郑厚峰博士（国家中组部青年“****”）
Houfeng Zheng,M.D, Ph. D.












“作为一位刚刚归国的年轻科学家，希望与高研院一起成长，一起见证真正的世界一流大学出现在中国。”




一、个人简介




郑厚峰，2004届临床医学本科毕业，2010年获医学博士学位，加拿大麦吉尔大学（McGill University）人类遗传学博士后（2010--2014）。2015年入选第十一批国家中组部青年“****”专家，同年入选杭州市侨界十大杰出人物。现为杭州师范大学教授，杭州欧美同学会理事。主要技术专长是利用生物信息学手段对遗传学大数据进行分析。基因型推演（Genotype imputation）技术，和二代测序大数据分析包的建立。熟悉各种生物统计软件的应用和编程。获得国家执业医师资格证书，熟练掌握常见皮肤病性病的诊疗。

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二、学术成果




一直致力于复杂疾病易感基因的遗传学研究。首次应用全基因组关联分析方法在中国汉族人群中发现系统性红斑狼疮多个易感基因；与新加坡国立基因组研究所合作发现中国从南到北各个省份汉族人遗传结构；应用meta分析和全基因组关联分析的方法，首次发现高加索人群腕部骨质疏松，骨折和骨厚度的易感基因；参与英国万人基因组计划（UK10K project, http://www.uk10k.org/），做为骨疾病项目的主要执行人，挖掘影响骨质密度的罕见变异。

先后在Nature、Nature Genetics、American Journal of Human Genetics、PLoS Genetics和Journal of Medical Genetics等SCI杂志发表第一作者和通讯作者论文21篇，在New England Journal Medicine，Nature和Nature Review Genetics等SCI杂志发表共同作者论文22篇。论文累计引用次数在GoogleScholar数据库中为3400余次。受邀编写美国Nova出版社出版的英文专著《Dermatology Research Advances》的“Research Strategies for Genetic Skin Disease”章节。受BoneKEy杂志特邀写关于骨质疏松罕见变异的评论文章，受Expert Reviews in Molecular Medicine杂志和Nature Review Genetics邀请写关于骨质疏松遗传学研究综述，受《中华内分泌代谢杂志》邀请书写骨质疏松遗传学专题。受美国人类遗传学年会和欧洲钙化组织学会邀请做大会报告。美国人类遗传学会议评审，国家自然科学基金评审。主持加拿大国立卫生研究院CIHR基金1项（2010--2013），国家自然科学基金1项（2016--2018），高层次留学回国人员在杭创业创新项目1项（2016）。浙江省自然科学基金杰出青年项目一项（2017-2020）。

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三、代表论文




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Book Chapters:
1.Zheng HF. Population genetics and its relevance to gene mapping In Yin X(Ed.),Statistical Genetics: Gene Mapping through Linkage and Association (pp.62-79).Beijing, Peoples Military Medical Press (2017). (Translation)

2.Zheng HF. ResearchStrategies for Genetic Skin Disease In Liang Y(Ed.), Dermatology Research Advances(pp.317-348).New York, NY: Nova (2014).

3.Xiao FL,Zheng HF. Hailey-Hailey DiseaseIn Zhang XJ(Ed.), Clinical case consultation and review-Dermatology Volume (pp82-83).Beijing, Peoples Military Medical Press (2008) (In Chinese).



Journal Articles:

First and corresponding author papers

*Equal contribution

?Corresponding Author

2017

1.XM Lyu, XW Zhu, M Zhao, XB Zuo, ZX Huang,…&HF Zheng?, X Li?. A regulatory mutant on TRIM26 conferring the risk ofnasopharyngeal carcinoma by inducing low immune response.Human Molecular Genetics2017 (under review)

2.Hu LY, Cheng Z, Zhang B, Yin Q, Zhu XW, Zhao PP, Han MY, Wang XB,ZhengHF?. Associationsbetween PTPN22 and TLR9 polymorphisms and systemic lupus erythematosus: acomprehensive meta-analysis.Arch Dermatol Res. 2017 Aug;309(6):461-477.

3.Zhu XW, Zhao PP,Zheng HF?. Insights into the geneticdeterminants of osteoporosis and related traits from genome-wide studies. ChinJ Endocrinol Metab. 2017 Apr; 33:276-284 (In Chinese)

4.Niu YF, Ye C, He J, Han F, Guo LB,Zheng HF?, Chen GB?. Reproducing and In-DepthEvaluation of Genome-Wide Association Studies and Genome-Wide Meta-AnalysesUsing Summary Statistics. G3 (Bethesda). 2017 Mar 10;7(3):943-952.
2016

5.Chou WC*,Zheng HF*,Cheng CH, Yan H, Wang L, Han F, Richards JB, Karasik D, Kiel DP, Hsu YH. A combinedreference panel from the 1000?Genomes and UK10K projects improved rare variantimputation in European and Chinese samples. Sci Rep. 2016 Dec 22;6:39313. doi:10.1038/srep39313.

