姓名：郑君芳 性别：女 职称：教授 招生院所：基础医学院 招生类型：科学学位(博) 科学学位(硕) 招生专业：生物化学与分子生物学(博) 生物化学与分子生物学(硕) 研究方向名称：肿瘤相关信号通路的调节和肿瘤分子标志物的鉴定 电子信箱：zhengjf@ccmu.edu.cn, @qq.com


社会任职
1. 美国抗癌协会会员
2. 中国生物化学与分子生物学会会员
个人简历
1. 199709-200007:北京中医药大学 学习
2. 200009-200312:北京大学医学部 学习
3. 200401-200606:清华大学生物科学与技术系 学习
4. 200606-:首都医科大学生化与分子生物学系 任职
5. 200806-200906:维也纳医科大学 访问
重要学术论文
1. Wang L#, Qi YJ #, Wang X#, Li LX, Ma YZ, Zheng JF*.ECHS1 Suppresses Renal Cell Carcinoma Development Through Inhibiting mTOR Signaling Activation . Biomed Pharmacother. 2020,123:109750.SCI
2. Qi Y#, Wang L#, Wang K#, Peng Z, Ma Y, Zheng Z, Shang D, Xu W, Zheng J*.New mechanistic insights of clear cell renal cell carcinoma from integrated miRNA and mRNA expression profiling studies. Biomed Pharmacother. 2019,111:821-834.SCI
3. Ma Y#, Qi Y#, Wang L, Zheng Z, Zhang Y, Zheng J*.SIRT5-mediated SDHA desuccinylation promotes clear cell renal cell carcinoma tumorigenesis. Free Radic Biol Med. 2019,134:458-467.SCI
4. Qi YJ, Zhang Y, Peng ZQ, Wang L, Wang KZ, Feng DP, He JQ, Zheng JF*.SERPINH1 overexpression in clear cell renal cell carcinoma: association with poor clinical outcome and its potential as a novel prognostic marker. J Cell Mol Med. 2018,22(2):1224-1235.SCI
5. Wang L#,Qi YJ#, Xiong Y#, Peng ZQ, Ma Q, Zhang Y, Song J, Zheng JF*.Ezrin-Radixin-Moesin Binding Phosphoprotein 50 (EBP50) Suppresses the Metastasis of Breast Cancer and HeLa Cells by Inhibiting Matrix Metalloproteinase-2 Activity. Anticancer Res. 2017,37(8):4353-4360.SCI
6. Wang L#, Peng ZQ#, Wang KZ#, Qi YJ, Yang Y, Zhang Y, An XY, Luo SD, Zheng JF*.NDUFA4L2 is associated with clear cell renal cell carcinoma malignancy and is regulated by ELK1. PeerJ. 2017,5:e4065.SCI
7. Sun LC#, Zheng JF#(Co-first author), Wang QQ, Song R, Liu H, Meng R, Tao T, Si Y, Jiang WG, He JQ*. .NHERF1 Regulates Actin Cytoskeleton Organization through Modulation of alpha-actinin 4 Stability. FASEB J. 2016,30(2):578-589.SCI
8. Zheng JF, Dai YP, Yang ZY, Yang LY, Peng ZQ, Meng R, Xiong Y, He JQ*.Ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50) Regulates EGF-induced AKT Activation through Interaction with EGFR and PTEN. Oncology Reports. 2016,35(1):530-537.SCI
9. Ma Q#, Peng ZQ#, Wang L, Li YM, Wang KZ, Zheng JF*, Liang ZY*, Liu TH*.miR-19a correlates with poor prognosis of clear cell renal cell carcinoma patients via promoting cell proliferation and suppressing PTEN/SMAD4 expression. Int J Oncol. 2016,49(4):2589-2599.SCI
10. Peng ZQ, Wang QQ, Zhang Y, He JQ*, Zheng JF* .EBP50 interacts with EGFR and regulates EGFR signaling to affect the prognosis of cervical cancer (CC) patients. Int J Oncol. 2016,49(4):1737-1745.SCI
11. 法朋燕,刘华,郑君芳,王磊,代元平,贺俊崎.NHERF3在肾癌组织中的表达变化及其意义. 首都医科大学学报. 2015,36(2):251-254.核心期刊
12. Yang LY#, Zheng JF#(Co-first author), Xiong Y, Meng R, Ma Q, Liu H, Shen H, Zheng S, Wang SL, He JQ*.Regulation of β2-Adrenergic Receptor Cell Surface Expression by Interaction with Cystic Fibrosis Transmembrane Conductance Regulator-associated Ligand (CAL). Amino Acids. 2015,47(7):1455-1464.SCI
