杨隽


女，理学博士。
2014年所院“引进人才”，现任细胞生物学系研究员。


研究方向：
利用多能干细胞研究BMP相关信号转导通路在心肺血管病中的作用机制及探索新型治疗策略，包括：
1． 研究肺动脉血管中关键转录因子的特异相互作用蛋白及组织特异性的效应基因。
2． 对多功能干细胞进行分化，得到相关的心血管细胞；并进行体外和体内功能研究。
3． 研究致病突变对心肺血管发育的影响并模拟疾病建立干细胞靶向药物筛选平台。
4． 研究肺高压中相关炎症因素在疾病发生和发展中的作用机制。

联系方式：
中国医学科学院/北京协和医学院，
基础医学研究所细胞生物学系654室
北京东单三条5号，100005
电子邮件：jy270@ibms.pumc.edu.cn

目前承担的主要课题：
1、国家重点基础研究发展计划-多能干细胞向内皮前体分化的协同调控机制研究（2016YFA**）。
2、中国医学科学院创新工程-心肺血管病EPC的作用机制及相关分子影像诊断的研究（2016-I2M-4-003）。
3、国家自然科学基金面上项目-TNFα等炎性因素在肺动脉高压内皮损伤中的调控机制（**）。
4、协和青年基金-人体细胞重编程及中胚层分化中的调控新机制（）。
5、British HeartFoundation Programme grant - Targeting the BMP signalling pathway for thetreatment of pulmonary arterial hypertension.

代表性研究论文：
1. Yanjiang Xing*, Shuang Zhao*, Qingxia Wei*, Shiqiang Gong, Xin Zhao, Fang Zhou, Rafia AI-Lamki, Daniel Ortmann, Mingxia Du, Roger Pedersen, Guangdong Shang, Shuyi Si, Nicholas W Morrell, Jun Yang*. A novel piperidine identified by stem cell based screening attenuates pulmonary arterial hypertension via regulating BMP2 and PTGS2 levels. Eur Respir J 2018; in press (https://doi.org/10.1183/**.02229-2017).
相关的我国自主知识产权专利已进入世界不同国家。

2. QingxiaWei*, Shuang Zhao*, Fang Zhou*, Yanjiang Xing*, Shiqiang Gong, Jiakuan Zhao,Rafia Ai-Lamki, Daniel Ortmann, Xin Zhao, Mingxia Du, Mariaestela Ortiz, RogerPedersen, Shuyi Si, Morrell W Nicholas, JunYang*. Identification of Id genes as major functional targets of BMPsignalling in endothelial cells: Potential for screening and therapy. Presented at 11th Pulmonary VascularResearch Institute World Congress 2017.


