黄波
导师简介
黄波，中国医学科学院基础医学研究所&北京协和医学院协和，博士生导师。现任中国医学科学院基础医学研究所副所（院）长，北京协和医学院免疫学系副主任，中国免疫学会副秘书长，中国免疫学会常务理事以及中国生物化学与分子生物学会理事，中国免疫学会肿瘤免疫专业委员会主任委员，中国抗癌协会肿瘤生物治疗专业委员会秘书长。1999年和2002年先后在华中科技大学同济医学院获得生物化学与分子生物学硕士和博士学位。先后获得首届“中国免疫学青年奖”、“教育部新世纪优秀人才支持计划”资助、“湖北省有突出贡献的中青年专家”称号、“国家基金”资助、“国家百千万人才和有突出贡献中青年专家”称号，并入选国家。担任European Journal of Immunology、Cancer Letters、Cellular and Molecular Immunology、Immunology Letters等杂志的编委。

实验室简介
实验室自2008年成立以来，围绕肿瘤免疫，肿瘤生物治疗，生物机械力，肿瘤休眠，肿瘤代谢等前沿医学科学问题。黄波教授回国后作为通信作者先后在Nature Materials、Cancer cell, Nature Cell Biology, Journal of Clinical Investigation、Nature Communications、Blood、EMBO Reports、Cancer Research、Cancer Immunology Research、Oncoimmunology、Journal of Immunology等国际主流杂志发表SCI文章60多篇，SCI引用3500余次。实验室目前有副教授/副研究员3名，在站博士后4名，博士研究生16名，硕士研究生7名。

实验室网站链接：http://huangbolab.cn/
代表性论文


2018 Publications
1. Liu Y, Zhang T, Zhou Y, Li J, Liang X, Zhou N, Lv J, Xie J, Cheng F, Fang Y, Gao Y, Wang N & Huang B*,Visualization of perforin/gasdermin/complement in real cell membranes using atomic force microscopy.Cell Mol Immunol. 2018; (Accepted). (IF=7.55)
2. Liu Y, Lv J, Huang B*,Mediating the death of dormant tumor cells. Molecular & Cellular Oncology.2018;5:e**.
3. Zhang H, Yu Y, Zhou L, Ma J, Tang K, Xu P, Ji T, Liang X, Lv J, Dong W, Zhang T, Chen D, Xie Jing, Liu Y, Huang B*. Circulating tumor microparticles promote lung metastasis by reprogramming inflammatory and mechanical niches via a macrophage-dependent pathway. Cancer Immunol Res. 2018;6:1046-56. (IF: 9.188)
4. Ma J, Wei K, Zhang H, Tang K, Li F, Zhang T, Liu J, Xu P, Yu Y, Sun W, Zhu L, Chen J, Zhou L, Liang X, Lv J, Fiskesund R, Liu Y, Huang B*. Mechanisms underlying presentation of tumor microparticle antigens to CD8+ T cells by dendritic cells. Cancer Immunol Res. 2018;6:1057-68. (IF: 9.188)
5. Liu Y, Lv J, Liang X, Yin X, Zhang L, Chen D, Jin X, Fiskesund R, Tang K, Ma J, Zhang H, Dong W, Mo S, Zhang T, Cheng F, Zhou Y, Xie J, Wang N, Huang B*. 3D Fibrin Stiffness mediates Dormancy of Tumor-repopulating cells via a Cdc42-driven Tet2 Epigenetic Program. Cancer Res. 2018;78:3926-37. (IF: 9.122)
6. Liu Y, Liang X, Dong W, Fang Y, Lv J, Zhang T, Fiskesund R, Xie J, Liu J, Yin X, Jin X, Chen D, Tang K, Ma J, Zhang H, Yu J, Yan J, Liang H, Mo S, Cheng F, Zhou Y, Zhang H, Wang J, Li J, Chen Y, Cui B, Hu ZW, Cao X, Qin FX,Huang B*. Tumor repopulating cells induce PD-1 expression in CD8+ T cells by transferring kynurenine and AhR activation. Cancer Cell. 2018;33:480-494.(IF: 27.407)
7. Liu Y, Lv J, Liu J, Liang X, Jin X, Xie J, Zhang L, Chen D, Fiskesund R, Tang K, Ma J, Zhang H, Dong W, Mo S, Zhang T, Cheng F, Zhou Y, Jia Q, Zhu B, Kong Y, Guo J, Zhang H, Hu ZW, Cao X, Qin FX,Huang B*. STAT3/p53 pathway activation disrupts IFN-β-induced dormancy in tumor-repopulating cells. J Clin Invest. 2018;128:1057-73. (IF: 12.784)
