税光厚
职称：研究员

职务：所级公共技术服务中心主任、脂组学平台主任

联系电话：86-

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研究方向：应用系统脂组学方法研究脂与遗传、发育相关疾病的内在联系。


税光厚，博士, 研究员，博士生导师
　　2004年获新加坡国立大学 (National University of Singapore)博士学位，同年进入新加坡国立大学生物化学系从事博士后研究。 2008-2012年任新加坡国立大学生命科学院高级研究员，新加坡国立大学脂组学中心副主任。 2013年加入中国科学院遗传与发育生物学研究所。2013年入选中国科学院****。

研究方向　　开发高通量、高敏度、新颖的系统脂组学方法，并应用系统脂组学方法研究 (1) 脂组分变化与遗传、发育异常的内在联系； (2) 脂类与发育、代谢相关的疾病（糖尿病、心血管病），神经退行性疾病（老年痴呆症、帕金森病）等的内在联系。

发表的文章(*通讯作者； #共同第一作者)
1. Li R, Sun Q, Lam SM, Chen R, Zhu J, Gu W, Zhang L, Tian H, Zhang K, Chen LC, Sun Q, Shui G*, Liu C*. Sex-dependent effects of ambient PM2.5 pollution on insulin sensitivity and hepatic lipid metabolism in mice. Part Fibre Toxicol. 2020 Apr 22;17(1):14.
2. Wang W, Li S, Li Z, Zhang J, Fan K, Tan G, Ai G, Lam SM,Shui G, Yang Z, Lu H, Jin P, Li Y, Chen X, Xia X, Liu X, Dannelly HK, Yang C, Yang Y, Zhang S, Alterovitz G, Xiang W, Zhang L. Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces. Nat Biotechnol. 2020, 38(1):76-83.
3. Che L, Chi W, Qiao Y, Zhang J, Song X, Liu Y, Li L, Jia J, Pilo M8, Wang J, Cigliano A, Ma Z, Kuang W, Tang Z, Zhang Z, Shui G, Ribback S, Dombrowski F, Evert M, Pascale RM, Cossu C, Pes GM, Osborne TF, Calvisi DF Chen X, Chen L. Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans. Gut. 2020, 69(1):177-186.
4. Shi JH,Lu JY,Chen HY,Wei CC,Xu X,Li H,Bai Q,Xia FZ,Lam SM,Zhang H,Shi YN,Cao D,Chen L,Shui G,Yang X,Lu Y,Chen YX,Zhang WJ. Liver ChREBP Protects Against Fructose-Induced Glycogenic Hepatotoxicity by Regulating L-Type Pyruvate Kinase. Diabetes.2020 Apr;69(4):591-602.
5. Tian H,Zhou Z,Shui G*,Lam SM*. Extensive Profiling of Polyphenols from twoTrolliusSpecies Using a Combination of Untargeted and Targeted Approaches. Metabolites.2020 Mar 23;10(3).
6. Zhao H,Ma B,Duan KX,Li XK,Lu X,Yin CC,Tao JJ,Wei W,Zhang WK,Xin P,Lam SM,Chu J,Shui G,Chen SY,Zhang JS. The GDSL Lipase MHZ11 Modulates Ethylene Signaling in Rice Roots. Plant Cell.2020 Mar 17. doi: 10.1105.
7. Li X, Shi Z, Zhu Y, Shen T, Wang H, Shui G, Loor JJ, Fang Z, Chen M, Wang X, Peng Z, Song Y, Wang Z1, Du X, Liu G. Cyanidin-3-O-glucoside improves non-alcoholic fatty liver disease by promoting PINK1-mediated mitophagy in mice. Br J Pharmacol. 2020 (in press) doi: 10.1111.
8. Hou B,Zhao Y,He P,Xu C,Ma P,Lam SM,Li B,Gil V,Shui G,Qiang G,Liew CW,Du G. Targeted lipidomics and transcriptomics profiling reveal the heterogeneity of visceral and subcutaneous white adipose tissue. Life Sci.2020 Mar 15;245:117352.
9. Wu L,Zhang X,Zheng L,Zhao H,Yan G,Zhang Q,Zhou Y,Lei J,Zhang J,Wang J,Xin R,Jiang L,Peng J,Chen Q,Lam SM,Shui G,Miao H,Li Y. RIPK3 Orchestrates Fatty Acid Metabolism in Tumor-Associated Macrophages and Hepatocarcinogenesis. Cancer Immunol Res.2020 Mar 2. doi: 10.1158.
10. Wang R，Li B，Lam SM*，Shui G*. Integration of lipidomics and metabolomics for in-depth understanding of cellular mechanism and disease progression. J Genet. Genomics. 2020 Feb 20;47(2):69-83.
11. Yue F,Xia K,Wei L,Xing L,Wu S,Shi Y,Lam SM,Shui G,Xiang X,Russell R,Zhang D. Effects of constant light exposure on sphingolipidomics and progression of NASH in high-fat-fed rats. J Gastroenterol Hepatol.2020 Feb 6. doi: 10.1111.
12. Chen Y, Lin C, Guo Z, Zhao S, Zhu Y, Huang F, Shui G, Lam SM, Pu J, Yan Y, Liu Z, Zhang B. Altered Expression Profile of Phosphatidylinositols in Erythrocytes of Alzheimer’s Disease and Amnestic Mild Cognitive Impairment Patients. J Alzheimers Dis. 2020;73(2):811-818.
