张森

张森， 药理学博士，副研究员，硕士生导师，1979年8月生。2002年从山东大学取得生物化学学士学位，而后分别在中国协和医科大学肿瘤研究所和药物研究所取得硕士和博士学位。2008到2011年期间，在新加坡南洋理工大学做访问。长期从事新药开发，主要参与过国家1.1类新药硝克柳胺和中药5类圆锥绣球提取物的开发工作。独立主持国家自然科学基金、教育部重点实验专项基金、中国医学科学院基本科研业务经费、中国医学科学院医学与健康科技创新工程子任务以及十三五重大专项子任务；参与北京“十病十药”科委项目、北京市自然基金重点项目以及863“结直肠癌早期诊断”等项目。近年来，以第一作者或并列第一作者发表SCI收录文章14篇，申请专利7项。
目前主要研究领域为肿瘤药理学和慢性肾脏病药理学。利用现代药理学的新思路和新方法，结合大数据分析和AI新算法，从生物数据库中预测同疾病相关核酸靶点和蛋白靶点。同时，利用分子生物学的方法，验证靶点的有效性，并筛选有效治疗药物。
联系方式：
电话：**
邮箱：zhangs@imm.ac.cn
发表论文
1. Zhang Yu, Han Wendan, Zhang Sen*. Seeking for correlative genes and signaling pathways with bone metastasis from breast cancer by integrated analysis, Frontiers in Oncology. 2019, 9:138. DOI: 10.3389/fonc.2019.00138
2. Zhang Sen, Wang Weida, Ma Jie, Sheng Li, Zhang Dongming, Chen Xiaoguang*, Coumarin glycosides from Hydrangea paniculata slow down the progression of diabetic nephropathy by targeting Nrf2 anti-oxidation and smad2/3-mediated profibrosis. Phytomedicine, 2019,57, 385-395.
3. Zhang Sen, Wang Weida, Yan Li, Li Zhaojun, Xue Nina, Chen Xiaoguang, Nicousamide attenuates renal dysfunction and glomerular injury in remnant kidneys by inhibiting TGF-β1 internalisation and renin activity. European journal of pharmacology, 2019, 845:74-84.
4. Zhang Sen, Fu Yonghong, Wang Dongjie, Wang Jing. Icotinib enhances lung cancer cell radiosensitivity in vitro and in vivo by inhibiting MAPK/ERK and AKT activation. Clinical and experimental pharmacology and physiology. 2018;45(9):969-977.
5. Zhang Sen, Ma Jie, Sheng Li, Zhang Dongming, Chen Xiaoguang*, Yang Jingzhi, et al. Total Coumarins from Hydrangea paniculata Show Renal Protective Effects in Lipopolysaccharide-Induced Acute Kidney Injury via Anti-inflammatory and Antioxidant Activities. Frontiers in Pharmacology. 2017;8(872). DOI: 10.3389/fphar.2017.00872.
6. Zhang Sen, Ma Jie, Yang Jingzhi, Wang Dongjie, Zhang Dongming, Chen Xiaoguang*. Total coumarins from Hydrangea paniculata protect against cisplatin-induced acute kidney damage in mice by suppressing renal inflammation and apoptosis, Evidence-Based Complementary and Alternative Medicine, Volume 2017 (2017), Article ID **, DOI:10.1155/2017/**.
7. Zhang Sen, Wang Dongjie, Xue Nina, Ji Ming, Lai Fangfang, Jinjin, Chen Xiaoguang. Nicousamide protects kidney podocyte by inhibiting the TGFβ receptor II phosphorylation and AGE-RAGE signaling, American Journal of Translational Research, 2017, 9(1):115-125.
8. Ma Pei*, Zhang Sen*, Su Qinglin, Qiu Guixing, Wu Zhihong. Protective effects of icariin on cisplatin-induced acute renal injury in mice, American Journal of Translational Research, 2015;7(10):2105-2114.
9. Xiao-kai Zhan^#,*, Sen Zhang^#, Bang-wei Cao, Jin-wan Wang, Jun-ling Li, Yong-kun Sun, Wen Zhang, Lin Yang, Ai-ping Zhou, Yi-he bali Chi, Ye-xiong Li, Jian-hui Ma and Chang-ling Li. Clinicopathological characteristics and treatment outcomes of Chinese patients with genitourinary embryonal rhabdomyosarcoma. World J Surg Oncol, 2015; 13: 190.
10. Sen Zhang, Hongqi Xin, Yan Li, Dongming Zhang, Jing Shi, Jingzhi Yang, and Xiaoguang Chen. Skimmin, a Coumarin from Hydrangea paniculata, slows down the Progression of Membranous Glomerulonephritis by Anti-Inflammatory Effects and Inhibiting Immune Complex Deposition. Evidence-Based Complementary and Alternative Medicine. 2013:819296. doi: 10.1155/2013/819296
11. Sen Zhang, Xiao Kai Zhan, Jin Jing, Zhang Yi, Zhou Wanqi, Chemosensitizing activities of cyclotides from Clitoria ternatea in paclitaxel-resistant lung cancer cells, Oncology Letters, 5: 641-644, 2013.
12. Sen Zhang, Jingzhi Yang, Hongyan Li, Yan Li, Xiaoguang Chen. Skimmin, a coumarin, suppresses the streptozotocin-induced diabetic nephropathy in wistar rats. European Journal of Pharmacology, 692(1-3): 78-83, 2012.
专利：
1. 名称：圆锥绣球总香豆素苷、其制备方法及其组合物与用途，申请号：5.2。
2. 名称：一种多肽在临床早期结直肠癌及癌前病变诊断中的应用，申请号：20**。
3. 名称：一种多肽、及其在结直肠癌的早期诊断中的应用，申请号：20**。
4. 名称：一种利用拉曼成像技术检测耐药性的方法，申请号：9.7。
5. 一种改良型低毒增生平组合物及其制备方法和用途, 申请号：8.9。
6．肠道菌Catabacter在肾病综合征早期诊断及治疗中的应用。申请号：3.3。
7．肠道菌Faecalitalea在肾病综合征早期诊断中的应用。中国，申请号：7.8。