姓名：安威 性别：男 职称：教授 招生院所：基础医学院 招生类型：科学学位(博) 科学学位(硕) 招生专业：细胞生物学(博) 细胞生物学(硕) 研究方向名称：肝细胞的保护与再生的分子生物学研究 电子信箱：anwei@ccmu.edu.cn


社会任职
个人简历
1. 197810-198407:中国医科大学英文医学班 学习
2. 198409-198707:北京医科大学病理生理学专业硕士研究生 学习
3. 198709-199007:大连医科大学生理系博士研究生 学习
4. 199006-199303:德国爱尔兰根大学医学院 进修 学习
5. 199006-199304:德国Erlangen-Nurnberg大学医学院博士后 学习
6. 199306-:首都医科大学 工作
7. 199603-199709:西班牙最高科学研究理事会生物医学所 进修 学习
重要学术论文
1. Xiao WC, Zhang J, Chen SL, Shi YJ, Xiao F, An W*.Alleviation of palmitic acid-induced endoplasmic reticulum stress by augmenter of liverregeneration through IP3R-controlled Ca2+ release.. J Cell Physiol. . 2018,233(8):6148-6157.SCI
2. Weng J, Li W, Jia X, An W*.Alleviation of ischemia-reperfusion injury in liver steatosis by augmenter of liver regeneration is attributed to antioxidation and preservation of mitochondria.. Transplantation. . 2017,101::2340-2348. .SCI
3. Zhang C, Huang J, An W*.. Hepatic stimulator substance resists hepatic ischemia/reperfusion injury by regulating Drp1 translocation and activation. . Hepatology.. 2017,66(6):1989-2001.SCI
4. Guo YY, Wu Y, Jia XW, An W*..Augmenter of liver regeneration potentiates doxorubicin anticancer efficacy by reducing the expression of ABCB1 and ABCG2 in hepatocellular carcinoma.. Lab Invest.. 2017,97(12):1400-1411.SCI
5. Xiao W, Ren M, Zhang C, Li S, An W*..Amelioration of nonalcoholic fatty liver disease by hepatic stimulator substance via preservation of carnitine palmitoyl transferase-1 activity.. Am J Physiol Cell Physiol. . 2015,309(4):C215-27.SCI
6. Han LH, Dong LY, Yu H, Sun GY, Wu Y, Gao J, Thasler W, An W*..Deceleration of liver regeneration by knockdown of augmenter of liver regeneration gene is associated with impairment of mitochondrial DNA synthesis in mice. Am J Physiol Gastrointest Liver Physiol. 2015,309(2):G112-22.SCI
7. Zhang H, Dong LY, Sun G, An W*.Downregulation of hepatic stimulator substance during the early phase of liver regeneration inhibits E-cadherin expression in mice.. Int J Biochem Cell Biol. 2014,47:38-46.SCI
8. Yu L, Yang L, An W*, Su X*.Anticancer bioactive peptide-3 inhibits human gastric cancer growth by suppressing gastric cancer stem cells.. J Cell Biochem.. 2014,115（4）:697-711.SCI
9. Zhang J#, Li Y#, Jiang S, Yu H, An W*..Enhanced endoplasmic reticulum SERCA activity by overexpression of hepatic stimulator substance gene prevents hepatic cells from ER stress-induced apoptosis.. Am J Physiol Cell Physiol.. 2014,306（3）:c279-90.SCI
10. Sun GY, Dong LY, An W*.Involvement of hepatic stimulator substance in regulation of hepatoblast maturation into heaptocytes in vitro.. Stem Cell Dev.. 2014,. 2014 23(14):1675-1687.SCI
11. Jiang SJ, Li W, An W*.Adenoviral gene transfer of hepatic stimulator substance confers resistance against hepatic ischemia-reperfusion injury by improving mitochondrial function.. Hum Gene Ther.. 2013,4（4）:443-56.SCI
12. Yu-Tao Zhan*, Li Li, Jing Weng, Xin Song, Shao-Qi Yang, Wei An*..Serum Autofluorescence, a Potential Serum Marker for the Diagnosis of Liver Fibrosis in Rats. . Int. J. Mol. Sci.. 2012,13:12130-12139.SCI
