王真真
王真真，女，博士，副研究员，硕士生导师。
联系方式
Email：wangzz@imm.ac.cn
Tel：
教育背景及工作经历
2006.09 – 2009.07 北京协和医学院，药理学专业，理学博士
2009.09 – 2013.07 军事医学科学院毒物药物研究所，博士后
2013.08 – 至今 中国医学科学院药物研究所，助理研究员、副研究员
专业研究领域
神经精神药理学研究方向，目前主要集中在对抑郁症新的发病机制和新的药物靶标的探究和解析，以及抗抑郁创新药物的药理学研究方面。具体研究内容如下：
1. 抑郁症新的发病机制和新的药物靶标的研究：主要是基于缝隙连接蛋白Cx43介导的星形胶质细胞间缝隙连接功能和半通道功能研究抑郁症的发病机制，以及对应激敏感和抵抗机制的探讨，糖皮质激素受体与抑郁症的关系研究等。
2. 抗抑郁创新药物的药理学研究：主要研究人参皂苷Rg1等天然产物的抗抑郁作用机制、选择性PDE4D抑制剂和快速起效抗抑郁创新药物的寻找和药效及机理研究。
工作情况简介
近年来先后主持科研项目7项，其中包括国家自然科学基金项目2项、北京市自然科学基金项目2项；先后参与过的国家级和院校级科研项目10余项。已发表文章50余篇，其中SCI收录37 篇，以（共同）第一作者或通讯作者发表的SCI文章10篇；参编学术论著3部。兼任北京药理学会神经精神药理专业委员会副秘书长、北京药理学会神经精神药理专业委员会青年工作委员会副主任委员、中国药理学会补益药药理专业委员会委员、北京神经科学学会青年专业委员会委员、国家自然科学基金通信评审专家、北京市自然科学基金评审专家库成员和Experimental Neurology、Journal of Ethnopharmacology等SCI期刊审稿人。2014年获得“中国药理学会-法国施维雅研究院”第十八届SERVIER青年药理学工作者奖。
发表SCI文章
1. Wang ZZ, Zhang Y, Liu YQ, Zhao N, Zhang YZ, Yuan L, An L, Li J, Wang XY, Qin JJ, Wilson SP, O’Donnell JM, Zhang HT, Li YF*. RNA interference-mediated phosphodiesterase-4D splice variants knockdown in the prefrontal cortex produces antidepressant-like and cognition-enhancing effects. British Journal of Pharmacology, 2013; 168: 1001-1014.
2. Wang ZZ, Yang WX, Zhang Y, Zhao N, Zhang YZ, Liu YQ, Xu Y, Wilson SP, O’Donnell JM, Zhang HT, Li YF*. Phosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in Mice. Scientific Reports, 2015; 5: 11332.
3. Wang ZZ, Zhang Y, Zhang HT, Li YF*. Phosphodiesterase (PDEs): An interface connecting cognitive deficits to neuropsychiatric and neurodegenerative diseases. Current Pharmaceutical Design, 2015; 21: 303-316.
4. Wang ZZ, Li G, Chen XY, Zhao M, Yuan YH, Wang XL, Chen NH*. Chemokine-like factor 1, a novel cytokine, induces nerve cell migration through the non-extracellular Ca2+-dependent tyrosine kinases pathway. Brain Research, 2010; 1308: 24-34.
5. Wang ZZ, Zhang Y, Yuan YH, Chen NH*. Developmental expression of chemokine-like factor 1, a novel member of chemokines family, in postnatal rat cerebral cortex. Neuroscience Letters, 2012; 519: 51-55.
6. Wang ZZ, Yuan YH, Zhang Y, Wang XF, Chu SF, Han N, Chen NH*. Chemokine-like factor 1 promotes the migration of rat primary cortical neurons by the induction of actin polymerization. Neuroreport, 2014; 25: 1221-1226.
7. Wang ZZ, Zhao WJ, Zhang XS, Tian XF, Wang YZ, Zhang F, Yuan JC, Han GZ, Liu KX, Yao JH*. Protection of Veratrum nigrum L. var. ussuriense Nakai alkaloids against ischemia-reperfusion injury of the rat liver. World Journal of Gastroenterology, 2007; 13: 564-571.
