曹雪涛

中国工程院院士，中国医学科学院院长、北京协和医学院校长。德国科学院外籍院士、法国医学科学院外籍院士、英国医学科学院外籍院士，兼任中国生物医学工程学会理事长、中国科协生命科学联合体主席、亚太免疫学会联盟秘书长、医学免疫学国家重点实验室主任。创办《中国肿瘤生物治疗杂志》并任主编，Cellular and Molecular Immunology共同主编、任Journal of Molecular Medicine、Cancer Immunology Research副主编,任Cell、Annual Review of Immunology、Science Translational Medicine、Science Advances、eLife、Cell Research等编委。
曹雪涛院士主要从事天然免疫与炎症的基础研究、肿瘤免疫治疗应用研究。以通讯作者在Cell、Nature、Science、NatureImmunology、Cancer Cell等发表SCI论文230余篇，引用1万余次。以第一完成人获国家自然科学二等奖1项（2003）、中华医学科技奖一等奖2项、军队和上海市科技进步一等奖2项、上海市自然科学一等奖4项，获得国家发明专利16项，获得国家II类新药证书2个。获得中国工程院光华工程奖（2012）、中科院陈嘉庚生命科学奖（2016）、中国青年科学家奖等。主编本科生、研究生《医学免疫学》统编教材，培养的12名博士生获得全国优秀博士论文。获得首届中国研究生教育特等奖(2014)和Nature杰出导师终身成就奖(2015)。

