- 扈洪波导师简介 -
基本信息
目前指导研究生
在籍
- 博士研究生4人 （其中 2013级:1 2014级:1 2015级:2） 硕士研究生4人 （其中 2014级:2 2015级:2）
不在籍
- 博士研究生3人 （其中 2009级:1 2010级:1 2011级:1） 硕士研究生10人 （其中 2009级:2 2010级:2 2011级:2 2012级:2 2013级:2）
个人简历
工作简历：
2008.9-至今 中国农业大学食品与营养工程学院 教授/博士生导师
2006.6-2008.8 美国明尼苏达大学Hormel研究所肿瘤生物学研究室 研究助理教授
2003.4-2006.5 美国明尼苏达大学Hormel研究所肿瘤生物学研究室 博士后
2002.6-2003.4 美国田纳西大学兽医学院分子生物学研究室博士后
2001.3-2002.3 韩国首尔大学兽医学院干细胞与肿瘤生物学研究室访问学者
1999.1-2003.12中国农业大学动物医学院 副教授
1993.8-1998.12中国农业大学动物医学院 讲师
1992.7-1993.7中国农业大学动物医学院 助教
遴选学科专业
不公开
论文与专著
1.Chong Zhao, Shutao Yin, Yinhui Dong, Xiao Guo, Lihong Fan, Min Ye and Hongbo Hu. Autophagy-dependent EIF2AK3/PERK activation compromises ursolic acid-induced apoptosis through upregulation of MCL1 in MCF-7 human breast cancer cells. Autophagy. Autophagy. 2012 Nov 26;9(2). [Epub ahead of print]
2. Xionghao Lin, Shuai Ji, Rui Li, Yinhui Dong, Xue Qiao, Hongbo Hu, Wenzhi Yang, Dean Guo, Pengfei Tu, and Min Ye. Terpecurcumins A?I from the Rhizomes of Curcuma longa: Absolute Configuration and Cytotoxic Activity. Journal of Natural Products.2012 Nov 15. [Epub ahead of print]
3. Tong J, Yin S, Dong Y, Guo X, Fan L, Ye M, Hu H. Pseudolaric Acid B Induces Caspase-Dependent Apoptosis and Autophagic Cell Death in Prostate Cancer Cells. Phytother Res. 2012 Aug 18. doi: 10.1002/ptr.4808. [Epub ahead of print]
4. Guo X, Yin S, Dong Y, Fan L, Ye M, Lu J, Hu H. Enhanced apoptotic effects by the combination of curcumin and methylseleninic acid: Potential role of Mcl-1 and FAK. Mol Carcinog. 2012 Jun 18. doi: 10.1002/mc.21933. Epub ahead of print
5. Yin S, Huo Y, Dong Y, Fan L, Yang H, Wang L, Ning Y, Hu H. Activation of c-Jun NH(2)-terminal kinase is required for porcine reproductive and respiratory syndrome virus-induced apoptosis but not for virus replication. Virus Res. 2012 Jun;166(1-2):103-8. Epub 2012 Mar 27.
6. Liu Q, Qin Y, Zhou L, Kou Q, Guo X, Ge X, Yang H, Hu H. Autophagy sustains the replication of porcine reproductive and respiratory virus in host cells. Virology. 2012 Aug 1;429(2):136-47
7. Yin S, Dong Y, Li J, Fan L, Wang L, Lu J, Vang O, Hu H. Methylseleninic acid potentiates multiple types of cancer cells to ABT-737-induced apoptosis by targeting Mcl-1 and Bad. Apoptosis. 2012 Apr;17(4):388-99.
