金晶

金晶，1982年2月出生，博士，副研究员，硕士研究生导师。
联系方式：
Tel：
Email：rebeccagold@imm.ac.cn
教育背景：
2000.09 ~ 2005.07 首都医科大学，预防医学专业，医学学士
2005.09 ~ 2010.07 清华大学医学部&北京协和医学院药物研究所，药理学，医学博士

工作经历：
2010.09 ~ 2012.04，中国医学科学院药物研究所，药理系，助理研究员
2012.04 ~ 2012.07，美国弗吉尼亚大学，肾脏病及免疫炎症再生医学系，访问
2012.07 ~ 2014.07，中国医学科学院药物研究所，药理系，助理研究员
2014.07-，中国医学科学院药物研究所，药理系，副研究员

专业研究领域：
主要从事自身免疫性疾病及肿瘤免疫学的药理学研究及新药临床前开发。2011年至今共发表SCI论文21篇，核心期刊9篇；申请专利5项，授权专利1项。近年来主持承担了国家自然科学基金青年基金、药物所基本科研业务费团队建设专项等多个研究项目，并作为主要研究人员参与了多项国家“十二五”重大新药创制专项课题、北京市自然科学基金重点项目及国家自然科学基金面上项目等。参与编写《应用分子药理学》、《多靶点药物研究及应用》、《肿瘤学》等专业书籍5部。目前担任中国药理学会生化与分子药理学专业委员会第一届青年委员会委员。作为临床前药效学研究的的主要完成人，全程参与研发与申报了2个1.1类新药，目前已获得了临床受理通知书。
近年来发表论著（2011-）：
1. Jing Jin, Jinping Hu, Wanqi Zhou, Xiaojian Wang, Qiong Xiao, Nina Xue, Dali Yin, Xiaoguang Chen. Development of a selective S1P1 receptor agonist, Syl930, as a potential therapeutic agent for autoimmune encephalitis. Biochemical Pharmacology. 2014, Jul 1; 90(1), 50-61.
2. Jin Jing, Zhang Yi, Li Yan, Zhang Haijing, Li Hongyan, Yuan Xia, Li Xiangyan, Zhou Wanqi, Xu Bailing, Zhang Chongjing, Zhang Zhihui, Zhu Lina, Chen Xiaoguang. RNA-interference-mediated downregulation of Pin1 suppresses tumoriigenicity of malignant melanoma A375 cells. Neoplasma. 2013, 60(1): 92-100.
3. Tian Yulin1, Jin Jing1, Wang Xiaojian, Hu Jinping, Xiao Qiong, Zhou Wanqi, Chen Xiaoguang, Yin Dali. Discovery of oxazole and triazole derivatives as potent and selective S1P(1) agonists through pharmacophore-guided design. Eur J Med Chem. 2014, Oct 6;85:1-15. (Co-First Author)
4. Jie Zhou1, Jing Jin1, Yi Zhang, Yuwen Yin, Xiaoguang Chen, Bailing Xu. Synthesis and antiproliferative evaluation of novel benzoimidazole contained oxazole-bridged analogs of combretastatin A-4.Eur J Med Chem. 2013, Oct; 68:222-232 (Co-First Author)
5. Chang Liu1, Jing Jin1, Liang Chen, Jie Zhou, Xiaoguang Chen, Decai Fu, Hongrui Song, Bailing Xu. Synthesis and biological evaluation of novel human Pin1 inhibitors with benzophenone skeleton. Bioorg Med Chem. 2012, 20(9): 2992-2999. (Co-First Author)
6. Yongkang Wang1, Jing Jin1, Lina Zhu, Yi Zhang, Xiaoguang Chen, Xinqin Gao, Bailing Xu. Synthesis and antitumor activity of novel 2-(1-substitutedpiperidin- 4-ylamino)quinazolines as antitumor agents. Acta Pharmaceutica Sinica B. 2012, 47(9):1164-1178 (Co-First Author)
7. Jing Jin, Li-na Zhu, Hai-jing Zhang, Yan Li, Yi Zhang, Wan-qi Zhou, Bai-ling Xu, Xiao-guang Chen. XLN306 induces apoptosis in human breast carcinoma MX-1 cells. Acta Pharmaceutica Sinica B. 2011, 1(2):84-88.
