Generation of ApoE deficient dogs via combination of embryo injection of CRISPR/Cas9 with somatic ce

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Chong Feng1, #,
Xiaomin Wang2, 3, #,
Hui Shi2, 3, #,
Quanmei Yan6,
Min Zheng7,
Jing Li7,
Quanjun Zhang9,
Yumin Qin10,
Yougang Zhong11 ,
Jidong Mi12 ,
Liangxue Lai13, 14
1Beijing SINOGENE Biotechnology Co., Ltd, Beijing 102200, China
2Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
3University of Chinese Academy of Sciences, Beijing 100049, China
6Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
7Beijing SINOGENE Biotechnology Co., Ltd, Beijing 102200, China
9Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
10College of Veterinary Medicine, China Agricultural University, Beijing 100193, China
11College of Veterinary Medicine, China Agricultural University, Beijing 100193, China
12Beijing SINOGENE Biotechnology Co., Ltd, Beijing 102200, China
13Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
14Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Veterinary Medicine, Jilin University, Changchun 130062, China

More InformationCorresponding author: E-mail address: 18911223116@126.com (Yougang Zhong);E-mail address: jidong-m@sinogene.com.cn (Jidong Mi);E-mail address: lai_liangxue@gibh.ac.cn (Liangxue Lai)
Received Date: 2017-10-24
Accepted Date:2017-11-14
Rev Recd Date:2017-11-13
Available Online: 2017-12-02 Publish Date:2018-01-20

Abstract

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http://www.jgenetgenomics.org/article/exportPdf?id=a3de8c4b-57a2-4cc6-8f4d-56b415dc2c91&language=en

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