陆发隆
职称：研究员

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研究方向：表观遗传与细胞命运决定


陆发隆，博士，研究员，博士生导师
教育经历
2000-2004， 北京大学生命科学学院， 获学士学位
2004-2011， 中国科学院遗传与发育生物学研究所， 获博士学位
工作经历
2012/1-2012/8， 北卡罗来纳大学教堂山分校/霍华德休斯医学研究所， 博士后
2012/8-2017/4， 波士顿儿童医院/哈佛医学院/霍华德休斯医学研究所， 博士后
2017/4-今， 中国科学院遗传与发育生物学研究所， 研究员

研究方向
1. 表观遗传调控的生物化学机理，例如DNA甲基化谱建立的生物化学基础；
2. 哺乳动物合子基因组激活机理；
3. 细胞命运决定过程中染色质上发生的可遗传变化及其机制。
博士后和实习生招聘信息
本实验室常年招生博士后和实习生，欢迎直接与导师直接联系。
发表论文:
https://scholar.google.com/citations?user=KpY_gqMAAAAJ&hl=en
1.Yusheng Liu, Hu Nie, Hongxiang Liu, and Falong Lu. (2019). Poly(A) inclusive RNA isoform sequencing (PAIso-seq) reveals wide-spread non-adenosine residues within RNA poly(A) tails. Nature Communications 10, 5292
2.Luis Tuesta, Mohamed Djekidel, Renchao Chen, Falong Lu, Wengang Wang, Bernardo Sabatini, and Yi Zhang. (2019). In vivo nuclear capture and molecular profiling identifies Gmeb1 as a transcriptional regulator essential for dopamine neuron function. Nature Communications 10(1): 2508.
3.Qi Qiu, Hailiang Mei, Xian Deng, Kaixuan He, Baixing Wu, Qingqing Yao, Jixiang Zhang, Falong Lu, Jinbiao Ma & Xiaofeng Cao. (2019). DNA methylation repels targeting of Arabidopsis REF6. Nature Communications 10(1): 2063.
4.Shogo Matoba, Huihan Wang, Lan Jiang, Falong Lu, Kumiko Iwabuchi, Xiaoji Wu, Kimiko Inoue, Lin Yang, William Press, Jeannie Lee, Atsuo Ogura, Li Shen, and Yi Zhang. (2018). Loss of H3K27me3 Imprinting in Somatic Cell Nuclear Transfer Embryos Disrupts Post-Implantation Development. Cell Stem Cell 23(3): 343-354 e345.
5.Mohamed Nadhir Djekidel, Azusa Inoue, Shogo Matoba, Tsukasa Suzuki, Chunxia Zhang, Falong Lu, Lan Jiang, Yi Zhang. (2018). Reprogramming of Chromatin Accessibility in Somatic Cell Nuclear Transfer Is DNA Replication Independent. Cell Reports 23(7): 1939-1947.
6.Falong Lu. (2018). The start of a human life program. Journal of Genetics and Genomics 45(4): 183-184.
7.Azusa Inoue#, Lan Jiang#, Falong Lu#, Tsukasa Suzuki, and Yi Zhang. (2017). Maternal H3K27me3 controls DNA methylation-independent imprinting. Nature 547(7664): 419-424. (# co-first author)
8.Azusa Inoue, Lan Jiang, Falong Lu, and Yi Zhang. (2017). "Genomic imprinting of Xist by maternal H3K27me3." Genes & Development 31(19): 1927-1932.
9.Falong Lu#, Yuting Liu#, Azusa Inoue#, Tsukasa Suzuki, Keji Zhao, and Yi Zhang. (2016). Establishing chromatin regulatory landscape during mouse preimplantation development. Cell 165(6): 1375-1388. (# co-first author)
10.Xia Cui#, Falong Lu#, Qi Qiu#, Bing Zhou#, Lianfeng Gu, Shuaibin Zhang, Yanyuan Kang, Xiekui Cui, Xuan Ma, Qingqing Yao, Jinbiao Ma, Xiaoyu Zhang, and Xiaofeng Cao. (2016). REF6 recognizes specific DNA sequence to regulate H3K27me3 demethylation and organ boundary formation. Nature Genetics 48(6): 694-699. (# co-first author)
11.Minchul Kim, Falong Lu and Yi Zhang. (2016). Loss of HDAC-Mediated Repression and Gain of NF-kappaB Activation Underlie Cytokine Induction in ARID1A- and PIK3CA-Mutation-Driven Ovarian Cancer. Cell Reports 17(1): 275-288.
12.Fangfang Jiang, Falong Lu, Peixue Li, Wei Liu, Lu Zhao, Qifu Wang, Xiaofeng Cao, Lei Zhang and Yong Q. Zhang. (2016). Drosophila Homolog of FMRP Maintains Genome Integrity by Interacting with Piwi. Journal of Genetics and Genomics 43(1): 11-24.
13.Falong Lu and Yi Zhang. (2015). Cell totipotency: molecular features, induction, and maintenance. National Science Review 2(2): 217-225.
14.Young Gie Chung, Shogo Matoba, Yuting Liu, Jin Hee Eum, Falong Lu, Wei Jiang, Jeoung Eun Lee, Vicken Sepilian, Kwang Yul Cha, Dong Ryul Lee, Yi Zhang. (2015). Histone Demethylase Expression Enhances Human Somatic Cell Nuclear Transfer Efficiency and Promotes Derivation of Pluripotent Stem Cells. Cell Stem Cell 17(6): 758-766.
15.Shuaibin Zhang, Bing Zhou, Yanyuan Kang, Xia Cui, Ao Liu, Angelique Deleris, Maxim V. C. Greenberg, Xiekui Cui, Qi Qiu, Falong Lu, James A. Wohlschlegel, Steven E. Jacobsen, and Xiaofeng Cao. (2015). C-terminal domains of histone demethylase JMJ14 interact with a pair of NAC transcription factors to mediate specific chromatin association. Cell Discovery 1: 15003.
