丁梅
职称：研究员

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研究方向：神经系统发育的分子机制


丁梅，博士， 研究员，博士生导师
　　　1995年厦门大学学士， 2004年美国加州大学圣克鲁斯分校(University of California, Santa Cruz)获博士学位，2004至2008年美国斯坦福大学(Stanford University)博士后。2008年任中国科学院遗传与发育生物学研究所研究员，****，博士生导师。

主要研究方向

　　　 人类感知、学习、记忆、思维、情绪均依赖于神经系统正确的信号传导。然而，神经系统信号传导究竟如何发生，是什么机制确保信息传导的连贯性和精确性并不清楚。本实验室综合利用分子生物学，遗传学，活体成像，生物化学等多种研究手段， 系统探索神经系统发育的分子机制。主要研究内容包括：轴突定向生长，神经细胞特异性识别，突触形成与稳态调控。
发表论文（*为通讯作者）:
1) Wang J# and Ding M*. (2018) Robo and Ror function in a common receptor complex to regulate Wnt-mediated neurite outgrowth in C. elegans. PNAS doi:10.1073/pnas..
2) Guan L#, Ma X#, Zhang J, Liu J, Wang Y, Ding M*. (2016) The Calponin Family Member CHDP-1 Interacts with Rac/CED-10 to Promote Cell Protrusions. PLoS Genetics Jul 14;12(7):e**.
3) Cheng Y#, Wang J#, Wang Y, and Ding M*. (2015) Synaptotagmin 1 directs repetitive release by coupling vesicle exocytosis to the Rab3 cycle. eLife 4:e05118.
4) Wu J#, Cheng Y, Wang J, Chen L, Ding M, and Wu J*.(2015) Structural insight into the mechanism of synergic autoinhibition of SAD kinases. Nature Communications (DOI:10.1038/ncomms9953).
5) Wang J#, Chitturi J, Ge Q, Laskova V, Wang W, Li X, Ding M, Zhen M* and Huang X#. (2015) The C. elegans COE transcription factor UNC-3 activates lineage-specific apoptosis and affects neurite growth in the RID lineage. Development 142:1447-1457
6) Qin J#, Liang J, and Ding M*. (2014) Perlecan antagonizes collagen IV and ADAMTS9/GON-1 in restricting the growth of presynaptic boutons. Journal of Neuroscience 34(31):10311-10324.
7) Liu, Z#., Li, X., Ge, Q., Ding, M. and Huang, X*. (2014) A lipid droplet-associated GFP reporter-based screen identifies new fat storage regulators in C. elegans. J. Genetics and Genomics 41:305-313
8) Zhang J#, Li X, Jevince AR, Guan L, Wang J, Hall DH, Huang X *, and Ding M*. (2013) Neuronal target identification requires AHA-1-mediated fine-tuning of Wnt signaling in C. elegans. PLoS Genetics 9(6): e**.
9) Song S#, Zhang B#, Sun H, Li X, Xiang Y, Liu Z, Huang X *, and Ding M*. (2010) A Wnt-Frz/Ror-Dsh pathway regulates neurite outgrowth in Caenorhabditis elegans. PLoS Genetics 6(8): e**.
10) Ding M* and Shen K. (2008) The role of the ubiquitin proteasome system in synapse remodeling and neurodegenerative diseases. Bioessay 30: 1075-1083.
11) Ding M#, King RS, Berry EC, Wang Y, Hardin J, and Chisholm AD. (2008) The cell signaling adaptor protein EPS-8 is essential for C. elegans epidermal elongation and interacts with the ankyrin repeat protein VAB-19. PloS One 3: e3346.
12) Ding M#, Chao D, Wang G, Shen K. (2007) Spatial regulation of an E3 ubiquitin ligase directs selective synapse elimination. Science 317, 947-951.
13) Ding M#, Woo WM, Chisholm AD. (2004) The cytoskeleton and epidermal morphogenesis in C. elegans. Exp Cell Res 301:84-90.
14) Ding M#, Goncharov A, Jin Y, Chisholm AD. (2003) C. elegans ankyrin repeat protein VAB-19 is a component of epidermal attachment structures and is essential for epidermal morphogenesis. Development 130:5791-5801.
15) Chin-Sang ID#, Moseley SL, Ding M, Harrington RJ, George SE, Chisholm AD. (2002). The divergent C. elegans ephrin EFN-4 functions in embryonic morphogenesis in a pathway independent of the VAB-1 Eph receptor. Development 129:5499-5510.
16) Chin-Sang ID#, George SE, Ding M, Moseley SL, Lynch AS, Chisholm AD. (1999) The ephrin VAB-2/EFN-1 functions in neuronal signalingto regulate epidermal morphogenesis in C. elegans. Cell 99:781-790