姓名：贺俊崎 性别：男 职称：教授 招生院所：基础医学院 招生类型：科学学位(博) 科学学位(硕) 招生专业：生物化学与分子生物学(博) 生物化学与分子生物学(硕) 研究方向名称：肿瘤转移标志物及信号转导研究 电子信箱：jq_he@ccmu.edu.cn


社会任职
1. 美国抗癌协会会员
2. 中国生物化学与分子生物学会会员
3. 中国药理学会会员
4. 中华医学科技奖评审委员会委员
5. 卫生部科教司卫生科研项目评审专家
6. 北京市科委生物医药项目评审专家
7. 《医学分子生物学杂志》编辑委员会特邀审稿专家
8. 《中国生物化学与分子生物学报》编委
9. 《生物物理学》编委
10. 《首都医科大学学报》编委
11. 中国抗癌协会肿瘤病因学专业委员会常务委员
12. 中国医药教育协会转化医学专业委员会委员
个人简历
1. 199509-199802:中国协和医科大学 学习
2. 199802-200301:Emory University（美国） 学习
3. 200301-200409: Emory University（美国） 任职
4. 200409-:首都医科大学生化与分子生物学系 教授
5. 201810-:美国Emory 大学 客座教授
重要学术论文
1. Wang Q, Song R, Zhao C, Liu H, Yang Y, Gu S, Feng D, He J(*).HPV16 E6 promotes cervical cancer cell migration and invasion by downregulation of NHERF1. Int J Cancer. 2019,144(7):1619-1632.SCI
2. Zhao C(#)，Tao T，Yang L，Qin Q，Wang Y，Liu H，Song R，Yang X，Wang Q，Gu S，Xiong Y,Zhao D,Wang S,Feng D,Jiang W,Zhang J(*),He J(*).Loss of PDZK1 expression activates PI3K/AKT signaling via PTEN phosphorylation in gastric cancer. Cancer Letters. 2019,453:107-121.SCI
3. Wang Q, Qin Q, Song R, Zhao C, Liu H, Yang Y, Gu S, Zhou D, He J(*).NHERF1 inhibits beta-catenin-mediated proliferation of cervical cancer cells through suppression of alpha-actinin-4 expression. Cell Death Dis.. 2018,9(6):668.SCI
4. Yang X, Du G, Yu Z, Si Y, Martin TA, He J*, Cheng S*, Jiang WG*..A Novel NHERF1 Mutation in Human Breast Cancer and Effects on Malignant Progression.. Anticancer Res.. 2017,37(1):67-73.SCI
5. Zheng J, Wang L, Peng Z, Yang Y, Feng D, He J*.Low level of PDZ domain containing 1 (PDZK1) predicts poor clinical outcome in patients with clear cell renal cell carcinoma.. EBioMedicine. 2017,15:62-72.SCI
6. Tao T , Yang X, Qin Q, Shi W, Wang Q , Yang Y* , He J*.NHERF1 Enhances Cisplatin Sensitivity in Human Cervical Cancer Cells.. INT J MOL SCI. 2017,18(1):doi: 10.3390.SCI
7. Tao T#, Yang X#, Zheng J, Feng D, Qin Q, Shi X, Wang Q, Zhao C, Peng Z, Liu H*, Jiang WG, He J*.PDZK1 inhibits the development and progression of renal cell carcinoma by suppression of SHP-1 phosphorylation. Oncogene. 2017,36(44):6119-6131.SCI
8. Wang Y, Peng Z, Meng R, Tao T, Wang Q, Zhao C, Liu H, Song R, Zheng J, Qin Q*, He J*.NHERF1 inhibits proliferation of triple-negative breast cancer cells by suppressing GPER signaling. Oncol Rep.. 2017,38(1):221-228.SCI
9. Yang X#, Si Y, Tao T, Martin TA, Cheng S, Yu H, Li J, He J*, Jiang WG*.The Impact of TIMM17A on Aggressiveness of Human Breast Cancer Cells. Anticancer Res.. 2016,36(3):1237-1241.SCI
10. Sun L#, Zheng J#, Wang Q, Song R, Liu H, Meng R, Tao T, Si Y, Jiang W, He J*.NHERF1 regulates actin cytoskeleton organization through modulation of α-actinin-4 stability. FASEB J.. 2016,30(2):578-589.SCI