8. Huang FX, Yang WZ, Ye F, Tian JY, Hu HB, Feng LM, Guo DA, Ye M. Microbial transformation of ursolic acid by Syncephalastrum racemosum (Cohn) Schroter AS 3.264 Phytochemistry 2012,82: 56–60
9. Yinhui Dong, Shutao Yin, Jinghua Li, Cheng Jiang, Min Ye, Hongbo Hu. Bufadienolide compounds sensitize human breast cancer cells to TRAIL-induced apoptosis via inhibition of STAT3/Mcl-1 pathway.Apoptosis2011; 16(4):394-403
10. Shutao Yin, Yinhui Dong, Jinghua Li, Junxuan Lu, Hongbo Hu. Penta-1,2,3,4,6-O-galloyl-beta-D-glucose induces senescence-like terminal proliferation arrest in HepG2 human hepatoma cells.Molecular Carcinogenesis 2011; 50(8):592-600
11. Jinghua Li, Shutao Yin, Yinhui Dong, Lihong Fan, Hongbo Hu. p53 activation inhibits ochratoxin A-induced apoptosis in monkey and human kidney epithelial cells via suppression of JNK activation. Biochemical and Biophysical Research Communications. 2011 Jul 29;411(2):458-63. Epub 2011 Jul 6
12. Hongbo Hu, Yubo Chai, Lei Wang, Jinhui Zhang, Hyo Jeong Lee, Sung-Hoon Kim, and Junxuan Lü Pentagalloylglucose induces autophagy and caspase-independent programmed deaths in human PC-3 and mouse TRAMP-C2 prostate cancer cells. Mol Cancer Ther October 2009 8:2833-2843
13. Hongbo Hu, Jinhui Zhang, Hyo Jeong Lee,Sung-Hoon Kim, Junxuan LüPenta-O-galloyl-beta-D-glucose induces S- and G1-cell cycle arrests in prostate cancer cells targeting DNA replication and cyclin D1. Carcinogenesis2009； 30(5):818-23
14. Hongbo Hu, Hyo-Jeong Lee,Cheng Jiang, Jinhui Zhang, Lei Wang, Yan Zhao, Qiu Xiang, Sung-Hoon Kim and Junxuan Lu. Penta-1,2,3,4,6-O-galloyl-beta-D- glucose induces p53 and inhibits STAT3 in prostate cancer cells in vitro and suppresses prostate xenograft tumor growth in vivo. Mol Cancer Ther. 2008 Sep;7(9):2681-91
15. Hongbo Hu, Guang-Xun Li, Lei Wang, Jenifer Watts, Gerald F Combs and Junxuan Lü.Methylseleninic acid enhances taxane drug efficacy against human prostate cancer and down regulates anti-apoptotic proteins Bcl-XL and survivin. Clinical Cancer Research. 2008;14,1150-1158
16. Zhe Wang, Hongbo Hu, Guang-Xun Li, Hyo-Jeong Lee, Cheng Jiang, Sung-Hoon Kim and Junxuan Lu.Methylseleninic acid inhibits microvascular endothelial G1 cell cycle progression and decreases tumor microvessel density. International Journal of Cancer. 2008; 122(1):15-24.
17. Guang-Xun Li, hyo-jeong lee, zhe wang Hongbo Hu, Joshua liao, jenifer watts, Gerald F Combs and Junxuan Lü. Superior in vivo inhibiting efficacy of methylseleninic acid against human prostate cancer over selenomethionine or selenite. Carcinogenesis. 2008 May;29(5):1005-12.
18. Guang-Xun Li, Hongbo Hu, Cheng Jiang, Todd Schuster, and Junxuan Lü. Differential involvement of reactive oxygen species in apoptosis induced by two classes of selenium compounds in human prostate cancer cells. International Journal of Cancer. 2007;120(9):2034-43.
19. Junming Guo, Cheng Jiang, Zhe Wang, Hyo-Jeong Lee, Hongbo Hu, Barbara Malewicz, Hyo-Jung Lee, Jae-Ho Lee, Nam-In Baek, Jin-Hyun Jeong, Dae-Keun Kim, Kyung-Sun Kang, Sung-Hoon Kim and Junxuan Lu. A novel class of pyranocoumarin anti–androgen receptor signaling compounds. Molecular Cancer Therapeutics 2007;6: 907-917, 2007
20. Hongbo Hu, Cheng Jiang, Todd Schuster, Guang-Xun Li, Peter T. Daniel and Junxuan Lü. Inorganic selenium sensitizes prostate cancer cells to TRAIL-induced apoptosis throughsuperoxide/p53/Bax-mediated activation of mitochondrial pathway.Mol Cancer Ther. 2006;5:1873-82. (Selected for oral presentation at the 2006 AACR Annual Meeting in Washington, DC).
21. Hongbo Hu, Cheng Jiang, Guang-Xun Li, and Junxuan Lü. PKB/AKT and ERK regulation of caspase-mediated apoptosis by methylseleninic acid in LNCaP prostate cancer cells. Carcinogenesis. 2005; 26(8):1374-81.
22. Hongbo Hu, Cheng Jiang, Clement Ip, Youcef M. Rustum and Junxuan Lü. Methylseleninic acid potentiates apoptosis induced by chemotherapeutic drugs in androgen-independent prostate cancer cells. Clinical Cancer Research. 2005;11: 2379-88.
23. Nam-Shik Ahn 1, Hongbo Hu 1, Jin-Sung Park, Joon-Suk Park, Jong-Sik Kim, Sungwhan An, Gu Kong, Okezie I. Aruoma, Yong-Soon Lee and Kyung-Sun Kang.Molecular mechanisms of the 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced inverted U-shaped dose responsiveness in anchorage independent growth and cell proliferation of human breast epithelial cells with stem cell characteristics. Mutation Research. 2005; 579:189-99.
