- 许文涛导师简介 -
基本信息
目前指导研究生
在籍
- 博士研究生2人 （其中 2013级:1 2015级:1） 硕士研究生6人 （其中 2014级:3 2015级:3）
不在籍
- 博士研究生 0人 硕士研究生9人 （其中 2011级:3 2012级:3 2013级:3）
个人简历
学习工作经历:
1997-2006年期间，在中国农业大学食品科学与营养工程学院攻读了学士（食品营养与生物技术专业）,博士（食品生物技术专业）
2013年-2014年期间，美国马里兰大学营养与食品科学系访学
2006自以来在中国农业大学任教，期间去加拿大，美国、欧盟四国短期交流访问
现任职务（社会兼职等）:
中国农业大学食品科学与营养工程学院博士生导师；
教育部新世纪优秀人才
北京市科技新星
农业部农产品贮藏保鲜质量安全风险评估实验室（北京）副主任；
农业部农产品质量监督检验测试中心（北京）主任助理兼重金属和微生物检测室主任；
农业部农业转基因生物食用安全监督检验测试中心（北京）主任助理兼分子检测室主任；
国家无公害食品评审委员会委员
“食品与营养科学”杂志 ("Hans Journal of Food and Nutrition Science (HJFNS)") 编委
"Austin Journal of Nutrition and Food sciences"杂志 编委
"Austin Journal of Proteomics, Bioinformatics & Genomics" 杂志 编委
相关科研杂志审稿人：Plos One, FCT, JAFC, JSFA, Food Contron, IUBMB Life, J Biotechnol,、Anal Biochem, 农业生物技术学报,生物工程学报,食品科学,东北农业大学学报等.
奖励及其他：
省部级成果鉴定7项；
校级优秀班主任；
教育部新世纪优秀人才
北京市科技新星
北京市科技进步三等奖（4）；
‘科技兴检奖’二等奖；
教育部科技推广二等奖；
国家教学成果奖二等奖（5）
遴选学科专业
不公开
论文与专著
代表著作与论文
在食品安全领域已经发表已发表论文150余篇，其中SCI收录90余篇，教育部成果鉴定7项，申请专利20余项，获得授权国家专利16余项。
主编和参编教材10部包括《转基因食品安全评价与检测技术》（主编），《食品安全案例解析》(主编)，《转基因食品社会文化伦理透视》（主编），《食品营养与安全》（主编），《转基因食品》（主编），《国际转基因生物食用安全检测及其标准化》（副主编），《食品安全检测技术》（参编），和《食品生物技术实验指导》（参编）等。
部分代表性论文（通讯作者*）：
53. A Review of Test strips in Rapid Detection of Food Safety. Austin J NutriFood. 2014; 2(7): 6. N. Cheng, L. Zhu, Y. Xu, W. Xu*
52. Proteomics as an Indicator for the Research of Cell Apoptpsis in Toxicology.Austin J Peotecmics, Bioinformatics & Genomics. 2014; 1(1): 6. X. Yang, W. Xu*
51. Dynamic changes of global DNA methylation and hypermethylation of cell adhesion-related genes in rat kidneys in response to ochratoxin A. World Mycotoxin Journal. 2014, In press. X. Li, J. Gao, K. Huang, X. Qi, Q. Dai, X. Mei, W. Xu*
50. Safety assessment of genetically modified rice expressing human serum albumin from urine metabonomics and fecal bacterial profile. Food Chem. Toxicol. .2014, In press,X. Qi, S. Chen, Y. Sheng, M. Guo, Y. Liu, X. He, K. Huang, W. Xu*
49. A 90-day subchronic feeding study of genetically modified rice expressing Cry1Ab protein in Sprague–Dawley rats,Transgenic Research , 2014, DOI 10.1007/s11248-014-9844-6. H. Song, X.He, S. Zou, T. Zhang, Y. Luo, K. Huang, Z. Zhu, W Xu*
48. Effect of BSO-supplemented ochartoxin A on proteome and GSH-related enzymes in Arabidopsis thaliana. Biologia Plantarum, 2014, In press. J. Hao, Y. Wang, W. Zhao, W Xu*, Y. Luo, Z. Yang, W. Wu, Z. Liang,
47. Ochratoxin A induces rat renal carcinogenicity with limited induction of oxidative stress responses. Toxicology and applied pharmacology. 2014,280(3): 543–549. X. Qi, S. Chen, Y. Sheng, M. Guo, Y. Liu, X. He, K. Huang, W. Xu*
46. Toxicological evaluation of lactase derived from recombinant Pichia pastoris. Plos One. 2014 9(9): e106470.S. Zou, X. Hea, Y. Liu, D. Chen, Y. Luo, K. Huang, W. Zhang, W. Xu*
