扈金萍

扈金萍，女，研究员，硕士生导师。
2003年毕业于首都医科大学药理专业，现于中国医学科学院药物研究所工作，先后任助理研究员、副研究员、研究员。2009年-2010年作为访问于美国纽约州卫生署研修。
目前主要从事新药药代动力学、药物代谢酶及转运蛋白的研究，包括活性先导物药代特性的早期评价，药物代谢酶/转运蛋白调控的分子机制及生物学效应，新药PK/PD研究等。参与完成多个新药（布格呋喃、IMMH001、IMMH002、MTC-220等）临床前药代动力学研究及临床报批工作。近年来作为课题负责人先后主持国家自然科学基金1项，中央级公益科研院所基本科研业务费3项。同时，作为主要完成人先后参与国家自然科学基金、北京市科委重点基金，全球结核药物研发联盟，国家“十一五”“十二五”新药重大专项，国家科技部“863项目”、“药代技术平台” 建设等国家级课题12项。到目前为止，发表相关论文40余篇，其中SCI收录的有30余篇，参与申请的专利有8项，参与编书2部。
联系方式：
电话： 邮箱：hujp@imm.ac.cn

代表性论文（2010-）
1. Jiaqi Mi, Manman Zhao, Shu Yang, Yufei Jia, Yan Wang, Baolian Wang, Jing Jin, Xiaojian Wang, Qiong Xiao, Jinping Hu*, Yan Li*. Identification of cytochrome P450 isoforms involved in the metabolism of Syl930, a selective S1PR1 agonist acting as a potential therapeutic agent for autoimmune encephalitis. Drug Metabolism and Pharmacokinetics. 2017; 32(1) :53-60
2. Xiangmeng Wu, Qinghao Zhang, Jiamei Guo, Yufei Jia, Ziqian Zhang, Manman Zhao, Yakun Yang, Baolian Wang, Jinping Hu, Li Sheng* and Yan Li*. Metabolism of F18, a Derivative of Calanolide A, in Human Liver Microsomes and Cytosol. Front Pharmacol.2017 Jul 19; 8:479.
3. Ziqian Zhang, Xiangmeng Wu, Manman Zhao, Yakun Yang, Yan Wang, Jinping Hu, Baolian Wang, Li Sheng*, Yan Li*. Determination of IMM-H004, a novel neuroprotective agent, in ratplasma and brain tissue by liquid chromatography–tandem mass spectrometry. Journal of Chromatography B, 1048 (2017) 49–55
4. Chen J¹,Lv H¹,Hu J,Ji M,Xue N,Li C,Ma S,Zhou Q,Lin B,Li Y,Yu S*,Chen X*.CAT3, a novel agent for medulloblastoma and glioblastoma treatment, inhibits tumor growth by disrupting the Hedgehog signaling pathway. Cancer Lett.381（2016）391-403
5. Wang YD,Bao XQ, Xu S, Yu WW, Cao SN, Hu JP, Li Y, Wang XL, Zhang D,Yu SS.A Novel Parkinson's Disease Drug Candidate with Potent Anti-neuroinflammatory Effects through the Src Signaling Pathway. J Med Chem.2016; 59(19):9062-9079
6. Yufei Jia, Baolian Wang, Xiangmeng Wu, Sheng Li, Jinping Hu, Dongmei Wang, Haibo Zhu, Yan Li* Simultaneous quantification of 2’,3’,5’-tri-O-acetyl-N6-(3-hydroxylaniline) adenosine and its principalmetabolites in hamster blood by LC–MS/MS and its application inpharmacokinetics study. Journal of Chromatography B, 1022 (2016) 46–53
7. Qiong Xiao, Jing Jin, Xiaojian Wang, Jinping Hu, Meiyang Xi , Yulin Tian , Dali Yin*. Synthesis, identification, and biological activity of metabolites of two novel selective S1P1 agonists. Bioorganic & Medicinal Chemistry 24 (2016) 2273–2279
8. Zhao M,Mi J,Liu X,Wang Y,Wu X,Hu J,Li Y*.Development of a validated UPLC-MS/MS method for PK/PD analysis ofSYL930and its two major metabolites in dogs. Biomed Chromatogr.2017 Feb; 31(2). doi: 10.1002/bmc.3798
9. Jiaqi Mi, Manman Zhao, Shu Yang, Shuang Yang, Jing Jin, Xiaojian Wang, QiongXiao, Jinping Hu*, Yan Li* Pharmacokinetics of H002, a novel S1PR1 modulator, and its metabolites in rat blood using liquid chromatography–tandem mass spectrometry. Acta Pharmaceutica Sinica B. 2016;6(6):576–583
10. Manman Zhao, Jiaqi Mi, Dan Li, Xin Liu, Shuang Yang, Baolian Wang, Li Sheng, Xiaojian Wang, Jing Jin, Jinping Hu*, Yan Li* Quantitative determination of 2-amino-2-(2-(4′-(2-propyloxazol-4-yl)-[1,1-biphenyl]-4-yl)ethyl)propane-1,3-diol and its active phosphorylated metabolite in ratblood by LC–MS/MS and application to PK/PD analysis. Anal Bioanal Chem (2015) 407:7511–7516
11. Baolian Wang, Zhihao Liu, Dan Li, Shuang Yang, Jinping Hu, Hui Chen, Li Sheng*, Yan Li. Application of physiologically based pharmacokinetic modeling in the prediction of pharmacokinetics of bicyclol controlled-release formulation in human. European Journal of Pharmaceutical Sciences 77 (2015) 265–272
12. Hu J, Sheng L, Li L, Zhou X, Xie F, D'Agostino J, Li Y, Ding X. Essential Role of the Cytochrome P450 Enzyme CYP2A5 in Olfactory Mucosal Toxicity of Naphthalene. Drug Metab Dispos. 2014 Jan; 42(1):23-7.