13. Wang LY, Diao ZL, Zhang DL, Zheng JF, Zhang QD, Ding JX, Liu WH*.The regulatory peptide apelin: a novel inhibitor of renal interstitial fibrosis. Amino Acids. 2014,46(12):2693-2704.SCI
14. 杨颖,刘华,郑君芳,郑帅,史小翠,马骞,赵君朋*.C-KIT基因突变对血液祖细胞免疫表型及增殖的影响. 基础医学与临床. 2013,33(10):1033-1037.核心期刊
15. 郑君芳,陈慧敏,宋然,胡家,沙莎,贺俊崎*.蛋白质组学方法分析多T迷宫训练后的小鼠空间记忆蛋白. 中国生物化学与分子生物学报. 2013,29(11):1054-1060.核心期刊
16. Sun CY#, Zheng JF#, Cheng S, Feng DP, He JQ*.EBP50 phosphorylation by cdc2/cyclin B kinase affects actin cytoskeleton reorganization and regulates functions of human breast cancer cell line MDA-MB-231. Mol Cells. 2013,36(1):47-54.SCI
17. Zeng XL, Zhang SY, Zheng JF, Yuan H, Wang Y.Altered miR-143 and miR-150 expressions in peripheral blood mononuclear cells for diagnosis of non-small cell lung cancer. Chin Med J-Peking. 2013,126(23):4510-4516.SCI
18. Yao WF, Feng DP, Bian WH, Yang LY, Li Y, Yang ZY, Xiong Y, Zheng JF*, Zhai RY*, He JQ*.EBP50 inhibits EGF-induced breast cancer cell proliferation by blocking EGFR phosphorylation. Amino acids. 2012,43:2027-2035.SCI
19. 曾小莉,张韶岩,郑君芳,王燕.微小RNA-150在非小细胞肺癌外周血中的表达及其临床意义. 中国肿瘤临床. 2012,39(22):1783-1786.核心期刊
20. Wang L, Zhang D, Zheng J, Feng Y, Zhang Y, Liu W.Actin cytoskeleton-dependent pathways for ADMA-induced NF-B activation and TGF- high expression in human renal glomerular endothelial cells. Acta Biochimica Et Biophysica Sinica. 2012,44(11):918-923.SCI
21. 郑君芳,李德龙,李硕,王松灵,贺俊崎.牙体组织相关蛋白质组学的研究进展. 北京口腔医学. 2011,19(6):351-354.核心期刊
22. Wang LY, Zhang DL, Zheng JF, Zhang Y, Zhang QD, Liu WH.Apelin-13 passes through the ADMA-damaged endothelial barrier and acts on vascular smooth muscle cells. Peptides. 2011,32(12):2436-2443.SCI
23. Li L, Boddul SV, Patil SS, Zheng JF, An G, Hoger H, Lubec G.Proteins linked to extinction in contextual fear conditioning in the C57BL/6J mouse. Proteomics. 2011,11(18):3706-3724.SCI
24. 郑君芳,刘华,熊英,王小柱,贺俊崎.恐惧记忆相关蛋白的蛋白质组学研究. 高等学校化学学报. 2010,31(4):736-741.SCI
25. 郑君芳,华琳,张秋霞,李德龙,贺俊崎.嗅觉记忆相关蛋白的蛋白质组学研究. 高等学校化学学报. 2010,31(8):1535-1540.SCI
26. Yang XM, Zheng JF, Xiong Y, Shen H, Sun LC, Huang Y, Sun CY, Li Y, He JQ.Beta-2 adrenergic receptor mediated ERK activation is regulated by interaction with MAGI-3. FEBS Letters. 2010,584:2207-2212.SCI
27. Li L#, Mauric V#, Zheng JF#, Kang SU, Patil S, Hoger H, Lubec G*.Olfactory bulb proteins linked to olfactory memory in C57BL/6J mice. Amino Acids. 2010,39(3):871-886.SCI
28. 刘仁慧,郑君芳,袁颖,郭忻.淫羊藿女贞子配伍调节哮喘大鼠NO/ET及HPA轴作用的研究. 中国中药杂志. 2010,35(12):1590-1593.核心期刊
29. Zheng JF, Sun LC, Liu H, Huang Y, Li Y, He JQ.EBP50 exerts tumor suppressor activity by promoting cell apoptosis and retarding extracellular signal-regulated kinase activity. Amino acids. 2010,38(4):1261-1268.SCI