24. Sung-Dae Cho, Guang-xun Li, Hongbo Hu, Cheng Jiang, Kyung-Sun Kang, Yong-Soon Lee, Sung-Hoon Kim, Junxuan Lu. Involvement of c-Jun N-terminal kinase in G2/M arrest and caspase-mediated apoptosis induced by sulforaphane in DU145 prostate cancer cells. Nutrition and Cancer. 2005;52(2):213-24
25. Cheng Jiang, Hongbo Hu, Barbara Malewicz, Zaisen Wang and Junxuan Lü. Selenite-induced p53 Ser-15 phosphorylation and caspase-mediated apoptosis in LNCaP human prostate cancer cells. Mol Cancer Ther. 2004;3:877-84.
26. Weiqin Jiang, Cheng Jiang, Hongying Pei Lei Wang, Jinhui Zhang, Hongbo Hu and Junxuan LüIn vivo molecular mediators of cancer growth suppression and apoptosis by selenium in mammary and prostate models: lack of involvement of gadd genes. Mol Cancer Ther. March 2009 8:682-691
27. Lei Wang, Melissa J. L. Bonorden, Guang-xun Li, Hyo-Jeong Lee, Hongbo Hu, Yong Zhang, Joshua D. Liao, Margot P. Cleary and Junxuan Lü Methyl-selenium compounds inhibit prostate carcinogenesis in the transgenic adenocarcinoma of mouse prostate model with survival benefit. Cancer Prevention Res, 2009
28. Junxuan Lü,Hongbo Huand Cheng Jiang. Regulation of signaling pathways by selenium in cancer.Invited book chapter:Dietary Modulation of Cell Signaling Pathways, Edited by Y-J Surh,L Packer, Z Dong, E Cadenas. CRC Press (Taylor & Francis Group).Chapter 11, pp274-314, 2008.
29. Jianxun Mei, Hongbo Hu, Michael McEntee, Howard Plummer III, Ping Song and Hwa-Chain R. Wang. Transformation of non-cancerous human breast epithelial cell line MCF10A by the tobacco-specific carcinogen NNK. Breast Cancer Research and Treatment. 2003;79(1):95-105.
30. Hongbo Hu , Nam-Shik Ahn , Xinlin Yang , Yong-Soon Lee, Kyung-Sun Kang Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF-7 human breast cancer cell. International Journal of Cancer. 2002;102(3):250-3.
31. Jong-Ho Cho, Sung-Dae Cho, Hongbo Hu, Sung-Hoon Kim, Song Koo Lee, Yong-Soon Lee and Kyung-Sun KangThe roles of ERK1/2 and p38 MAP kinases in the preventive mechanisms of mushroom Phellinus linteus against the inhibition of gap junctional intercellular communication by hydrogen peroxide. Carcinogenesis, 2002; 23(7):1163-9
32. Wang Z, Lee HJ, Chai Y, Hu H, Wang L, Zhang Y, Jiang C, Lü J. Persistent p21Cip1 induction mediates G(1) cell cycle arrest by methylseleninic acid in DU145 prostate cancer cells. Curr Cancer Drug Targets. 2010 May;10(3):307-18
33. Lu, C, Luo Y, Duan L, Hou Y, Hu H, Wang Z, Xiang P. MAPKs and Mst1/Caspase-3 pathways contribute to H2B phosphorylation during UVB-induced apoptosis. Sci China Life Sci. 2010 Jun;53(6):663-8. Epub 2010 Jul 3.
近五年承担的主要项目
1. 国家自然科学基金面上项目五没食子酰葡萄糖诱导肿瘤细胞类衰老作用与分子机制研究2011.1-2013.12主持人
2. 国家自然科学基金面上项目猪呼吸与繁殖障碍综合征病毒诱导抗凋亡作用的分子机制研究 2010.1-2012.12主持人
3. 教育部留学归国人员启动基金 五没食子酰葡萄糖诱导肿瘤细胞自噬的分子机制及其生物学功能研究2010年度 主持人
4. 科技部十二五支撑项目子课题 食源性生物活性物质的研究与开发 2012.1-2015.12 主持人
5. 国际合作项目( 美国Abbott和丹麦Roskilde University) Combinatory effect of methylseleninic acid and ABT-737 on apoptosis2010.6-2012.6中方主持人
承担的教学工作
1. 饮食、营养与慢性疾病 本科生
2. 饮食、营养与慢性疾病（全英文）本科生
3. 细胞凋亡研究方法 研究生
4. 分子营养学专题 研究生
