张晓伟

张晓伟，博士，副研究员，硕士生导师，北京药理学会心脑血管药理专业委员会委员。
联系方式 电话： Email: zhxw@imm.ac.cn

教育背景
1999.09 – 2003.07 沈阳药科大学 工商管理学院，管理学学士
2003.09 – 2006.07 沈阳药科大学 药学院，药理学硕士
2006.09 – 2009.07 中国医学科学院&北京协和医学院 药物研究所，药理学博士

工作经历
2009.09 – 2013.06 美国辛辛那提大学 医学院 药理及细胞生物物理系，博士后
2013.08 – 2014.08 中国医学科学院&北京协和医学院 药物研究所，助理研究员
2014.09 - 今 中国医学科学院&北京协和医学院药物研究所，副研究员
专业研究领域
主要从事具有调节细胞自噬活性的小分子多肽以及天然产物活性分子在肝纤维化与糖尿病性心肌病发病过程中的作用和分子机制研究。近年来，作为课题负责人先后获得美国心脏学会、国家自然科学基金青年项目和面上项目、天然药物活性物质与功能国家重点实验室优秀青年基金、中国医学科学院协和青年基金、中国医学科学院“协和新星”基金、中国医学科学院药物所创新人才基金等多项基金资助。主要研究成果申请国家专利5项，并先后发表SCI论文十余篇，作为第一作者在Circulation、J Mol Cell Cardiol、Cardiovasc Res等国际权威心血管杂志发表多篇研究论文，单篇最高他引次数超过200。先后获得中国医学科学院2014年度“协和新星”称号及第十八届SERVIER青年药理学工作者奖。
发表论文
1. Zhang XW, Zhou JC, Peng D, Hua F, Li K, Yu JJ, Lv XX, Cui B, Liu SS, Yu JM, Wang F, Jin CC, Yang ZN, Zhao CX, Hou XY, Huang B, Hu ZW*. Disrupting the TRIB3-SQSTM1 interaction reduces liver fibrosis by restoring autophagy and suppressing exosome-mediated HSC activation. Autophagy, 2019 Jul 9:1-14. doi: 10.1080/**.2019.**
2. Jin W, Cui B, Li PP, Hua F, Lv XX, Zhou JC, Hu ZW, Zhang XW*. 1,25- Dihydroxyvitamin D3 protects obese rats from metabolic syndrome via promoting regulatory T cell-mediated resolution of inflammation. Acta Pharm Sin B, 8(2):178-187, 2018
3. Wu RN, Yu TY, Zhou JC, Li M, Gao HK, Zhao C, Dong RQ, Peng D, Hu ZW, Zhang XW*, Wu YQ*. Targeting HMGB1 ameliorates cardiac fibrosis through restoring TLR2-mediated autophagy suppression in myocardial fibroblasts. Int J Cardiol, 267:156-162, 2018
4. Zhang XW, Mi S, Li Z, Zhou JC, Xie J, Hua F, Li K, Cui B, Lv XX, Yu JJ, Hu ZW*. Antagonism of Interleukin-17A ameliorates experimental hepatic fibrosis by restoring the IL-10/STAT3-suppressed autophagy in hepatocytes. Oncotarget, 8(6):9922-9934, 2017 (IF:5.168)
5. Zhang XW, Zhou JC, Hu ZW*. Autophagy as a target for development of anti-diabetes drugs derived from natural compounds. J Asian Nat Prod Res, 19(4):314-319, 2017
6. Zhang XW, Wang XH, Zhu HY, Kranias EG, Tang YL, Peng TQ, Chang J, Fan GC*. Hsp20 functions as a novel cardiokine in promoting angiogenesis via activation of VEGFR2. PLoS One, 7(3):e32765, 2012 (IF:3.730)
7. Ma YG†, Zhang XW†, Bao HY, Mi S, Cai WF, Yan HM, Wang QQ, Wang ZY, Yan J, Fan GC, Lindsey ML, Hu ZW*. Toll-like receptor (TLR) 2 and TLR4 differentially regulate doxorubicin induced cardiomyopathy in mice. PLoS One, 7(7):e40763, 2012 († co-first author, IF:3.730)
8. Wang XH†, Zhang XW†, Ren XP, Chen J, Liu HZ, Yang JQ, Medvedovic M, Hu ZW, Fan GC*. MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia/ reperfusion-induced cardiac injury. Circulation, 122(13):1308-18, 2010 († co-first author, IF:14.432)
9. Zhang XW, Wang XH, Zhu HY, Zhu C, Wang YG, Pu WT, Jegga AG, Fan GC*. Synergistic effects of the GATA4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death. J Mol Cell Cardiol, 49(5):841-50, 2010（IF:5.499）
10. Cai WF†, Zhang XW†, Yan HM, Ma YG, Wang XX, Yan J, Xin BM, Lv XX, Wang QQ, Wang ZY, Yang HZ, Hu ZW*. Intracellular or extracellular heat shock protein 70 differentially regulates cardiac remodelling in pressure overload mice. Cardiovasc Res, 88(1):140-9, 2010 († co-first author, IF:6.051)
