姓名：尚永丰 性别：男 职称：教授 招生院所：基础医学院 招生类型：科学学位(博) 科学学位(硕) 招生专业：生物化学与分子生物学(博) 生物化学与分子生物学(硕) 研究方向名称：基因表达调控的表观遗传机制/乳腺癌发生发展的分子机理 电子信箱：yshang@hsc.pku.edu.cn


社会任职
1. 首都医科大学校长
个人简历
1. 199905-200107:美国哈佛大学 博士后
2. 200108-200204:美国哈佛大学 任职
3. 200204-:北京大学医学部 任职
4. 201108-201610:天津医科大学 任职
5. 201610-:首都医科大学 任职
重要学术论文
1. Lin He, Xinhua Liu, Jianguo Yang, Wanjin Li, Shumeng Liu, Xujun Liu, Ziran Yang, Jie Ren, Yue Wang, Lin Shan, Chengjian Guan, Fei Pei, Liandi Lei, Yu Zhang, Xia Yi, Xiaohan Yang, Jing Liang, Rong Liu, Luyang Sun*, Yongfeng Shang*.Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis. Cell Research. 2018,28:934–951.SCI
2. Shumeng Liu, Huajing Yu, Yongqing Liu, Xinhua Liu, Yu Zhang, Chen Bu, Shuai Yuan, Zhe Chen, Guojia Xie, Wanjin Li, Bosen Xu, Jianguo Yang, Lin He, Tong Jin, Yundong Xiong, Luyang Sun, Xiaohui Liu, Chunsheng Han, Zhongyi Cheng, Jing Liang*, and Yongfeng Shang*.Chromodomain Protein CDYL Acts as a Crotonyl-CoA Hydratase to Regulate Histone Crotonylation and Spermatogenesis. Molecular Cell. 2017,67:853–866.SCI
3. Wanjin Li, Zihan Zhang, Xinhua Liu, Xiao Cheng, Yi Zhang, Xiao Han, Yu Zhang, Shumeng Liu, Jianguo Yang, Bosen Xu, Lin He, Luyang Sun, Jing Liang, and Yongfeng Shang*.The FOXN3-NEAT1-SIN3A repressor complex promotes progression of hormonally responsive breast cancer. The Journal of Clinical Investigation. 2017,127(9):3421–3440.SCI
4. Lifang Li , Xinhua Liu, Lin He , Jianguo Yang , Fei Pei, Wanjin Li , Shumeng Liu , Zhe Chen , Guojia Xie , Bosen Xu , Xia Ting , Zihan Zhang , Tong Jin , Xujun Liu , Wenting Zhang , Shuai Yuan , Ziran Yang , Chongyang Wu , Yu Zhang , Xiaohan Yang, Xia Yi , Jing Liang , Yongfeng Shang*, Luyang Sun*.ZNF516 suppresses EGFR by targeting the CtBP/ LSD1/CoREST complex to chromatin. Nature Communications. 2017,8:691.SCI
5. Lei Li, Lan Shi, Shangda Yang, Ruorong Yan, Di Zhang, Jianguo Yang, Lin He, Wanjin Li, Xia Yi, Luyang Sun, Jing Liang, Zhongyi Cheng, Lei Shi, Yongfeng Shang*, Wenhua Yu*.SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability. Nature Communications. 2016,7:12235.SCI
6. Yang Duan, Dawei Huo, Jie Gao, Heng Wu, Zheng Ye, Zhe Liu, Kai Zhang, Lin Shan, Xing Zhou, Yue Wang, Dongxue Su, Xiang Ding, Lei Shi, Yan Wang, Yongfeng Shang*, Chenghao Xuan*.Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5. Nature Communications. 2016,7:12648.SCI
7. Lin Shan, Xing Zhou, Xinhua Liu, Yue Wang, Dongxue Su, Yongqiang Hou, Na Yu, Chao Yang, Beibei Liu, Jie Gao, Yang Duan, Jianguo Yang, Wanjin Li, Jing Liang, Luyang Sun, Kexin Chen, Chenghao Xuan, Lei Shi, Yan Wang, Yongfeng Shang*.FOXK2 Elicits Massive Transcription Repression and Suppresses the Hypoxic Response and Breast Cancer Carcinogenesis. Cancer Cell. 2016,30(5):708–722.SCI
8. Yu Zhang, Di Zhang, Qian Li, Jing Liang, Luyang Sun, Xia Yi, Zhe Chen, Ruorong Yan, Guojia Xie, Wanjin Li, Shumeng Liu, Bosen Xu, Lei Li, Jianguo Yang, Lin He, Yongfeng Shang*.Nucleation of DNA repair factors by FOXA1 links DNA demethylation to transcriptional pioneering. Nature Genetics. 2016,48(9):1003-1013.SCI