6.Zhu XW, Wang Y, Wei YH, Zhao PP, Wang XB, Rong JJ, Zhong WY, Zhang XW, Wang L,Zheng HF?.Comprehensive Assessment of theAssociation between FCGRs polymorphisms and the risk of systemic lupuserythematosus: Evidence from a Meta-Analysis. Sci Rep. 2016 Aug 19;6:31617.
2015

7.Zheng HF,Forgetta V, Hsu YH, Estrada K, Rosello-Diez A, Leo PJ, Dahia CL, Park-Min KH, Tobias JH, Kooperberg C, et al. Whole-genomesequencing identifies EN1 as a determinant of bone density and fracture.Nature.2015 Oct 1;526(7571):112-7.

8.Guo BR, Rong JJ, Wei YH, Zhong WY, LiCS, Liu M, Li W, Wang XB, Wang L,ZhengHF?. Ethnicity-stratifiedanalysis of the association between IL-18 polymorphisms and systemic lupuserythematosus in a European population: a meta-analysis.Arch Dermatol Res. 2015Oct;307(8):747-55.

9.Rong J*,Zheng H*,Liu M, et al. Probiotic and anti-inflammatoryattributes of an isolate Lactobacillus helveticus NS8 from Mongolian fermentedkoumiss. BMC Microbiol. 2015 Oct 2;15(1):196.

10.Zheng HF?,Rong JJ, Liu M, Han F, Zhang XW,Richards JB, Wang L. Performance of genotype imputation for low frequency andrare variants from the 1000 genomes. PLoS One. 2015 Jan 26;10(1):e0116487.
2013-2014

11.Li CS, GuoBR, Guo Z, Yang J,Zheng HF?,Wang AL?. Associationbetween C-reactive protein gene +1059 G/C polymorphism and the risk of coronaryheart disease: a meta-analysis. Chin Med J. 2013 Dec;126(24):4780-5.

12.Shen FF,Zhou FY, Xue QS, Pan Y, Zheng L, Zhang H, Wang LD,Zheng HF?. Association between CYP1A1 polymorphisms andesophageal cancer: a meta-analysis. Mol Biol Rep. 2013 Oct;40(10):6035-42.

13.Zheng HF. Anexample design of large-scale next generation sequencing study for bone mineraldensity. IBMS BoneKEy 10: 398 (2013)/doi:10.1038/bonekey.2013.132

14.Zheng HF?,Duncan EL,et al.Meta-analysis of genome-wide studies identifies MEF2C SNPsassociated with bone mineral density at forearm.J MedGenet. 2013 Jul;50(7):473-8.

15.Ladouceur M*,Zheng HF*,Greenwood CM,Richards JB. Empirical power of very rare variants for common traits anddisease: results from sanger sequencing 1998 individuals. Eur J Hum Genet. 2013Jan 16. doi: 10.1038/ejhg.2012.284.
2012

16.Zheng HF?,Ladouceur M, Greenwood CM, Richards JB?. Effect ofgenome-wide genotyping and reference panels on rare variants imputation. JGenet Genomics. 2012 Oct 20;39(10):545-50.

17.Zheng HF, Tobias JH, Duncan E, Evans DM, Eriksson J, et al. (2012) WNT16Influences Bone Mineral Density, Cortical Bone Thickness, Bone Strength, andOsteoporotic Fracture Risk.PLoS Genet.2012 Jul;8(7): e1002745. doi:10.1371/journal.pgen.1002745



2011

18.Zheng HF, Spector TD, Richards JB. Insights into the genetics ofosteoporosis from recent genome-wide association studies.Expert Rev Mol Med.2011 Aug 26;13:e28.

19.Zheng HF, Zuo XB, Lu WS, Li Y, ChengH, Zhu KJ,et al.Variants in MHC,LCE and IL12B have epistatic effects on psoriasis risk in Chinese population. JDermatol Sci. 2011 Feb;61(2):124-8.

20.Zhang C*, Zhu KJ*,Zheng HF*, Cui Y,et al.The Effect of Overweight andObesity on Psoriasis Patients in Chinese Han Population: a hospital-basedstudy. J Eur Acad Dermatol Venereol. 2011 Jan;25(1):87-91.
2008-2010

21.Zheng HF, Zhang C, Sun LD, Ni C, Zuo XB, Zhang Z,et al.A Single Nucleotide Polymorphismof MHC region is associated with Subphenotypes of Psoriasis in Chinesepopulation. J Dermatol Sci. 2010 Jul;59(1):50-2.

22.Chen J*,Zheng H*,Bei JX,et al.Genetic Structure of the HanChinese Population Revealed by Genome-wide SNP Variation,Am J Hum Genet.2009 Dec;85(6):775-85.

23.Han JW*,Zheng HF*,Cui Y*,Sun LD, Ye DQ, Hu Z, et al.Genome-wide association study in a Chinese Han population identifies nine newsusceptibility loci for systemic lupus erythematosus.Nat Genet.2009 Nov;41(11):1234-7.

24.Zheng HF,Wang PG, Yang S,Zhang XJ. Molecular genetic advances of Peutz-Jeghers syndrome. InternationalJournal of Genetics. 2008; 31(3), 227-229. (In Chinese)



四、联系方式




电子邮箱：zhenghoufeng@wias.org.cn

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