13. Huang D, Sun Y, Ma Z, Ke M, Cui Y, Chen Z, Chen C, Ji C, Tran TM, Yang L, Lam SM, Han Y, Shui G, Friml J, Miao Y, Jiang L, Chen X. Salicylic acid-mediated plasmodesmal closure via Remorin-dependent lipid organization. Proc Natl Acad Sci. 2019, 116(42): 21274-21284.
14. Quan LH, Zhang C, Dong MJiang J, Xu H, Yan C, Liu X, Zhou H, Zhang H, Chen L, Zhong FL, Luo ZB, Lam SM, Shui G, Li D, Jin W. Myristoleic acid produced by enterococci reduces obesity through brown adipose tissue activation. Gut. 2019 Nov 19. pii: gutjnl-2019-319114.
15. Sun X, Li X, Jia H, Wang H, Shui G, Qin Y, Shu X, Wang Y, Dong J, Liu G, Li X. Nrf2 mediates oxidative stress-induced lipid accumulation in adipocytes by increasing adipogenesis and decreasing lipolysis. Antioxid Redox Signal. 2020, 32(3):173-192.
16. Lu J#, Lam SM#, Wan Q, Shi L, Huo Y, Chen L, Tang X, Li B, Wu X, Peng K, Li M, Wang S, Xu Y, Xu M, Bi Y, Ning G, Shui G*, Wang W*. High-Coverage Targeted Lipidomics Reveals Novel Serum Lipid Predictors and Lipid Pathway Dysregulation Antecedent to Type 2 Diabetes Onset in Normoglycemic Chinese Adults. Diabetes Care. 42(2019):2117-2126..
17. Yang X, Liang J, Ding L, Li X, Lam SM, Shui G, Ding M, Huang X. Phosphatidylserine synthase regulates cellular homeostasis through distinct metabolic mechanisms. PLoS Genet. 2019,15(12):e**.
18. He P, Hou B, Li Y, Xu C, Ma P, Lam SM, Gil V, Yang X, Yang X, Zhang L,Shui G, Song J, Qiang G, Liew CW, Du G. Lipid Profiling Reveals Browning Heterogeneity of White Adipose Tissue by Β3-Adrenergic Stimulation. Biomolecules.2019, 9,444
19. Chen L, Ma MY, Sun M, Jiang LY, Zhao XT, Fang XX, Lam SM,Shui GH, Luo J, Shi XJ, Song BL. Endogenous sterol intermediates of the mevalonate pathway regulate HMG-CoA reductase degradation and SREBP-2 processing. J Lipid Res.60(2019):1765-1775.
20. Pan J, Tao C, Cao C, Zheng Q, Lam SM,Shui G, Liu X, Li K, Zhao J, Wang Y. Adipose lipidomics and RNA-Seq analysis revealed the enhanced mitochondrial function in UCP1 knock-in pigs. Biochim Biophys Acta Mol Cell Biol Lipids.1864(2019):1375-1383.
21. Cao Z, Hao Y, Fung CW, Lee YY, Wang P, Li X, Xie K, Lam WJ, Qiu Y, Tang BZ,Shui G, Liu P, Qu J, Kang BH, Mak HY. Dietary fatty acids promote lipid droplet diversity through seipin enrichment in an ER subdomain. Nat Commun. 10(2019):2902.
22. Pan S, Lin Y, Liu Q, Duan J, Lin Z, Wang Y, Wang X, Lam SM, Zou Z, Shui G, Zhang Y, Zhang Z, Zhan X. Convergent genomic signatures of flight loss in birds suggest a switch of main fuel. Nat Commun. 2019, 10(1):2756.
23. Li B, Li L, Li M, Lam SM, Wang G, Wu Y, Zhang H, Niu C, Zhang X, Liu X, Hambly C, Jin W, Shui G, Speakman JR. Microbiota Depletion Impairs Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue. Cell Rep. 2019, 26(10):2720-2737.
24. Wang XH, Su M, Gao F, Xie W, Zeng Y, Li DL, Liu XL, Zhao H, Qin L, Li F, Liu Q, Clarke OB, Lam SM, Shui GH, Hendrickson WA, Chen YH. Structural basis for activity of TRIC counter-ion channels in calcium release. Proc Natl Acad Sci. 2019, 116(10): 4238-43.
25. Liu Y, Ji Y, Li X, Shui G, Huang X. Lipid storage regulator CdsA is essential for Drosophila metamorphosis. J Genet Genomics. 2019, 46(4):231-234.
26. Wang X, Cao C, Li Y, Hai T, Jia Q, Zhang Y, Zheng Q, Yao J, Qin G, Zhang H, Song R, Wang Y, Shui G, Lam SM, Liu Z, Wei H, Meng A, Zhou Q, Zhao J. A harlequin ichthyosis pig model with a novel ABCA12 mutation can be rescued by acitretin treatment. J Mol Cell Biol. 2019, 11(12):1029-1041.
27. Ma J, Wang R, Lam SM, Zhang C, Shui G*, Li W*. Plasma lipidomic profiling in murine mutants of Hermansky-Pudlak syndrome reveals differential changes in pro- and anti-atherosclerotic lipids. Biosci Rep. 2019, 39(2): BSR**.
28. Wang W, Xin J, Yang X, Lam SM,Shui G*, Wang Y*, Huang X*. Lipid-gene regulatory network reveals coregulations of triacylglycerol with phosphatidylinositol/lysophosphatidylinositol and with hexosyl-ceramide. Biochim Biophys Acta Mol Cell Biol Lipids. 2018, 1864(2):168-180.