11. Zheng J#, Dai Y#, Yang Z, Yang L, Peng Z, Meng R, Xiong Y, He J*.Ezrin-radixin-moesin -binding phosphoprotein-50 regulates EGF-induced AKT activation through interaction with EGFR and PTEN. Oncol Rep.. 2016,35(1):530-537.SCI
12. Du G#, Hao C, Gu Y, Wang Z, Jiang WG, He J*, Cheng S*.A Novel NHERF1 Mutation in Human Breast Cancer Inactivates Inhibition by NHERF1 Protein in EGFR Signaling. Anticancer Res.. 2016,36(3):1165-1173.SCI
13. Peng Z, Wang Q, Zhang Y, He J*, Zheng J*.EBP50 interacts with EGFR and regulates EGFR signaling to affect the prognosis of cervical cancer patients.. Int J Oncol.. 2016,49(4):1737-1745.SCI
14. Ma Q#, Zhang Y#, Meng R, Xie KM, Xiong Y, Lin S, He ZL, Tao T, Yang Y, Zhao JZ*, He JQ*.MAGI3 Suppresses Glioma Cell Proliferation via Upregulation of PTEN Expression. Biomed Environ Sci.. 2015,28(7):502-9.SCI
15. Yang L#, Zheng J#, Xiong Y, Meng R, Ma Q, Liu H, Shen H, Zheng S, Wang S, He J*.Regulation of β2-adrenergic receptor cell surface expression by interaction with cystic fibrosis transmembrane conductance regulator-associated ligand (CAL). Amino Acids. 2015,47(7):1455-1464.SCI
16. Zheng S#, Yang Y, Song R, Yang X, Liu H, Ma Q, Yang L, Meng R, Tao T, Wang S, He J*.Ang-(1-7) promotes the migration and invasion of human renal cell carcinoma cells via Mas-mediated AKT signaling pathway. Biochem Biophys Res Commun. 2015,460(2):333-340.SCI
17. Du G#, Yang X#, Hu M, Hao C, Gu Y, Zhi X, Jiang J, He J* and Cheng S*.Designing a novel high-throughput AlphaLISA assay to quantify plasma NHERF1 as a non-small cell lung cancer biomarker. RSC Adv.. 2015,5:84164–84171.SCI
18. Teng X#, Cheng S, Meng R, Zheng S, Yang L, Ma Q, Jiang W, He J*.A Facile Way for Fabricating PEGylated Hollow Mesoporous Silica Nanoparticles and Their Drug Delivery Application. J Nanosci Nanotechnol.. 2015,15(5):3773-3779.SCI
19. Cheng S, Li Y, Yang Y, Feng D, Yang L, Ma Q, Zheng S, Meng R, Wang S, Wang S, Jiang WG, He J*.Breast cancer-derived K172N, D301V mutations abolish Na+/H+ exchanger regulatory factor 1 inhibition of platelet-derived growth factor receptor signaling. FEBS LETT. 2013,587(20):3289-3295.SCI
20. Bian W, Sun L, Yang L, Li JF, Hu J, Zheng S, Guo R, Feng D, Ma Q, Shi X, Xiong Y, Yang X, Song R, Xu J, Wang S, He J*.Stabilization of the Angiotensin -(1-7) Receptor Mas through Interaction with PSD95. Biochem J.. 2013,453(3):345-356.SCI
21. Sun C, Zheng J, Cheng S, Feng D, He J*.EBP50 Phosphorylation by Cdc2/Cyclin B Kinase Affects Actin Cytoskeleton Reorganization and Regulates Functions of Human Breast Cancer Cell Line MDA-MB-231. Mol. Cells. 2013,36(1):47-54.SCI
