蒋澄宇


导师简介：
蒋澄宇，中国医学科学院基础医学研究所研究员，北京协和医学院教授。毕业于中国科学技术大学生物系，获理学学士学位；美国布朗大学医学院病理与实验室药学系，获博士学位。随后于哈佛医学院麻省总医院从事博士后工作。蒋澄宇回国后致力于植物药新组分小RNA的药理学及呼吸系统肺损伤相关疾病研究。发现了草药新的有效成分小RNA以脂质汤剂体形式进入机体的递送方式，阐述了植物来源小RNA的药效机理。解析了不同病原体引起的病死率高达20%-50%的严重呼吸窘迫综合症（ARDS）的分子机制，提出了临床诊断或干预方法。研究论文发表在Nature，Nature Medicine，Molecular Psychiatry，Cell Research和Nature Communications等杂志，连续5年入选爱思唯尔中国高被引榜单。蒋澄宇现任中国生物化学与分子生物学学会副理事长，北京市生物化学与分子生物学学会理事长。先后获得国家基金，中国青年女科学家等荣誉称号，是973研究计划呼吸系统疾病领域项目的首席科学家。


实验室简介：
实验室自从2003年建立以来，长期致力于呼吸系统肺损伤相关疾病的致病机理的研究和药物研发。阐述了SARS冠状病毒，禽流感H5N1，甲流，和艾博拉等病毒和微纳米细颗粒物引发致病的分子机理。研究成果发表在《自然》、《自然·医学》、《自然·通讯》、和《科学·信号》等杂志上。曾获得中, 美, 欧盟等国专利，并曾独家转让给世界排名前五名的制药公司和欧盟的生物技术公司。目前课题组有教授1名，副研究员1名，助理研究员1名，高级技师1名，博士后2名，技术员2名，研究生10余名。