3. Xiao Di ,Dong Hua Ji, Yu Chen,ChangWei Liu,Bao Liu, Jun Yang .Endovasculartreatment of ectopic bronchial artery aneurysm with brachiocephalic arterystent placement and coil embolization: A case report and literature review. Medicine(Baltimore), 2016, 95(35): e4461.
4. Rafia S. Al-Lamki, Jun Wang, Jun Yang, Simon Pacey, Timothy Eisen,and John R. Bradley Tumor necrosisfactor receptor 2-signaling inCD133-expressing cells in renal clear cell carcinoma，Oncotarget，2016，7(17)：24111.
5. Shiqiang Gong ，XiaowanHan，XuehongLi，XiaoboHe，Jun Yang, Shuyi Si，Development of a high-throughput screeningstrategy for up-regulators of the OPG/RANKL ratio with the potential foranti-osteoporosis effects，JBiomolScreen，2016;21(7):738-48.
6. Jun Yang, Li X, Morrell NW.Id proteins in the vasculature: frommolecular biology to cardiopulmonary medicine. Cardiovasc Res. Dec 1;104(3):388-398, 2014（通讯并第一作者）.
7. Jun Yang, Xiaohui Li,Changxin Wu, Astrid Weiss, Ralph Schermuly, and Nicholas Morrell. SildenafilPotentiates Bone Morphogenetic Protein Signaling in Pulmonary Arterial SmoothMuscle Cells and in Experimental Pulmonary Hypertension. Arteriosclerosis,Thrombosis, and Vascular Biology. 33(1), 34-41, 2013 （通讯并第一作者）.
8.Jun Yang, Xiaohui Li,Mark Southwood, Ye Linying, Nicholas W. Morrell. Id proteins are criticaldownstream effectors of BMP signaling in human pulmonary arterial smooth musclecells. Am J Physiol Lung Cell Mol Physiol. 305(4)，ppL312-L321, 2013（通讯并第一作者）.
9. Rafia S. Al-Lamki, Wanhua Lu, Jun Wang, Jun Yang,John R. Brdaley. TNF, Acting through inducibly expressed TNFR2, drivesactivation and cell cycle entry of c-kit+ cardiac stem cells in ischemic heartdisease. Stem Cells. 31(9) : 1881-92，2013.
10. Takeshi Ogo, H. M. Chowdhury, Jun Yang, LuLong, Xiaohui Li, Yamila N. Torres Cleuren, Nicholas W Morrell, Ralph T.Schermuly, Richard C. Trembath and Md. Talat Nasim. Inhibition of overactiveTGF-??signaling by prostacyclin analogues in pulmonary arterial hypertension(PAH). Am. J. Respir. Cell Mol. Biol. 48(6):733-41，2013.
11. Jun Yang, Xiaohui Li, Rafia Al-Lamki, Andrewlever, Nicholas W. Morrell. Induction Of Id1by Prostacyclin Analogues InhibitsProliferation Of Pulmonary Artery Smooth Muscle Cells In Vitro And In Vivo. CirculationResearch. 107(2), 252-262, 2010.
12. Hannah J. Durrington, Paul D. Upton, Simon Hoer,Jessica Boname, Benjamin Dunmore, Jun Yang, Nicholas W. Morrell.Identification of a lysosomal pathway regulating degradation of the bonemorphogenetic protein receptor type-II. Journal of Biological Chemistry.285(48): 37641-9，2010.
13. Xue Li, Jun Yang, Xiaobo He, Zhangyong Yang,Yan Ding, Huayi Shao, Zhuorong Li, Yueqin Zhang, Shuyi Si. Identification ofBMP2 Up-regulators via High-Throughput Screening of a Synthetic and NaturalCompound Library. Journal of Biomolecular Screening. 14(10)，1251-1256, 2009 (并列第一作者).
14. Mark Toshner, Robert Voswinkel, Mark Southwood, RafiaAl-Lamki, Jun Yang, Nicholas W. Morrell et al. Evidence for Dysfunctionof Endothelial Progenitors in Pulmonary Arterial Hypertension. Am J RespirCrit Care Med. 180(8) :780-7，2009.
15. Jun Yang,Rachel Davies, Lu Long, Xudong Yang, Paul Upton, Anastasia Sobolewski, RichardTrembath and Nick Morrell. Mutations in BMPRII cause dysregulation of Id geneexpression in pulmonary arterial smooth muscle cells: Implication for familialpulmonary arterial hypertension. Circulation Research. 102(10), 1212-1221,2008.
16. AnastasiaSobolewski, Nung Rudarakanchana, Jun Yang, Trina K. Jeffery, RichardTrembath, Nicholas W. Morrell. Functional rescue of mutant bone morphogeneticprotein receptor type II in pulmonary arterial hypertension. Human MolecularGenetics. 17(20):3180-90，2008.
17. JunYang, Yueqin Zhang. Study on a novel anti-osteoporosis drug screening modeltargeted on Cathepsin K. Biomedical andEnvironmental Sciences. 17(3): 273-80, 2004.
18. Jun Yang, Shuyi Si, Yueqin Zhang.The regulation of SMAD in TGF-β superfamily signaling pathway [review]. China Biotechnology. 2003, 23(12).
19.Yan Ding, Jun Yang, Shuyi Si, Li Ruan.Themechanism of Statins upregulate BMP-2 expression inosteoblast. China Biotechnology，25(4):18-21，2005.
20. Jun Yang, Bin Liu, Yueqin Zhang.Study on the screening model of anti-osteoporosis drugs targeting on cathepsinL. Chinese Journal of Antibiotics. 2002, 27(5):264-266.
21. Jun Yang, Shan Cen, Yueqin Zhang.Establishment and application of screening model for anti-bactieria drugs with lipoteichoic acidas a target. Chinese Journal of NewDrugs. 2002, 11(8)：605-608.

获奖：
2016 基础所2016年优秀科研人员
2009 Pfizer PulmonaryVascular Disease European Young Researcher Award First Prize
2007 British Associationof Lung Research-British Thoracic Society Young Investigator First Prize