22. Wen-fang Yao,Dui-ping Feng,Wei-hua Bian,Long-yan Yang,Yang Li,Zhi-yu Yang,Ying Xiong,Jun-fang Zheng,Ren-you Zhai,Jun-qi He*.EBP50 inhibits EGF-induced breast cancer cell proliferation by blocking EGFR phosphorylation. AMINO ACIDS. 2012,43:2027–2035.SCI
23. Li-zheng Qin,Xi-bao Liu,Qi-fei Sun,Zhi-peng Fan,Deng-sheng Xia,Gang Ding,Hwei Ling Ong,David Adams,William A. Gahl,Chang-yu Zheng,Sen-rong Qi,Lu-yuan Jin,Chun-mei Zhang,Lian-kun Gu,Jun-qi He,Da-jun Deng, Indu S. Ambudkar and Song-ling Wang*.Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane. P NATL ACAD SCI USA. 2012,109(33):13434-13439.SCI
24. Long-yan Yang,Ying Wang,Peng Chen,Jia Hu,Ying Xiong,Dui-ping Feng,Hua Liu,Hong Zhang,Hui Yang,Jun-qi He*.Na(+)/H(+) Exchanger Regulatory Factor 1 (NHERF1) Is Required for the Estradiol-Dependent Increase of Phosphatase and Tensin Homolog (PTEN) Protein Expression. ENDOCRINOLOGY. 2011,152(12):4537-4549.SCI
25. Xing-lu Huang, Xu Teng, Dong Chen, Fang-iong Tang*, Jun-qi He.The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function. BIOMATERIALS. 2010,31:438–448.SCI
26. Lin-lin Li,Fang-qiong Tang*,Hui-yu Liu,Tian-long Liu,Nan-jing Hao,Dong Chen, Xu Teng,and Jun-qi He.In Vivo Delivery of Silica Nanorattle Encapsulated Docetaxel for Liver Cancer Therapy with Low Toxicity and High Efficacy. ACS NANO. 2010,4:6874-6882.SCI
27. Tian-long Liu, Lin-lin Li, Xu Teng, Xing-lu Huang, Hui-yu Liu, Dong Chen, Jun Ren, Jun-qi He,Fang-qiong Tang*.Single and repeated dose toxicity of mesoporous hollow silica nanoparticles in intravenously exposed mice. BIOMATERIALS. 2010,32(6):1657-1668.SCI
28. Jun-Fang Zheng，Li-Cui Sun，Hua Liu，Yan Huang，Yang Li，Junqi He*.EBP50 exerts tumor suppressor activity by promoting cell apoptosis and retarding extracellular signal-regulated kinase activity. AMINO ACIDS. 2010,38:1261–1268.SCI
29. Jun-fang Zheng，Hui Shen，Ying Xiong，Xiao-mei Yang，Jun-qi He*.The β1-adrenergic receptor mediates extracellular signal-regulated kinase activation via Gαs. AMINO ACIDS. 2010,38:75-84.SCI
30. Xiao-mei Yang, Jun-fang Zheng, Ying Xiong, Hui Shen, Li-cui Sun, Yan Huang, Chao-yuan Sun, Yang Li, Jun-qi He *.Beta-2 Adrenergic Receptor Mediated ERK Activation is Regulated by Interaction with MAGI-3. FEBS LETT. 2010,584（11）:2207-2212.SCI
31. Shan Cheng,Jiu-qin Zhang,Ping Zhu,Yan-mei Ma,Ying Xiong,Li-cui Sun,Jian-guo Xu,Hong Zhang，Jun-qi He*.The PDZ domain protein CAL interacts with mGluR5a and modulates receptor expression. J NEUROCHEM. 2010,112:588–598.SCI
32. 郑君芳,孙超渊,孙丽翠,杨晓梅,王小柱,黄艳,李洋,贺俊崎*.空间记忆相关蛋白的蛋白质组学研究. 化学学报. 2010,68（10）:996-1002.SCI
33. 郑君芳，华琳，张秋霞，李德龙，贺俊崎*.嗅觉记忆相关蛋白的蛋白质组学研究. 高等学校化学学报. 2010,8（31）:1535-1540.SCI