29. Gong H, Li J, Xu A, Tang Y, Ji W, Gao R, Wang S, Yu L, Tian C, Li J, Yen HY, Man Lam S,Shui G, Yang X, Sun Y, Li X, Jia M, Yang C, Jiang B, Lou Z, Robinson CV, Wong LL, Guddat LW, Sun F, Wang Q, Rao Z. An electron transfer path connects subunits of a mycobacterial respiratory supercomplex. Science. 2018, 362(6418).
30. Si X, Li Y, Shang W,Shui G, Lam SM, Blanchard CL, Strappe P, Zhou Z. Gamma-Aminobutyric Acid Attenuates High-Fat Diet Induced Cerebral Oxidative Impairment via Enhanced Synthesis of Hippocampal Sulfatides. J Agric Food Chem. 2019; 67(4):1081-1091/
31. Zhang F,Wang Y,Wang T,Yao L,Lam SM, Huang X,Fan J,Wang Q,Liu L,Jiang Y,Zhang H,Shi L,Yu M, Shui G,Wang Y,Gao F,Zhang X,Xu Z. cTAGE5/MEA6 plays a critical role in neuronal cellular components trafficking and brain development. PNAS. 2018, 115(40):E9449-E9458.
32. Deng X, Yuan S, Cao H, Lam SM, Shui G, Hong Y, Wang X. Phosphatidylinositol-hydrolyzing phospholipase C4 modulates rice response to salt and drought. Plant Cell Environ. 2019;42(2):536-548.
33. Ding L, Yang X, Tian H, Liang J, Zhang F, Wang G, Wang Y, Ding M, Shui G, Huang X.EMBO J. Seipin regulates lipid homeostasis by ensuring calcium-dependent mitochondrial metabolism. EMBO J. 2018, 37(17): e97572.
34. Li TY, Song L, Sun Y, Li J, Yi C, Lam SM, Xu D, Zhou L, Li X, Yang Y, Zhang CS, Xie C, Huang X, Shui G, Lin SY, Reue K, Lin SC. Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate. Nat Commun. 2018, 15;9(1):1916.
35. Liao J, Guan Y, Chen W, Shi C, Yao D, Wang F, Lam SM, Shui G, Cao X. ACBD3 is required for FAPP2 transferring glucosylceramide through maintaining the Golgi integrity. J Mol Cell Biol. 2019;11(2):107-117..
36. Lam SM, Wang R, Miao H, Li B, Shui G*: An integrated method for direct interrogation of sphingolipid homeostasis in the heart and brain tissues of mice through postnatal development up to reproductive senescence. Anal. Chim. Acta. 2018, 1037:152-158
37. Si X, Shang W, Zhou Z,Shui G, Lam SM, Blanchard C, Strappe P. Gamma-aminobutyric Acid Enriched Rice Bran Diet Attenuates Insulin Resistance and Balances Energy Expenditure via Modification of Gut Microbiota and Short-Chain Fatty Acids. J Agric Food Chem. 66(2018):881-890.
38. Gao M, Yin X, Yang W, Lam SM, Tong X, Liu J, Wang X, Li Q, Shui G, He Z, GDSL lipases modulate immunity through lipid homeostasis in rice. PLoS pathogens 2017, 13(11):e**.
39. Tian H, Li B, Shui G*, Untargeted LC–MS Data Preprocessing in Metabolomics. Journal of Analysis and Testing 2017, 1:187-192.
40. Lam SM, Wang Z, Li J, Huang X, Shui G*: Sequestration of polyunsaturated fatty acids in membrane phospholipids of Caenorhabditis elegans dauer larva attenuates eicosanoid biosynthesis for prolonged survival. Redox Biol 2017(12), 12:967-977.
41. Yan Y, Wang H, Hu M, Jiang L, Wang Y, Liu P, Liang X, Liu J, Li C, Lindstrom-Battle A , Lam SM, Shui G, Deng W, Jiao R*, HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila. Dev Cell 2017, 43(1):99-111.
42. Zhang J, Zhang Y, Wu W, Wang F, Liu X, Shui G, Nie CL: Guanylate-binding protein 2 regulates Drp1-mediated mitochondrial fission to suppress breast cancer cell invasion. Cell Death Dis 2017, 8(10):e3151
43. Lam SM, Tian H, Shui G*: Lipidomics, en route to accurate quantitation. BBA-Mol Cell Biol L 2017, 1862(8):752-761.
44. Fan W, Lam SM, Xin J, Yang X, Liu Z, Liu Y, Wang Y, Shui G, Huang X: Drosophila TRF2 and TAF9 regulate lipid droplet size and phospholipid fatty acid composition. Plos Genet 2017, 13(3) :e**.
45. Lam SM, Wang Y, Li B, Du J, Shui G*: Metabolomics through the lens of precision cardiovascular medicine. J Genet Genomics 2017, 44(3):127-138.
46. Li Q, Lu X, Song Q, Chen H, Wei W, Tao J, Bian X, Shen M, Ma B, Zhang W, Bi Y, Li W, Lai Y, Lam SM,Shui G, Chen S, Zhang J, Selection for a Zinc-Finger Protein Contributes to Seed Oil Increase during Soybean Domestication. Plant Physiol 2017, 173(4):2208-2224.
47. Su X, Liu S, Zhang X, Lam SM, Hu X, Zhou Y, Chen J, Wang Y, Wu C, Shui G, Lu MJ, Pei RJ, Chen XW*: Requirement of cytosolic phospholipase A2 gamma in lipid droplet formation. BBA-Mol Cell Biol L 2017, 1862(7):692-705.
