Chao Mao
Yuelong Yan
Li Zhuang
Boyi Gan
1. Department of Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, China;
2. Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA;
3. The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA
Funds: B.G. is supported by Radiation Oncology Strategic Initiatives (ROSI) from The University of Texas MD Anderson Cancer Center.
Received Date: 2021-02-18
Rev Recd Date:2021-03-29
Publish Date:2021-11-12
Abstract
Abstract
Ferroptosis, an iron-dependent form of regulated cell death driven by peroxidative damages of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently been revealed to play an important role in radiotherapy-induced cell death and tumor suppression, and to mediate the synergy between radiotherapy and immunotherapy. In this review, we summarize known as well as putative mechanisms underlying the crosstalk between radiotherapy and ferroptosis, discuss the interactions between ferroptosis and other forms of regulated cell death induced by radiotherapy, and explore combination therapeutic strategies targeting ferroptosis in radiotherapy and immunotherapy. This review will provide important frameworks for future investigations of ferroptosis in cancer therapy.Keywords: ferroptosis,
lipid peroxidation,
GPX4,
SLC7A11,
radiotherapy,
immunotherapy,
radiosensitization,
combination therapy
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