8. Chen D, Xie J, Fiskesund R, Dong W, Liang X, Lv J, Jin X, Liu J, Mo S, Zhang T, Cheng F, Zhou Y, Zhang H, Tang K, Ma J, Liu Y, Huang B*. Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages towards M1 phenotype.Nat Commun. 2018;9:873. (IF: 12.124)
9. Ma R, Ji T, Zhang H, Dong W, Chen X, Xu P, Chen D, Liang X, Yin X, Liu Y, Ma J, Tang K, Zhang Y, Peng Y, Lu J, Zhang Y, Qin X, Cao X, Wan Y,Huang B*. A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells. Nat Cell Biol. 2018;20:21-27. (IF: 20.060)
2017 Publications

1.Luo S, Li Y, Ma R, Liu J, Xu P, Zhang H, Tang K, Ma J, Liu N, ZhangY, Sun Y, Ji T, Liang X, Yin X, Liu Y, Tong W, Niu Y, Wang N, Wang X,Huang Bo*. Downregulation of PCK2remodels tricarboxylic acid cycle in tumor-repopulating cells of melanoma. Oncogene.2017 Jun 22;36(25):3609-3617. (IF:7.932)
2. SunY, Zheng Z,Zhang H, Yu Y, Ma J, Tang K, Xu P, Ji T, LiangX, Chen D, Jin X, Zhang T, Long Z, Liu Y,Huang Bo*.Chemotherapeutic tumor microparticles combining low doseirradiation reprogram tumor-promoting macrophages through a tumor-repopulatingcell-curtailing pathway.Oncoimmunology. 2017 Mar 31;6(6):e**. (IF:7.644)
3. Liu Y, Liang X, Yin X, Lv J, Tang K, Ma J, Ji T, Zhang H, Dong W, Jin J,Chen D, Li Y, Zhang S, Xie H, Zhao B, Zhao T, Lu J, Hu Z, Cao X, Qin X,HuangBo*. Blockade of IDO-kynurenine-AhR metabolic circuitry abrogatesIFN-γ-induced immunologic dormancy of tumor-repopulating cells.NatCommun. 2017 May10;8:15207. (IF:12.123)
4. Dong W, Zhang H, Yin X, Liu Y, Chen D, Liang X, Jin X, Lv J, Ma J, TangK, Hu Z, Qin X,Huang Bo*. Oral delivery of tumor microparticlevaccines activates NOD2 signaling pathway in ileac epithelium rendering potentantitumor T cell immunity.OncoImmunology. 2017 Jan19;6(3):e**. (IF:7.644)
5. Jin X, Ma J, Liang X, Tang K, Liu Y, Yin X, Zhang Y, Zhang H, Xu P, ChenD, Zhang T, Lu J, Hu Z, Qin X, Zeng X, Li L,Huang Bo*.Pre-instillation of tumor microparticles enhances intravesical chemotherapy ofnonmuscle-invasive bladder cancer through a lysosomal pathway. Biomaterials. 2017 Jan;113:93-104. (IF=8.402)
2016 Publications
1.Ma J, Zhang Y, Tang K, Zhang H, Yin X, Li Y, Xu P, Sun Y, Ma R, JiT, Chen J, Zhang S, Zhang T, Luo S, Jin Y, Luo X, Li C, Gong H, Long Z, Lu J,Hu Z, Cao X, Wang N, Yang X,Huang Bo*. Reversing drug resistance of soft tumor-repopulating cells bytumor cell-derived chemotherapeutic microparticles.Cell Res. 2016 Jun;26(6):713-27.(IF=15.606)
2. Ran L, Tan X, Li Y, Zhang H, Ma R, Ji T, Dong W, Tong T, Liu Y, Chen D,Yin X, Liang X, Tang K, Ma J, Zhang Y, Cao X, Hu Z, Qin X,Huang Bo* . Delivery of oncolytic adenovirusinto the nucleus of tumorigenic cells by tumor microparticles for virotherapy.Biomaterials. 2016 May;89:56-66. (IF=8.402)