9. Ruorong Yan, Lin He, Zhongwu Li, Xiao Han, Jing Liang, Wenzhe Si, Zhe Chen, Lei Li, GuojiaXie, Wanjin Li, Peiyan Wang, Liandi Lei, Hongquan Zhang, Fei Pei, Dengfeng Cao, Luyang Sun*, Yongfeng Shang* .SCFJFK is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer. Genes & Development. 2015,29(6):672-685.SCI
10. Wenzhe Si, Wei Huang, Yu Zheng, Yang Yang, Xujun Liu, Lin Shan, Xing Zhou, Yue Wang, Dongxue Su, Jie Gao,Ruorong Yan, Xiao Han, Wanjin Li, Lin He, Lei Shi, Chenghao Xuan, Jing Liang, Luyang Sun, Yan Wang*, Yongfeng Shang* .Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis. Cancer Cell. 2015,27(6):822-836.SCI
11. Xiao Han, Bin Gui, Cong Xiong, Linnan Zhao, Jing Liang, Luyang Sun, Xiaohan Yang, Wenhua Yu, Wenzhe Si, Ruorong Yan, Xia Yi, Di Zhang, Wanjin Li, LifangLi,Jianguo Yang, Yan Wang, Yi Eve Sun, Dai Zhang, AnmingMeng, Yongfeng Shang*.Destabilizing LSD1 by Jade-2 Promotes Neurogenesis: an Anti-brakingSystem in Neural Development. Molecular Cell. 2014,55:482-494.SCI
12. Feng Wang, Lin He, Peiwei Huangyang, Jing Liang, Wenzhe Si, Ruorong Yan, Xiao Han, Shumeng Liu, Bin Gui, Wanjin Li, Di Miao, Chao Jing, Zhihua Liu, Fei Pei, Luyang Sun*, Yongfeng Shang*.JMJD6 Promotes Colon Carcinogenesis through Negative Regulation of p53 by Hydroxylation. PLoS Biology. 2014,12(3):e**.SCI
13. Xin Li, Ling Liu, Shangda Yang, Nan Song, Xing Zhou, JieGao, Na Yu, Lin Shan, Qian Wang, Jing Liang, ChenghaoXuan, Yan Wang, Yongfeng Shang*, Lei Shi*.Histone demethylase KDM5B is a key regulator of genome stability. Proc Natl Acad Sci U S A.. 2014,111(19):7096-7101.SCI
14. Xiaohan Yang, Lei Li, Jing Liang, Lei Shi, Jianguo Yang, Xia Yi, Di Zhang, Xiao Han, Na Yu, Yongfeng Shang* .Histone acetyltransferase 1 promotes homologous recombination in DNA repair by facilitating histone turnover. Journal of Biological Chemistry. 2013,288(25):18271-18282.SCI
15. Fen Yang, Luyang, Sun Qian Li, Xiao Han, Liandi Lei, Hua Zhang*, Yongfeng Shang*.SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities. Embo Journal . 2012,31(1):110-123.SCI
16. Xia Yi, Mei Hong, Bin Gui, Zhe Chen, Lei Li, Guojia Xie, Jing Liang, Xiaocheng Wang, Yongfeng Shang*.RNA Processing and Modification Protein, Carbon Catabolite Repression 4 (Ccr4), Arrests the Cell Cycle through p21-dependent and p53-independent Pathway. Journal of Biological Chemistry. 2012,287(25):21045-21057.SCI
17. Dandan Wang, Jing Liang, Yu Zhang, Bin Gui, Feng Wang, Xia Yi, Luyang Sun, Zhi Yao* , Yongfeng Shang*.Steroid Receptor Coactivator-interacting Protein (SIP) Inhibits Caspase-independent Apoptosis by Preventing Apoptosis-inducing Factor (AIF) from Being Released from Mitochondria. Journal of Biological Chemistry. 2012,287(16):12612-12621.SCI
主编或副主编的著作/译著
重要奖项
1. 雌激素和三苯氧胺诱发妇科肿瘤的分子机制 国家自然科学奖 二等奖 200812
2. 雌激素及其拮抗剂三苯氧胺诱发妇科肿瘤的分子机制研究 中华医学科技奖 一等奖 200712