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中国科学院遗传与发育生物学研究所导师教师师资介绍简介-戴建武

本站小编 Free考研考试/2020-05-26


戴建武
职称:研究员

职务:再生医学中心主任、分子发育生物学国家重点实验室副主任

联系电话:86-

传真:86-

附件:
E-mail:

实验室主页:http://dailab.genetics.ac.cn

研究方向:再生医学


戴建武,博士,研究员,博士生导师
教育经历及任职::
武汉大学生物系细胞生物学专业 本科
北京医科大学生物物理学专业 硕士
美国杜克大学细胞生物学专业 博士
哈佛大学医学院 博士后研究
2003-至今:中国科学院遗传与发育生物学研究所研究员,再生医学研究中心主任。
中科院“****”杰出人才,国家****基金获得者。
国家食品药品监督管理局医疗器械审评专家
国家标准化管理委员会全国外科植入物和矫形器械标准化技术委员会组织工程医疗器械产品分技术委员会委员
英国皇家化学学会生物材料咨询委员会委员
Biomaterials 杂志编委
联合国教科文组织科学伦理委员会中国代表
中国干细胞分会秘书长

主要研究方向:
1)组织器官再生修复产品的研发
2)组织器官再生机理的研究
2)组织器官制造
承担的国家项目:
2006-2010
科技部国家重大科学研究计划项目“干细胞自我更新调控网络的研究”项目首席科学家

2010-2012
国家自然基金委,重大科学研究计划培育项目“OCT4异构体的表达、功能和调节机制研究”,项目负责人

2010-2013
国家自然基金委重点项目“神经再生环境的构建”,项目负责人

2011-2013
国家自然基金委,中加(NSFC-CIHR)健康研究合作计划“胶原结合能力的血管内皮生长因子对猪心肌损伤的治疗作用及安全性评价”,项目负责人

2011-2015
科技部国家重大科学研究计划项目“三维培养干细胞自我更新调控网络的研究”,项目首席科学家

2011-2015
中国科学院“干细胞与再生医学”战略性科技先导专项“人工组织器官构建”项目负责人

2013-2015
中国科学院科研装备研制项目“面向干细胞微环境构建的低温细胞3D重建系统”项目负责人

2016-2018
中国科学院重点部署项目“组织器官再生与损伤修复”项目负责人

2016-2021
国家重点研发计划项目“出生缺陷组织器官再生修复产品的研发”项目首席科学家

2017-2022 中国科学院“器官重建与制造”战略性科技先导专项“临床研究转化”项目负责人及“脊髓组织制造”课题负责人
2019-2023 国家自然基金委重大项目“脊髓损伤再生修复机理及临床转化研究”项目负责人

获奖情况:
2010年:中国科学院遗传与发育生物学研究所益海嘉里“优秀导师奖”
2012年:心肌梗死后心肌组织修复和功能重建的机制研究及临床应用,国家科技部,国家科学技术进步奖二等奖
2014年:中央电视台年度科技创新人物。
2016年:第六届中国侨界再生医学创新成果奖。
2017年:中国细胞生物学学会干细胞生物学分会干细胞成果转化奖
2018年:2018年度江苏省科学技术一等奖
代表性成果
? 突破了再生医学关键技术。研发了具有自主知识产权的系列再生医学产品,在脊髓损伤再生修复、子宫内膜、脊髓、心肌等组织损伤的大动物实验中都显示了良好的修复效果;提出组织内源干细胞的激活与分化是组织再生的重要机理;在率先组织领导了包括子宫内膜再生、卵巢再生、脊髓损伤再生,心肌再生等多个产品的临床研究。
? 合作研发子宫内膜再生修复产品并进入临床研究阶段,为子宫内膜损伤的不孕患者提供了一种有效的治疗手段,入选2014年中央电视台年度科技创新人物;卵巢再生修复取突破,第一个卵巢早衰患者2018年1月12日诞生世界上首位健康宝宝。子宫内膜再生卵巢再生及脊髓损伤再生成果入选国家改革开放40周年创新成果展。
? 脊髓损伤再生研究取得重大突破。提出利用功能生物材料重建神经再生微环境的技术思路。研发的神经再生胶原支架材料可有效引导全横断脊髓损伤动物和患者神经再生和自主运动功能恢复。脊髓损伤再生修复的临床研究已走在世界前列。
团队成员:
工作人员:
陈 冰
博士
副研究员
肖志峰
博士
副研究员