3. Ma R, Ji T, Chen D, Dong W, Zhang H, Yin X, Ma J, Liang X, Zhang Y, ShenG, Qin X,Huang Bo*.Tumor cell-derived microparticles polarize M2 tumor-associated macrophages fortumor progression.Oncoimmunology. 2016 Feb18;5(4):e**. (IF=7.644)
4.Liu Y, Gu Y, Han Y, Zhang Q, Jiang Z, Zhang X,Huang Bo,Xu X, Zheng J, Cao X. Tumor Exosomal RNAs Promote Lung Pre-metastatic NicheFormation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils.CancerCell. 2016 Aug 8;30(2):243-56. (IF:27.407)
2015 Publications
1. Tang K, Hu L, Ma J, Zhang H, Zhang Y, Li Y, Ma R, Luo S, Liu D,Long G, Han M, Liu S, Song A, Shen M, Hu G,HuangBo*. Brief Report: Human Mesenchymal Stem-Like Cells Facilitate FloatingTumorigenic Cell Growth via Glutamine-Ammonium Cycle.Stem Cells. 2015Sep;33(9):2877-84. (IF: 5.599)
2. Wang Z, Cheng Q, Tang K, Sun Y, Zhang K, Zhang Y, Luo S, ZhangH, Ye D,Huang Bo*.Lipid mediator lipoxin A4 inhibits tumor growth by targeting IL-10-producingregulatory B (Breg) cells.CancerLett. 2015 Aug 10;364(2):118-24. (IF: 6.375)
3. Zhang H &HuangBo*. Tumor cell-derived microparticles: a new form of cancer vaccine.Oncoimmunology. 2015May 27;4(8):e**.（IF=7.644）
4. Cao Y, Liu C, Gu Z, Zhang Y, Duan Y, Zhang Y, Zhang H, Tang K,Huang Bo*.Microparticles mediate human papillomavirus type 6 or 11 infection of humanmacrophages.Cell Mol Immunol. 2015 Apr 20. (IF: 5.897)
5. Li Y, Luo S, Ma R, Liu J, Xu P, Zhang H, Tang K, Ma J, Zhang Y,Liang X, Sun Y, Ji T, Wang N,HuangBo*. Upregulation of cytosolic phosphoenolpyruvate carboxykinase is acritical metabolic event in melanoma cells that repopulate tumors.Cancer Res. 2015 Apr1;75(7):1191-6. (IF: 9.122)
6. Zhang H, Tang K, Zhang Y, Ma R, Ma J, Li Y, Luo S, Liang X, JiT, Gu Z, Lu J, He W, Cao X, Wan Y,HuangBo*. Cell-free tumor microparticle vaccines stimulate dendritic cellsvia cGAS/STING signaling.CancerImmunol Res. 2015 Feb;3(2):196-205. (IF: 8.284)
7.Huang Bo*.Tumor microenvironment: a mechanical force link. Sci China Life Sci. 2015Feb;58(2):202-4. (IF: 2.781)
8. Hua F, Li K, Yu JJ, Lv XX, Yan J, Zhang XW, Sun W, Lin H, ShangS, Wang F, Cui B, Mu R,HuangBo, Jiang JD, Hu ZW. TRB3 links insulin/IGF to tumour promotion by interactingwith p62 and impeding autophagic/proteasomal degradations.Nat Commun.2015Aug 13;6:7951. (IF:12.123)
2014Publication
1. Zhao J, Zeng W, Cao Y, Liang X,Huang Bo*.Immunotherapy of HPV infection-caused genital warts using low dose cyclophosphamide. Expert Rev Clin Immunol. 2014 Jun;10(6):791-9. (IF: 3.27)
2. Tan Y, Tajik A, Chen J, Jia Q, Chowdhury F, Wang L, Chen J,Zhang S, Hong Y, Yi H, Wu D, Zhang Y, Wei F, Poh Y, Seong J, Singh R, Lin LJ,Do?anay S, Li Y, Jia H, Ha T, Wang Y,HuangBo, Wang N. Matrix softness regulates plasticity oftumour-repopulating cells via H3K9 demethylation and Sox2 expression.Nat Commun. 2014 Aug6;5:4619. (IF:12.123)
2013Publications
