姓名：王仁喜 性别：男 职称：教授 招生院所：脑重大疾病研究院 招生类型：科学学位(博) 科学学位(硕) 招生专业：神经生物学(博) 免疫学(硕) 研究方向名称：脑重大疾病的免疫学机制研究 电子信箱：renxi_wang@ccmu.edu.cn


社会任职
1. Annals of Clinical Case Reports for Allergy & Immunology Case reports编委
2. Indian Journal of Immunology and Respiratory Medicines编委
3. Austin Journal of Clinical Immunology编委
4. JSM Renal Medicine编委
5. Remedy Open Access Journal for Allergy & Clinical Immunology section编委
个人简历
1. 199509-199907:河南师范大学 学士
2. 200008-200306:军事医学科学院 硕士
3. 200308-200606:军事医学科学院 博士
4. 200606-201412:军事医学科学院 助理研究员
5. 200907-201005:美国Nebreska大学 博士后
6. 201006-201205:美国NIH 博士后
7. 201412-201708:军事医学科学院 副研究员
8. 201708-201911:军事医学研究院 副研究员
9. 201911-:首都医科大学脑院 教授
重要学术论文
1. Zhai B#, Hou C#, Xu R#, Fang Y#, Ma N, Xing C, Wang X, Xiao H, Chen G, Han G*, Wang R*.Gm6377 suppressed SP 2/0 xenograft tumor by down-regulating Myc transcription. Clinical & Translational Oncology. 2020,Doi :10.1007/s12094-019-02280-y.SCI
2. Wei Y#, Zhang F#, Zhang Y#, Wang X, Xing C, Guo J, Zhang H, Suo Z, Li Y, Wang J, Wang R*, Cai Z*.Posttranscriptional regulator Rbm47 elevates IL-10 production and promotes immunosuppression of B cells. Cellular & Molecular Immunology. 2019,16(6):580-589.SCI
3. Liu X#, Zhang Y#, Wei Y#, Wang Z, Zhu G, Fang Y, Zhai B, Xu R, Han G, Chen G, Xiao H, Hou C, Shen B, Li Y, Ma N *, Wang R *.The E3 ubiquitin ligase Itch is required for B-cell differentiation. Scientific Reports. 2019,9(1):421.SCI
4. Fang Y, Xu R, Zhai B, Hou C, Ma N, Wang L, Han G, Jiang Z*, Wang R*.Gm40600 suppressed SP 2/0 isograft tumor by reducing Blimp1 and Xbp1 proteins. BMC Cancer. 2019,19(1):700.SCI
5. Li G, Hou C, Dou S, Zhang J, Zhang Y, Liu Y, Wang Z, Xiao H, Wang R*, Chen G, Li Y, Feng J, Shen B, Han G*.Monoclonal antibody against human Tim-3 enhances antiviral immune response. Scandinavian Journal of Immunology. 2019,89(2):e12738.SCI
6. Zhai B#, Hou C#, Xu R#, Fang Y#, Xiao H, Chen G, Wang X, Ma N, Han G*, Wang R*.Loc suppressed myeloma cell growth by p53-mediated apoptosis. Leukemia & Lymphoma. 2019,60 (10):2541-2548.SCI
7. Ma N#, Fang Y#, Xu R, Zhai B, Hou C, Wang X, Jiang Z, Wang L, Liu Q *, Han G *, Wang R *.Ebi3 promotes T- and B-cell division and differentiation via STAT3. Molecular Immunology. 2019,107:61-70.SCI
8. Zhu G#, Liu X#, Fang Y#, Zhai B, Xu R, Han G, Chen G, Xiao H, Hou C, Shen B, Li Y, Iwakura Y, Wang L, Jiang Z, Ma N *, Liu G*, Wang R*.Increased mTOR cancels out the effect of reduced Xbp-1 on antibody secretion in IL-1α-deficient B cells. Cellular Immunology. 2018,328:9-17.SCI
9. Wang X#, Zhang Y#, Wang Z#, Liu X, Zhu G, Han G, Chen G, Hou C, Wang T, Shen B, Li Y, Xiao H, Ma N*, Wang R*.Anti-IL-39 (IL-23p19/Ebi3) polyclonal antibodies ameliorate autoimmune symptoms in lupus-like mice. Molecular Medicine Reports. 2018,17(1):1660-1666.SCI
10. Xu R#, Fang Y#, Hou C#, Zhai B#, Jiang Z, Ma N, Wang L *, Han G *, Wang R *.BC094916 suppressed SP 2/0 xenograft tumor by down-regulating Creb1 and Bcl2 transcription. Cancer Cell International. 2018,18:138.SCI
11. Xing C#, Zhu G#, Xiao H#, Fang Y, Liu X, Han G, Chen G, Hou C, Shen B, Li Y, Ma N*, Wang R*.B cells regulated thymic CD8+T cell differentiation by IgG antibody in lupus-prone mice. Oncotarget. 2017,8 (52):89486-89499.SCI
