omae, Sae Shimizu-Sato, Tetsuo Oikawa, Qian Qian, Minoru Nishimura, Hidemi Kitano, He Xie, Xiaohua Fang, Hitoshi Yoshida, Junko Kyozuka, Fan Chen, and Yutaka Sato. LAX PANICLE2 of Rice Encodes a Novel Nuclear Protein and Regulates the Formation of Axillary Meristems. Plant Cell, 2011, 23: 3276-3287
Dongyuan Zhang, Gongke Zhou, Binbin Liu, Yingzhen Kong, Na Chen, Qiang Qiu, Hongju Yin, Jiaxing An, Fang Zhang, and Fan Chen. HCF243 Encodes a Chloroplast-localized Protein Involved in the D1 Protein Stability of the Arabidopsis PSII Complex. Plant Physiol. 2011, 157: 608-619.
　
Jing Yang, Ming-Feng Yang, Wen-Peng Zhang, Fan Chen and Shi-Hua Shen. A putative flowering-time-related Dof transcription factor gene, JcDof3, is controlled by the circadian clock in Jatropha curcas. Plant Science, 2011, 181: 667-674.
　
Xi Yang, Ya-Nan Yang, Liang-Jiao Xue, Mei-Juan Zou, Jian-Ying Liu, Fan Chen, and Hong-Wei Xue. Rice ABI5-Like1 Regulates Abscisic Acid and Auxin Responses by Affecting the Expression of ABRE-Containing Genes. Plant Physiol. 2011 156: 1397-1409.
　
Min Ouyang, Xiaoyi Li, Jinfang Ma, Wei Chi, Jianwei Xiao, Meijuan Zou, Fan Chen, Congming Lu & Lixin Zhang. LTD is a protein required for sorting light-harvesting chlorophyll-binding proteins to the chloroplast SRP pathway. Nature Communications 2011, 2, 277, doi:10.1038/ncomms1278
　
Jing Yang, Ming-Feng Yang, Dan Wang, Fan Chen and Shi-Hua Shen. JcDof1, a Dof transcription factor gene, is associated with the light-mediated circadian clock in Jatropha curcas. Physiologia Plantarum, 2010, 139: 324–334.
　
Xiao-Juan Li, Ming-Feng Yang, Hui Chen, Le-Qing Qu, Fan Chen, Shi-Hua Shen. Abscisic acid pretreatment enhances salt tolerance of rice seedlings: Proteomic evidence. Biochimica et Biophysica Acta (BBA-PROTEINS PROTEOM), 2010, 1804: 929–940.
　
Xinyu Jian, Lin Zhang, Guanglin Li, Liang Zhang, Xiujie Wang, Xiaofeng Cao, Xiaohua Fang, Fan Chen. Identification of novel stress-regulated microRNAs from Oryza sativa L. Genomics, 2010, 95: 47-55
　
Yucheng Guan, Haibo Ren, He Xie, Zeyang Ma and Fan Chen. Identification and characterization of bZIP-type transcription factors involved in carrot (Daucus carota L.) somatic embryogenesis. The Plant Journal , 2009, 60: 207–217.
　
Ming-Feng Yang, Yu-Jun Liu, Yun Liu, Hui Chen, Fan Chen and Shi-Hua Shen. Proteomic analysis of oil mobilization in seed germination and postgermination development of Jatropha curcas. Journal of Proteome Research, 2009, 8 (3): 1441–1451.
　
Dangwei Zhou, Jie Zhou, Lihua Meng, Qingbiao Wang, He Xie, Yucheng Guan, Zeyang Ma, Yang Zhong, Fan Chen and Jianquan Liu. Duplication and adaptive evolution of the COR15 genes within the highly cold-tolerant Draba lineage (Brassicaceae). Gene, 2009, 441: 36–44.
　
Ruoyu Luo, Haibin Wei, Lin Ye, Kankan Wang, Fan Chen, Lijun Luo, Lei Liu, Yuanyuan Li, M. James C. Crabbe, Li Jin, Yixue Li, and Yang Zhong. Photosynthetic metabolism of C₃ plants shows highly cooperative regulation under changing environments: A systems biological analysis. Proc Natl Acad Sci U S A, 2009, 106:847-852.