45. Discovery of systematic responses and potential biomarkers induced by Ochratoxin A using metabolomics. Food Additives and Contaminants Part A, 2014, 31(11):1904-13. K. Xia; X. He; Q. Dai; W.H. Cheng; X. Qi; M. Guo; Y. Luo; K. Huang;C. Zhao; W. Xu*;
44. A-T linker adapter polymerase chain reaction for determining flanking sequences by rescuing inverse PCR or thermal asymmetric interlaced PCR products. Analytical biochemistry. 2014,466C:24-26. Q. Trinh; P. Zhu; H. Shi; W. Xu*; J. Hao; Y. Luo; K. Huang
43. Mitochondrial proteomic analysis reveals the molecular mechanisms underlying reproductive toxicity of zearalenone in MLTC-1 cells. Toxicology.2014,141(1):314-323. Y. Li, B Zhang, K. Huang, X. He, Y. Luo, R. Liang, H. Luo, X.L. Shen, W. Xu*
42. Combination of metagenomics and culture based methods to study the interaction between ochratoxin A and gut microbiota. Toxicological Sciences. 2014, 141(1):314-323. M. Guo, K. Huang, S.Chen, X. Qi, X. He, W.H. Cheng, Y. Luo, K. Xia, W. Xu*
41. Subchronic toxicity study in vivo and allergenicity study in vitro for genetically modified rice that expresses pharmaceutical protein (human serum albumin). Food Chem. Toxicol. 2014,72:242-246 Y. Sheng, X. Qi, Y. Liu, M. Guo, S. Chen, X. He, K. Huang, W. Xu*
40Ochratoxin A induced early hepatotoxicity: new mechanistic insights from microRNA, mRNA and proteomic profiling studies.Scientific reports. 2014,4: 5163. X.Z Qi, X. Yang, S.Y. Chen, X.Y. He, H. Dweep, M.Z. Guo, W.H. Cheng, W.T. Xu*, Y.B. Luo, N. Gretz, Q. Dai, K.L. Huang
39DNA damage and S phase arrest induced by Ochratoxin A in human embryonic kidney cells (HEK 293). Mutat Res-Fund Mol M. 2014,765: 22-31. Q. Yang, X.Y. He, X.H. Li, W.T. Xu*, Y.B. Luo, X. Yang, Y. Wang, Y.C. Li, K.L. Huang
38microRNA profilingof rats with ochratoxin A nephrotoxicity. BMC Genomics. 2014,15:333. Q. Dai, J. Zhao, X.Z. Qi, W.T. Xu*, X.Y He, M.Z. Guo, H. Dweep, W.H. Cheng, Y.B. Luo, K. Xia, N. Gretz, K.L. Huang
37Protective effect of N-acetylcysteine against DNA damage and S-phase arrest induced by Ochratoxin A in human embryonic kidney cells (HEK-293). Food Chem. Toxicol. 2014,70：40-47. Q. Yang, L. Shi, K.L. Huang, W.T. Xu*
36Development and Application of a Quantitative Loop mediated Isothermal Amplification Method for Detecting Genetically Modified Maize MON863. J. Sci. Food Agric. 2014,DOI: 10.1002/jsfa.6707. S.C. Huang, Y.C Xu, X.H. Yan, Y. Shang, P.Y. Zhu , W.Y. Tian , W.T. Xu*.
35Central role of Nix in the autophagic response to orchratoxin AFood Chem. Toxicol. 2014,69:202-209.X.L. Shen, B.Y. Zhang, R. Liang, W.H. Cheng, W.T. Xu*, Y.B. Luo, C.H. Zhao, K.L. Huang.
