姓名：李纤 性别：女 职称：教授 招生院所：基础医学院 招生类型：科学学位(博) 科学学位(硕) 招生专业：生物化学与分子生物学(博) 生物化学与分子生物学(硕) 研究方向名称：神经元保护和神经免疫调节 电子信箱：qianli@ccmu.edu.cn


社会任职
个人简历
1. 200309-201107:北京大学 学士、博士
2. 201108-201801:美国约翰霍普金斯大学 博士后
3. 201801-:首都医科大学 教授
4. 201811-:首都医科大学 系副主任
重要学术论文
1. Li Q#, Lan X#, Han X, Wang J*.Characterizing mouse microglia and macrophage after experimental intracerebral hemorrhage. Frontiers in Cellular Neuroscience. 2019,12:520:doi: 10.3389/fncel.2018.00520.SCI
2. Han X, Li Q, Lan X, EL-Mufti L, Wang J*.Microglial depletion with clodronate liposomes induces astrocyte activation, neuronal degeneration and reduction of blood vessel integrity. Molecular Neurobiology. 2019,Feb 08:doi: 10.1007/s12035-019-1502-9.SCI
3. Li Q#, Weiland A#, Chen X, Lan X, Han X, Durham F, Liu X, Wan J, Ziai W, Hanley DF, Wang J*.Ultrastructural characteristics of neuronal death and white matter injury in mouse brain tissues after intracerebral hemorrhage: coexistence of ferroptosis, autophagy, and necrosis. Frontiers in Neurology. 2018,9:581:doi: 10.3389/fncel.2018.00581.SCI
4. Weiland A, Wang Y, Wu W, Lan X, Han X, Li Q*, Wang J*.Ferroptosis and its Role in Diverse Brain Diseases. Molecular Neurobiology. 2018,Nov 8:doi: 10.1007/s12035-018-1403-3.SCI
5. Han X, Zhao X, Lan X, Li Q, Gao Y, Liu X, Wan J, Yang ZJ, Chen X, Guo AM, Falck JR, Koehler RC, Wang J*.20-HETE synthesis inhibition promotes cerebral protection after intracerebral hemorrhage without inhibiting angiogenesis. Journal of Cerebral Blood Flow & Metabolism. 2018,Jan 1:doi:10.1177/**X**.SCI
6. Lan X, Han X, Li Q, Yang QW, Wang J*.Modulators of microglial activation and polarization after intracerebral hemorrhage. Nature Reviews Neurology. 2017,May, 19:doi:10.1038/nrneurol.2017.69.SCI
7. Lan X, Han X, Li Q, Li Q, Gao Y, Cheng T, Wan J, Zhu W, Wang J*.Pinocembrin protects hemorrhagic brain primarily by inhibiting toll-like receptor 4 and reducing M1 phenotype microglia. Brain Behavior and Immunity. 2017,61:326-339.SCI
8. Jiang C*, Kong W, Wang Y, Ziai W, Yang Q, Zuo F, Li F, Wang Y, Xu H, Li Q, Yang J, Lu H, Zhang J, Wang J*.Changes in the cellular immune system and circulating inflammatory markers of stroke patients. Oncotarget. 2017,8(2):3553-3567.SCI
9. Li Q, Han X, Lan X, Hong X, Gao Y, Li Q, Koehler RC, Zhai Y*, Zhou J*, Wang J*.Inhibition of tPA-induced hemorrhagic transformation involves adenosine A2b receptor activation after cerebral ischemia. Neurobiology of Disease. 2017,108:173-182.SCI
10. Yang J, Li Q, Wang Z, Qi C, Han X, Lan X, Wan J, Wang W, Zhao X, Hou Z, Gao C, Carhuapoma JR, Mori S, Zhang J*, Wang J*.Multimodality MRI assessment of grey and white matter injury and blood-brain barrier disruption after intracerebral hemorrhage in mice. Scientific Reports. 2017,7:40358:doi: 10.1038/srep40358.SCI
11. Li Q#, Wan J#, Lan X, Han X, Wang Z, Wang J*.Neuroprotection of brain-permeable iron chelator VK-28 against intracerebral hemorrhage in mice. Journal of Cerebral Blood Flow & Metabolism. 2017,37(9):3110-3123.SCI
12. Li Q, Han X, Lan X, Gao Y, Wan J, Durham F, Cheng T, Yang J, Wang Z, Jiang C, Ying M, Koehler RC, Stockwell BR, Wang J*.Inhibition of neuronal ferroptosis protects hemorrhagic brain. JCI Insight. 2017,2(7):e90777. doi: 10.1172/jci.insight.90777.SCI
13. Cheng T, Wang W, Li Q, Han X, Xing J, Qi C, Lan X, Wan J, Potts A, Guan F*, Wang J*.Cerebroprotection of Flavanol (-)-Epicatechin after Traumatic Brain Injury via Nrf2-dependent and -independent Pathways. Free Radical Biology & Medicine. 2016,92:15-28.SCI