8. Zhang Y#,*, Wang ZZ#, Sun HM, Li P, Li YF, Chen NH. Systematic review of traditional chinese medicine for depression in Parkinson's disease. American Journal of Chinese Medicine, 2014; 42: 1035-1051. ( # co-first author)
9. Yang PF#, Wang ZZ#, Zhang Z, Liu DD, Manolios EN, Chen C, Yan X, Zuo W, Chen NH*, The extended application of The Rat Brain in Stereotaxic Coordinates in rats of various body weight. Journal of Neuroscience Methods, 2018; 307: 60-69. ( # co-first author)
10. Xia CY, Chu SF, Zhang S, Gao Y, Ren Q, Lou YX, Luo P, Tian MT, Wang ZQ, Du GH, Tomioka Y, Yamakuni T, Zhang Y, Wang ZZ*, Chen NH*. Ginsenoside Rg1 alleviates corticosterone-induced dysfunction of gap junctions in astrocytes. Journal of Ethnopharmacology, 2017; 208: 207-213. (* co-corresponding author)
11. Xia CY, Wang ZZ, Zhang Z, Chen J, Wang YY, Lou YX, Gao Y, Luo P, Ren Q, Du GH, Chen NH*. Corticosterone impairs gap junctions in the prefrontal cortical and hippocampal astrocytes via different mechanisms. Neuropharmacology, 2017; 131: 20-30.
12. Xia CY, Wang ZZ, Tomioka Y, Chen NH*. A novel mechanism of depression: role for connexins. European Neuropsychopharmacology, 2018; 28(4): 483-498.
13. Jin C, Wang ZZ, Zhou H, Lou YX, Chen J, Zuo W, Tian MT, Wang ZQ, Du GH, Kawahata I, Yamakuni T, Zhang Y, Chen NH*, Zhang DS*. Ginsenoside Rg1-induced antidepressant effects involve the protection of astrocyte gap junctions within the prefrontal cortex. Prog Neuropsychopharmacol Biol Psychiatry, 2017; 75: 183-191.
14. Chen J, Wang ZZ, Zuo W, Zhang S, Chu SF, Chen NH*. Effects of chronic mild stress on behavioral and neurobiological parameters - Role of glucocorticoid. Hormones and Behavior, 2015; 78: 150-159.
15. Chen J, Wang ZZ, Zhang S, Ai QD, Chu SF, Chen NH*. Possible target-related proteins of stress-resistant rats suggested by label-free protemic analysis. RSC Advances, 2017; 7: 40957-40964.
16. Chen J, Wang ZZ, Zhang S, Zuo W, Chen NH*. Does mineralocorticoid receptor play a vital role in the development of depressive disorder? Life Sciences, 2016; 152: 76-81.
17. Ren Q, Wang ZZ, Chu SF, Xia CY, Chen NH*. Gap junction channels as potential targets for the treatment of major depressive disorder. Psychopharmacology (Berl), 2018; 235(1):1-12.
18. Zhang Y, Wang ZZ, Sun HM*. Lack of association between p.Ser167Asn variant of Parkin and Parkinson's disease: A meta-analysis of 15 studies involving 2,280 cases and 2,459 controls. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2012; 159B: 38-47.
19. Zhang Y, Wang ZZ, Sun HM*. A meta-analysis of the relationship of the Parkin p.Val380Leu polymorphism to Parkinson’s disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2013; 162: 235-244.
20. Zhang Y, Wang ZZ, Sun HM*. Meta-analysis of the influence of Parkin p.Asp394Asn variant on the susceptibility of Parkinson's disease. Neuroscience Letters, 2012; 524: 60-64.
21. Lou YX, Li J, Wang ZZ, Xia CY, Chen NH*. Glucocorticoid receptor activation induces decrease of hippocampal astrocyte number in rats. Psychopharmacology (Berl), 2018; 235(9): 2529-2540.
22. Zhang Y*, Gong XG, Wang ZZ, Sun HM*, Guo ZY, Hu JH, Ma L, Li P, Chen NH. Overexpression of DJ-1/PARK7, the Parkinson's disease-related protein, improves mitochondrial function via Akt phosphorylation on threonine 308 in dopaminergic neuron-like cells. European Journal of Neuroscience, 2016; 43(10): 1379-1388.
23. Zhang Y*, Gong XG, Wang ZZ, Sun HM*, Guo ZY, Gai C, Hu JH, Ma L, Li P Chen NH*. Protective effects of DJ-1 medicated Akt phosphorylation on mitochondrial function are promoted by Da-Bu-Yin-Wan in 1-methyl-4-phenylpyridinium-treated human neuroblastoma SH-SY5Y cells. Journal of Ethnopharmacology, 2016; 187: 83-93.
24. Li G*, Li GY, Wang ZZ, Ji HJ, Wang DM, Hu JF, Yuan YH, Liu G, Chen NH*. The chemokine-like factor 1 induces asthmatic pathological change by activating nuclear factor-kappaB signaling pathway. International Immunopharmacology, 2014; 20(1): 81-88.
25. Yao JH, Li YH, Wang ZZ, Zhang XS, Wang YZ, Yuan JC, Zhou Q, Liu KX, Tian XF*. Proteasome inhibitor lactacystin ablates liver injury induced by intestinal ischaemia-reperfusion. Clinical and Experimental Pharmacology and Physiology, 2007; 34: 1102-1108.
