鲍秀琦

鲍秀琦，博士，副研究员
电话：
E-mail:baoxiuqi@imm.ac.cn
教育背景：
1994.9 -1999.7 济宁医学院 临床医学学士
1999.9 -2002.7 天津医科大学生理学硕士
2005.9 -2008.7 北京协和医学院 药理学博士
工作经历：
2002.7 – 2005.8 中科院电工研究所实习研究员
2008.9 – 2011.9 中国医学科学院药物研究所助理研究员
2011.10 – 中国医学科学院药物研究所副研究员
专业研究领域：
主要从事神经退行性疾病发病机制及药物新靶点的发现和新药开发研究。作为课题负责人主持国家自然基金和中央级公益性科研院所基本科研业务费课题。参与多项科研项目，包括十一五国家科技重大专项综合大平台分课题项目和“十一五”重大新药创制科技重大专项FLZ品种研究，科技部973 计划子课题，北京自然基金重大项目等。近5年以第一作者或通讯作者发表文章9篇，SCI收录8篇。参与申请专利1项。
发表论文
1. Bao XQ, Kong XC, Kong LB, Wu LY, Sun H, Zhang D.Squamosamide derivative FLZ protected dopaminergic neuron by activating Akt signaling pathway in 6-OHDA-induced in vivo and in vitro Parkinson's disease models.Brain Res. 2013 Dec 30. doi: 10.1016/j.brainres.2013.12.026. [Epub ahead of print]
2. Ye X, Tai W, Bao X, Chen X, Zhang D.FLZ inhibited γ-secretase selectively and decreased Aβ mitochondrial production in APP-SH-SY5Y cells.Naunyn Schmiedebergs Arch Pharmacol. 2014;387(1):75-85.
3. Bao XQ, Li N, Wang T, Kong XC, Tai WJ, Sun H, Zhang D.FLZ Alleviates the Memory Deficits in Transgenic Mouse Model of Alzheimer's Disease via Decreasing Beta-Amyloid Production and Tau Hyperphosphorylation. PLoS One. 2013;8(11):e78033.
4. Tai W, Ye X, Bao X, Zhao B, Wang X, Zhang D. Inhibition of Src tyrosine kinase activity by squamosamide derivative FLZ attenuates neuroinflammation in both invivo and invitro Parkinson's disease models. Neuropharmacology. 2013; 75:201-12.
5. Bao XQ, Kong XC, Qian C, Zhang D. FLZ protects dopaminergic neuron through activating Akt/mTOR pathway and inhibiting RTP801 expression in Parkinson’s disease models. Neuroscience. 2012;202:396-404.
6. Kong XC, Zhang D, Qian C, Liu GT, Bao XQ*. FLZ, a novel HSP27 and HSP70 inducer, protects SH-SY5Y cells from apoptosis caused by MPP(+).Brain Res. 2011;1383:99-107.
7. Hou Y*, Bao XQ*, Wei HL, Luo Y, Liu GT. Long-term deprivation of gonadal hormone accelerates brain aging in mice. Neurol Res. 2011;33(1):43-9.(co-first author)
8. Bao XQ, Liu GT. The anti-hepatocyte apoptosis of bicyclol in HepG2 cells intoxicated with D-galactosamine is mediated through its induction of heat shock protein 27. Acta Pharmacol Sin. 2010; 31(2):219-226.
9. Bao XQ, Liu GT. Involvement of HSP70 in the protection of bicyclol on apoptosis of HepG2 cells intoxicated by d-galactosamine. J Asian Nat Prod Res. 2010;12(4):313-23.
10. Bao XQ, Liu GT. Induction of heat shock protein 27 and 70 overexpression by bicyclol attenuates concanavalin A -induced liver injury through suppression of NF-{kappa}B in mice.Mol Pharmacol. 2009;75(5):1180-1188.
11. Bao XQ, Liu GT. Bicyclol: a novel antihepatitis drug with hepatic heat shock protein 27/70-inducing activity and cytoprotective effects in mice. Cell Stress Chaperones. 2008 Sep;13(3):347-55.
12.鲍秀琦，孔祥臣，刘耕陶. 番荔枝酰胺衍生物FLZ对自然衰老小鼠学习记忆障碍的改善作用及机制.中国新药杂志. 2010; 19(10):867-872.