赵燕南
博士
副研究员
吴宪明

博士
副研究员

韩素芳
博士
助理研究员

施 雅

硕士

工程师


李佳音
博士
工程师

侯祥林
硕士
工程师


尹艳云
硕士
助理工程师
杨 斌

硕士
助理工程师


张娇娇
硕士
助理工程师
刘文斌
硕士
助理工程师

张权
学士
助理工程师




博士后:
徐白张琪薛伟伟
博士研究生:
薛晓钰 杨亚明 舒慕娅 杨颖 张海鹏 马德尊 范永恒 金辰
硕士研究生:
刘为远 孙政
客座研究人员:
崔熠 邹云龙 郝王平 沈贺
毕业离所学生:
索广力 博士 (中科院苏州纳米所)
张经余 博士 (赛默飞世尔科技)

赵艳红 博士 (中检院)
林 航 博士 (匹兹堡大学)

赵文学 博士 (加州大学旧金山分校)
王 霞 博士 (清华大学)

王 斌 博士 (南京大学鼓楼医院)
孙文杰 博士 (山东大学)

张 晶 博士 (首都医科大学)
高 原 博士 (北京宝洁技术有限公司)

韩倩倩 博士 (中检院)
高 健 硕士 (雀巢(中国)有限公司)

曹佳妮 博士 (中科院动物所)
陈 磊 博士 (河南信阳师范学院)

苏冠男 博士 (重庆医科大学附属第一医院)
肖汉山 硕士 (天风证券)

魏建树 博士 (北京301医院)
杨 赟 博士 (加州大学圣地亚哥分校)

施春英 博士 (青岛大学)
刘素梅 博士 (宣武医院)

栾梁琪 硕士


媒体报道:(网页视频链接形式)