12. Zhu G #, Wang X #, Xiao H #, Liu X, Fang Y, Zhai B, Xu R, Han G, Chen G, Hou C, Shen B, Li Y, Ma N, Wu H*, Liu G*, Wang R*.Both Notch1 and its ligands in B cells promote antibody production. Molecular Immunology. 2017,91:17-23.SCI
13. Zhang Y#, Wang Z#, Xiao H#, Liu X, Zhu G, Han G, Chen G, Hou C, Ma N, Shen B, Li Y, Wang T *, Wang R*.Foxd3 suppresses IL-10 expression in B cells. Immunology. 2017,150(4):478-488.SCI
14. Zhang Y#, Zhu G#, Xiao H#, Liu X, Han G, Chen G, Hou C, Shen B, Li Y, Ma N*, Wang R*.CD19 controls the differentiation from marginal zone precursor (MZP) to MZ B cells by regulating ADAM28-mediated Notch2 cleavage. Journal of Cellular and Molecular Medicine. 2017,21 (12):3658-3669.SCI
15. Ma N#, Zhang Y#, Liu Q#, Wang Z, Liu X, Zhu G, Yu D, Han G, Chen G, Hou C, Wang T, Ma Y, Shen B, Li Y, Xiao H*, Wang R*.B-cell Activating Factor (BAFF) selected IL-10-B cells over IL-10+B Cells in inflammatory response. Molecular Immunology. 2017,85:18-26.SCI
16. Liu X, Zhang Y, Wang Z, Wang X, Zhu G, Han G, Chen G, Hou C, Wang T, Shen B, Li Y, Ma N, Xiao H*, Wang R*.Metabotropic glutamate receptor 3 is involved in B-cell-related tumor apoptosis. International Journal of Oncology. 2016,49 (4):1469-1478.SCI
17. Wang X#, Wei Y#, Xiao H#, Liu X, Zhang Y, Han G, Chen G, Hou C, Zhang L, Ma N, Shen B, Li Y, Egwuagu CE*, Wang R*.Pre-existing CD19-independent GL7- Breg cells are expanded during inflammation and in mice with lupus-like disease. Molecular Immunology. 2016,71:54-63.SCI
18. Wang X, Liu X, Zhang Y, Wang Z, Zhu G, Han G, Chen G, Hou C, Wang T, Ma N, Shen B, Li Y, Xiao H*, Wang R*.Interleukin (IL)-39 [IL-23p19/Epstein–Barr virus-induced 3 (Ebi3)] induces differentiation/expansion of neutrophils in lupus-prone mice. Clinical and Experimental Immunology. 2016,186 (2):144-156.SCI
19. Wang X#, Wei Y#, Xiao H#, Liu X, Zhang Y, Han G, Chen G, Hou C, Ma N, Shen B, Li Yan, Egwuagu CE*, Wang R*.Novel IL-23p19/Ebi3 (IL-39) Cytokine Mediates Inflammation in Lupus-like Mice. European Journal of Immunology. 2016,46(6):1343-1350.SCI
20. Wang X#, Wei Y#, Liu X#, Xing Chen, Han G, Chen G, Hou C, Dambuza IM, Shen B, Li Yan, Xiao H*, Wang R*.IL-15-secreting γδT cells induce memory T cells in experimental allergic encephalomyelitis (EAE) mice. Molecular Immunology. 2015,66(2):402-408.SCI
21. Xing C, Ma N, Xiao H, Wang X, Zheng M, Han G, Chen G, Hou C, Shen B, Li Y*, Wang R*.Critical role for thymic CD19+CD5+CD1dhiIL-10+ regulatory B cells in immune homeostasis. Journal of Leukocyte Biology. 2015,97(3):547-556.SCI
22. Wang X, Xiao H, Wei Y, Liu X, Han G, Chen G, Hou C, Shen B, Li Y, Wang R*.Blockade of B-cell activating factor (BAFF) with TACI-IgG effectively reduced Th1 and Th17 cells but not memory T cells in EAE mice. Central European Journal of Immunology. 2015,40 (2):142-148.SCI
23. Ma N#, Liu X#, Xing C#, Wang X, Wei Y, Han G, Chen G, Hou C, Shen B, Li Y, Xiao H*, Wang R*.Ligation of metabotropic glutamate receptor 3 (Grm3) ameliorates lupus-like disease by reducing B cells. Clinical Immunology. 2015,160(2):142-154.SCI
24. He Y#, Ma N#, Xing C, Wang X, Xiao H, Zheng M, Han G, Chen G, Hou C, Shen B, Li Y, Jiang Z*, Wang R*, Wu W*.Novel IL-6-secreting γδT (γδT6) cells increased in patients with atherosclerotic cerebral infarction. Molecular Medicine Reports. 2015,11(2):1497-1503.SCI
主编或副主编的著作/译著
重要奖项