48. Tian H, Lam SM,Shui G*. Metabolomics, a Powerful Tool for Agricultural Research.Int J Mol Sci11(2016):1871.
49. Huang Y, Huang S, Lam SM, Liu Z,Shui G, Zhang YQ. Acsl, the Drosophila ortholog of intellectual-disability-related ACSL4, inhibits synaptic growth by altered lipids.J Cell Sci129(2016):4034-4045.
50. Lam SM, Chua GH, Li XJ, Su B,Shui G*. Biological relevance of fatty acyl heterogeneity to the neural membrane dynamics of Rhesus macaques during normative aging.Oncotarget7 (2016): 55970-89.
51. Wang Y, Liu L, Zhang H, Fan J, Zhang F, Yu M, Shi L, Yang L, Lam SM, Wang H, Chen X, Wang Y, Gao F, Shui G, Xu Z.Mea6 controls VLDL transport through the coordinated regulation of COPII assembly.Cell Res.26(2016):787-804.
52. Chatterjee P, Lim WL,Shui G, Gupta VB, James I, Fagan AM, et al.Plasma Phospholipid and Sphingolipid Alterations in Presenilin1 Mutation Carriers: A Pilot Study.J Alzheimers Dis.50(2016):887-94.
53. Begum H, Li B,Shui G, Cazenave-Gassiot A, Soong R, Ong RT, Little P, Teo YY, Wenk MR.Discovering and validating between-subject variations in plasma lipids in healthy subjects.Sci Rep. 6(2016):19139
54. Jin J, Li Y, Ren J, Lam SM, Zhang Y, Hou Y, Zhang X, Xu R, Shui G, Ma RZ.Neonatal Respiratory Failure with Retarded Perinatal Lung Maturation in Mice Caused by Reticulocalbin 3 Disruption.Am J Respir Cell Mol Biol. 54(2016):410-23.
55. Xiang Y, Lam SM, Shui G*. What can lipidomics tell us about the pathogenesis of Alzheimer disease?Biol Chem.396(2015):1281-91
56. Heinz LX, Baumann CL, K？berlin MS, Snijder B, Gawish R,Shui G,et al. The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity.Cell Rep. 11(2015):1919-28.
57. Chua EC,Shui G, Cazenave-Gassiot A, Wenk MR, Gooley JJ. Changes in Plasma Lipids during Exposure to Total Sleep Deprivation.Sleep. 38(2015):1683-91.
58. Portevin D, Sukumar S, Coscolla M,Shui G, Li B, Guan XL, Bendt AK, Young D, Gagneux S, Wenk MR.Lipidomics and genomics of Mycobacterium tuberculosis reveal lineage-specific trends in mycolic acid biosynthesis.Microbiologyopen.3(2014):823-35.
59. Lam SM, Tong L, Duan X, Acharya UR, Tan JH, Petznick A, Wenk MR,Shui G*.Longitudinal changes in the levels of tear fluid lysophospholipids and O-acyl-omega-hydroxy fatty acids brought about by eyelid-warming treatment in a cohort of Meibomian Gland Dysfunction patients.J Lipid Res55(2014):1959-69.
60. Shui G*，Huang X*.Lipid is moving to the forefront of bio-medical research.J Genet Genomics.41(2014): 229-30.
61. Cheong WF, Wenk MR,Shui G*. Comprehensive compositional study of lipid molecular species in crude palm oil using multiple lipidomic approaches.J Genet Genomics.41(2014):293-304
62. Guyen LN, Ma D,Shui G, Wong P, Cazenave-Gassiot A, Zhang XD, Wenk MR, Goh ELK, Silver DL. Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid.Nature509(2014):503-6.
63. Nakamura Y, Teo NZ,Shui G, Chua CH, Cheong WF, Parameswaran S, Koizumi R, Ohta H, Wenk MR, Ito T.Transcriptomic and lipidomic profiles of glycerolipids during Arabidopsis flower development.New Phytol.203(2014):310-22。
64. Liu L, Jiang Q, Wang X, Zhang Y, Lin RC, Lam SM,Shui G, Zhou L, Li P, Wang Y, Cui X, Gao M, Zhang L, Lv Y, Xu G, Liu G, Zhao D, Yang H.Adipose-specific knockout of Seipin/Bscl2 results in progressive lipodystrophy.Diabetes, 63(2014):2320-31.
65. Zhang S,Shui G, Wang G, Wang C, Sun S, Zouboulis CC, Xiao R, Ye J, Li W, Li P.Cidea Control of Lipid Storage and Secretion in Mouse and Human Sebaceous Glands.Mol Cell Biol.34(2014):1827-38.
66. Ng LF, Gruber J, Cheah I, Kiat Goo C, Fun Cheong W,Shui G, Ping Sit K, Wenk MR, Halliwell B.The mitochondria-targeted antioxidant, MitoQ extends lifespan and improves healthspan of a transgenic C. elegans models of Alzheimer disease.Free Radic Biol Med.71(2014):390-4.
67. Liu YF, Li QT, Lu X, Song QX, Lam SM, Zhang WK, Ma B, Lin Q, Man WQ, Du WG,Shui GH, Chen SY, Zhang JS.Soybean GmMYB73 promotes lipid accumulation in transgenic plants.BMC Plant Biol.14(2014):73.
68. Lam S.M., Wang Y., Duan XR, Wenk MR, Kalaria,RN, Chen CP, Lai MKP，Shui G*. The brain lipidomes of subcortical ischemic vascular dementia and mixed dementia.Neurobiology of Aging, 35(2014):2369-81.
69. Ang ML, Zainul Rahim SZ,Shui G, et al, Alonso S. An ethA/R-deficient Mycobacterium bovis BCG mutant displays increased adherence to mammalian cells and greater persistence in vivo which correlate with altered mycolic acids composition.Infection and Immunity82(2014):1850-9.