1. Ma R, Zhang W, Tang K, Zhang H, Zhang Y, Li D, Li Y, Xu P, Luo S,Cai W, Ji T, Katirai F, Ye D,HuangBo*. Switch of glycolysis to gluconeogenesis by dexamethasone fortreatment of hepatocarcinoma.NatCommun. 2013;4:2508. (IF: 12.123)
2. Li D, Cai W, Gu R, Zhang Y, Zhang H, Tang K, Xu P, Katirai F,Shi W, Wang L, Huang T,HuangBo*. Th17 cell plays a role in the pathogenesis of Hashimoto'sthyroiditis in patients.ClinImmunol. 2013 Dec;149(3):411-20. (IF:4.034)
3. Ma J, Cai W, Zhang Y, Huang C, Zhang H, Liu J, Tang K, Xu P,Katirai F, Zhang J, He W, Ye D, Shen GX,HuangBo*. Innate immune cell-derived microparticles facilitatehepatocarcinoma metastasis by transferring integrin αMβ2 to tumor cells.J Immunol. 2013 Sep15;191(6):3453-61. (IF: 4.856)
4. Xu Z, Zhao J, Zhang H, Ke T, Xu P, Cai W, Katirai F, Ye D,Huang Y,Huang Bo*.Spontaneous miscarriages are explained by the stress/glucocorticoid/lipoxin A4axis.J Immunol. 2013Jun 15;190(12):6051-8. (IF: 4.856)
2012Publications
1. Liu J, Tan Y, Zhang H, Zhang Y, Xu P, Chen J, Poh YC, Tang K,Wang N,Huang Bo*.Soft fibrin gels promote selection and growth of tumorigenic cells.Nat Mater. 2012 Jul1;11(8):734-41. (IF: 39.737)
2. Tang K, Zhang Y, Zhang H, Xu P, Liu J, Ma J, Lv M, Li D,Katirai F, Shen GX, Zhang G, Feng ZH, Ye D,HuangBo*. Delivery of chemotherapeutic drugs in tumour cell-derivedmicroparticles.Nat Commun.2012;3:1282. (IF: 12.123)
3. Zhang Y, Zhang R, Zhang H, Liu J, Yang Z, Xu P, Cai W, Lu G,Cui M, Schwendener RA, Shi HZ, Xiong H,HuangBo*.Microparticles released by Listeria monocytogenes-infected macrophagesare required for dendritic cell-elicited protective immunity.Cell Mol Immunol.2012;9:489-496. (IF: 5.897)
4. Li D, Jia H, Zhang H, Lv M, Liu J, Zhang Y, Huang T,Huang Bo*.TLR4signaling induces the release of microparticles by tumor cells that regulateinflammatory cytokine IL-6 of macrophages via microRNA let-7b.Oncoimmunology.2012;1:687-693. (IF: 7.644)
5. Lv M, Zhang X, Jia H, Li D, Zhang B, Zhang H, Hong M, Jiang T,Jiang Q, Lu J, Huang X,HuangBo*. An oncogenic role of miR-142-3p in human T cell acutelymphoblastic leukemia (T-ALL) by targeting glucocorticoid receptor alpha andcAMP/PKA pathways.Leukemia.2012;26:769-777. (IF: 12.104)
2011Publications
1. Liu J, Zhao J, Hu L, Cao Y,HuangBo*. Low Dosages: new chemotherapeutic weapons on the battlefield ofimmune-related diseases.Cell Mol Immunol. 2011;8:289-295. (IF:5.897)
2. Liu J, Zhang Y, Zhao J, Yang Z, Li D, Katirai F,Huang Bo*. Mast cell:insight into remodeling a tumor microenvironment.Cancer Metastasis Rev.2011;30:177-184. (IF: 4.697)
3. Ouyang X, Yang Z, Zhang R, Arnaboldi P, Lu G, Li Q, Wang W,Zhang B, Cui M, Zhang H, Liang-Chen J, Qin L, Zheng F,Huang Bo*, Xiong H*.Potentiation of Th17 cytokines in aging process contributes to the developmentof colitis.Cell Immunol.2011;266:208-217. (IF: 3.172)
2010Publications