近期发表的文章(2015年至今[l1]):
1. Xue, W., Zhao, Y., Xiao, Z., Wu, X., Han, J., Li, X., Xue, X., Yang, Y., Fang, Y., Fan, C., Liu, S., Xu, B., Han, S., Chen, B., Zhang, H., Fan, Y., Liu, W., Dong, Q., Dai, J*., EGFR-ERK blockade upregulates TRIM32 signaling cascade and promotes. Stem Cells, 2019 (Accepted)
2. Fan, C., Shi, J., Zhuang, Y., Zhang, L., Huang, L., Yang, W., Chen, B., Chen, Y., Xiao, Z., Shen, H., Zhao, Y., Dai, J*., Myocardial Infarction Responsive Smart Hydrogels Targeting Matrix Metalloproteinase for On-Demand Growth Factor Delivery. Adv. Mater. 2019. https://doi.org/10.1002/adma.
3. Liu, D., Li, X., Xiao, Z,. Yin, W., Zhao, Y., Tan, J., Chen, B., Jiang, X., Dai, J.* Different functional bio-scaffolds share similar neurological mechanism to promote locomotor recovery of canines with complete spinal cord injury. Biomaterials. 214:119230, 2019
4. Shen, H., Chen, X., Li, X., Jia, K., Xiao, Z., Dai, J.* Transplantation of adult spinal cord grafts into spinal cord transected rats improves their locomotor function. Sci China Life Sci. 62(6):725-733, 2019
5. Xue, B., Liu, D., Song, M., Zhao, G., Cao, Y., Yan, G., Dai, J.,* Hu, Y. * Leukemia inhibitory factor promotes the regeneration of rat uterine horns with full-thickness injury. Wound Repair Regen. doi: 10.1111/wrr.12729. [Epub ahead of print], 2019
6. Li, X., Chen, Z., Zhang, H., Zhuang, Y., Shen, H., Chen, Y., Zhao, Y., Chen, B., Xiao, Z., Dai, J.*Aligned scaffolds with biomolecular gradients for regenerative medicine. Polymers. 197: 20-31, 2019
7. Li, X., Liu, D., Xiao, Z., Zhao, Y., Han, S., Chen, B., Dai, J.* Scaffold-facilitated locomotor improvement post complete spinal cord injury: Motor axon regeneration versus endogenous neuronal relay formation. Biomaterials 197: 20-31, 2019
8. Han S, Yin W, Li X, Wu S, Cao Y, Tan J, Zhao Y, Hou X, Wang L, Ren C, Li J, Hu X, Mao Y, Li G, Li B, Zhang H, Han J, Chen B, Xiao Z, Jiang X, Dai, J.* Pre-Clinical Evaluation of CBD-NT3 Modified Collagen Scaffolds in Completely Spinal Cord Transected Non-Human Primates. J Neurotrauma. doi.org/10.1089/neu.2018.6078 [Epub ahead of print]. 2019
9. Liu, S.,Xiao, Z.,Li, X.,Zhao, Y.,Wu, X.,Han, J.,Chen, B.,Li, J.,Fan, C.,Xu, B.,Xue, X.,Xue, W.,Yang, Y.,Dai, J.* Vascular endothelial growth factor activates neural stem cells through epidermal growth factor receptor signal after spinal cord injury. CNS Neurosci Ther. 197:20-31, 2019
10.Ding, L., Yan, G., Wang, B., Xu, L., Gu, Y., Ru, T., Cui, X., Lei, L., Liu, J., Sheng, X., Wang, B., Zhang, C., Yang, Y., Jiang, R., Zhou, J., Kong, N., Lu, F., Zhou, H., Zhao, Y., Chen, B., Hu, Y.*, Dai, J.*, Sun, H.* Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility. Sci China Life Sci. 61(12):1554-1565, 2018
11.Li, J.,Chen, T.,Huang, X.,Zhao, Y.,Wang, B.,Yin, Y.,Cui, Y.,Zhao, Y.,Zhang, R.,Wang, X.,Wang, Y.,Dai, J.* Substrate-independent immunomodulatory characteristics of mesenchymal stem cells in three-dimensional culture. PloS One.13(11):e**. 2018
12.Yin, W.,Li, X.,Zhao, Y.,Tan, J.,Wu, S.,Cao, Y.,Li, J.,Zhu, H.,Liu, W.,Tang, G.,Meng, L.,Wang, L.,Zhu, B.,Wang, G.,Zhong, M.,Liu, X.,Xie, D.,Chen, B.,Ren, C.,Xiao, Z.,Jiang, X.*,Dai, J.* Taxol-modified collagen scaffolds implantation promotes functional recovery after long-distance spinal cord complete transection in canines. Biomaterials Sci. 6(5):1099-1108. 2018
13.Cui, Y., Yao, Y., Zhao, Y., Xiao, Z., Cao, Z., Han, S., Li, X., Huan, Y., Pan, J.* Dai, J.* Functional collagen conduits combined with human mesenchymal stem cells promote regeneration after sciatic nerve transection in dogs. J Tissue Eng Regen Med. 12(5):1285-1296. 2018
