刘雁勇


刘雁勇，教授，博士生导师，现任中国药理学会抗衰老与老年痴呆专业委员会委员，中国老年学及老年医学学会老年病学分会认知障碍专家委员会委员，中国研究型医院学会神经再生与修复专业委员会委员，北京药理学会理事，北京药理学会心脑血管药理专业委员会委员、北京药理学会神经精神药理专业委员会常务委员。
课题组致力于神经精神疾患和肿瘤发病机制和创新药物的研究，承担、参与包括科技重大专项、国家重大科学研究计划课题及国家重点基础研究发展计划（973计划）等课题，已获5项国家发明专利授权。申请国际专利1项，目前已获韩国授权，欧洲、美国、日本专利在审查中。
课题组具有良好的原代细胞及细胞系培养、动物模型建立及行为学评价等研究平台及技术储备，研究策略集成药理、药化、药分、药剂以及生物学等交叉学科。

研究兴趣与方向：
（1）神经精神药理学： 关注抑郁症、神经退行性疾病的发病机制及创新药物研究。采用包括蛋白组学、平面微阵列电极等技术，重点研究神经环路重建、突触发生与疾病发生的关系，并探讨新干预靶点及创新药物的设计与评价。
（2）肿瘤药理学：利用多肽偶联、纳米等技术，发展新型肿瘤分子靶向药物；关注精神、免疫等因素在肿瘤发生、发展中的作用。
课题团队： 左萍萍，研究员，博士生导师（返聘）
杨楠，副研究员，硕士生导师
黄薇，助理研究员
郑吉，实习研究员

授权专利：
1. 左萍萍，刘雁勇，杨楠，陈友生，纪超。5-(4-羟基-3-甲氧基苯亚甲基) 罗丹宁在制备治疗帕金森氏病药物中的用途申请日期：2011.3.14，授权日：2014.7.9，ZL 8.8；
2. 左萍萍，刘雁勇，杨楠，姜尧，张慧丰。一种肿瘤特异性靶向多肽及其应用，申请日期：2013.6.26，授权日：2014.10.8；授权号：ZL 6.0；
3. 左萍萍，刘雁勇，杨楠，姜尧，张慧丰。一种肿瘤特异性靶向多肽及其应用，申请日期：2013.6.26，授权日：2016.11.2；授权号：ZL 2.7；
4. 刘雁勇，杨楠，左萍萍。Hsp90抑制肽偶联物及其在肿瘤治疗中的应用。申请日期：2015.10.20，授权日：2017.09.26，授权号：ZL 4.X；
5. 刘雁勇，杨楠，左萍萍。5-(4-羟基-3-甲氧基苯亚甲基) 罗丹宁在制备治疗预防或治疗脑神经组织损伤的药物中的用途申请日期：2015.101.0，授权日：2017.8.16，ZL 20**.
6. 刘雁勇，杨楠，左萍萍。Hsp90抑制肽偶联物及其在肿瘤治疗中的应用。韩国授权号：，申请日期：2017.09.13；授权日：2018.05.10.
发表相关论文：
1. Wei Huang#, Yuan Liu#, Jun Wang, Xia Yuan, Hong-Wei Jin, Liang-Ren Zhang, Jian-Ting Zhang, Zhen-Ming Liu*, Jing-Rong Cui. Small-molecule compounds targeting the STAT3 DNA-binding domain suppress survival of cisplatin-resistant human ovarian cancer cells by inducing apoptosis. European Journal of Medicinal Chemistry 2018; 157: 887–897. (Co-author)
2. Wei Huang#, Xia Yuan, Ting Sun, Shujie Fan, Jun Wang, Quan Zhou, Wei Guo, Fuxiang Ran, Zemei Ge, Huayu Yang, Runtao Li*, Jingrong Cui*. Proteasome inhibitor YSY01A abrogates constitutive STAT3 signaling via down-regulation of Gp130 and JAK2 in human A549 lung cancer cells. Frontiers in Pharmacology 2017; 8(476): 1–10.
3. Yao Jiang#, Nan Yang#, Huifeng Zhang, Bo Sun, ChunyingHou, Chao Ji, Ji Zheng, Yanyong Liu*, Pingping Zuo*. Enhanced in vivo Antitumor Efficacy of Dual-functional Peptide-modified Docetaxel Nanoparticles through Tumor Targeting and Hsp90 Inhibition. J Controlled Release 2016；221: 26–36.