1. Zhang B, Jia H, Liu J, Yang Z, Jiang T, Tang K, Li D, Huang C,Ma J, Shen GX, Ye D,HuangBo*. Depletion of T regulatory cells facilitates growth of establishedtumors: a mechanism involving the regulation of myeloid-derived suppressorcells by lipoxin A4.JImmunol.2010;185:7199-7206. (IF: 4.856)
2. Tang K, Liu J, Yang Z, Zhang B, Zhang H, Huang C, Ma J, ShenGX, Ye D,Huang Bo*.Microparticles mediate enzyme transfer from platelets to mast cells: A newpathway for lipoxin A4 biosynthesis.BiochemBiophys Res Commun. 2010;400:432-436. (IF: 2.446)
3. Zhao J, Cao Y, Lei Z, Yang Z, Zhang B,Huang Bo*. SelectiveDepletion of CD4+CD25+Foxp3+ Regulatory T Cells by Low-Dose Cyclophosphamide IsExplained by Reduced Intracellular ATP Levels.Cancer Res.2010;70:4850-4858. (IF: 9.122)
4. Cao Y, Zhao J, Yang Z, Cai Z, Zhang B, Zhou Y, Shen GX, Chen X,Li S,Huang Bo*.CD4+FOXP3+ regulatory T cell depletion by low-dose cyclophosphamide preventsrecurrence in patients with large condylomataacuminata after laser therapy.Clin Immunol.2010;136:21-29. (IF: 4.034)
5. Zhou Y, Wang S, Ma JW, Lei Z, Zhu HF, Lei P, Yang ZS, Zhang B,Yao XX, Shi C, Sun LF, Wu XW, Ning Q, Shen GX,Huang Bo*.HBx-induced expression of the CXC chemokine IP-10 is mediated throughactivation of NF-kappaB and increases migration of leukocytes.J Biol Chem.2010;285:12159-12168. (IF: 4.125)
6. Yang Z, Zhang B, Li D, Lv M, Huang C, Shen GX,Huang Bo*. Mast cellsmobilize myeloid-derived suppressor cells and Treg cells in tumormicroenvironment via IL-17 pathway in murine hepatocarcinoma model.PLoS One.2010;5:e8922. (IF: 2.806)
7. Li B, Lei Z, Lichty BD, Li D, Zhang GM, Feng ZH, Wan Y,Huang Bo*. Autophagyfacilitates major histocompatibility complex class I expression induced byIFN-gamma in B16 melanoma cells.CancerImmunol Immun. 2010;59:313-321. (IF: 4.711)
8. Yang Z, Lei Z, Li B, Zhou Y, Zhang GM, Feng ZH, Zhang B, ShenGX,Huang Bo*.Rapamycin inhibits lung metastasis of B16 melanoma cells throughdown-regulating alphav integrin expression and up-regulating apoptosissignaling.Cancer Sci.2010; 101:494-500. (IF: 3.974)
2009Publications
1. Lei Z, Li B, Yang Z, Fang H, Zhang GM, Feng ZH,Huang Bo*. Regulationof HIF-1alpha and VEGF by miR-20b tunes tumor cells to adapt to the alterationof oxygen concentration.PLoSOne. 2009; 4:e7629. (IF:2.806)
2. Zhao J, Lei Z, Liu Y, Li B, Zhang L, Fang H, Song C, Wang X,Zhang GM, Feng ZH,HuangBo*. Human Pregnancy Upregulates Tim-3 in Innate Immune Cells forSystemic Immunity.JImmunol. 2009; 182:6618-6624. (IF: 4.856)
3.Huang Bo*,Zhao J, Lei Z, Shen S, Li D, Shen GX, Zhang GM, Feng ZH*. miR-142-3p RegulatescAMP Production in T cells by Targeting Adenylyl Cyclase 9 mRNA.EMBO Rep. 2009;10:180-185. (IF: 8.568)
4. Lei Z, Zhang GM, Hong M, Feng ZH,Huang Bo*. Fusion ofdendritic cells and CD34+CD38- acute myeloid leukemia (AML) cells potentiatestargeting AML-initiating cells by specific CTL induction.J Immunother. 2009;32:408-414. (IF:3.712)