70. Liu Y, Wang W, Shui G*,Huang X*. CDP-diacylglycerol synthetase coordinates cell growth and fat storage through phosphatidylinositol metabolism and the insulin pathway.Plos Genetics.10(2014), e**.
71. Ee SM, Lo YL, Shui G, Wenk MR, Shin EJ, Kim HC, Ong WY.Distribution of Secretory Phospholipase A2 XIIA in the Brain and its Role in Lipid Metabolism and Cognition.Mol Neurobiol.50(2014):60-75.
72. Lam SM, Tong L, Reux B, Duan X, Petznick A, Yong SS, Khee CB, Lear MJ, Wenk MR,Shui G*.Lipidomic analysis of human tear fluid reveals structure-specific lipid alterations in dry eyesyndrome.J Lipid Res55(2014):299-306.
73. Lam SM, Tong L, Duan X, Petznick A, Wenk MR,Shui G*.Extensive characterization of human tear fluid collected using different techniques unravels the presence of novel lipid amphiphiles.J Lipid Res55(2014):289-298
74. Tan S,Shui G, Zhou J, Shi Y, Huang J, Xia D, Wenk M, Shen HM.Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled Akt-FoxO1 signalling pathway.Autophagy10(2014):226-42.
75. Xue Y,Shui G, Wenk MR.TPS1 drug design for rice blast disease in magnaporthe oryzae.Springerplus3(2014):18.
76. Yaligar J, Gopalan V, Kiat OW, Sugii S,Shui G, Lam BD, Henry CJ, Wenk MR, Tai ES, Velan SS.Evaluation of dietary effects on hepatic lipids in high fat and placebo diet fed rats by in vivo MRS and LC-MS techniques.PLoS One9(2014):e91436.
77. Lam SM,Shui G*.Lipidomics as a principal tool for advancing biomedical research.J Genet Genomics.40(2013):375-90.　
78. Liu Z, Lim CY, Su MY, Soh SL,Shui G, Wenk MR, Grove KL, Radda GK, Han W, Xiao X. Neonatal overnutrition in mice exacerbates high-fat diet-induced metabolic perturbations.J Endocrinol.219(2013):131-43.
79. Lam SM, Tong L, Reux B, Lear MJ, Wenk MR,Shui G*.Rapid and sensitive profiling of tear wax ester species using high performance liquid chromatography coupled with tandem mass spectrometry.J. Chromatogr. A.1308(2013):166-71.
80. Chua ECP^#, Shui G^#,Lee I, Lau P; Tan LC, Yeo SY, Lam BD, Puvanendran K, Bulchand S, Summers SA, Rozen S, Wenk MR, Gooley JJ. Extensive diversity in the circadian lipidome: evidence for different circadian metabotypes.PNAS. 110(2013):14468-73.(^#co-first author).
81. Shui G*, Lam SM, Stebbins J, Kusunoki J, Duan X, Li B, Wei Cheong F, Soon D, Kelly R, & Wenk M Polar lipid derangements in type 2 diabetes mellitus: potential pathological relevance of fatty acyl heterogeneity in sphingolipid.Metabolomics 4(2013) 786-799.
82. Lim WL, Lam SM,Shui G, Mondal A, Ong D, Duan X, Creegan R, Martins IJ, Sharman MJ, Taddei K, Verdile G, Wenk MR, Martins RN.Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E ε3 and ε4 knock-in mice. Neurobiol Aging34(2013):2217-24.
83. Baig S, Lim JY, Fernandis AZ, Wenk MR, Kale A, Su LL, Biswas A, Vasoo S,Shui G*,Choolani M*.Lipidomic analysis of human placental syncytiotrophoblast microvesicles i n adverse pregnancy outcomes.Placenta34(2013):436-42.
84. Jovanovi？ V, Abdul Aziz N, Lim YT, Ng Ai Poh A, Jin Hui Chan S, Ho Xin Pei E, Lew FC,Shui G, Jenner AM, Bowen L, McKinney EF, Lyons PA, Kemeny MD, Smith KG, Wenk MR, Macary PA.Lipid anti-lipid antibody responses correlate with disease activity in systemic lupus erythematosus.PLoS One8(2013)：e55639.
85. Blanc M, Hsieh wy, Robertson KA, Kai KA, Forster T,Shui G, Lacaze P, Watterson S, Griffiths SJ, Spann NJ, Meljon A, Talbot S, Krishnan K, Covey DF, Wenk MR, Craigon M, Ruzsics Z, Haas J, Angulo A, Griffiths WJ, Glass CK, Wang Y, Ghazal P. Signal transducer and activator of transcription (Stat-1) couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response.Immunity38(2013):106-18.
86. Guan XL, Cestra G，Shui G, Kuhrs A, Schittenhelm R, Hafen E, van der Goot FG, Gonzalez-Gaitan M, Wenk MR. Biochemical membrane lipidomics during Drosophila development -an informational resource.DevelopmentCell24(2013):98-111.
87. Summermatter S,Shui G, Maag D, Santos G, Wenk MR, Handschin C. PGC-1α improves glucose homeostasis in skeletal muscle in an activity-dependent manner.Diabetes62(2013):85-95
88. Vigant F, Lee J, Hollman A, Tanner L, Akyol-Ataman Z, Yun T,Shui G, et al. A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion.Plos Pathogens9(2013): e**.