4. Mingyang Wang#,Yi Zhang#, Lu Feng,Ji Zheng, Shujie Fan, Junya Liu, Nan Yang*, Yanyong Liu*, Pingping Zuo. Compound porcine cerebroside and ganglioside injection attenuates cerebral ischemia–reperfusion injury in rats by targeting multiple cellular processes. Neuropsychiatric Disease and Treatment 2017:13 927–935.
5. Mingyang Wang, Lu Feng, Ji Zheng, Junya Liu, Shujie Fan, Jun Zhao, Nan Yang, Yanyong Liu*, Zhanjun Yang*, Caiying Ye*, Pingping Zuo. Improvement of mitochondrial function mediated the neuroprotective effect of 5-(4-hydroxy-3-dimethoxybenzylidene)-2-thioxo-4-thiazolidinone in rats with cerebral ischemia reperfusion injuries. Oncotarget. 2017 Sep 22; 8(37): 61193–61202.
6. ChunyingHou, Bo Sun, Yao Jiang, Ji Zheng, Nan Yang, Chao Ji, Zhen Liang, Jiaojiao Shi, Rui Zhang, Yanyong Liu*, Caiying Ye*, PingpingZuo*. MicroRNA-31 inhibits lung adenocarcinoma stem-like cells via down-regulation of MET-PI3K-Akt signaling pathway. Anti-Cancer Agents in Medicinal Chemistry 2016, 16, 501-518.
7. Nan Yang#, Yao Jiang#, Huifeng Zhang#, Bo Sun, ChunyingHou, Ji Zheng, Yanyong Liu*, Pingping Zuo*. Active targeting docetaxel-PLA nanoparticles eradicate the circulating lung cancer stem like cells and inhibit the liver metastasis. Mol Pharmaceut 2015, 12, 232?239.
8. Bo Sun, Nan Yang, Yao Jiang, Huifeng Zhang, Chunying Hou, Chao Ji, Yanyong Liu*, Pingping Zuo*.Antagomir-1290 suppresses CD133+ cells in non-small cell lung cancer by targeting fyn-related Src family tyrosine kinase. Tumor Biol. 2015; 36:6223–6230.
9. Zhen Liang#, Nan Yang#, Yao Jiang, Chunying Hou, Ji Zheng, Jiaojiao Shi, Rui Zhang, Dongmei Li, Yanyong Liu*, Pingping Zuo*. Targeting Docetaxel-PLA nanoparticles simultaneously inhibit tumor growth and liver metastases of small cell lung cancer. Int J Pharm. 2015; 494 (1): 337–345.
10. Nan Yang#, Yan-yong Liu#, Yinglu Ji, Zhili Ren, Jie Meng, Chao Ji, Jian Liu, Ji Zheng, Xiaochun Wu*, Pingping Zuo*, Haiyan Xu*. Motor coordination dysfunction induced by gold nanorods core /silver shell nanostructures in mice: disruption in mitochondrial transport and neurotransmitter release involved. RSC Advances 2014, 4, 59472- 59480.（Co-author）
11. Zhang H, N Yang, B. Sun, Y. Jiang, C. Hou, C. Ji, Y. Zhang, Yanyong Liu*, Pingping Zuo*. CD133 positive cells isolated from A549 cell line exhibited high liver metastatic potential. Neoplasma 2014, 61:153-160.
12. MingyangWang#,Yi Zhang#, Lu Feng,Ji Zheng, Shujie Fan, Junya Liu, Nan Yang*, Yanyong Liu*, Pingping Zuo. Compound porcine cerebroside and ganglioside injection attenuates cerebral ischemia–reperfusion injury in rats by targeting multiple cellular processes. Neuropsychiatric Disease and Treatment 2017:13 927–935.
13. Mingyang Wang, Lu Feng, Ji Zheng, Junya Liu, Shujie Fan, Jun Zhao, Nan Yang, Yanyong Liu*, Zhanjun Yang*, Caiying Ye*, Pingping Zuo. Improvement of mitochondrial function mediated the neuroprotective effect of 5-(4-hydroxy-3-dimethoxybenzylidene)-2-thioxo-4-thiazolidinone in rats with cerebral ischemia reperfusion injuries. Oncotarget. 2017 May 22. doi: 10.18632/oncotarget.18048.
14. Dongmei Li#, Ji Zheng#, Mingyang Wang, Lu Feng, Yanyong Liu*, Nan Yang*, Pingping Zuo. Wuling powder prevents the depression-like behavior in learned helplessness mice model through improving the TSPO mediated-mitophagy. Journal of Ethnopharmacology. 2016; 186：181-188.