代表性论文：
1. Du, J., Liang, Z., Xu, J.,Zhao, Y., Li, X., Zhang, Y., ... & Jiang,C. (2017). Plant-derived phosphocholine facilitates cellular uptake ofanti-pulmonary fibrotic HJT-sRNA-m7. Science China Life Sciences, 1-12.
2. Zhang, Y.L., Tang, J., Yang,N., Liu, Q., Zhang, Q.C., Zhang, Y.X., Li, N., Zhao, Y., Li, S.W., Liu, S.,Zhou, H.D., Li, X., Tian, M.Y., Deng, J.J., Xie, P., Sun, Y., Lu, H.J., Zhang,M.Q., Jin, N.Y., Jiang, C., FAT10 IsCritical in Influenza A Virus Replication by Inhibiting Type I IFN, Journalof Immunology, 2016
3. Ju X., Yan Y., Liu Q., Li N.,Sheng M., Zhang L., Li X., Liang Z., Huang F., Liu K., Zhao Y., Zhang Y., ZouZ., Du J., Zhong Y., Zhou H., Yang P., Lu H., Tian M., Li D., Zhang J., Jin N., Jiang C. Neuraminidase of influenzaA virus binds lysosome-associated membrane proteins directly and induceslysosome rupture, Journal of Virology, 2015
4.Zou, Z,Yan, Y, Shu, Y, Gao, R, Sun, Y, Li, X, Ju, X, Liang, Z, Liu, Q, Zhao, Y, Guo,F, Bai, T, Han, Z, Zhu, J, Zhou, H, Huang, F, Li, C, Lu, H, Li, N, Li, D, Jin,N, Penninger*, JM, Jiang*, C (2014)Angiotensin-Converting Enzyme 2 protects from lethal Avian Influenca A H5N1Infections Nat Commun 10.1038/ncomms4594.
5.Huang,F, Guo, J, Zou, Z, Liu, J, Cao, B, Zhang, S, Li, H, Wang, W, Sheng, M, Liu, S,Pan, J, Bao, C, Zeng, M, Xiao, H, Qian, G, Hu, X, Chen, Y, Chen, Y, Zhao, Y,Liu, Q, Zhou, H, Zhu, J, Gao, H, Yang, S, Liu X, Zheng, S, Yang, J, Diao, H,Cao, H, Wu, Y, Zhao, M, Tan, S, Guo, D, Zhao, X, Ye,Y, Wu, W, Xu, Y, Penninger,JM, Li, D, Gao*, G, Jiang*, C, Li*,L (2014) Angiotensin II plasma levels are linked to disease severity andpredict fatal outcomes in H7N9-infected patients. Nat Commun 10.1038/ncomms4595
6.Xu*, C,Ju, X, Song, D, Huang, F, Tang D, Zou, Z, Zhang, C, Joshi, T, Jia, L, Xu, W,Xu, K, Wang, Q, Xiong, Y, Guo, Z, Chen, X, Huang, F, Xu, J, Zhong, Y, Zhu, Y,Peg, Y, Wang, L, Zhang, X, Jiang, R, Li, D, Jiang, T, Xu, D, Jiang*, C (2014) An associationanalysis between psychophysical characteristics and genome-wide gene expressionchanges in human adaption to the extreme climate at the Antarctic Dome Argus MolPsychiatry 10.1038/mp.2014.72.
7.Sheng,M, Zhong, Y, Chen, Y, Du, J, Ju, X, Zhao, C, Zhang, G, Zhang, L, Liu, K, Yang,N, Xie, P, Li, D, Zhang*, M.Q, Jiang*, C (2014) Hsa-miR-1246,hsa-miR-320a and hsa-miR-196b-5p inhibitors can reduce the cytotoxicity ofEbola virus glycoprotein in vitro Sci China Life Sci. 57(10):959-72
8.Wang, W,Yang, P, Zhong, Y, Zhao, Z, Xing, L, Zhao, Y, Zou, Z, Zhang, Y, Li, C, Li, T,Wang, C, Wang, Z, Yu, X, Cao, B, Gao, X, Penninger, J, Wang*, X, Jiang*, C (2013) Monoclonal AntibodyAgainst CXCL-10/ IP-10 Ameliorated Influenza A (H1N1) Induced Acute LungInjury. Cell Res. 23:577-580
9.Yan, Y,Zou, Z, Sun, Y, Li, X, Xu, K, Wei, Y, Jin*, N, Jiang*, C (2013) Anti-Malaria Drug Chloroquine is Highly Effectivein Treating Avian Influenza A H5N1 Virus Infection in an Animal Model CellRes. 23:300-302
10.Zhang,Y, Deng, J, Zhang, Y, Guo, F, Li, C, Zou, Z, Xi, W, Tang, J, Sun, Y, Yang, P,Han, Z, Jiang*, C (2013)Functionalized Single-Walled Carbon Nanotubes Cause Reversible Acute LungInjury and Induce Fibrosis in Mice J. Mol. Med. 91:117-128
11.Sun,Y, Li, C, Shu, Y, Wang, H, Ju, X, Zou, Z，Wang, H, Rao, S, Guo, F, Liu,H, Nan, W, Zhao, Y, Yan, Y, Tang, J, Zhao, C, Yang, P, Liu, K, Wang, S, Lu, H,Li, X, Tan, L, Gao, R, Song, J, Gao, X, Tan, X, Qin, Y, Xu, K, Li D, Jin*, N, Jiang*, C (2012) Inhibition ofAutophagy Ameliorates Acute Lung Injury Caused by Avian Influenza A H5N1Infection. Science Signaling (CoverStory) 5 (212) ra16
12.Yang,N, Ma, P, Lang, J, Zhang, Y, Deng, J, Ju, X, Zhang, G, Jiang*, C (2012) Phosphatidylinositol4-Kinase III_ Is Required forSevere Acute Respiratory Syndrome Coronavirus Spike-mediated Cell Entry. J. Biol. Chem. 287(11) 8457-8467
13.Li,C, Yang, P, Sun, Y, Li, T, Wang, C, Wang, Z, Zou, Z, Yan, Y, Wang, W, Wang, C,Chen, Z, Xing, L, Tang, C, Ju, X, Guo, F, Deng, J, Zhao, Y, Yang, P, Tang, J,Wang, H, Zhao, Z, Yin, Z, Cao, B, Wang*, X, Jiang*, C (2012) IL-17 response mediates acute lung injury induced by the 2009 PandemicInfluenza A (H1N1) Virus. Cell Res. 22:528-538