14.Hao, Y.*, Ran, Y., Lu, B., Li, J., Zhang, J., Feng, C., Fang, J., Ma, R., Qiao, Z., Dai, X., Xiong, W., Liu, J., Zhou, Q., Hao, J., Li, R.*, Dai, J.* Therapeutic Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells on Canine Radiation-Induced Lung Injury. Int J Radiat Oncol Biol Phys. 102(2):407-416. 2018
15.Cui, Y., Lu, C., Chen, B., Han, J., Zhao, Y., Xiao, Z., Han, S., Pan, J.*, Dai, J.* Restoration of mandibular bone defects with demineralized bone matrix combined with three-dimensional cultured bone marrow-derived mesenchymal stem cells in minipig models. J Mater Sci Mater Med. 29(9):147. 2018
16.Hao, W., Han, J., Chu, Y., Huang, L., Zhuang, Y., Sun, J., Li, X., Zhao, Y., Chen, Y., Dai, J.* Collagen/Heparin Bi-Affinity Multilayer Modified Collagen Scaffolds for Controlled bFGF Release to Improve Angiogenesis In Vivo. Macromol Biosci. e**. 2018
17.Li, X., Fan, C., Xiao, Z., Zhao, Y., Zhang, H., Sun, J., Zhuang, Y., Wu, X., Shi, J., Chen, Y., Dai, J.* A collagen microchannel scaffold carrying paclitaxel-liposomes induces neuronal differentiation of neural stem cells through Wnt/β-catenin signaling for spinal cord injury repair. Biomaterials. 183:114-127. 2018
18.Cao, Y., Sun, H., Zhu, H., Zhu, X., Tang, X., Yan, G., Wang, J., Bai, D., Wang, J., Wang, L., Zhou, Q., Wang, H., Dai, C., Ding, L., Xu, B., Zhou, Y., Hao, J., Dai, J.*, Hu, Y.* Allogeneic cell therapy using umbilical cord MSCs on collagen scaffolds for patients with recurrent uterine adhesion: a phase I clinical trial. Stem Cell Res Ther. 9(1):192. 2018
19.Liu, W., Xie, Y., Gao, T., Huang, F., Wang, L., Ding, L., Wang, W., Liu, S., Dai, J.*, Wang, B.* Reflection and observation: cell-based screening failing to detect HBV in HUMSCs derived from HBV-infected mothers underscores the importance of more stringent donor eligibility to reduce risk of transmission of infectious diseases for stem cell-based medical products. Stem Cell Res Ther. 9(1):177. 2018
20.Chen, X., Fan, Y., Xiao, Z., Li, X., Yang, B., Zhao, Y., Hou, X., Han, S., Dai, J.* Promotion of transplanted collagen scaffolds combined with brain-derived neurotrophic factor for axonal regeneration and motor function recovery in rats after transected spinal cord injury. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 32(6):650-659. 2018
21.Li, J., Li, X., Xiao, Z., Dai, J.* Review of the regeneration mechanism of complete spinal cord injury. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 32(6):641-649. 2018
22.Guan, D.,Mi, J.,Chen, X.,Wu, Y.,Yao, Y.,Wang, L.,Xiao, Z.,Zhao, Y.,Chen, B.,Dai, J.* Lungendothelialcell-targetedpeptide guided bFGF promotes the regeneration afterradiation induced lunginjury. Biomaterials.184:10-19. 2018
23.Chen, X., Zhao, Y., Li, X., Xiao, Z., Yao, Y., Chu, Y., Farkas, B., Romano, I., Brandi, F., Dai, J.* Functional multichannel Poly(Propylene Fumarate)-collagen scaffold with collagen-binding neurotrophic factor 3 promotes neural regeneration after transected spinal cord injury. Adv Healthc Mater. 7(14):e**. 2018
24.Fan, C., Li, X., Zhao, Y., Xiao, Z., Xue, W., Sun, J., Li, X., Zhuang, Y., Chen, Y., Dai, J.* Cetuximab and Taxol co-modified collagen scaffolds show combination effects for the repair of acute spinal cord injury. Biomater Sci. 6(7):1723-1734. 2018
25.Li, X., Yang, B., Xiao, Z., Zhao, Y., Han, S., Yin, Y., Chen, B., Dai, J.* Comparison of subacute and chronic scar tissues after complete transected spinal cord injury. Experimental Neurology. 306:132-137. 2018
26.Li, L., Chen, B., Yan, H., Zhao, Y., Lou, Z., Li, J., Fu, B., Zhu, X., McManus, D.P., Dai, J.*, Jia, W. Three-dimensional hepatocyte culture system for the study of Echinococcus multilocularis larval development. PLoS Negl Trop Dis. 12(3):e**. 2018