11. Li K, Zhang TT, Wang F, Cui B, Zhao CX, Yu JJ, Lv XX, Zhang XW, Yang ZN, Huang B, Li X, Hua F, Hu ZW. Metformin suppresses melanoma progression by inhibiting KAT5-mediated SMAD3 acetylation, transcriptional activity and TRIB3 expression. Oncogene, 37(22):2967-2981, 2018
12. Li K, Wang F, Cao WB, Lv XX, Hua F, Cui B, Yu JJ, Zhang XW, Shang S, Liu SS, Yu JM, Han MZ, Huang B, Zhang TT, Li X, Jiang JD, Hu ZW*. TRIB3 Promotes APL Progression through Stabilization of the Oncoprotein PML-RARα and Inhibition of p53-Mediated Senescence. Cancer Cell, 31(5):697-710, 2017 (IF:27.407)
13. Xie J, Yun JP, Yang YN, Hua F, Zhang XW, Lin H, Lv XX, Li K, Zhang PC, Hu ZW*. A novel ECG analog 4-(S)-(2,4,6-trimethylthiobenzyl)-epigallocatechin gallate selectively induces apoptosis of B16-F10 melanoma via activation of autophagy and ROS. Sci Rep, 7:42194, 2017
14. Qi MY, Zhou JC, Zhang XW, Zhong XG, Zhang YP, Zhang XJ, Deng XL, Li HY, Wang QQ*. Effect of Xiaoqinglong decoction on mucus hypersecretion in the airways and cilia function in a murine model of asthma. J Tradit Chin Med Sci, 4:290-296, 2017
15. Hua F, Li K, Yu JJ, Lv XX, Yan J, Zhang XW, Sun W, Lin H, Shang S, Wang F, Cui B, Mu R, Huang B, Jiang JD, Hu ZW*. TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations. Nat Commun, 6:7951, 2015 (IF:11.470)
16. Yan HM, Cui Bing, Zhang XW, Fu XM, Yan J, Wang XX, Lv XX, Chen Z, Hu ZW*. Antagonism of toll-like receptor 2 attenuates the formation and progression of abdominal aortic aneurysm. Acta Pharmaceutica Sinica B, 45(3), 2015
17. Wang XH, Zhu HY, Zhang XW, Liu Y, Chen J, Medvedovic M, Li HL, Weiss MJ, Ren XP, Fan GC*. Loss of the miR-144/451 cluster impairs ischaemic preconditioning- mediated cardioprotection by targeting Rac-1. Cardiovasc Res, 94(2):379-90, 2012 (IF:6.051)
18. Ma YG, Zhang XW, Bao HY, Yu SS, Hu ZW, Sun W. Blocking extracellular HMGB1 activity protects against doxorubicin induced cardiac injury in mice. Yao Xue Xue Bao, 47(11):1489-1495, 2012.
19. Yan J, Wang ZY, Yang HZ, Liu HZ, Mi S, Lv XX, Fu XM, Yan HM, Zhang XW, Zhan QM, Hu ZW*. Timing is critical for an effective anti-metastatic immunotherapy: the decisive role of IFNγ/STAT1-mediated activation of autophagy. PLoS One, 6(9):e24705, 2011
20. Wang QQ, Yang HZ, Liu HZ, Mi S, Zhang XW, Yan HM, Ma YG, Wang XX, Hu ZW*. Interleukin-17A is involved in development of spontaneous pulmonary emphysema caused by Toll-like receptor 4 mutation. Acta Pharmacol Sin, 32(8):1045-54, 2011
21. Xin BM, Wang XX, Jin W, Yan HM, Cui B, Zhang XW, Hua F, Yang HZ, Hu ZW*. Activation of Toll-like receptor 9 attenuates unilateral ureteral obstruction-induced renal fibrosis. Acta Pharmacol Sin, 31(12):1583-92, 2010
22. Zhang XW, Cai WF, Hu ZW. Advances in the study of immunopathological mechanism of dilated cardiomyopathy. Advances in Cardiovascular Diseases, 30(5):814-817, 2009.
专著
1. 张晓伟，胡卓伟. 血管及血压调节的分子机制及药物应用. 王晓良等编著：应用分子药理学（第二版）. 中国协和医科大学出版社, 2015
2. 胡卓伟，张晓伟. 调节心脏组织重构和心肌再生治疗慢性心血管疾病. 王晓良等编著：应用分子药理学（第二版）. 中国协和医科大学出版社，2015
3. 吕晓希，张晓伟，胡卓伟. 自噬流检测的意义和方法. 秦正红等编著：自噬-生物学与疾病（第二版）. 科学出版社, 2015
4. 张晓伟，严君，胡卓伟. 皮肤纤维化实验方法和技术. 张均田等编著：现代药理实验方法（第二版）. 中国协和医科大学出版社，2012
5. 张晓伟，杨红振，贲长恩. 重要的促纤维化因子和抑纤维化因子. 牛建昭等编著：器官纤维化基础及中医药防治. 人民卫生出版社，2008
专利
1. 盐酸小檗碱和水苏糖组成的组合物及其应用. 2016.5.25, 1.6
2. 鲜地黄中高纯度水苏糖的制备方法. 2016.5.23, 9.1
3. 一类二氢黄酮化合物在预防或治疗肝癌中的应用.2015.5.25, 9.6
4. 一类黄烷化合物在预防或治疗黑色素瘤中的应用. 2014.9.29，8.3
5. 甘草酸治疗扩张型心肌病心脏重构和心功能障碍的用途. 2011.11.23，0.9