26. Zhang XL, Yuan YH, Shao QH, Wang ZZ, Zhu CG, Shi JG, Ma KL, Yan X, Chen NH*. DJ-1 regulating PI3K-Nrf2 signaling plays a significant role in bibenzyl compound 20C-mediated neuroprotection against rotenone-induced oxidative insult. Toxicology Letters,2017; 271: 74-83.
27. Xia CY, Zhang S, Gao Y, Wang ZZ, Chen NH*. Selective modulation of microglia polarization to M2 phenotype for stroke treatment. International Immunopharmacology, 2015; 25: 377-382.
28. Xia CY, Zhang S, Chu SF, Wang ZZ, Song XY, Zuo W, Gao Y, Yang PF, Chen NH*. Autophagic flux regulates microglial phenotype according to the time of oxygen-glucose deprivation/reperfusion. International Immunopharmacology, 2016; 39: 140-148.
29. Zhou H, Xue W, Chu SF, Wang ZZ, Li CJ, Jiang YN, Luo LM, Luo P, Li G, Zhang DM and Chen NH*. Polygalasaponin XXXII, a triterpenoid saponin from Polygalae Radix, attenuates scopolamine-induced cognitive impairments in mice. Acta Pharmacologica Sinica, 2016; 37(8): 1045-1053.
30. Tian XF, Zhang XS, Li YH, Wang ZZ, Zhang F, Wang LM, Yao JH*. Proteasome inhibition attenuates lung injury induced by intestinal ischemia reperfusion in rats. Life Sciences, 2006; 79: 2069-2076.
31. Kong LL, Wang ZY, Han N, Zhuang XM, Wang ZZ, Li H*, Chen NH*. Neutralization of chemokine-like factor 1, a novel C-C chemokine, protects against focal cerebral ischemia by inhibiting neutrophil infiltration via MAPK pathways in rats. Journal of Neuroinflammation, 2014; 11: 112.
32. Zhang Z, Chu SF, Mou Z, Gao Y, Wang ZZ, Wei GN, Chen NH*. Ganglioside GQ1b induces dopamine release through the activation of Pyk2. Molecular and Cellular Neuroscience, 2016; 71: 102-113.
33. Tian XF, Yao JH, Li YH, Gao HF, Wang ZZ, Yang CM, Zheng SS*. Protective effect of pyrrolidine dithiocarbamate on liver injury induced by intestinal ischemia-reperfusion in rats. Hepatobiliary & Pancreatic Diseases International, 2006; 5: 90-95.
34. Yao JH, Zhang XS, Zheng SS, Li YH, Wang LM, Wang ZZ, Chu L, Hu XW, Liu KX, Tian XF*. Prophylaxis with carnosol attenuates liver injury induced by intestinal ischemia/reperfusion. World Journal of Gastroenterology, 2009; 15: 3240-3245.
35. Tian XF, Yao JH*, Zhang XS, Zheng SS, Guo XH, Wang LM, Wang ZZ, Liu KX. Protective effect of carnosol on lung injury induced by intestinal ischemia/reperfusion. Surgery Today, 2010; 40: 858-865.
36. Gao Y, Chu SF, Li JP, Zhang Z, Yan JQ, Wen ZL, Xia CY, Mou Z, Wang ZZ, He WB, Guo XF, Wei GN, Chen NH*. Protopanaxtriol protects against 3-nitropropionic acid-induced oxidative stress in a rat model of Huntington's disease. Acta Pharmacologica Sinica, 2015; 36: 311-322.
37. Chu SF, Zhang Z, Zhou X, He WB, Chen C, Luo P, Liu DD, Ai QD, Gong HF, Wang ZZ, Sun HS, Feng ZP, Chen NH*. Ginsenoside Rg1 protects against ischemic/reperfusion-induced neuronal injury through miR-144/Nrf2/ARE pathway. Acta Pharmacol Sin, 2018; online (doi: 10.1038/s41401-018-0154-z).
专著
1. 王真真, 陈乃宏. 人参皂苷Rg3. 《天然药物-来自植物的小分子药物》, 杜冠华主编. 北京: 人民卫生出版社, 2018, 211-214.
2. 王真真, 陈乃宏. 抗衰老药物的临床前药理研究及技术指导原则. 《老年药理学与药物治疗学》, 张洪泉主编. 北京: 人民卫生出版社, 2010, 932-946.
3. 王真真, 张有志, 李云峰. 抗精神分裂症的多靶点药物. 《多靶点药物研究及应用》, 李学军主编. 北京: 人民卫生出版社, 2011, 252-266.