34Analysis of Individual and Combined Effects of Ochratoxin A and Zearalenone on HepG2 and KK-1 Cells with Mathematical Models. Toxins. 2014,6(4):1177-92. Y.Z. Li, B.Y. Zhang, X.Y. He, W.H. Cheng, W.T. Xu*, Y.B. Luo, R. Liang , H.S. Luo, K.L. Huang.
33Protective role of the mitochondrial Lon protease 1 in ochratoxin A-induced cytotoxicity in HEK293 cells. Journal of Proteomics. 2014,101:154-68.B.Y. Zhang, X.L. Shen, R. Liang, Y.Z. Li, K.L. Huang, C.H. Zhao, Y.B. Luo, W.T. Xu*.
32Restriction enzyme cutting site distribution regularity for DNA looping technology
Gene. 2014,534(2):222-228.Y. Shang, N. Zhang, P.Y. Zhu, Y.B. Luo, K.L. Huang, W.Y. Tian, W.T. Xu*.
31A peach (Prunuspersica)-speci?c gene, Lhcb2, used as an endogenous reference gene for qualitative and real-time quantitative PCR to detect fruit products. LWT-Food Science and Technology. 2014,55(1):218-223Y Shang, P Zhu, K Huang, W Liu, W Tian, Y Luo, W.T. Xu*.
30Randomly broken fragment PCR with 5’ end-directed adaptor for genome walking. Scientific reports. 2013,3: 3465.W.T. Xu, Y. Shang, P.Y. Zhu, Z.F. Zhai, J.He, K.L. Huang, Y.L. Luo.
29An iTRAQ-based mitoproteomics approach for profiling the nephrotoxicity mechanisms of ochratoxin A in HEK 293 cells. Journal of Proteomics. 2013,78(14):398-415. X.L. Shen, Y. Zhang, W.T. Xu*, R. Liang, J.J. Zheng, Y.B. Luo, Y. Wang, K.L. Huang
28Zinc protects HepG2 cells against the oxidative damage and DNA damage induced by ochratoxin A. Toxicol Appl Pharm. 2013,268(2):123-131. J Zheng, Y Zhang, W.T. Xu*, YB Luo, J Hao, X Shen, X Yang, X Li, K Huang.
27Comparative proteomics and physiological characterization of Arabidopsis thaliana seedlings in responses to Ochratoxin A.Plant molecular biology.2013,82(4-5):321-337.Y Wang, J Hao, W Zhao, Z Yang, W Wu, Y Zhang, W.T. Xu*, YB Luo, K Huang.
26A 90-day feeding study of glyphosate-tolerant maize with the G2-aroA gene in Sprague–Dawley rats. Food Chem. Toxicol.2013,51: 280-287. Y Zhu, X He, Y, S Zou,X Zhou, KHuang, W Xu*.
25Effects of genetically modified T2A-1 rice on the GI health of rats after 90-day supplement. Scientific reports. 2013,3:1962.Y Yuan, W Xu*, X He, H Liu, S Cao, X Qi, K Huang, Y Luo.
24The transcriptional response of virulence genes in Listeria monocytogenes during inactivation by nisin. Food Control. 2013,31(2):519–524.H Shi,Q Trinh, W Xu*, Y Luo, W Tian, K Huang.
23Development and optimization of an efficient method to detect the authenticity of edible oils. Food Control. 2013,31(1):71-79.J He, W Xu*, Y Shang, P Zhu, X Mei, W Tian, K Huang.
22Single universal primer multiplex ligation-dependent probe amplification with sequencing gel electrophoresis analysis.Analytical Biochemistry. 2013,443(2):243-248.Y Shang, P Zhu, W Xu*, T Guo, W Tian, Y Luo, K Huang.
21Restriction enzyme cutting site distribution regularity for DNA looping technology. Gene. 2013,534(2):222-8.Y Shang, N Zhang, P Zhu, Y Luo, K Huang, W Tian, W Xu*
20Transcript and protein profiling analysis of OTA-induced cell death reveals the regulation of the toxicity response process in Arabidopsis thaliana. Journal of Experimental Botany. 2012,63(5):2171-2087. Y Wang, X Peng, W Xu*, Y Luo, W Zhao, J Hao, Z Liang, Y Zhang, K Huang.
