Nicolas Lebonvallet
Fran?ois Berthod
Laurent Misery
1 Univ Brest, LIEN, 29200 Brest, France;
2 Laboratoire d'Organogenèse Expérimentale(LOEX), University of Laval, Quebec, Canada;
3 Department of Dermatology, Brest University Hospital, Brest, France;
4 Univ Brest, IBSAM(Institut Brestois de Santé Agro matière), 29200 Brest, France
Funds: Jiangsu Provincial Medical Innovation Team (Zhang F), National Natural Science Foundation of China (81600417, 81670495 and 81873548), and China National Center for Clinical Research of Digestive Diseases (201502026).
Primary Research & Development Plan of Jiangsu Province (BE2018751)
This work was supported by publicly donated Intestine Initiative Foundation
Received Date: 2019-07-26
Rev Recd Date:2019-12-16
Abstract
Abstract
Cutaneous nociception is essential to prevent individuals from sustaining injuries. According to the conventional point of view, the responses to noxious stimuli are thought to be exclusively initiated by sensory neurons, whose activity would be at most modulated by keratinocytes. However recent studies have demonstrated that epidermal keratinocytes can also act as primary nociceptive transducers as a supplement to sensory neurons. To enlighten our understanding of cutaneous nociception, this review highlights recent and relevant findings on the cellular and molecular elements that underlie the contribution of epidermal keratinocytes as nociceptive modulators and noxious sensors, both under healthy and pathological conditions.Keywords: keratinocyte,
nociception,
skin,
TRP,
pain,
inflammation
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