89. Watterson S, Guerriero ML, Blanc M, Mazein A, Loewe L, Robertson KA, Gibb H,Shui G, Wenk MR, Hillston J and Ghazal P. A model of flux regulation in the cholesterol biosynthesis pathway: Immune mediated graduated flux reduction versus statin-like led stepped flux reduction.Biochimie95(2013):613-21.
90. Nakatsu F, Baskin JM, Chung J, Tanner LB,Shui G, Lee SY, Pirruccello M, Ingolia NT, Wenk MR, Camilli PD. A plasma membrane PI4P pool controlled by PI 4-kinase III impacts cholesterol homeostasis.J Cell Biol.199(2012):1003-1016.
91. Thibault G,Shui G, Woong K, McAlister G, Gygi SP, Wenk MR, Ng DTW. The unfolded protein response buffers the lethal effects of lipid disequilibrium.Molecular Cell: 48(2012):16-27.
92. Patkar RN, Suresh A, Xue YK,Shui G, Wenk MR, Naqvi NI. Abc3-mediated efflux of an endogenous digoxin-like steroidal glycoside by Magnaporthe oryzae is necessary for host invasion during blast disease.Plos Pathogen8(2012):e**.
93. Siddique MM, Bikman BT, Wang L, Ying L, Reinhardt E,Shui G, Wenk MR, Summers SA.Ablation of dihydroceramide desaturase confers resistance to etoposide-induced apoptosis in vitro.PLoS One: 7(2012):e44042
94. Bikman BT, Guan Y,Shui G, Siddique MM, Holland WL, Kim JY, Fabriàs G, Wenk MR, Summers SA. Fenretinide prevents lipid-induced insulin resistance by inhibiting dihydroceramide desaturase and blocking ceramide synthesis.J. Bio. Chem.287(2012):17426-37.
95. Tan SH,Shui G, Zhou J, Wenk MR, Shen HM. Induction of autophagy by palmitic acid via a PKC-mediated signaling pathway independent of Mtor.J. Bio. Chem. 287(2012):14364-76.
96. Mathuru AS, Kibat C, Cheong CF,Shui G, Korzh V, Wenk MR, Friedrich RW and Jesuthasan S. Chondroitin fragments are odorants that trigger fear behavior.Current Biology22(2012):538-44.
97. Rodriguez-Navarro JA, Kaushik S, Koga H, Dall’Armi C,Shui G, Wenk MR, Di Paolo G, Cuervo AM. Inhibitory effect of dietary lipids on chaperone-mediated autophagy.PNAS109(2012):E705-14 .
98. Wang WS, Lv Na, Zhang S,Shui G, Qian H, Zhang J, Chen Y, Ye J, Xie Y, Shen Y, Wenk MR, Li P. Cidea is an essential transcriptional co-activator of C/EBP|？ to control newborn survival and lipid secretion in mammary gland.Nature Medicine18(2012):235-43.
99. Sundram JR, Chan HH, Poore CP, Pareek T, Cheong WF,Shui G, Tan N, Low CM, Wenk MR and Kesavapany S.Cdk5/p25-Induced Cytosolic PLA2-Mediated Lysophosphatidylcholine Production Regulates Neuroinflammation and Triggers Neurodegeneration.J. Neurosci. 32(2012):1020-34.
100. Chan R, Oliveira TG, Small SA, Duff KE, Wenk MR,Shui G*, Di Paolo G*. Comparative lipidomic analysis of mouse and human brain with Alzheimer disease.J. Bio. Chem.287(2012):2678-88.
101. Poh MK,Shui G, Shi PY,Wenk MR, Gu F. The importance of cholesterol during the entry and replication event of dengue virus.Antiviral Res:93(2012):191-8.
102. Shui G*,et al. Mycolic acids as diagnostic markers for tuberculosis case detection and drug efficacy.EMBO Mol Med:4(2012):27-37.
103. Gong J, Sun Z, Wu L, Xu W，Schieber N,Xu D,Shui G, Yang H, Parton RG, Li P. Fsp27 is localized to the contact site of lipid droplets and promotes their growth by fusion.J Cell Biol:195(2011):953-63.
104. Lee HW, Tan CH, Long LY, Farooqui AQ,Shui G, Wenk MR, Ong WY. Lipidomic analyses of the rat brain after transcranial magnetic stimulation.Metabolomics: 8(2012): 19-33.
105. Lee HW, Tan CH,Shui G, Wenk MR, Ong WY. Role of prefrontal cortex calcium independent phospholipase A2 activity in the antidepressant like effect of maprotiline.Int J Neuropsychopharmacol.15(2012):1087-98.
106. Ma MT; Yeo JF;Shui G, Wenk MR, Ong WY. Systems wide analyses of lipids in the brainstem during inflammatory orofacial pain -Evidence of increased phospholipase A(2) activity.Eur J Pain16(2012):38-48.
107. Lim L, Jackson-Lewis V, Wong LC, Shui G, Goh XH, Kesavapany S, Jenner AM, Fivaz M, Przedborski S, Wenk MR. Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from oxidative stress.Cell Death and Diff.19(2012): 416-27.
108. Fei W, Zhong L, Ta MT,Shui G, Wenk MR, Yang H.The size and phospholipid composition of lipid droplets can influence their proteome.Biochem Biophys Res Commun. 415(2011):455-62.
109. Fei W, Li H,Shui G, Bielby C, Du X, Brown AJ, Wenk MR, Li P, Yang H. Molecular characterization of seipin and its mutants: implications for seipin in triacylglycerol synthesis.J Lipid Res52(2011):2136-47.