19A novel Universal Primer-Multiplex-PCR method with sequencing gel electrophoresis analysis. PLOS ONE. 2012,7(1): e22900. W Xu, Z Zhai, K Huang, N Zhang, Y Yuan, Y Shang, Y Luo.
18A mitochondria-dependent pathway mediates the apoptosis of GSE-induced yeast. PLOS ONE. 2012,7(3): e32943.S Cao, W Xu*, N Zhang, Y Wang, Y Luo, X He, K Huang.
17Safety assessment of transgenic Bacillus thuringiensis rice T1c-19 in Sprague–Dawley rats from metabonomics and bacterial profile perspectives.IUBMB Life. 2012, 64(3):242-250. S Cao, X He, W Xu*, Y Luo,Y Yuan, P Li, B Cao, H Shi, K Huang
16The effect of genetically modified Lactobacillus plantarum 590 on the gut health of Sprague–Dawley rats. IUBMB Life. 2012,64(7):617–627.H Liu, W Xu*, Y Yuan, S Cao, X He, S Li, K Huang, Y Luo.
15Loop-linker PCR: An advanced PCR technique for genome walking. IUBMB Life. 2012,64(10):841–845. Q Trinh, H Shi, W Xu*, J Hao, Y Luo, K Huang.
14A universal primer multiplex PCR method for typing of toxinogenic Pseudomonas aeruginosa. Appl. Microbiol. Biot. 2012,95(6):1579-87. H Shi, Q Trinh, W Xu*, B Zhai, Y Luo, K Huang.
13Subchronic feeding study of stacked trait genetically-modified soybean (3?5423×40-3-2) in Sprague-Dawley rats. Food Chem. Toxicol.2012,50(9): 3256-3263. X Qi, X He, Y Luo, S Li, S Zou, S Cao, M Tang, B Delaney, W Xu*, K Huang.
12Safety assessment of dehydration-responsive element-binding (DREB) 4 protein expressed in E. coli. Food Chem. Toxicol. 2012,50(11): 4077-4084. B Cao, X He, Y Luo, L Ma, P Liu, S Cao, X Liu,S Zou, W Xu*,K Huang
11A 90-day subchronic feeding study of genetically modified maize expressing Cry1Ac-M protein in Sprague–Dawley rats. Food Chem. Toxicol.2012,50(9): 3215–3221.P Liu, X He, D Chen, Y Luo, S Cao, H Song, T Liu, K Huang, W Xu*.
10An A-T Linker Adapter PCR Method for Chromosome Walking without Restriction-site Cloning Bias. Analytical Biochemistry. 2012,425: 62–67.Q Trinh, W Xu* , H Shi, Y Luo, K Huang.
9Establishment of a viable cell detection system for microorganisms in wine based on ethidiummonoazide and quantitative PCR. Food Control. 2012, 27(1): 81-86. H Shi, W Xu*, Q Trinh, Y Luo, Z Liang, Y Li, K Huang.
8Potential allergenicity research of Cry1C protein from genetically modified rice.Regul Toxicol Pharm. 2012,63: 181–187. S Cao; X He; W Xu*, Y Luo; W Ran; L Liang; Y Dai; K Huang.
7Comparative analysis of the proteomic and nutritional composition of transgenic rice seeds with Cry1ab/ac genes and their non-transgenic counterparts. Journal of cereal science. 2012,55(2):236-233. Y Wang, W Xu*, W Zhao, J Hao, Y Luo, X Tang, Y Zhang, K Huang.
6Establishment and optimization of a wheat germ cell-free protein synthesis system and its application in venom kallikrein. Protein Expres. Purif. 2012,84(2):173-80. Y Wang, W Xu*, X Kou, Y Luo, Y Zhang, B Ma, M Wang, K Huang.
5Metabonomics Study of Transgenic Bacillus Thuringiensis Rice (T2A-1) Meal in a 90-Day Dietary Toxicity Study in Rats. Molecular BioSystems. 2011,7:2304 -2310. S Cao, W Xu*, Y Luo, X He, Y Yuan, W Ran, L Liang, K Huang.
4The effect of various environmental factors on the ethidium monazite and quantitative PCR method to detect viable bacteria. J Appl. Microbiol. 2011,111, 1194–1204. H Shi., W Xu*, Y Luo., L Chen, Z Liang, X Zhou, K Huang.