13. Hu J, You F, Yang S, Li Y. Quantitative determination of Lx2-32C, a novel taxane derivative, in rat plasma by liquid chromatography–tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 88:483-488,2014
14. Jin J¹, Hu J¹, Zhou W, Wang X, Xiao Q, Xue N, Yin D*, Chen X*. Development of a selective S1P1 receptor agonist, Syl930, as a potential therapeutic agent for autoimmune encephalitis. Biochem Pharmacol. 2014 Jul 1; 90(1):50-61.
15. Li X, Hu J, Wang B, Sheng L, Liu Z, Yang S, Li Y. Inhibitory effects of herbal constituents on P-glycoprotein in vitro and in vivo: Herb-drug interactions mediated via P-gp. Toxicology and Applied Pharmacology 275 (2014) 163–175
16. Shu Yang, Jinping Hu, Yan Li*.Simultaneous determination of SYL-1119 and SYL-1119-P in rat plasma using HPLC coupled with tandem mass spectrometry. Journal of Chromatography B, 945– 946 (2014) 193– 198
17. Wang B, Yang S, Hu J, Li Y. Multifaceted interaction of the traditional Chinese medicinal herb Schisandra chinensis with cytochrome P450-mediated drug metabolism in rats. J Ethnopharmacol. 2014 Sep 29; 155(3):1473-82.
18. Yulin Tian¹, Jing Jin ¹, Xiaojian Wang*, Jinping Hu , Qiong Xiao , Wanqi Zhou , Xiaoguang Chen , Dali Yin*. Discovery of oxazole and triazole derivatives as potent and selective S1P1 agonists through pharmacophore-guided design. European Journal of Medicinal Chemistry 85 (2014) 1-15
19. Xin Liu, Manman Zhao, Jiaqi Mi, Zhihao Liu, Jinping Hu, Li Sheng, Baolian Wang, Dan Li,Shuang Yang, Yan Li*. Simultaneous quantification of MTC-220 and its metabolites in beagledog plasma by liquid chromatography–tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 99 (2014) 1–7
20. Yan-Bo Tang, Jun-Zheng Liu, Shu-En Zhang, Xin Du, Feilin Nie, Jin-Ying Tian, Fei Ye, Kai Huang, Jin-Ping Hu, Yan Li, and Zhiyan Xiao*. 3-Phenylpropanoic Acid-Based Phosphotyrosine (pTyr) Mimetics: Hit Evolution to a Novel Orally Active Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitor. ChemMedChem 2014, 9, 918-921
21. Qian Zhao, Yan Li, Jinping Hu, Xin Zheng, Ji Jiang, Pei Hu. LC–MS–MS Method to Simultaneously Determine Six Probe Drugs for CYP450 Isozymes in Human Liver Microsomes. Chromatographia (2014) 77:913–922
22. You F, Hu J, Li X, Li Y. The elimination of MTC-220, a novel anti-tumor agent of conjugate of paclitaxel and muramyl dipeptide analogue, in rats. Cancer Chemother Pharmacol. 2013; 71(6): 1453-62.
23. Wang Bao-lian, Hu Jin-ping, Sheng Li, Chen Hui, Li Yan. Chemical –pharmacokinetic -pharmacodynamic fingerprints of Schisandra chinensis alcoholic extract. Acta Pharmaceutica Sinica 2013, 48 (5): 734 −740
24. Huang K, Hu J, Li X, Li Y*. Role of P-glycoprotein in intestinal absorption of FB2, a promising Abl/Src dual tyrosine kinase inhibitor. Drug Metab Pharmacokinet. 27(5), 486-94. 2012
25. Zhang QH, Hu JP, Wang BL, Li Y*. Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo. J Asian Nat Prod Res. 14(4), 382-95. 2012
26. Hu JP, Wang WJ, Chen H, Li YW, Fan JH, Li Y. Pharmacokinetics, tissue distribution, and excretion of buagafuran in rats. Journal of Asian Natural Products Research. 13(3), 205–214, 2011
27. Li L, Wei Y, Van Winkle L, Zhang QY, Zhou X, Hu J, Xie F, Kluetzman K, Ding X. Generation and Characterization of a Cyp2f2-Null Mouse and Studies on the Role of CYP2F2 in Naphthalene-Induced Toxicity in the Lung and Nasal Olfactory Mucosa .The Journal of Pharmacology and Experimental Therapeutics 339:62–71, 2011.
28. En Li; Jin-Ping Hu; Bao-Lian Wang; Yan Li. Effect of buagafuran on liver microsomal cytochrome P450 in rats. Journal of Asian Natural Products Research 2010, 12(5),371–381
29. Zhang Q, Hu J, Sheng L, Li Y.. Simultaneous quantification of capsaicin and dihydrocapsaicin in rat plasma using HPLC coupled with tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2010; 878(24):2292-7.
30. Hai Xue, Xiaofan Lu, Purong Zheng, Li Liu, Chunyan Han, Jinping Hu, Zijie Liu, Tao Ma, Yan Li, Lin Wang, Zhiwei Chen, Gang Liu. Highly Suppressing Wild-Type HIV-1 and Y181C Mutant HIV-1 Strains by 10-Chloromethyl-11-demethyl-12-oxo-calanolide A with Druggable Profile. J. Med. Chem. 2010, 53, 1397–1401
31. Li Sheng, Jinping Hu, Baolian Wang, Hui Chen, Yan Li. Determination of bicyclol in dog plasma using liquid chromatography–tandem mass spectrometry. Journal of Chromatography B, 2010 (878) 2106–2110