2008Publications
1. Song C, Luo L, Lei Z, Li B, Liang Z, Liu G, Li D, Zhang G,Huang Bo*, Feng ZH*.IL-17-producing alveolar macrophages mediate allergic lung inflammation relatedto asthma.J Immunol.2008; 181:6117-6124. (IF: 4.856)
2.Huang Bo*,Lei Z, Zhang GM, Li D, Song C, Li B, Liu Y, Yuan Y, Unkeless J, Xiong H, FengZH*.SCF-mediated mast cell infiltration and activation exacerbate theinflammation and immunosuppression in tumor microenvironment.Blood. 2008;112:1269-1279. (IF: 11.840)
3. Gong W, Zhang GM, Liu Y, Lei Z, Li D, Yuan Y,Huang Bo*, Feng ZH*.IFN-γ withdrawal after immunotherapy potentiates B16 melanoma invasion andmetastasis by intensifying tumor integrin αvβ3 signaling.Int J Cancer. 2008;123:702-708. (IF: 6.513)
4. Cao Y, Zhao J, Lei Z, Shen S, Liu C, Li D, Liu J, Shen GX,Zhang GM, Feng ZH,HuangBo*. Local Accumulation of FOXP3+ Regulatory T Cells: Evidence for anImmune Evasion Mechanism in Patients with Large Condylomata Acuminata.J Immunol.2008; 180:7681-6. (IF: 4.856)
5. Lei Z, Liu G, Huang Q, Lv M, Zu R, Zhang GM, Feng ZH,Huang Bo*. SCF andIL-31 rather than IL-17 and BAFF are potential indicators in patients withallergic asthma.Allergy.2008; 63:327-32. (IF: 7.361)
6.Huang Bo*,Zhao J, Unkeless JC, Feng ZH, Xiong H*. TLR signaling by tumor and immunecells: a double-edged sword.Oncogene.2008; 27:218-24. (IF:7.932)
2007Publications
1. Xiao H,HuangBo(co-first author), Yuan Y, Li D, Han LF, Liu Y, Gong W, Wu FH, ZhangGM, Feng ZH. Soluble PD-1 facilitates 4-1BBL-triggered antitumor immunityagainst murine H22 hepatocarcinoma in vivo.ClinCancer Res. 2007; 13:1823-1830. (IF: 9.619)
2. Liu Y,HuangBo(co-first author),Yuan Y, Gong W, Xiao H, Li D, Yu ZR, Wu FH, Zhang GM, Feng ZH.Inhibition ofhepatocarcinoma and tumor metastasis to liver by gene therapy with recombinantCBD-HepII polypeptide of fibronectin.IntJ Cancer. 2007; 121:184-192. (IF: 6.513)
3.Huang Bo,Zhao J, Shen S, Li H, He KL, Shen GX, Mayer L, Unkeless J, Li D, Yuan Y, ZhangGM, Xiong H, Feng ZH. Listeria monocytogenes promotes tumor growth via tumorcell Toll-like receptor 2 signaling.CancerRes. 2007; 67:4346-4352. (IF:9.122)
4.Huang Bo,Lei Z, Zhao J, Gong W, Liu J, Chen Z, Liu Y, Li D, Yuan Y, Zhang GM, Feng ZH.CCL2/CCR2 pathway mediates recruitment of myeloid suppressor cells to cancers.Cancer Lett.2007; 252:86-92. (IF: 6.375)
2006Publication
1.Huang Bo,Pan PY, Li Q, Sato AI, Levy DE, Bromberg J, Divino CM, Chen SH. Gr-1⁺CD115⁺immature myeloid suppressor cellsmediate the development of tumor specific T regulatory cell and T cell anergy.Cancer Res. 2006;66:1123-1131. (IF: 9.122)
2005Publication
1.Huang Bo,Zhao J, Li H, He KL, Chen Y, Chen SH, Mayer L, Unkeless JC, Xiong H. Toll like receptor(TLR)on tumor cells facilitate evasion of immune surveillance.Cancer Res. 2005;65:5009-5014. (IF: 9.122)