3Safety assessment of Cry1C protein from genetically modified rice according to the national standards of PR China for a new food resource. Regul Toxicol. Pharm. 2010,58,474–481. S Cao, X He, W Xu*, W Ran, L Liang, Y Luo, Y Yuan, N Zhang, X Zhou, K Huang.
2Event-specific Detection of Stacked Genetically Modified Maize Bt11×GA21 by UP-M-PCR and Real-time PCR. J. Agric. Food Chem. 2009,57: 395–402. W Xu, Y Yuan, L Luo, W Bai, C Zhang, K Huang.
1Safety Assessment of Cry1Ab/Ac fusion protein. Food Chem. Toxicol. 2009,47:1459–1465. W Xu, S Cao, X He, Y Luo, X Guo, Y Yuan, K Huang.
近五年承担的主要项目
主要科研项目
主要科研项目主要科研项目
1、已完成课题：
参与和主持完成国家级课题20余项，主要有国家自然基金“转基因产品品系特异性检测新技术的研究”（主持人）、教育部青年教师科研项目“线粒体参与调控拟南芥抗赭曲霉毒素A毒性作用机制的初步研究”（主持）、转基因专项子任务“转基因作物精准检测相关研究”（主持人）、转基因专项子任务“转基因作物代谢产物检测相关研究”（主持人）、转基因专项子任务“转基因作物食用安全关键技术相关研究”（主持人）、国家标准“转基因生物及其产品食用安全检测 蛋白氨基酸序列检测方法” （主持人）、转基因专项子任务“转基因生物食用安全能力建设相关课题”（主持人）、国家“863”项目“复合性状转基因农产品精准检测技术研究”（2006AA10Z440）（副主持）、农业部项目“转基因农作物检测与标识追溯体系的研究” （副主持）、农业部项目“农产品市场转基因成分例行监测” （副主持）、农业部“948”项目“外源基因删除技术的引进及其在我国转基因作物研发中的应用”（2008-Z41）（主要参加人）、“农业转基因生物及其产品安全检测技术、关键设备及相关材料的引进”（引进国际先进农业科学技术项目 948项目 2005-Z32）（主要参加人）、北京市重点项目“粮油原料中主要真菌毒素检测及控制技术研究及应用示范”（子课题主持）、农业部“948”项目“国际农业转基因生物安全评价、检测技术体系与标准化体系的引进与建立”（2007-Z8）（主要参加人）、国家“十五”重大专项“食品安全关键技术”子课题“食品包装、贮藏与运输过程中的安全控制技术”(主要参加人员)等；
2、在研课题
目前参与和主持的在课题10余项，主要有国家“863计划”“食用农产品中病原菌安全控制技术”（任务主持），国家科技支撑计划“产毒真菌核酸快速检测技术的研究”（子任务主持），转基因重大专项"复合性状转基因成分检测、溯源技术及标识阈值研究"（课题主持），“转基因作物核酸精准检测技术研究-转基因作物快速检测及品系鉴定新技术研究” （任务主持），“新性状转基因植物安全评价与控制技术及转基因产品定量标识阈值研究”（任务主持），国家科技支撑计划“食源性致病菌高通量现场快速检测关键技术及其设备的研发”（任务副主持），教育部青年教师科研项目“microRNA组学研究赭曲霉毒素A毒性在体内体外模型中的联系与差异"(主持)，北京市科技新星项目“食源性致病菌新型等温PCR现场快速检测及核酸试纸条关键技术研究”（主持），教育部新世纪人才项目“ASK1参与调控赭曲霉毒素A诱导的肾细胞毒性作用机制研究”（主持）。
承担的教学工作
教学工作
主讲课程：《现代饮食营养安全与健康》（学院路公共课）；《转基因食品社会文化伦理透视》（本科生）；《双向电泳实验》（硕士生）、《酶联免疫检测技术实验》（硕士生）。
参讲课程：本科生课程《转基因食品食用安全评价》、《食品生物技术概论》和《食品生物技术进展》，硕士生课程《转基因食品安全评价》和《食品质量与仪器分析》，博士生课程《食品生物技术研究进展》。