16.Falong Lu#, Yuting Liu#, Lan Jiang#, Shinpei Yamaguchi, and Yi Zhang. (2014). Role of Tet proteins in enhancer activity and telomere elongation. Genes & Development 28(19): 2103-2119. (# co-first author)
17.Shogo Matoba, Yuting Liu, Falong Lu, Kumiko A. Iwabuchi, Li Shen, Azusa Inoue, and Yi Zhang. (2014). Embryonic Development following Somatic Cell Nuclear Transfer Impeded by Persisting Histone Methylation. Cell 159(4): 884-895.
18.Li Shen, Azusa Inoue, Jin He, Yuting Liu, Falong Lu, and Yi Zhang. (2014). Tet3 and DNA Replication Mediate Demethylation of Both the Maternal and Paternal Genomes in Mouse Zygotes. Cell Stem Cell 15(4): 459-470.
19.Runlai Hang, Chunyan Liu, Ayaz Ahmad, Yong Zhang, Falong Lu, and Xiaofeng Cao. (2014). Arabidopsis protein arginine methyltransferase 3 is required for ribosome biogenesis by affecting precursor ribosomal RNA processing. Proc Natl Acad Sci USA 111(45): 16190-16195.
20.Xia Cui#, Falong Lu#, Yue Li, Yongming Xue, Yanyuan Kang, Shuaibin Zhang, Qi Qiu, Xiekui Cui, Suzhi Zheng, Bin Liu, Xiaodong Xu, and Xiaofeng Cao. (2013). Ubiquitin-specific proteases UBP12 and UBP13 act in circadian clock and photoperiodic flowering regulation in Arabidopsis. Plant Physiology 162(2): 897-906. (# co-first author)
21.Lifang Niu#, Falong Lu#, Taolan Zhao#, Chunyan Liu, and Xiaofeng Cao. (2012). The enzymatic activity of Arabidopsis protein arginine methyltransferase 10 is essential for flowering time regulation. Protein & Cell 3(6): 450-459. (# co-first author)
22.Falong Lu#, Xia Cui#, Shuaibin Zhang, Thomas Jenuwein, and Xiaofeng Cao. (2011). Arabidopsis REF6 is a Histone H3 Lysine 27 Demethylase. Nature Genetics 43(7): 715-719. (# co-first author)
23.Yuan Cheng, Monica Frazier, Falong Lu, Xiaofeng Cao and Matthew R. Redinbo. (2011). Crystal Structure of the Plant Epigenetic Protein Arginine Methyltransferase 10. Journal of Molecular Biology 414(1): 106-122.
24.Falong Lu#, Xia Cui#, Shuaibin Zhang, Chunyan Liu, and Xiaofeng Cao. (2010). JMJ14 is an H3K4 demethylase regulating flowering time in Arabidopsis. Cell Research 20, 387-390. (# co-first author)
25.Chunyan Liu, Falong Lu, Xia Cui, and Xiaofeng Cao. (2010). Histone methylation in higher plants. Annual Review of Plant Biology 61, 395-420.
26.Soichi Inagaki, Asuka Miura-Kamio, Yasukazu Nakamura, Falong Lu, Xia Cui, Xiaofeng Cao, Hiroshi Kimura, Hidetoshi Saze, and Tetsuji Kakutani. (2010). Autocatalytic differentiation of epigenetic modifications within the Arabidopsis genome. EMBO Journal 29, 3496-3506.
27.Xian Deng, Lianfeng Gu, Chunyan Liu, Tiancong Lu, Falong Lu, Zhike Lu, Peng Cui, Yanxi Pei, Baichen Wang, Songnian Hu, and Xiaofeng Cao. (2010). Arginine methylation mediated by the Arabidopsis homolog of PRMT5 is essential for proper pre-mRNA splicing. Proc Natl Acad Sci USA 107, 19114-19119.
28.Falong Lu#, Guanglin Li#, Xia Cui#, Chunyan Liu, Xiu-Jie Wang and Xiaofeng Cao. (2008). Comparative analysis of JmjC domain-containing proteins in higher plants and human reveals potential histone demethylases in Arabidopsis and rice. Journal of Integrative Plant Biology. 50 (7): 886–896. (# co-first author)
29.Lifang Niu#, Falong Lu#, Yanxi Pei, Chunyan Liu and Xiaofeng Cao. (2007). Regulation of Flowering Time by a Protein Arginine Methyltransferase, AtPRMT10. EMBO Reports. 8(12):1190-1195. (# co-first author)
30.Yanxi Pei#, Lifang Niu#, Falong Lu#, Chunyan Liu#, Jixian Zhai, Xiangfeng Kong and Xiaofeng Cao. (2007). Mutations in the Type II protein arginine methyltransferase AtPRMT5 result in pleiotropic developmental defects in Arabidopsis thaliana. Plant Physiology. 144:1913-1923. (# co-first author)
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Nat Comm | 陆发隆组发开PAIso-seq方法揭示RNA poly(A)尾巴内部广泛存在其他碱基修饰
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