章晓辉
职称：教授,博士生导师
研究领域 ：
电话：（86-10）5880-4978
通讯地址：北京师范大学3号院315B室
邮编：100875
电子邮件：xhzhang#bnu.edu.cn
课题组网址：http://brain.bnu.edu.cn/home/xhzhang/index.php

简 介
研究方向
研究人员
论文成果
图片


1994年毕业于杭州大学生物系，1999年获中国科学院上海生理所神经生物学博士学位。1999-2002年在美国UC San Diego 和UC Berkeley从事神经可塑性方面博士后研究，期间获International Human Frontier Science Program（HFSP）long-term fellowship资助。2003年获中科院“引进国外杰出人才（）”资助，任中科院神经科学所神经可塑性组联合组长；2004-2006获HFSP Career Development Award；2007-2013任中科院神经科学所神经元信息处理与可塑性组组长，研究员，博士生导师；2010年获中国科学院优秀研究生指导教师奖与赛洛菲•安万特优秀青年科学家奖（SIBS-Sanofi Aventis Yong Faculty Award）。2013年9月，加入北京师范大学认知神经科学和学习国家重点实验室。
实验室采用（在体和脑片）电生理、光遗传学、双光子激光细胞显微成像与神经疾病转基因小鼠模型，解析海马-大脑皮层功能性环路（特别是γ-氨基丁酸GABA能抑制性环路）的长程和局部神经连接（突触）的基本规则、及其学习或早期经验对环路连接的修饰机制（“关键期”可塑性），以阐明学习和脑可塑性的神经环路机制、以及神经精神发育性疾病（瑞特综合症、精神分裂症）发生和发展相关的异常环路机理。
见实验室网页：http://brain.bnu.edu.cn/home/xhzhang/index.php
Li Y.D., Xu J.M., Liu Y.F., Zhu J., Liu N., Zeng W.B., Huang N., Rasch M.J., Jiang H.F., Gu X., Li X., Luo M.H., Li C.Y., Teng J.L., Chen J.G., Zeng S.Q., Lin L.N., and Zhang X.H.* (2017) A distinct entorhinal cortex to hippocampal CA1 direct circuit for olfactory associative learning. Nat Neurosci. 20:559–570 doi:10.1038/nn.4517. Cover Story
Miao Q.L., Yao L., Malte J.R., Ye Q., Li X. and Zhang X.H.* (2016) Selective maturation of temporal dynamics of intracortical excitatory transmission at the critical period onset. Cell Rep. 16, 1677–1689, http://dx.doi.org/10.1016/j.celrep.2016.07.013.
Chen G., Rasch M.J., Wang R. and Zhang X.H.* (2015) Experience-dependent emergence of beta and gamma band oscillations in the primary visual cortex during the critical period. Sci Rep. 5, 17847; doi: 10.1038/srep17847.
Liu Y.G.^#, Miao Q.L. ^#, Yuan J.C, Rao Z.P., Ye Q., Geng J.L., Zhang. X.H.*, and Cheng L.P.* (2015) Ascl1 converts dorsal midbrain astrocytes into functional neurons in vivo. J. Neurosci. 35(25):9336-9355 (^#: equal contribution).
He L.J., Liu N., Chen T.L., Chen X.J., Li Y,D., Shu Y.S., Qiu Z.L., and Zhang X.H.* (2014) Conditional deletion of MeCP2 in parvalbumin-expressing GABAergic cells results in absence of critical period plasticity. Nat. Commun. 5:5036 doi: 10.1038/ncomms6036.
Chen X.J., Rasch M., Chen G., Wu S., Zhang X.H.* (2014) Binocular input coincidence mediates the critical period plasticity of developing mouse visual cortex. The Journal of Neuroscience, 34: 2940-2955.
Gong L.Q., He L.J., Dong Z.Y., Lu X.H., Poo M.M.*, Zhang X.H.* (2011) Post-induction requirement of NMDA receptor activation for late phase long-term potentiation of developing retinotectal synapses in vivo. The Journal of Neuroscience, 31 3328-3335.
Ye C.Q., Poo M. M., Dan Y., Zhang X.H.* (2010) Synaptic mechanisms of direction selectivity in primary auditory cortex. The Journal of Neuroscience, 30: 1861-1868.
Zhang X.H.*, Poo M.M. (2010) Progress in neural plasticity. Science in China Life Sciences, 53: 322-329. (Invited review in the special issue: Neuroscience in China 2000-2009)
Hao, J., Wang, X., Dan, Y., Poo, M. M.*, Zhang, X.H.* (2009) A simple arithmetic rule for spatial summation of excitatory and inhibitory inputs in pyramidal neurons. Proceedings of National Academy of Sciences USA, 106: 21906-21911.
Zhang S.Y., Xu M., Miao Q.L., Poo M.M.*, Zhang X.H.* (2009) Endocannabinoid- dependent homeostatic regulation of inhibitory synapses by miniature excitatory synaptic activities. The Journal of Neuroscience, 29: 13222-13231.
Gao L.X., Meng X.K., Ye C.Q., Liu C.H., Zhang H.T., Dan Y., Poo M.M., He J., Zhang X.H.* (2009) Entrainment of show oscillations of auditory thalamic neurons by repetitive sound stimuli. The Journal of Neuroscience, 29: 6023-6031.
Xu C., Zhao M.X., Poo M.M.*, Zhang X.H.* (2008) GABA_B receptor activation mediates frequency-dependent plasticity of developing GABAergic Synapses. Nature Neuroscience, 11:1410-1418. (Highlighted by Nature China)
Lu J.T., Li C.Y., Poo M.M.*, Zhang X.H.* (2007) Spike timing-dependent plasticity of neocortical excitatory synapses on inhibitory interneurons depends on target cell type. The Journal of Neuroscience, 27: 9711-9720.