13. Li S, Tang Z, Yu H, Li W, Jiang Y, Wang Y, An W*..Administration of naked plasmid encoding hepatic stimulator substance by hydrodynamic tail vein injection protects mice from hepatic failure by suppressing the mitochondrial permeability transition.. J Pharmacol Exp Ther.. 2011,338（3）:750-7.SCI
14. Sheng-lan Li, Zuo-qing Tang, Hao Yu, Wen Li,Ying Jiang, Yu-tong Wang, Wei An*.Administration of naked plasmid encoding hepatic stimulator substance by hydrodynamic tail vein injection protects mice from hepatic failure by suppressing the mitochondrial permeability transition. J Pharmacol Exp Ther. 2011,338(3):750-7.SCI
15. Yan-hong Yang, Ying Jiang, Yu-tong Wang*, Wei An*.Suppression of ABCA1 by unsaturated fatty acids leads to lipid accumulation in HepG2 cells. Biochimie. 2010,92:958-963.SCI
16. Wen Li, Jing Zhang, Wei An*.The conserved CXXC motif of hepatic stimulator substance is essential for its role in mitochondrial protection in H2O2-induced cell apoptosis. FEBS Lett. 2010,584(18):3929-35.SCI
17. Ling-yue Dong, Guang-yong Sun, Luan Jiang, Lei Shao, Yang Hu, Ying Jiang, Yu-tong Wang,Wei An*.Epidermal growth factor down-regulates the expression of uman hepatic timulator substance via CCAAT/enhancer-binding proteinβin HepG2 cells. Biochem J. 2010,431:277–287.SCI
18. 57.Yuan Wu, Jing Zhang, Ling-yue Dong, Wen Li, Ji-dong Jia, Wei An*.Hepatic stimulator substance mitigates hepatic cell injury through suppression of the mitochondrial permeability transition. FEBS J. 2010,277:1297–1309.SCI
19. Ying Jiang, Hua Zhang, Ling-Yue Dong, Dan Wang, Wei An* .Increased hepatic UCP2 expression in rats with nonalcoholic steatohepatitis is associated with upregulation of Sp1 binding to its motif within the proximal promoter. J Cell Biochem . 2008,105(1):277-89.SCI
20. Ping Wang, Hai-Yan Zhang, Wei-Hong Li, Yong-Mei Zhao, Wei An*.Promoter-defined isolation and identfication of hepatic progenitor cells from human fetal liver . Histochem & Cell Biol. 2008,130(2):375-85.SCI
21. Duo Guo, Ling-yue Dong, Yuan Wu, Lin Yang, Wei An*.Downregulation of hepatic nuclear factor 4alpha on expression of human hepatic stimulator substance via its action on the proximal promoter in HepG2 cells. Biochem J. 2008,415(1):111-21.SCI
22. Ling-Yue Dong, Xin-Nan Wang, Zhi-Gang Song, Duo Guo, Yan-Yan Zhao and Wei An*.Identification of human hepatic stimulator substance gene promoter and demonstration of dual regulation of AP1/AP4 cis-acting element in different cell lines. Int J Biochem Cell Biol. 2007,39(1):181-186.SCI
23. Yuan Wu, Li Chen, Hao Yu, He-jia Liu，Wei An*.Transfection of hepatic stimulator substance gene desensitizes hepatoma cells to H2O2-induced cell apoptosis via preservation of mitochondria. Arch Biochem Biophys. 2007,464:48–56.SCI
主编或副主编的著作/译著
1. 《医学细胞生物学》,主编,北京大学医学出版社,201901
2. 《医学细胞生物学（第三版）》,主编,北京大学医学出版社,2014
3. 《医学细胞生物学（第二版）》,主编,北京大学医学出版社,2009
4. 《医学细胞生物学》,主编,北京大学医学出版社,200307
5. 《医学细胞分子生物学》,主编,中国协和医科大学出版社,200207
重要奖项
1. 新世纪百千万人才工程北京市人选 1 200406
2. 多种增殖性疾病基因治疗的实验研究 1 200212
3. 人原发性肝癌基因治疗的实验研究 1 200112