110. Lam SM, Tong L, Yong SS, Li BW, Chaurasia SS,Shui G*, Wenk MR*. Meibum lipid composition in Asians with Dry Eye Disease.Plos One6(2011): e24339
111. Fei W^#,Shui G^#, Zhang P, Fergsuon C, Kapterian TS, Lin RC, Dawes IW, Zhang Y, Brown AJ, Li P, Huang X, Parton RG, Wenk MR, Walther TC and Yang H. A role for phosphatidic acid in the formation of “supersized” lipid droplets.Plos Genetics7(2011): e**.(^#co-first author).
112. Shui G*.Systems level analysis of lipidome.Front. Biol.6(2011): 183-189
113. Gruber J, Ng LF, Fong S, Wong YT, Koh SA, Chen CB, Shui G, Cheong WF, Schaffer S, Wenk MR, Halliwell B. Mitochondrial ageing inCaenorhabditis elegans- shutting down rather than vicious cycling.Plos One6 (2011): e19444
114. Shui G*,Cheong WF, Jappar IA, Hoi A, Xue YK, Fernandis AZ, Tan BKH, Wenk MR. Derivatization-independent cholesterol analysis in crude lipid extracts by liquid chromatography/mass spectrometry: Applications to a rabbit model for atherosclerosis.J. Chromatogr. A.1218 (2011): 4357-4365.
115. Shui G*,Stebbins JW, Lam BD, Cheong WF,Lam SM, Gregoire F, Kusonoki J, Wenk MR.Comparative plasma lipidome between human and cynomolgus monkey: are plasma polar lipids good biomarkers for diabetic monkeys?Plos One6 (2011): e19731
116. Tian Y, Bi J,Shui G, Xiang Y, Liu Y, Liu Z, Yang H, Wenk MR, and Huang X.Tissue-autonomous function of Drosophila Seipin in preventing ectopic lipid accumulation.Plos Genetics7(2011):e**.
117. Holland WL, Bikman BT, Wang LP, Guan YG, Sargent KM, Knotts TA,Shui G, Wenk MR, Pagliassotti MJ and Summers SA.Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice.J. ClinInvest.121(2011):1858-70.
118. Peng ZF, Chen MJ, Manikandan J, Melendez AJ,Shui G,Russo-Marie F, Whiteman M, Beart PM, Moore PK, Cheung NS. Multifaceted involvement of NO in mouse neuronal injury model: transcriptomic profiling defines the temporal recruitment of death signaling cascades.J Cell Mol Med:16(2012):41-58
119. Gamage AM, Shui G, Wenk MR, Chua KL. N-octanoyl homoserine lactone is the major quorum signaling molecule regulating biofilm formation and antibiotic production inB. pseudomallei.Microbiology157(2011):1176-1186.
120. Blanc M, Watterson S, O’Sullivan MC,Shui G, Gibbs H, Sing S, Khondoker M, Dickinson P, Lacaze P, Wall DM, Rodríguez-Martín S, Riemersma R, Wenk MR, Angulo A, Ghazal P.Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis.Plos Biology9(2011): e**.
121. Cheng D, Jenner AM, Shui G, Cheong WF, Mitchell TW, Nealon JR, Kim WS, McCann H, Wenk MR, Halliday GM, Garner B. Lipid pathway alterations in Parkinson’s disease primary visual cortex.Plos One6(2011): e17299.
122. Oliveira T, Chan R, Tian H, Laredo M,Shui G, Staniszewski A, Zhang H, Wang L, Kim TW, Duff K, Wenk MR, Arancio O and Di Paolo G. Phospholipase D2 ablation ameliorates Alzheimer’s disease-linked synaptic dysfunction and cognitive deficits.J. Neurosci.30(2010), 16419-16428.
123. Shui G*, Guan XL, Gopalakrishnan P, Xue Y, Goh JSY, Yang H, Wenk MR Characterization of Substrate Preference for Slc1p and Cst26p in Saccharomyces cerevisiae Using Lipidomic Approaches and Non-radioactive LPAAT Activity Assay.Plos One5(2010): e11956.
124. Low KL, Shui G, Natter K, Yeo WK, Kohlwein S, Dick T, Rao S, Wenk MR.. Lipid droplet-associated proteins in Mycobacterium bovis BCG function in the biosynthesis and hydrolysis of triacylglycerol.J. Bio. Chem. 285(2010):21662-70
125. Jenner AM, Lim WLF, Ng MPE, Wenk MR,Shui G, Sharman MJ, Gandy SE, Martins RN. The effect of APOE genotype on brain levels of oxysterols in young and old human APOE e2, e3 and e4 mice.Neurosciences169(2010):109-15.
126. Shui G*,Guan XL, Low CP, Goh SYJ, Yang H, Wenk MR.. Toward One Step Analysis of Cellular Dynamic Lipidome Using Liquid Chromatography Coupled with Mass Spectrometry: Application toSaccharomyces CerevisiaeandSchizosaccharomyces PombeLipidomics.Mol BioSyst6(2010):1008-17
127. Wu YT, Tan HL, Shui G, Bauvy C, Huang Q, Wenk MR, Ong CN, Codogno P, Shen HM. Dual role of 3-methyladenine on modulation of autophagy via different temporal patterns on Class I and III phosphoinositide 3-kinase.J. Bio. Chem.285(2010):10850-61
128. Sharman MJ^#,Shui G^#,Fernandis AZ, Lim WL, Berger T, Hone E, Taddei K, Martins IJ, Ghiso J, Buxbaum J, Gandy S, Wenk MR and Martins RN. Subtle changes in brain and plasma lipids in agedAPOEknock-in mice.J Alzheimers Dis.20(2010):105-11(^#Co-First Author)
129. Nakamura Y,Koizumi R,Shui G, Shimojima M, Wenk MR, Ito T, Ohta H. Arabidopsis lipins mediate eukaryotic pathway of lipid metabolism to/and cope critically with phosphate starvation.PNAS106(2009):20978-83.