　
Qiuyun Wang, Yucheng Guan, Yaorong Wu, Honglin Chen, Fan Chen, Chengcai Chu. Overexpression of a rice OsDREB1F gene increases salt, drought, and low temperature tolerance in both Arabidopsis and rice. Plant Molecular Biology, 2008. 67:589–602.
　
Wei Chi, Jinfang Ma, Dongyuan Zhang, Jinkui Guo, Fan Chen, Congming Lu, Lixin Zhang. The PPR Protein DG1 is Involved in the Regulation of Early Chloroplast Development and Chloroplast Gene Expression in Arabidopsis thaliana. Plant Physiology, 2008, 147: 573-584
　
Jun Fang, Chenglin Chai, Qian Qian, Chunlai Li, Jiuyou Tang. Lei Sun, Zejun Huang, Xiaoli Guo, Changhui Sun, Ming Liu, Yan Zhang, Qingtao Lu, Yiqing Wang, Congming Lu, Bin Han, Fan Chen, Zhukuan Cheng, Chengcai Chu. Mutations of genes in synthesis of the carotenoid precursors of ABA lead to preharvest sprouting and photo-oxidation in rice. The Plant Journal, 2008. 54:177–189
　
Meijuan Zou, Yucheng Guan, Haibo Ren, Fang Zhang, Fan Chen. A bZIP transcription factor, OsABI5, is involved in rice fertility and stress tolerance. Plant Molecular Biology, 2008. 66:675–683
　
Yue-Ping Ma, Xiao-Hua Fang, Fan Chen, Si-Lan Dai. DFL, a FLORICAULA/LEAFY homologue gene from Dendranthema lavandulifolium is expressed both in the vegetative and reproductive tissues. Plant Cell Rep. 2008, 27:647–654
　
Huawu Jiang, Meiru Li, Naiting Liang, Hongbo Yan, Yubo Wei, Xinlan Xu, Jian Liu, Zhifang Xu, Fan Chen, Guojiang Wu. Molecular cloning and function analysis of the stay green gene in rice. The Plant Journal, 2007, 52(2): 197-209.
　
Pingfang Yang, Xiaojuan Li, Xiaoqin Wang, Hui Chen, Fan Chen and Shihua Shen. Proteomic analysis of rice (Oryza sativa) seeds during germination. Proteomics 2007, 7: 3358–3368
　
Meijuan Zou, Yucheng Guan, Haibo Ren, Fang Zhang, Fan Chen. Characterization of alternative splicing products of bZIP transcription factors OsABI5. Biochem. Biophys. Res. Commun. 2007, 360: 307-313.
　
Mingjuan Tang, Jingwen Sun, Yun Liu, Fan Chen, Shihua Shen. Isolation and functional characterization of the JcERF gene, a putative AP2/EREBP domain-containing transcription factor, in the woody oil plant Jatropha curcas. Plant Mol Biol .,2007, 63:419–428
　
Yan LIU, Chang-an GUO, Haibo REN, Fan CHEN. Isolation and characterization of a novel cis-acting sequences regulating root-specific gene from Daucus carota L. Chinese Science Bulletin, 2004, 49（22）:2393-2398.
　
XiaohuaFang, SuhaiGu, ZhanyouXu, FanChen, DedongGuo, Hong-BinZhang and NaihuWu. Construction of a binary BAC library for an apomictic monosomic addition line of Beta corolliflora in sugar beet and identification of the clones derived from the alien chromosome. Theoretical and Applied Genetics, 2004, 108：1420-1425.
　
Mei QI, Meijuan HUANG, Fan CHEN. Isolation of the transcription factors that binding auxin response elements using a yeast one-hybrid system. Science in China (Serial C), 2002, 45(2):177-185.
　
Lan NAN, Huixin LIN, Yucheng GUAN, Fan CHEN. Functional analysis of cis-acting sequences regulating root-specific expression in transgenic tobacco. Chinese Science Bulletin, 2002,47(17):1441-1445.
　
Fan Chen, Youichi Okabe, Kaoru Osano, and Shigeyuki Tajima. Purification and characterization of a NAD-malic enzyme from Bradyrhizobium japonicum A1017. Applied and Environmental Microbiology. 1998. 64 (10): 4073-4075.
　
Fan Chen, Youichi Okabe, Kaoru Osano, and Shigeyuki Tajima. Purification and characterization of the NADP-malic enzyme from Bradyrhizobium japonicum A1017. Bioscience, Biotechnology, and Biochemistry. 1997. 61 (2): 384-386.