34. 黄艳，熊英，刘华，孙超渊，李洋，贺俊崎*.PLC-β3与syntrophin蛋白的相互作用. 基础医学与临床. 2010,30（7）:708-713.核心期刊
35. 郑君芳,刘华,熊英,王小柱,贺俊崎*.恐惧记忆相关蛋白的蛋白质组学研究. 高等学校化学学报. 2010,31（4）:736-741.SCI
36. 郑君芳，刘琨，马桂伶，陈鹏，贺俊崎*.EBP50抑制HeLa细胞增殖及基质金属蛋白酶表达. 基础医学与临床. 2009,29（3）:314-315.核心期刊
37. Lin-lin Fan,Shuang Ren, Hong Zhou, Ying Wang, Ping-xiang XuJun-qi He, Da-li Luo*.alpha(1D)-Adrenergic receptor insensitivity is associated with alterations in its expression and distribution in cultured vascular myocytes. ACTA PHARMACOL SIN. 2009,30:1585–1593.SCI
38. 程杉，熊英，贺俊崎*.RNA干扰及其在肿瘤研究中的应用. 首都医科大学学报. 2008,29（1）:87-95.核心期刊
39. Jiu-qin Zhang,Shan Cheng,Ying Xiong,Yan-mei Ma,Da-li Luo,Andreas Jeromin,Hong Zhang,Jun-qi He*.A novel association of mGluR1a with the PDZ scaffold protein CAL modulates receptor activity . FEBS LETT. 2008,582:4117–4124.SCI
40. 郑君芳，贺俊崎*.磷酸化蛋白50(EBP50)--一种新的抑癌蛋白. 生物化学与生物物理进展. 2008,35（6）:620-624.SCI
41. 孙丽翠，胡家，郑君芳，苏雷，贺俊崎*.几种不同提取方法对Hela细胞总蛋白双向电泳结果的影响. 首都医科大学学报. 2008,29(4):451-454.核心期刊
42. 迟锦玉, 熊英, 贺俊崎*.PDGFR_与_2_syntrophin蛋白相互作用的初步研究. 医学分子生物学杂志. 2008,5（2）:119-123.核心期刊
43. Yan-mei Ma,Shan Cheng,Michael L. Leski,Da-li Luo,Jun-qi He*.Development and Validation of a Sensitive LC–Tandem-MS Method for the Quantitative Determination of Picroside II in Rat Plasma. CHROMATOGRAPHIA. 2008,68:1027–1032.SCI
44. Shan Cheng，Feng Qiu，Jia Huang，Jun-qi He.Simultaneous determination of vitexin-2. J SPAT SCI. 2007,30（5）:717-721.SCI
45. Shan Cheng, Feng Qiu, Jia Huang, and Jun-qi He.Development and validation of a simple and rapid HPLC method for the quantitative determination of voriconazole in rat and beagle dog plasma. J CHROMATOGR SCI. 2007,6:409-414.SCI
46. 陈鹏,杨晓梅,熊英,迟锦玉,张松,杨慧,贺俊崎*.PTEN与NHERF_1相互作用. 基础医学与临床. 2007,27(4):372-376.核心期刊
47. 李积凤，熊英, 李延华,杨晓梅，陈鹏，江琪，安云庆，贺俊崎*.血管紧张素_1_7_的受体MAS与PSD_95的相互作用. 中国生物化学与分子生物学报. 2007,23（5）:370-374.核心期刊
48. Shan Cheng, Jia Huang, Jun-qi He.Development and validation of an accurate HPLC method for the quantitative determination of picroside II in tablets. PHARMAZIE. 2007,62:577–579.SCI
49. Shan Cheng, Feng Qiu, Shuhui Wang, Jun-qi He.HPLC analysis and pharmacokinetics of icariin in rats. J SPAT SCI. 2007,30(9):1307-1312.SCI
50. Jun-qi He, Michele Bellini, Hiroyuki Inuzuka, Jian-guo Xu, Ying Xiong,Xiao-ming Wang, Amanda M. Castleberry，Randy A. Hall*.Proteomic Analysis of beta 1-Adrenergic Receptor Interactions with PDZ Scaffold Proteins. J BIOL CHEM. 2006,281（5）:2820-2827.SCI
51. Shan Cheng, Feng Qiu, Shu-hui Wang, Jun-qi He. HPLC analysis and pharmacikinetic study of paeoniflorin after intravenous adminnistration of a new frozen dry powder formulation in rats. CHROMATOGRAPHIA. 2006,64:661–666.SCI