14. Li Q#, Han X#, Wang J*.Organotypic Hippocampal Slices as Models for Stroke and Traumatic Brain Injury. Molecular Neurobiology. 2016,53(6):4226-37.SCI
15. Lan X, Han X, Li Q, Wang J*.(-)-Epicatechin, a natural flavonoid compound, protects astrocytes against hemoglobin toxicity via Nrf2 and AP-1 signaling pathways. Molecular Neurobiology. 2016,Nov 18:doi: 10.1007/s12035-016-0271-y.SCI
16. Wang W, Li M, Wang Y, Li Q, Deng G, Wan J, Yang Q, Chen Q*, Wang J*.GSK-3β inhibitor TWS119 attenuates rtPA-induced hemorrhagic transformation and activates the Wnt/β-catenin signaling pathway after acute ischemic stroke in rats. Molecular Neurobiology. 2016,53(10):7028-7036.SCI
17. Zhao X, Wu T*, Chang CF, Wu H, Han X, Li Q, Gao Y, Li Q, Hou Z, Maruyama T, Zhang J, Wang J*.Toxic role of prostaglandin E2 receptor EP1 after intracerebral hemorrhage in mice. Brain Behavior and Immunity. 2015,46:293-310.SCI
18. Wang J*, Liu X, Lu H, Jiang C, Cui X, Yu L, Fu X, Li Q, Wang J*.CXCR4+CD45- BMMNC subpopulation is superior to unfractionated BMMNCs for protection after ischemic stroke in mice. Brain Behavior and Immunity. 2015,45:98-108.SCI
19. Feng Y, Zhu M, Dangelmajer S, Lee Y, Wijesekera O, Castellanos CX, Denduluri A, Chaichana KL, Li Q, Zhang H, Levchenko A, Guerrero-Cazares H, Quinones-Hinojosa A*.Hypoxia-cultured human adipose-derived mesenchymal stem cells are non-oncogenic and have enhanced viability, motility, and tropism to brain cancer. Cell Death Disease. 2014,5:e1567:doi: 10.1038/cddis.2014.521.SCI
20. Li Q, Wijesekera O, Salas SJ, Wang JY, Zhu M, Aprhys C, Chaichana KL, Chesler DA, Zhang H, Smith CL, Guerrero-Cazares H, Levchenko A*, Quinones-Hinojosa A*.Mesenchymal Stem Cells from Human Fat Engineered to Secrete BMP4 Are Nononcogenic, Suppress Brain Cancer, and Prolong Survival. Clinical Cancer Research. 2014,20(9):2375-87.SCI
21. Pendleton C#, Li Q#, Chesler DA, Yuan K, Guerrero-Cazares H, Quinones-Hinojosa A*.Mesenchymal Stem Cells Derived from Adipose Tissue vs Bone Marrow: In Vitro Comparison of Their Tropism towards Gliomas. PLoS One. 2013,8(3):e58198. doi: 10.1371/journal.pone.**.SCI
22. Yang F, Sun L, Li Q, Han X, Lei L, Zhang H*, Shang Y*.SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities. EMBO Journal. 2012,31(1):110-23.SCI
23. Li Q, Shi L, Gui B, Yu W, Wang J, Zhang D, Han X, Yao Z, Shang Y*.Binding of the JmjC Demethylase JARID1B to LSD1/NuRD Suppresses Angiogenesis and Metastasis in Breast Cancer Cells by Repressing Chemokine CCL14. Cancer Research. 2011,71(21):6899-908.SCI
24. Yang X, Yu W, Shi L, Sun L, Liang J, Yi X, Li Q, Zhang Y, Yang F, Han X, Zhang D, Yang J, Yao Z, Shang Y*.HAT4, a Golgi Apparatus-Anchored B-Type Histone Acetyltransferase, Acetylates Free Histone H4 and Facilitates Chromatin Assembly. Molecular Cell. 2011,44(1):39-50.SCI
25. Shi L, Sun L, Li Q, Liang J, Yu W, Yi X, Yang X, Li Y, Han X, Zhang Y, Xuan C, Yao Z, Shang Y*.Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis. Proceedings of the National Academy of Sciences. 2010,108(18):7541-6.SCI
26. Wang Y, Zhang H, Chen Y, Sun Y, Yang F, Yu W, Liang J, Sun L, Yang X, Shi L, Li R, Li Y, Zhang Y, Li Q, Yi X, Shang Y*.LSD1 Is a Subunit of the NuRD Complex and Targets the Metastasis Programs in Breast Cancer. Cell. 2009,138(4):660-72.SCI
主编或副主编的著作/译著
重要奖项
1. 白介素10定向分化少突胶质前体细胞以修复脑出血后白质损伤的机制研究 北京市教委青年拔尖人才培育计划 北京市 201901
2. 白介素10在出血性脑卒中小胶质细胞极化调节中的作用研究 美国心脏学会 博士后基金 201607