27.Jia, W., Jiang, X.*, Liu, W., Wang, L., Zhu, B., Zhu, H., Liu, X., Zhong, M., Xie, D., Huang, W., Jia, W., Li, S., Liu, X., Zou, X., Cheng, D., Dai, J.*, Ren, C.* Effects of three-dimensional collagen scaffolds on the expression profiles and biological functions of glioma cells. Int J Oncol. 52(6):1787-1800. 2018.
28.Xiao, Z., Tang, F., Zhao, Y., Han, G., Yin, N., Li, X., Chen, B., Han, S., Jiang, X., Yun, C., Zhao, C., Cheng, S., Zhang, S.*, Dai, J.* Significant improvement of acute complete spinal cord injury patients diagnosed by a combined criteria implanted with neuroRegen scaffolds and mesenchymal stem cells. Cell Transplantation.27(6):907-915.2018
29.Wang, Z., Shen, H., Song, S., Zhang, L., Chen, W., Dai, J., Zhang, Z.* Graphene oxide incorporated PLGA nanofibrous scaffold for solid phase gene delivery into mesenchymal stem cells. J Nanosci Nanotechnol. 18(4):2286-2293. 2018
30.Hao, W., Han, J., Chu, Y., Huang, L., Sun, J., Zhuang, Y., Li, X., Ma, H., Chen, Y.*, Dai, J.* Lower fluidity of supported lipid bilayers promotes neuronal differentiation of neural stem cells by enhancing focal adhesion formation. Biomaterials. 161:106-116. 2018
31.Cui, Y., Han, J.*, Xiao, Z., Qi, Y., Zhao, Y., Chen, B., Fang, Y., Liu, S., Wu, X., Dai, J.* Systematic Analysis of mRNA and miRNA expression of 3D-cultured neural stem cells (NSCs) in spaceflight. Front Cell Neurosci. 11:434. 2018
32.Wang, N., Xiao, Z., Zhao, Y., Wang, B., Li, X., Li, J., Dai, J.* Collagen scaffold combined with human umbilical cord-derived mesenchymal stem cells promote functional recovery after scar resection in rats with chronic spinal cord injury. J Tissue Eng Regen Med. 12(2):e1154-e1163. 2018
33.Tang, H.,Jia, W.,Hou, X.,Zhao, Y.,Huan, Y.,Chen, W.,Yu, W.,Mi Ma, O.,Ye, G.,Chen, B. *,Dai, J.* Collagen scaffolds tethered with bFGF promote corpus spongiosum regeneration in a beagle model. Biomed Mater.13(3):03100. 2018
34.Han, S., Li, X., Xiao, Z., Dai, J.* Complete canine spinal cord transection model: a large animal model for the translational research of spinal cord regeneration. Sci China Life Sci. 61(1):115-117. 2018
35.Shi, C.,Zhao, Y.,Yang, Y.,Chen, C.,Hou, X., Shao, J., Yao, H.,Li, Q.,Xia, Y., Dai, J.*Collagen-binding VEGF targeting cardiac extracellular matrix promotes recovery in porcine chronic myocardial infarction. Biomaterials Science. 6(2):356-363. 2018
36.Li, X., Dai, J.* Bridging the gap with functional collagen scaffolds: tuning endogenous neural stem cells for severe spinal cordinjuryrepair. Biomater Sci.6(2):265-271. 2018
37.Sun, J., Mou, C., Shi, Q., Chen, B., Hou, X., Zhang, W., Li, X., Zhuang, Y., Shi, J., Chen, Y., Dai, J.* Controlled release of collagen-binding SDF-1α from the collagen scaffold promoted tendon regeneration in a rat Achilles tendon defect model. Biomaterials. 162:22-33. 2018
38.Wang, X., Hu, H., Zhang, H., Li, C., An, B., Dai, J. * Single ultrasmall Mn2+-doped NaNdF4 nanocrystal as multimodal nanoprobe for magnetic resonance and second near-infrared fluorescence imaging. Nano Research. 11(2): 1069-1081. 2018
39.Han, S., Xiao, Z., Li, X., Zhao, H., Wang, B., Qiu, Z., Li, Z., Mei, X., Xu, B., Fan, C., Chen, B., Han, J., Gu, Y., Yang, H., Shi, Q., Dai, J.* Human placenta-derived mesenchymal stem cells loaded on linear ordered collagen scaffold improves functional recovery after completely transected spinal cord injury in canine. Sci China Life Sci. 61: 2-13. 2018
40.Wang, L., Shi, Q., Dai, J.*, Gu, Y., Feng, Y., Chen, L.* Increased vascularization promotes functional recovery in the transected spinal cord rats by implanted vascular endothelial growth factor-targeting collagen scaffold. J Orthop Res. 36(3):1024-1034. 2018