8. Zhu Lina1, Jin Jing1, Liu Chang, Zhang Chongjing, Sun Yan, Chen Xiaoguang, Xu Bailing. Synthesis and biological evaluation of novel quinazoline-derived human Pin1 inhibitors. Bioorg Med Chem. 2011, 19(9):2797-807. (Co-First Author)
9. 金晶，张海婧，汪小涧，周琬琪，扈金萍，尹大力，陈晓光.新型免疫抑制剂SYL934的抗皮肤移植排斥反应研究.中国药理学通报.2014, 30(6):763-773.
10. 金晶，汪小涧，周琬琪，薛妮娜，尹大力，陈晓光.新型前药类S1P1激动剂Sy1978的药理活性.中国药科大学学报.2014, 45(3) :358-361.
11. 席月月¹，金晶¹，孙艳，陈晓光，宋宏锐，徐柏玲. 新型含嘧啶环二芳基醚类Pin1抑制剂的设计、合成及活性评价. 药学学报. 2013, 48(8): 1266 −1272.
12. 金晶，张海婧，汪小涧，周琬琪，尹大力，陈晓光.新型S1P1受体激动剂Sy1948抗皮肤移植排斥反应研究.药学学报.2014, 49(5):627-631.
13. Zhang L, Jin J, Zhang L, et al. Quantitative analysis of differential protein expression in cervical carcinoma cells after zeylenone treatment by stable isotope labeling with amino acids in cell culture. J Proteomics. 2015, Aug 3;126:279-87.
14. Xue nina, Jin Jing, Liu Di, et al. Antiproliferative effect of HSP90 inhibitor Y306zh against pancreatic cancer is mediated by interruption of AKT and MAPK signaling pathways. Curr Cancer Drug Targets. 2014, 14(7):671-83.
15. Zhu Zhixiang, Jin Jing, Xue Nina, et al. Development and validation of high-throughput screening assays for poly(ADP-ribose) polymerase-2 inhibitors. Anal Biochem. 2014, Mar 15;449:188-94.
16. Haijing Zhang, Jing Jin, Wanqi Zhou, et al. Nicousamide, a potent inhibitor of phosphorylation by TGF-b receptor II. Acta Pharmaceutica Sinica B. 2011, 1(3):160–165.
17. 李康宁，金晶，陈晓光. 膜联蛋白A1增加人慢性髓系白血病细胞K562对伊马替尼的敏感性.药学学报. 2013, 48 (6): 866 −873.
18. Miao J, Cui H, Jin J, Lai F, Wen H, Zhang X, Ruda GF, Chen XG, Yin D. Development of 3-alkyl-6-methoxy-7-hydroxy-chromones(AMHCs) from natural isoflavones, a new class of fluorescent scaffolds for biological imaging. Chem Commue (Camb). 2015, 18;51(5):881-4.
19. Chunwan Lu, Di Liu, Jing Jin, Hemantkumar Deokar , Yi Zhang , John K. Buolamwini ,Xiaoming Yu , Chunhong Yan , Xiaoguang Chen . Inhibition of gastric tumor growth by a novel Hsp90 inhibitor. Biochemical Pharmacology 2013,85:1246–1256.
20. Sen Z, Zhan XK, Jing J, et al. Chemosensitizing activities of cyclotides from Clitoria ternatea in paclitaxel-resistant lung cancer cells. Oncol Lett, 2013, Feb;5(2):641-644.
