姓名：吴巍 性别：男 职称：教授 招生院所：基础医学院 招生类型：科学学位(博) 科学学位(硕) 招生专业：生物化学与分子生物学(博) 生物化学与分子生物学(硕) 研究方向名称：天然抗癌药物抗癌机理 电子信箱：weiwu207@ccmu.edu.cn


社会任职
个人简历
1. 198307-199107:哈尔滨医科大学预防医学系 学士和硕士
2. 199109-199411:北京医科大学生物化学与分子生物学系 博士
3. 199605-199807:美国西保留地大学遗传学系 博士后
4. 199809-199909:美国得克萨斯大学加尔维斯顿医学分部内科系 博士后
5. 200008-200204:美国加利福尼亚大学河滨校生物医学分部 博士后
6. 200204-200704:美国加利福尼亚大学河滨校生物医学分部及生化系 研究助理教授
7. 200711-201202:首都医科大学公共卫生与家庭医学学院流行病与卫生统计学系 教授、博士生导师
8. 201203-:首都医科大学基础医学院生物化学与分子生物学系 教授、博士生导师
重要学术论文
1. Zhou Y, Yang GX, Tian H, Hu YB, Wu S, Geng Y, Lin K, Wu W*.Sulforaphane metabolites cause apoptosis via microtubule disruption in cancer. Endocr Relat Cancer. 2018,25(3):255-268.SCI
2. Hu Y, Zhou Y, Yang G, Wang Y, Zheng Z, Li J, Yan Y, Wu W*.Sulforaphane-N-Acetyl-Cysteine inhibited autophagy leading to apoptosis via Hsp70-mediated microtubule disruption. Cancer Lett. 2018,431:85-95.SCI
3. Wang Y, Zhou Y, Zheng Z, Li J, Yan Y, Wu W*.Sulforaphane metabolites reduce resistance to paclitaxel via microtubule disruption. Cell Death Dis. 2018,9(11):1134.SCI
4. Wu S, Zhou Y, Yang G, Tian H, Geng Y, Hu Y, Lin K, Wu W* .Sulforaphane-cysteine induces apoptosis by sustained activation of ERK1/2 and caspase 3 in human glioblastoma U373MG and U87MG cells. Oncol Rep. 2017,37(5):2829-2838.SCI
5. Geng Y, Zhou Y, Wu S, Hu Y, Lin K, Wang Y, Zheng Z, Wu W*. Sulforaphane induced apoptosis via promotion of mitochondrial fusion and ERK1/2-Mediated 26S proteasome degradation of novel pro-survival Bim and upregulation of Bax in human non-small cell lung cancer cells. J Cancer . 2017,8(13):2456-2470.SCI
6. 杨高祥，周 妍，田 华，吴 巍*.N-乙酰半胱氨酸萝卜硫素通过上调 Bak 和下调 Bcl - 2 蛋白表达诱导前列腺癌细胞凋亡. 山西医科大学学报. 2016,47(4):311-314.核心期刊
7. Peng X, Zhou Y, Tian H, Yang G, Li C, Geng Y, Wu S, Wu W*..Sulforaphane inhibits invasion by phosphorylating ERK1/2 to regulate E-cadherin and CD44v6 in human prostate cancer DU145 cells . Oncol Rep. 2015,34:1565-1572.SCI
8. Li C, Zhou Y, Peng X, Du L, Tian H, Yang G, Niu J, Wu W*..Sulforaphane inhibits invasion via activating ERK1/2 signaling in human glioblastoma U87MG and U373MG cells. Plos One. 2014,9(2):e90520.SCI
9. Li Z, Li C, Du L, Zhou Y, Wu W*..Human Chorionic Gonadotropin b Induces Migration and Invasion via Activating ERK1/2 and MMP-2 in Human Prostate Cancer DU145 Cells. Plos One. 2013,8（2）:e54592.SCI
10. Li Z, Du L, Li C, Wu W*. .Human chorionic gonadotropin β induces cell motility via ERK1/2 and MMP-2 activation in human glioblastoma U87MG cells.. J Neurooncol . 2013,111:237–244.SCI
11. Du L, Wu W*..A mimic of phosphorylated prolactin induces apoptosis by activating AP‑1 and upregulating p21/waf1 in human prostate cancer PC3 cells. Oncology Letters. 2012,4:1064-1068.SCI
12. 共同责任作者.Bacteria Peptidoglycan Promoted Breast Cancer Cell Invasiveness and Adhesiveness by Targeting Toll-Like Receptor 2 in the Cancer Cells. Plos One. 2010,5(5):e10850.SCI
13. 并列第一作者(IF: 2.595).SNAP-25 enhances insulin secretion by blocking Kv2.1 channels in rat pancreatic islet β-cells. Biochemical and Biophysical Research Communications. 2009,379:812-816.SCI
14. 责任作者 （IF: 16.144).Control of avian influenza A H5N1 in China . Lancet Infectious Diseases. 2009,9(8):460-461.SCI
15. 第一作者 (IF: 3.377).S179D Prolactin sensitizes human prostate cancer cells such that physiological concentrations of 1, 25 dihydroxy vitamin D 3 result in growth inhibition and cell death. Prostate. 2007,67 (14):1498-1506.SCI
16. 第一作者 (IF: 0.826).Different forms of prolactin have opposing effects on the expression of cell cycle regulatory proteins in differentiated mammary epithelial cells. Oncology Research. 2006,16(2):75-84.SCI
17. 第一作者 (IF: 8.234).S179D prolactin increases vitamin D receptor and p21 through up-regulation of short 1b prolactin receptor in human prostate cancer cells. Cancer Research. 2005,65(16):7509-7515.SCI
18. 第一作者 (IF: 3.226).Different biological effects of unmodified prolactin and a molecular mimic of phosphorylated prolactin involve different signaling pathways. Biochemistry. 2003,42(24):7561-7570.SCI
19. 第一作者 (IF: 6.908).Development of hypertension induced by subpressor infusion of angiotensin II: Role of sensory nerves. Hypertension. 2000,36(4):549-552.SCI
主编或副主编的著作/译著
重要奖项