组内人员：
姜明红 博士 副研究员，硕士生导师
王春梅 博士 副研究员，硕士生导师
许小青 博士 助理研究员
王冰晶 博士 助理研究员
刘音 主管技师


论文发表：
1. ZhengQ, Hou J, Zhou Y, Li Z, Cao X. The RNA helicase DDX46 inhibits innate immunityby entrapping m6A-demethylated antiviral transcripts in the nucleus. Nat Immunol. 2017 Aug 28.
2. ChenK, Liu J, Liu S, Xia M, Zhang X, Han D, Jiang Y, Wang C, Cao X.Methyltransferase SETD2-mediated methylation of STAT1 is critical for interferonantiviral activity. Cell. 2017;170(3):492-506
3. Liu Y,Gu Y, Han Y, Zhang Q, Jiang Z, Zhang X, Huang B, Xu X, Zheng J, Cao X. TumorExosomal RNAs promote lung pre-metastatic niche formation by activating alveolarepithelial TLR3 to recruit neutrophils. CancerCell. 2016;30(2):243-256.
4. DingY, Guo Z, Liu Y, Li X, Zhang Q, Xu X, Gu Y, Zhang Y, Zhao D, Cao X. The lectinSiglec-G inhibits dendritic cell cross-presentation by impairing MHC classI-peptide complex formation. NatImmunol. 2016;17(10):1167-75.
5. Li X, Zhang Q,Ding Y, Liu Y, Zhao D, Zhao K, Shen Q, Liu X, Zhu X, Li N, Cheng Z, Fan G, WangQ, Cao X.Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinaseTBK1 for activation of antiviral innate immunity. Nat Immunol. 2016;17(7):806-15.
6. Yang M, Chen T, LiX, Yu Z, Tang S, Wang C, Gu Y, Liu Y, Xu S, Li W, Zhang X, Wang J, Cao X.K33-linked polyubiquitination of Zap70 by Nrdp1 controls CD8+ T cellactivation. Nat Immunol. 2015;16(12):1253-62.
7. Zhang Q, Zhao K,Shen Q, Han Y, Gu Y, Li X, Zhao D, Liu Y, Wang C, Zhang X, Su X, Liu J, Ge W,Levine RL, Li N, Cao X. Tet2 is required to resolveinflammation by recruiting Hdac2 to specifically repress IL-6. Nature. 2015;525(7569):389-93.
8. Liu J, Han C,Xie B, Wu Y, Liu S, Chen K, Xia M, Zhang Y, Song L, Li Z, Zhang T, Ma F, WangQ, Wang J, Deng K, Zhuang Y, Wu X, Yu Y, Xu T, Cao X. Rhbdd3 controls autoimmunity by suppressing the productionof IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO. Nat Immunol. 2014;15(7):612-22.
9. Chen T, Yang M,Yu Z, Tang S, Wang C, Zhu X, Guo J, Li N, Zhang W, Hou J, Liu H, Han C, Liu Q,Gu Y, Qian C, Wan T, Cui L, Zhu M, Zheng W, Cao X. Small GTPase RBJ mediates nuclear entrapment of MEK1/MEK2 intumor progression. Cancer Cell.2014;25(5):682-96.
10. Hou J, Zhou Y,Zheng Y, Fan J, Zhou W, Ng IO, Sun H, Qin L, Qiu S, Lee JM, Lo CM, Man K, YangY, Yang Y, Yang Y, Zhang Q, Zhu X, Li N, Wang Z, Ding G, Zhuang SM, Zheng L,Luo X, Xie Y, Liang A, Wang Z, Zhang M, Xia Q, Liang T, Yu Y, Cao X. Hepatic RIG-I predicts survivaland interferon-α therapeutic response in hepatocellular carcinoma. Cancer Cell. 2014;25(1):49-63
11. Wang P, Xue Y, Han Y, Lin L, Wu C, Xu S, JiangZ, Xu J, Liu Q, Cao X. TheSTAT3-binding long noncoding RNA lnc-DC controls human dendritic celldifferentiation. Science.2014;344(6181):310-3.
12. Chen W, Han C, Xie B, Hu X, Yu Q, Shi L, Wang Q, Li D,Wang J, Zheng P, Liu Y, Cao X.Induction of Siglec-G by RNA viruses inhibits the innate immune response bypromoting RIG-I degradation. Cell.2013;152(3):467-78
13. Xia M, Liu J, Wu X, Liu S, Li G, Han C, Song L, Li Z,Wang Q, Wang J, Xu T, Cao X. HistoneMethyltransferase Ash1l Suppresses Interleukin-6 Production and InflammatoryAutoimmune Diseases by Inducing the Ubiquitin-Editing Enzyme A20. Immunity. 2013, 39(3): 470-481
14. Xu S, Liu X, Bao Y, Zhu X, Han C, Zhang P, Zhang X, Li W, Cao X. Constitutive MHC class Imolecules negatively regulate TLR-triggered inflammatory responses via theFps-SHP-2 pathway. Nat Immunol.2012;13(6):551-9.
15. Liu X,Zhan Z, Li D, Xu L, Ma F, Zhang P, Yao H, CaoX. Intracellular MHC class II molecules promote TLR-triggered innate immuneresponses by maintaining Btk activation. NatImmunol. 2011, 12(5):416-424
16. Ma F,Xu S, Liu X, Zhang Q, Xu X, Liu M, Hua M, Li N, Yao H, Cao X. The microRNA miR-29 controls innate and adaptive immuneresponses to intracellular bacterial infection by targeting interferon-γ. Nat Immunol. 2011,24;12(9):861-869
17. Hou J,Lin L, Zhou W, Wang Z, Ding G, Dong Q, Qin L, Wu X, Zheng Y, Yang Y, Tian W,Zhang Q, Wang C, Zhang Q, Zhuang S, Zheng L, Liang A, Tao W, and Cao X. Identification of miRNomes inhuman liver and hepatocellular carcinoma reveals miR-199a/b-3p as a therapeutictarget for hepatocellular carcinoma. CancerCell. 2011, 19(2):232-243
18.Yang P, An H, Liu X, Wen M,Zheng Y, Rui Y, Cao X. The cytosolicnucleic acid sensor LRRFIP1 mediates the production of type I interferon via abeta-catenin-dependent pathway. NatImmunol. 2010; 11(6):487-494
19.Han C, Jin J, Xu S, Liu H, LiN, Cao X. Integrin CD11b negatively regulates TLR-triggered inflammatoryresponse by activating Syk and promoting MyD88 and TRIF degradation via cbl-b. Nat Immunol, 2010, 11(8):734-742
20.Wang C, Chen T, Zhang J,Yang M, Li N, Xu X, Cao X. The E3ubiquitin ligase Nrdp1 preferentially promotes TLR-mediated type I interferonproduction. Nat Immunol, 2009, 10(7): 744-752
21. An H,Hou J, Zhou J, Zhao Y, Xu H, Zheng Y, Yu Y, Liu S and Cao X. Phosphatase SHP-1 promotes TLR- and RIG-I-activatedproduction of type I interferon by inhibiting kinase IRAK-1. Nat Immunol, 2008, 9(5):542-550.


在研课题：
1. 973课题：免疫识别、免疫应答与免疫调控的新型信号分子机制与表观调控研究，项目编号2013CB530503；起止时间：2013年～2017年
2. 国家自然基金重大项目：乙型肝炎病毒逃逸天然免疫的细胞与分子机制研究，项目编号2013CB530503；起止时间：2013年～2017年
3. 重大协同创新项目：炎症机制与感染性疾病的防治，项目编号2016-I2M-1-003；起止时间：2016年-2018年
4. 国家自然基金委基础科学研究中心项目：天然免疫与炎性疾病；起止时间：2017年-2022年