52. Jun-qi He, Michele Bellini, Jian-guo Xu, Amanda M. Castleberry, Randy A. Hall *.Interaction with CAL Inhibits beta 1-Adrenergic Receptor Surface Expression . J BIOL CHEM. 2004,279:50190–50196.SCI
53. Jun-qi He, Jian-guo Xu, Xiang-Xi Xu，Randy A Hall*.Cell cycle-dependent phosphorylation of Disabled-2 by cdc2. ONCOGENE. 2003,22:4524–4530.SCI
54. Jian-guo Xu, Jun-qi He, Amanda M. Castleberry, Srividya Balasubramanian, Anthony G. Lau,Randy A. Hall*.Heterodimerization of alpha-2A-and beta-1- adrenergic receptors. J BIOL CHEM. 2003,278（12）:10770–10777.SCI
55. Dong-Hua Yang, Elizabeth R. Smith, Isabelle H. Roland,Ze-juan Sheng, Jun-qi He, W. David Martin, Thomas C. Hamilton,J. David Lambeth,Xiang-Xi Xu.Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis. DEV BIOL. 2002,251:27–44.SCI
56. Jun-qi He, Jian-guo Xu, Amanda M. Castleberry, Anthony G. Lau，Randy A. Hall*.Glycosylation of beta(1)-adrenergic receptors regulates receptor surface expression and dimerization. BIOCHEM BIOPH RES CO. 2002,297(3):565-572.SCI
57. Jun-qi He, Elizabeth R. Smith,Xiang-Xi Xu.Disabled-2 exerts its tumor suppressor activity by uncoupling c-Fos　expression and MAP kinase activation. J BIOL CHEM. 2001,276（29）:26814–26818.SCI
58. Elizabeth R. Smith, Callinice D. Capo-chichi, Jun-qi He, Jennifer L. Smedberg, Dong-Hua Yang,Amanda H. Prowse, Andrew K. Godwin, Thomas C. Hamilton,Xiang-Xi Xu*.Disabled-2 mediates c-Fos suppression and the cell growth regulatory activity of retinoic acid in embryonic carcinoma cells. J BIOL CHEM. 2001,276（50）:47303-47310.SCI
59. Jun-qi He, Anthony G. Lau, Michael B. Yaffe，Randy A. Hall*.Phosphorylation and cell cycle-dependent regulation of Na+/H+ exchanger regulatory factor-1 by Cdc2 kinase. J BIOL CHEM. 2001,276（45）:41559-41565.SCI
60. Ze-juan Sheng, Elizabeth R. Smith, Jun-qi He, Joseph A. Tuppen, W. David Martin,Feng B. Dong, Xiang-Xi Xu*.Chromosomal location of murine disabled-2 gene and structural comparison with its human ortholog. GENE. 2001,268 :31-39.SCI
61. Ze-juan Sheng, Jun-qi He,Joseph A. Tuppen, Wen-ping Sun, Zia Fazili,Elizabeth R. Smith, Feng B. Dong,Xiang-Xi Xu*.Structure, sequence, and promoter analysis of human disabled-2 gene (DAB2). GENOMICS. 2000,70 :381–386.SCI
主编或副主编的著作/译著
1. 《生物化学（第四版）（国家级规划教材）》,主编,北京大学医学出版社,201806
2. 《人体分子和细胞基础（卫计委规划教材）》,副主编,人民卫生出版社,201803
3. 《生物化学（第3版）》,副主编,北京大学医学出版社,201312
4. 《biochemistry》,副主编,高等教育出版社,2012
5. 《生物化学（第2版）》,副主编,北京大学医学出版社,200908
6. 《细胞信号转导研究技术》,主编,中国协和医科大学出版社,200808
7. 《人体生物化学与疾病》,副主编,科学出版社,200806
重要奖项
1. 北京市 6
2. 教育部新世纪优秀人才资助 5
3. 北京市教委“创新人才建设计划”资助 4
4. 北京市人事局留学人员科技活动择优资助 3
5. 《生物化学》课程 北京市精品课程 201106
6. 北京市优秀人才培养个人项目资助 2
7. 北京市新世纪百千万人才工程资助