21. Wang tianen, Wang yongkang, Jin Jing, Xu bailing, Chen xiaoguang. A novel derivative of quinazoline, WYK431 induces G2/M phase arrest and apoptosis in human gastric cancer BGC823 cells through the PI3K/Akt pathway. International Journal of Oncology. 2014, 45: 771-781.
22. Qing Zhou, Yan Li, Jing Jin, et al.Lx2-32c, a novel taxane derivative, exerts anti-resistance activity by initiating intrinsic apoptosis pathway in vitro and inhibits the growth of resistant tumor in vivo. Biol. Pharm. Bull. 2012, 35: 2170-2179.
23. 周琬琪, 张海婧, 金 晶, 李 燕, 李 超, 陈晓光。S1P1受体激动剂FTY720 的免疫抑制作用。药学学报. 2012, 47:546-550.
24. Li Yan, Zhou Wanqi, Lang Liwei, Jin Jing, Tang Ke, Li Chao, Bin Tena T, Chen Xiaoguang *.The effect of Aurora kinases on cell proliferation,cell cycle regulation and metastasis in renal cell carcinoma. International Journal of Oncology. 2012, 41:2139-2149.
25. Mei Mei, Dan Xie, Yi Zhang, Jing Jin, Feng You, Yan Li, Jungui Dai, Xiaoguang Chen. A New 2a,5a,10b,14b-tetraacetoxy-4(20),11-taxadiene(SIA) Derivative Overcomes Paclitaxel Resistance by Inhibiting MAPK Signaling and Increasing Paclitaxel Accumulation in Breast Cancer Cells. plos one. 2014, 9 (8): e104317.
26. Xia Yuan, Zhang Y, Zhang H, Jing J, Li X, Liu H, Feng Z, Chen X. Activity of the potent dual Abl/Src tyrosine kinase inhibitor FB2 against Bcr-Abl positive cell lines in vitro and in vivo. Leuk Res. 2011, 35(2):237-42.
27. Qin Zhou, Ming Ji, Jie Zhou, Jing Jin, Nina Xue, Ju Chen, Bailing Xu, Xiaoguang Chen. Poly (ADP-ribose) polymerases inhibitor, Zj6413, as a potential therapeutic agent against breast cancer. Biochemical Pharmacology. 2016, 107:29-40
28. Wen J, Li HZ, Ji ZG, Jin J. Effect of sunitinib malate on growth of human bladder transitional cell line T24 in vitro. Chin Med Sci J. 2015, Mar 30(1): 51-5.
29. Niu Fei, Li Yan, Lai Fangfang, Ji Ming, Jin Jing, Yang Hanze, Zhou Wanqi, Zhang Dongming, Chen Xiaoguang. LB-1 Exerts Antitumor Activity in Pancreatic Cancer by Inhibiting HIF-1α and Stat3 Signaling. J Cell Physiol. 2015, 230(9): 2212-2223.
30. Xiangyan Li, Yan Li, Yi Zhang, Ke Wang, Xia Yuan, Jing Jin, Yan Zhang, Zhanzhu Liu, Xiaoguang Chen. A novel bisindolymaleimide derivative (WK234) inhibits proliferation and induces apoptosis through the protein kinase Cβpathway, in chronic myelogenous leukemia K562 cells. Leukemia & Lymphoma. 2011, 52(7): 1312-1320.
专利：
1. 胺基丙二醇类衍生物、其制备方法和其药物组合物与用途。授权号：ZL7.7。
2. 苯并咪唑类衍生物、及其制法和药物组合物与用途。申请号：6.2。
3. 胺基丙二醇类衍生物、其制备方法和其药物组合物与用途。申请号： PCT/CN2012/078244。
4. 胺基丙二醇类衍生物、其制备方法和其药物组合物与用途。申请号：8.4。
5. 含五元芳杂环的氨基丙二醇类化合物、其制备方法及其医药用途。申请号：0.1。
6. 喹唑啉酮类PARP-1抑制剂及含有它们的组合物和抗肿瘤用途。申请号：1.7。