41.Yao, Y., Cui, Y., Zhao, Y., Xiao, Z., Li, X., Han, S., Chen, B., Fang, Y., Wang, P., Pan, J.*, Dai, J.* Effect of longitudinally oriented collagen conduit combined with nerve growth factor on nerve regeneration after dog sciatic nerve injury. J Biomed Mater Res B Appl Biomater. 106(6):2131-213. 2018
42.Zhu, W.,Qiu, Y.,Sheng, F.,Yuan, X.,Xu, L.,Bao, H.,Dai, J.*,Zhu, Z.* An effective delivery vehicle of demineralized bone matrix incorporated with engineered collagen-binding human bone morphogenetic protein-2toacceleratespinalfusionatlowdose. J Mater Sci Mater Med.29(1):2. 2017
43.Shi, L., Zhao, Y., Xie, Q., Fan, C., Hilborn, J., Dai, J.* Ossipov, D.* Moldable hyaluronan hydrogel enabled by dynamic metal-bisphosphonate coordination chemistry for wound healing. Advanced Healthcare Materials. 5(12):2427-2436. 2017
44.Xu, B., Zhao, Y., Xiao, Z., Wang, B., Liang, H., Li, X., Fang, Y., Han, S., Li, X., Fan, C., Dai, J.* A Dual functional scaffold tethered with EGFR antibody promotes neural stem cell retention and neuronal differentiation for spinal cord injury repair. Adv Healthc Mater. 6(9):**. 2017
45.Xu, R., Zhao, M., Yang, Y., Huang, Z., Shi, C., Hou, X., Zhao, Y., Chen, B., Xiao, Z., Liu, J., Miao, Q.*, Dai. J.* MicroRNA-449c-5p inhibits osteogenic differentiation of human VICs through Smad4-mediated pathway. Sci Rep. 7(1):8740. 2017
46.Xu, L., Ding, L., Wang, L., Cao, Y., Zhu, H., Lu, J., Li, X., Song, T., Hu, Y.*, Dai, J.* Umbilical cord-derived mesenchymal stem cells on scaffolds facilitate collagen degradation via upregulation of MMP-9 in rat uterine scars. Stem Cell Res Ther. 8(1):84. 2017
47.Li, X.,Zhao, Y.,Cheng, S.,Han, S.,Shu, M.,Chen, B.,Chen, X.,Tang, F.,Wang, N.,Tu, Y.,Wang, B.,Xiao, Z.*,Zhang, S.*,Dai, J.* Cetuximab modified collagen scaffold directs neurogenesis of injury-activated endogenousneural stem cells for acute spinal cord injury repair. Biomaterials.137:73-86. 2017
48.Shi, C., Chen, W., Chen, B., Shan, T., Jia, W., Hou, X., Li, L., Ye, G.*, Dai, J.* Bladder regeneration in a canine model using a bladder acellular matrix loaded with a collagen-binding bFGF. Biomater Sci. 5(12):2427-2436. 2017
49.Huang, J., Fu, H., Li, C., Dai, J.*, Zhang, Z.* Recent advances in cell-laden 3D bioprinting: materials, technologies and applications. Journal of 3D printing in medicine. 1(4): 245–268. 2017
50.Chen, B., Xiao, Z., Zhao, Y., Dai, J.* Functional biomaterial-based regenerative microenvironment for spinal cord injury repair. National Science Review. 4(4):530-532. 2017
51.Zhao, Y., Xiao, Z., Chen, B., Dai, J.* The neuronal differentiation microenvironment is essential for spinal cord injury repair. Organogenesis. 9:1-8. 2017
52.Li, X., Tan, J., Xiao, Z., Zhao, Y., Han, S., Liu, D., Yin, W., Li, J., Li, J., Wanggou, S., Chen, B., Ren, C., Jiang, X., Dai, J.* Transplantation of hUC-MSCs seeded collagen scaffolds reduces scar formation and promotes functional recovery in canines with chronic spinal cord injury. Sci Rep. 7:43559. 2017
53.Fan,C.,Li, X.,Xiao, Z.,Zhao, Y.,Liang, H.,Wang, B.,Han, S.,Li, X.,Xu, B.,Wang, N.,Liu, S.,Xue, W.,Dai, J.* A modified collagen scaffold facilitates endogenous neurogenesis for acute spinal cord injuryrepair. Acta Biomater. 51:304-316. 2017
54.Fang, Y., Wang, B., Zhao, Y., Xiao, Z., Li, J., Cui, Y., Han, S., Wei, J., Chen, B., Han, J., Meng, Q., Hou, X., Luo, J., Dai, J.*, Jing, Z.* Collagen scaffold microenvironments modulate cell lineage commitment for differentiation of bone marrow cells into regulatory dendritic cells. Sci Rep. 7:42049. 2017
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