130. McGehee AM, Dougan SK, Klemm E,Shui G, Park B, Kim YM, Wenk MR, Ploegh HL, Hu CC. XBP-1-deficient plasmablasts have normal protein folding but defects in glycosylation and lipid synthesis.Journalof Immunology183(2009):3690-3699.
131. Novem V, Shui G, Wang D, Bendt AK, Sim SH, Liu Y, Thong TW, Sivalingam SP, Ooi EE, Wenk MR, Tan G.Structural characterization and comparison of lipid A fromBurkholderia pseudomalleiandBurkholderia thailandensis.Clinical and Vaccine Immunology16(2009):1420-1428
132. Low KL, Rao S,Shui G, Bendt AK, Pethe K, Dick T, Wenk MR. Tetrahydrolipstatin, a lipase inhibitor is bactericidal to non-replicative Mycobacterium bovis BCG.Journalof Bacteriol.: 191(2009):5037-43.
133. Deng Y, Almsherqi ZA, Shui G, Wenk MR, Kohlwein SD. Docosapentaenoic acid (DPA) is a critical determinant of cubic membrane formation in amoeba Chaos mitochondria.FASEB J. 23(2009):2866-71.
134. Lee HW,Shui G, Farooqui AQ, Wenk MR, Tan CH, Ong WY. Lipidomic analyses of the mouse brain after antidepressant treatment – evidence for endogenous release of omega-3 fatty acids?Int J Neuropsychopharmacol12(2009) : 953-964
135. Kutik S, Rissler m, Guan X, Guiard B, Shui G, Meisinger G, Rehling P, Wenk MR, Pfanner N, Wiedemann N. The translocator maintenance protein Tam41 is required for mitochondrial cardiolipin biosynthesis.J Cell Biol.183(2008):1213-1221.
136. Chan R, Uchil OD, Jin J, Shui G, Ott DE, Mothes W, and Wenk MR.Retroviruses Human Immunodeficiency Virus and Murine Leukemia Virus Are Enriched in Phosphoinositides.J Virol.82(2008): 11228-38.
137. Low CP,Shui G, Li PL, Buttner S, Madeo F, Dawes IW, Wenk MR, and Yang H. Distinct lipotoxic cell death pathways in the fission yeast.J Cell Sci.121(2008):2671-84.
138. Fei W,Shui G, Gaeta B, Du X, Kuerschner L, Li P, Brown AJ, Wenk MR, Parton RG, Yang H. Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast.J Cell Biol. 180(2008):473-82.
139. Lu LE, Yung LYL, Ong CN, Tan YL, Balasubramaniam S, Hartono D,Shui G, Wenk MR, and Ong WY. Translocation and effects of gold nanoparticles after inhalation exposure in rats.Nanotoxicology1 (2007), 235-242.
140. Shui G, Bendt AK, Pethe K, Dick T and Wenk MR. Sensitive profiling of chemically diverse bioactive lipids.J. Lipid Res.48(2007):1976-84.
141. Wang H, Jenner A, Lee CY,Shui G, Tang SY, Whiteman M, Wenk MR, Halliwell B. The identification of antioxidants in dark soya sauce.Free Radical Res. 41(2007):479-88
142. Guan XL,He X, Ong WY, Yeo WK,Shui G.and Wenk MR. Unbiased global profiling of lipids during kainite induced neuronal injury.FASEB J.20(2006), 1152-61.
143. Huang Q, Shen HM,Shui G, Wenk MR, Wong CN. Emodin inhibits tumor cell adhesion through disruption of the membrane lipid rafts-associated integrin signaling pathway.Cancer Res. 66 (2006), 5807-15.
144. Shui G,Leong LP. Residue from star fruitJuice processing waste as a value-added food ingredient and its potential as antioxidant nutraceuticals.Food Chem.97 (2006), 277-284.
145. Shui G, Leong LP. Rapid Screening and Identification of Antioxidants in Biological Samples Using High Performance Liquid Chromatography/Mass Spectrometry and Its Application onSalacca Edulis Reinw.J. Agric. Food Chem.(2005), 53(4), 880-886.
146. Shui G, Leong LP and Wong SP. “Rapid Screening and Characterisation of Antioxidants of Cosmos Caudatus Using Liquid Chromatography Coupled with Mass Spectrometry.J. Chromatogr. B.827(2005), 127-138.
147. Shui G, Wong SP, Leong LP. Characterization of Antioxidants and Change of Antioxidant Levels during Storage ofManilkara zapotaL.J. Agric. Food Chem.52(2004), 7834-7841.
148. Shui G, Leong LP. An Improved Method for the Analysis of Major Antioxidants ofHibiscus EsculentusLinn.J. Chromatogr. A.1048 (2004) 17-24.
149. Shui G, Leong LP. Analysis of Polyphenolic Antioxidants in Star Fruit Using High Performance Liquid Chromatography and Mass Spectrometry.J. Chromatogr. A.1022 (2004) 67-75.
150. Shui G, Leong LP. Separation and Determination of Organic Acids and Phenolic Compounds of Fruit Juices and Drinks by High Performance Liquid Chromatography.J. Chromatogr. A977 (2002) 89-97
151. Leong LP,Shui G. An Investigation of Antioxidant Capacity of fruits in the Singapore markets.Food Chem.76(2002) 69-75.