15. Dongmei Li, Ji Zheng, Mingyang Wang, Lu Feng, Yanyong Liu*, Nan Yang*, Pingping Zuo. Changes of TSPO-mediated mitophagy signaling pathway in learned helplessness mice. Psychiatry Research. 2016; 245:141-147.
16. Zhili Ren#, Nan Yang#, Chao Ji, Ji Zheng, Tao Wang, Yanyong Liu*, Pingping Zuo*. Neuroprotective effects of 5-(4-hydroxy-3-dimethoxybenzylidene)- thiazolidinone in MPTP induced Parkinsonism model in mice. Neuropharmacology. 2015;93:209-218.
17. Nan Yang#, Zhili Ren#, Ji Zheng#, Lu Feng, Dongmei Li, Kai Gao, Lianfeng Zhang, Yanyong Liu*, Pingping Zuo. 5-(4-hydroxy-3-dimethoxybenzylidene)-rhodanine (RD-1)-improved mitochondrial function prevents anxiety- and depressive-like states induced by chronic corticosterone injections in mice. Neuropharmacology 2016; 105: 587-593.
18. Rui Zhang, Nan Yang, Chao Ji, Ji Zheng, Zhen Liang, Chun-Ying Hou, Yan-Yong Liu*, Ping-Ping Zuo*. Aceglutamide attenuated motor dysfunctions induced by cerebral ischemia injury through suppressing TRAF1-mediated apoptosis signaling pathway. Restorative Neurology and Neuroscience 2015; 33:741–759.
19. Nan Yang, He Liu, Yao Jiang, Ji Zheng, Dong-mei Li, Chao Ji, Yan-yong Liu*, Pingping Zuo. Improved cognitive function in minimal hepatic encephalopathy rat model：neuroplasticity enhancement. Neural Regeneration Research. 2015, 10(9):1457-1462.
20. Jie Xu, Rui Zhang, Pingping Zuo, Nan Yang, Chao Ji, Weiran Liu, Yun Wang, Hui Wang, Anshi Wu, Yun Yue, Yanyong Liu*. Aggravation Effect of Isoflurane on Ab25–35-Induced Apoptosis and Tau Hyperphosphorylation in PC12 Cells. Cell Mol Neurobiol 2012; 32:1343–1351. （11）
21. Tao Wang#, Yanyong Liu#, Nan Yang, Chao Ji, Piu Chan, Pingping Zuo. Anti-parkinsonian effects of octacosanol in MPTP-treated mice. Neural Regen Res. 2012;7(14):1080-1087. (Co-author).
22. Yanyong Liu#, Haji AkberAisa, Chao Ji, Nan Yang, Haibo Zhu, PingpingZuo. Effects of GossypiumHerbaceam Extract Administration on the Learning and Memory Function in the Naturally Aged Rats: Neuronal Niche Improvement. J Alzheimer’s Dis 2012; 31:101–111.
23. Yanyong Liu, Nan Yang, Wenyu Hao, Qing Zhao, Tianyi Ying, Shangyi Liu, Qing Li, Yan Liang, Tao Wang, Yilong Dong, Chao Ji, and Pingping Zuo. Dynamic proteomic analysis of protein expression profiles in whole brain of Balb/c mice subjected to unpredictable chronic mild stress: implications for depressive disorders and future therapies. NeurochemInt 2011; 58: 904-913.
24. Yanyong Liu, Nan Yang, PingpingZuo. cDNA microarray analysis of gene expression in the cerebral cortex and hippocampus of Balb/c mice. Cell Mol Neurobiol 2010;30(7):1035-1047.
25. Yan-yong Liu, Ling Hu, Chao Ji, Dongwen Chen, Xi Shen, Nan Yang, Yun Yue, Jing-mei Jiang, Xia Hong, Qinsheng Ge, Pingping Zuo. Effects of hormone replacement therapy on magnetic resonance imaging of brain parenchyma hyperintensities in postmenopausal women. Acta Pharmacologica Sinica 2009; 30: 1065–1070.
26. Qing Zhang*, Yanyong Liu*, Nan Yang, Xuancai Wan, Pingping Zuo. Nasal administration of cholera toxin B subunit-nerve growth factor improves the space learning and memory abilities in β-amyloid protein25-35-induced amnesic mice. Neuroscience 2008; 155: 234–240.（Co-author）.