30. Zheng JF, Shen H, Xiong Y, Yang XM, He JQ.The beta1-Adrenergic receptor mediates extracellular signal-regulated kinase activation via Galphas. Amino Acids. 2010,38(1):75-84.SCI
31. 郑君芳,孙超渊,孙丽翠,杨晓梅,王小柱,黄艳,李洋,贺俊崎.空间记忆相关蛋白的蛋白质组学研究. 化学学报. 2010,68(10):996-1002.SCI
32. 郑君芳,刘琨,马桂伶,陈鹏,贺俊崎.EBP50抑制HeLa细胞增殖及基质金属蛋白酶表达. 基础医学与临床. 2009,29(3):314-315.核心期刊
33. 王瑛,杨晓梅,郑君芳,陈鹏,赵晶晶,贺俊崎.雌激素对乳腺癌细胞中PDZK1蛋白水平的影响. 首都医科大学学报. 2009,30(2):185-188.核心期刊
34. Liu K, Zheng JF, Wang Y, Chen P, He JQ.Distribution and localization of microfilament cytoskeleton is regulated by EBP50. The Chinese-German Journal of Clinical Oncology. 2009,8(5):282-285.核心期刊
35. Zheng JF, Patil SS, Chen WQ, An W, He J, Hoger H, Lubec G.Hippocampal protein levels related to spatial memory are different in the Barnes maze and in the Multiple T-maze. Journal of Proteome Research. 2009,8(10):4479-4486.SCI
36. 郑君芳,杨荟敏,张红.用于酵母双杂交的EBP50诱饵载体的构建和鉴定. 中国生物工程杂志. 2008,28(6s):148-153.核心期刊
37. 孙丽翠,胡家,郑君芳,苏雷,贺俊崎.几种不同提取方法对HeLa细胞总蛋白双向电泳结果的影响. 首都医科大学学报. 2008,29(4):451-454.核心期刊
38. 郑君芳,贺俊崎.磷酸化蛋白50 (EBP50)--一种新的抑癌蛋白. 生物化学与生物物理进展. 2008,35(6):620-624.SCI
39. 郑君芳,王瑛,陈鹏,贺俊崎.EBP50影响HeLa细胞微丝骨架的分布和定位. 中国肿瘤临床. 2008,35(20):1192-1195.核心期刊
40. 郑君芳,刘桂荣,刘树林,贺俊崎.根瘤菌参比菌株23S rRNA 基因数量和定位及其系统发育群. 浙江大学学报(农业与生命科学版). 2008,34(5):482-490.核心期刊
41. 孙丽翠,贺俊崎,郑君芳,王雅梅,张松,张玉国,仲飞,刘朋朋,齐顺章.鸡α-珠蛋白基因5′端MAR调控GFP基因在COS7细胞中表达的研究. 首都医科大学学报. 2007,28(4):479-483.核心期刊
42. 郑君芳,刘桂荣,刘树林.幽门螺杆菌临床分离株的基因组结构多样性研究. 山东医药. 2007,47(32):64-65.核心期刊
43. Zheng JF, Liu GR, Liu SL.Phylogenetically clustering of rhizobia by genome structure: application to unclassified Rhizobium. Journal of Environmental Sciences-CHINA. 2006,18(2):530-536.SCI
44. Zheng JF, Liu GR, Zhu WF, Zhou YG, Liu SL.Phylogenetic clusters of rhizobia revealed by genome structures. Science in China Ser.C. 2004,47(3):268-278.SCI
45. 郑君芳,朱万孚.根瘤菌系统发育分类方法研究进展. 微生物学通报. 2004,31(2):126-129.核心期刊
46. 郑君芳,刘桂荣,朱万孚,周宇光,刘树林.基因组结构揭示的根瘤菌系统发育群. 中国科学(C辑). 2003,33(6):514-524.SCI
47. 郑君芳,陈文峰,刘桂荣,隋新华,朱万孚,陈文新,Randal N. J,刘树林.根瘤菌基因组结构的多样性及其与系统发育的关系. 微生物学通报. 2003,30(4):72-76.核心期刊
48. Liu SL, Liu GR, Li SX, Liu WQ, Zheng JF, Zhu WF, Gu HX, Guo XK, Sanderson KE, Zhou YG, Johnston RN.Bacterial genome structure: a molecular marker to reveal phylogenetic clusters. J.Peking Univ.[Med]. 2002,34(5):457-463.核心期刊
49. Wang L, Wang TF, Kang CJ, Liu XL, Liu Y, Zhang CZ, Zheng JF.Experimental Study on Effect s of Xiaopi Yishen Oral Liquid on Hypothalamus-Pituitary-Adrenal Gland-Thymus Axis in Stressed Rats. CJIM. 2000,6(2):131-133.核心期刊
50. 王天芳,张翠珍,季绍良,刘雁峰,焦扬,张冰,王琳,郑君芳,姚俊清.慢性疲劳综合征病人的疲劳特征及中药的治疗作用. 中国医药学报. 2000,15(4):58-60.核心期刊
51. 王天芳,焦扬,郑君芳,刘雁峰,张翠珍,王琳,刘晓兰,刘燕,康纯洁."消疲怡神口服液”对肝郁脾虚型慢性疲劳综合征病人免疫功能的调节作用. 北京中医药大学学报. 2000,3(增刊):32-34.核心期刊
主编或副主编的著作/译著
重要奖项
1. 北京市青年拔尖人才 201212
2. 教育部留学回国人员科研启动基金 201203
3. Avon Foundation-AACR International Travel Grant for the American Association for Cancer Research (AACR) 201011
4. 北京市优秀人才培养资助 201006
5. 北京市科技新星 200812
6. 欧亚太平洋网络奖学金 200712
7. 北京市优秀人才培养资助 200706
8. 北京大学光华奖学金 2002